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Saturday, September 3, 2005
1:30 PM–4:30 PM
Garden A/B Room
Attendance is free of charge.
THE HUMN WORKSHOP
Chairs: Errol Zeiger, Errol Zeiger Consulting, Chapel
Hill, NC, United States and
Michael Fenech, CSIRO Health Science and Nutrition, Adelaide, SA, Australia
The HUMN project is an international collaboration involving 35 labs from
22 countries aimed at studying the frequency of micronuclei and the relevance
of this endpoint in human populations. This project was originally launched
at the 7th ICEM in Toulouse. We have since had a workshop at each ICEM and
ICEMHP aimed at updating knowledge about the use of the micronucleus assay
in human populations, reviewing progress of our research program, and launching
new initiatives. All registered 9th ICEM attendees are encouraged to attend.
The purpose of the HUMN project would be to:
- Review new knowledge on the mechanisms of micronucleus formation and
related biomarkers (nucleoplasmic bridges, nuclear buds) which has emerged
over the past 4 years.
- Review new data relating to the CBMN assay (e.g. effect of diet, genotypes,
related biomarkers measured in the same assay etc.)
- Report results of the HUMN project prospective study linking micronucleus
frequency in lymphocytes with cancer risk, which will be completed at the
end of this year.
- Report outcome of buccal cell micronucleus assay review (currently underway).
- 1:30 PM BRIEF INTRODUCTION TO
THE HUMN PROJECT, HISTORY, MISSION AND OBJECTIVES
- Errol Zeiger, Errol Zeiger Consulting, Chapel Hill, NC, Untied
States
- 1:45 PM REVIEW OF NEW KNOWLEDGE
ON THE MECHANISMS OF MICRONUCLEUS FORMATION AND RELATED BIOMARKERS (NUCLEOPLASMIC
BRIDGES, NUCLEAR BUDS) AND EFFECTS OF MICRONUTRIENTS
- Michael Fenech, CSIRO Health Science and Nutrition, Adelaide,
SA, Australia.
- 2:10 PM #3 REVIEW OF THE EFFECT
OF OCCUPATIONAL EXPOSURE TO GENOTOXINS AND GENOTYPE ON MICRONUCLEUS FREQUENCIES
IN HUMAN POPULATIONS
- Micheline Kirsch-Volders,Vrije Universiteit Brussels, Brussels,
Belgium
- 2:35 PM RESULTS OF THE HUMN
PROJECT PROSPECTIVE STUDY LINKING MICRONUCLEUS FREQUENCY IN LYMPHOCYTES
WITH CANCER RISK WHICH WAS COMPLETED IN 2005
- Stefano Bonassi, National Cancer Research Institute, Genova,
Italy
- 3:05 PM DISCUSS CURRENT STATUS
AND PROSPECTS FOR AUTOMATION OF MICRONUCLEUS ASSAYS BY FLOW CYTOMETRY
- Steve Dertinger, Litron Laboratories, Rochester, NY, United
States
- 3:30 PM REPORT OUTCOME OF BUCCAL
CELL MICRONUCLEUS ASSAY REVIEW AND DISCUSSION OF FEASIBILITY AND SCOPE OF
A HUMN BUCCAL CELL PROJECT
(ESTABLISHMENT OF SCORING CRITERIA, INTER-LABORATORY SLIDE SCORING, AND INTERNATIONAL
DATA BASE COLLATION/COMPARISON/ANALYSIS TO IDENTIFY KEY METHODOLOGICAL, DEMOGRAPHIC
AND GENETIC VARIABLES)
- Claudia Bolognesi, National Cancer Research Institute, Genoa,
Italy
- 4:00 PM OPEN DISCUSSION ON FUTURE
OF HUMN PROJECT
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