Wednesday, September 7, 2005

Wednesday, September 7, 2005
7:30 AM–12:30 PM
Market Street Foyer

REGISTRATION OPEN

Wednesday, September 7, 2005
7:00 AM–8:30 AM

EDUCATION AND STUDENT AFFAIRS COMMITTEE

(Garden A/B)

HOLLAENDER COMMITTEE

(Marina Room)

GENOMICS AND NEW TECHNOLOGIES SPECIAL INTEREST GROUPS

(Seacliff C/D)

Wednesday, September 7, 2005
8:30 AM–9:15 AM
Grand Ballroom

PLENARY LECTURE—EUGENIA DOGLIOTTI

Introduction

Silvio De Flora, President of the 10^th ICEM, University of Genoa, Italy

#666 CELL-TYPE SPECIFICITY IN DNA DAMAGE RESPONSE:
THE EXAMPLE OF SKIN CELLS

Eugenia Dogliotti, Istituto Superiore di Sanitá, Rome, Italy

Wednesday, September 7, 2005
9:15 AM–10:00 AM
Grand Ballroom

PLENARY LECTURE—INDER M. VERMA

Introduction

C. K. K. Nair, Representative of the Indian Environmental Mutagen Society (IEMS), Bhabha Atomic Research Centre, Mumbai, India

#667 THE PROMISES AND PITFALLS OF GENE THERAPY

Inder M. Verma, The Salk Institute, La Jolla, CA, United States

Wednesday, September 7, 2005
10:00 AM–10:30 PM
Grand Ballroom Foyer

REFRESHEMENT BREAK

Wednesday, September 7, 2005
10:30 AM–12:30 PM
Grand Ballroom B

CURRENT ISSUES SYMPOSIUM—ENVIRONMENTAL MUTAGENESIS/CARCINOGENESIS

ANIMAL MODELS FOR ENVIRONMENTAL CARCINOGENESIS AND PREVENTION

Chairs: Toby G. Rossman, New York University, Tuxedo, NY, United States and
Silvio De Flora, University Genoa, Genoa, Italy

Sponsored by US EPA, Office of Research and Development

10:30 AM #668 IDENTIFICATION OF HUMAN CANCER MODIFIER GENES USING MOUSE MODELS

Allan Balmain, University California, San Francisco, CA, United States

11:00 AM INFILTRATIVE IMMUNE REGULATION OF TUMOR ANGIOGENESIS

Douglas Hanahan, University California, San Francisco, CA, United States

11:30 AM #669 TRANSPLACENTAL CARCINOGENESIS BY ENVIRONMENTAL AGENTS

Michael P. Waalkes, NIEHS, Research Triangle Park, NC, United States

11:50 AM #670 THE HAIRLESS MOUSE MODEL FOR COCARCINOGENESIS AND CHEMOPREVENTION

Toby G. Rossman, New York University, Tuxedo, NY, United States

12:10 PM #671 PREVENTION OF TOBACCO AND UV CARCINOGENESIS

Silvio De Flora, University Genoa, Genoa, Italy

Wednesday, September 7, 2005
10:30 AM–12:30 PM
Bayview

CURRENT ISSUES SYMPOSIUM—DNA REPAIR

APOPTOSIS: MECHANISMS AND THERAPEUTIC TARGETS

Chairs: Bernd Kaina, University Mainz, Mainz, Germany and
Mats Ljungman, University of Michigan, Ann Arbor, MI, United States

10:30 AM #672 DNA DAMAGE-TRIGGERED APOPTOSIS: CRITICAL LESIONS AND PATHWAYS

Bernd Kaina, University Mainz, Mainz, Germany

11:00 AM #673 ROLE OF APOPTOSIS IN CANCER THERAPY AND TISSUE TOXICITY

Andrei V. Gudkov, Cleveland Clinic, Cleveland, OH, United States

11:30 AM #674 REGULATION OF DIFFERENTIATION AND APOPTOSIS BY GENOTOXIC STRESS

Jean Y.J. Wang, University of California, San Diego, CA, United States

11:50 AM #675 TRANSCRIPTION AS A THERAPEUTIC APOPTOSIS-INDUCING TARGET

Mats Ljungman, University of Michigan, Ann Arbor, MI, United States

12:10 PM #676 DNA DAMAGE AND REPLICATION INVOLVED IN UV-INDUCED APOPTOSIS IN DNA REPAIR DEFICIENT HUMAN CELLS

Carlos F. Menck, University Sao Paulo, Sao Paulo, Brazil

Wednesday, September 7, 2005
10:30 AM–12:30 PM
Grand Ballroom A

CURRENT ISSUES SYMPOSIUM—DNA REPAIR

ENVISIONING DNA DAMAGE AND REPAIR RESPONSES: STRUCTURAL BIOLOGY FROM ATOMS TO CELLS

Chairs: John A. Tainer, The Scripps Research Institute, La Jolla, CA, United States and
Roland Kanaar, Erasmus University, Rotterdam, Netherlands

10:30 AM #677 MULTI-PROTEIN REPAIR MACHINES: FROM MIRACLES TO MOLECULES

John A. Tainer, The Scripps Research Institute, La Jolla, CA, United States

11:00 AM #678 SUPRAMOLECULAR ASSEMBLIES FOR CELLULAR DNA REPAIR

Claire Wyman, Erasmus University, Rotterdam, Netherlands

11:30 AM #679 NONHOMOLOGOUS END-JOINGING BY CELL-FREE EXTRACTS

Gilbert Chu, Stanford University Medical Center, Stanford, CA, United States

11:50 AM #680 STRUCTURE AND MECHANISM OF RecBCD

Dale B. Wigley, London Research Institute, Hertfordshire, United Kingdom

12:10 PM #681 MANAGING DNA STRAND BREAKS: CRYSTAL STRUCTURES AND CATALYTIC SELECTIVITIES OF DNA LIGASES

Tom Ellenberger, Harvard Medical School, Boston, MA, United States

Wednesday, September 7, 2005
10:30 AM–12:30 PM
Seacliff C/D

CURRENT ISSUES SYMPOSIUM—MUTAGENESIS AND HUMAN DISEASE

NUTRIGENOMICS: A SYSTEMS BIOLOGY APPROACH TO STUDYING GENE-DIET INTERACTIONS

Chairs: Lynn R. Ferguson, University Auckland Medical School, Auckland, New Zealand and
Michael Fenech, CSIRO, Adelaide, SA, Australia

Sponsored by National Institutes of Health, Office of Dietary Supplements

10:30 AM #682 NUTRITIONAL GENOMICS: THE NEXT FRONTIER IN THE POST-GENOMIC ERA

James Kaput, UC Davis Centre of Excellence in Nutrigenomics, Davis, CA, United States

11:00 AM #683 SEEING THE TREES IN THE FOREST: REDUCING THE DIMENSIONALITY OF COMPLEX DATASETS

Kevin Dawson, UC Davis Centre of Excellence in Nutrigenomics, Davis, CA, United States

11:30 AM #684 FOLATE, MTHFR POLYMORPHISMS AND GENOME INSTABILITY

Michael Fenech, CSIRO, Adelaide, SA, Australia

11:50 AM HUMAN DIVERSITY AND GENETIC EPIDEMIOLOGY

Jose M. Ordovas, USDA, Tufts University, Boston, MA, United States

12:10 PM #685 UNCOUPLING GENE-DIET INTERACTIONS IN INFLAMMATORY BOWEL DISEASE

Lynn R. Ferguson, University Auckland Medical School, Auckland, New Zealand

Wednesday, September 7, 2005
10:30 AM–12:30 PM
Seacliff A/B

CURRENT ISSUES SYMPOSIUM—RISK ASSESSMENT

TOXICO-INFORMATICS: EMERGING CAPABILITIES FOR IMPROVED PUBLIC DATA ACCESS AND EXPLORATION

Chairs: Ann M. Richard, US EPA, Research Triangle Park, NC, United States and
Andrew Worth, Institute for Health and Consumer Protection, Ispra, Italy

Sponsored by National Institute of Environmental Health Sciences and US EPA National Center for Computational Toxicology

10:30 AM #686 TOXICO-CHEMOINFORMATICS:EMERGING CAPABILITIES FOR IMPROVED PUBLIC DATA ACCESS AND EXPLORATION

Ann M. Richard, US EPA, Research Triangle Park, NC, United States

11:00 AM #687 OPEN-SOURCE TECHNOLOGIES FOR DATABASE PROCESSING AND ANALYSIS

Marc C. Nicklaus, NIH/NCI, Bethesda, MD, United States

11:30 AM #688 A STANDARDIZED GENETIC TOXICITY DATABASE FOR IMPROVED (Q)SAR IN COLLABORATION WITH US FDA

Chihae Yang, Leadscope, Inc., Columbus, OH, United States

11:50 AM #689 QSAR AND TOXICITY DATABASES WITHIN THE EUROPEAN UNION

Andrew Worth, Institute for Health and Consumer Protection, Ispra, Italy

12:10 PM #690 BUILDING A TOXICOGENOMICS KNOWLEDGE BASE

Michael D. Waters, NIEHS, Research Triangle Park, NC, United States

Wednesday, September 7, 2005

OPEN AFTERNOON (OPTIONAL TOURS)

Pre-registration is required for tours.

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