Thursday, September 8, 2005

Thursday, September 8, 2005
7:30 AM–1:30 PM
Market Street Foyer

REGISTRATION OPEN

Thursday, September 8, 2005
7:00 AM–8:30 AM

2006 PROGRAM COMMITTEE MEETING, 2ND MEETING

(Garden AB)

IAEMS BUSINESS MEETING, 2ND MEETING

(Seacliff A/B)

Thursday, September 8, 2005
8:30 AM–9:15 AM
Grand Ballroom

PLENARY LECTURE—TAKEHIKO NOHMI

Introduction

Jia Cao, Vice President of the Chinese Environmental Mutagen Society (CEMS), Third Military Medical University, Chongqing, P.R. China

#691 ENVIRONMENTAL MUTAGENESIS: FROM MOLECULES TO MAN

Takehiko Nohmi, NIHS, Tokyo, Japan

Thursday, September 8, 2005
9:15 AM–10:00 AM
Grand Ballroom

PLENARY LECTURE—SAM H. WILSON

Introduction

Malyn Chulasiri, President of the Thai Environmental Mutagen Society (TEMS), Mahidol University, Bangkok, Thailand

#692 ROLE OF POLYMERASES IN MUTAGENESIS AND DNA REPAIR

Sam H. Wilson, NIEHS, Research Triangle Park, NC, United States

Thursday, September 8, 2005
10:00 AM–10:30 AM
Grand Ballroom Foyer

REFRESHEMENT BREAK

Thursday, September 8, 2005
10:30 AM–12:30 PM
Grand Ballroom A

CURRENT ISSUES SYMPOSIUM—ENVIRONMENTAL MUTAGENESIS/CARCINOGENESIS

ENVIRONMENTAL FACTORS ASSOCIATED WITH HUMAN CANCER

Chairs: Martina L. Veigl, Case Western Reserve University, Cleveland, OH, United States and
Young-In Kim, University Toronto, Toronto, ON, Canada

Sponsored by Berlex, Inc.

10:30 AM TBA

 

11:00 AM #694 ENVIRONMENTAL FACTORS ASSOCIATED WITH HUMAN CANCER: BREAST CANCER

P. David Josephy, University Guelph, Guelph, ON, Canada

11:30 AM #695 H2AX IS A MARKER OF NUCLEOTIDE EXCISION REPAIR AND DNA REPLICATION IN XERODERMA PIGMENTOSUM AND COCKAYNE SYNDROME

James E. Cleaver, University California, San Francisco, CA, United States

11:50 AM #696 ENVIRONMENTAL FACTORS ASSOCIATED WITH COLON CANCER

Young-In Kim, University of Toronto, Toronto, ON, Canada

12:10 PM #697 ENVIRONMENTAL ESTROGENS AS CANCER RISK FACTORS

Suzanne E. Fenton, US EPA, Research Triangle Park, NC, United States

Thursday, September 8, 2005
10:30 AM–12:30 PM
Seacliff C/D

CURRENT ISSUES SYMPOSIUM—ENVIRONMENTAL MUTAGENESIS/CARCINOGENESIS

ENVIRONMENTAL MUTAGENS IN WATER, SOIL, AND SEDIMENT

Chairs: Takeshi Ohe, Kyoto Women’s University, Kyoto, Japan and
Kirby C. Donnelly, Texas A&M University, College Station, TX, United States

10:30 AM #698 EPIDEMIOLOGY OF DRINKING WATER

Kenneth Cantor, NIH/NCI, Bethesda, MD, United States

11:00 AM #699 MUTAGENS IN DRINKING WATER

Michael J. Plewa, University of Illinois, Urban, IL, United States

11:30 AM #700 MUTAGENS IN SURFACE WATERS

Tetsushi Watanabe, Kyoto Pharmaceutical University, Kyoto, Japan

11:50 AM #701 MUTAGENIC HAZARDS OF AQUATIC SEDIMENTS

Guosheng Chen, Health Canada, Ottawa, ON, Canada

12:10 PM #702 GENOTOXICITY OF SOILS

Kirby C. Donnelly, Texas A&M University, College Station, TX, United States

Thursday, September 8, 2005
10:30 AM–12:30 PM
Bayview

CURRENT ISSUES SYMPOSIUM—MUTATIONAL MECHANISMS

NEW FRONTIERS IN GERM-CELL RESEARCH

Chairs: Carole L. Yauk, Health Canada, Ottawa, ON, Canada and
Carol D. Swartz, US EPA, Research Triangle Park, NC United States

10:30 AM #703 LONG-TERM EFFECTS OF EXPOSURE TO RADIATION

Yuri E. Dubrova, University of Leicester, Leicester, United Kingdom

11:00 AM #704 MOLECULAR MECHANISMS OF PATERNALLY TRANSMITTED CHROMOSOMAL DAMAGE

Francesco Marchetti, Lawrence Livermore National Laboratory, Livermore, CA, United States

11:30 AM #705 TRANS GENERATIONAL EPIGENETIC ACTIONS OF ENDOCRINE DISRUPTORS ON THE MALE GERM LINE

Michael K. Skinner, Washington State University, Pullman, WA, United States

11:50 AM #706 THE CONSERVED PROTEIN-CODING TRANSCRIPTOME OF MAMMALIAN MALE GERM CELLS

Michael Primig, Biozentrum and Swiss Institute of Bioinformatics, Basel, Switzerland

12:10 PM #707 ROLE OF EPIGENETIC CHANGES IN RADIATION-INDUCED TRANSGENERATION CARCINOGENESIS

Olga Kovalchuk, University of Lethbridge, Lethbridge, AB, Canada

Thursday, September 8, 2005
10:30 AM–12:30 PM
Seacliff A/B

CURRENT ISSUES SYMPOSIUM—RISK ASSESSMENT

RISK ASSESSMENT AND GENETIC TOXICOLOGY

Chairs: Lutz Müller, Hoffmann-La Roche, Basel, Switzerland and
Kerry L. Dearfield, US EPA, Washington, DC, United States

Sponsored by Johnson & Johnson Pharmaceutical Research & Development

10:30 AM #708 INCORPORATION OF MOLECULAR ENDPOINTS INTO QUANTITATIVE CANCER RISK ASSESSMENTS

R. Julian Preston, US EPA, Research Triangle Park, NC, United States

11:00 AM #709 RISK FROM LOW DOSE EXPOSURE TO GENOTOXINS—STRATEGY AND EXAMPLES FROM GENOTOXIC IMPURITIES IN DRUG SUBSTANCES

Lutz Müller, Hoffmann-La Roche, Basel, Switzerland

11:30 AM #710 RISK ASSESSMENT OF METALS:
COBALT AS AN EXAMPLE

Micheline Kirsch-Volders, Free University of Brussels, Brussels, Belgium

11:50 AM #711 GERM CELL RISK ASSESSMENT OF ACRYLAMIDE

Kerry L. Dearfield, USDA, Washington, DC, United States

12:10 PM #712 PATHOGEN INACTIVATION BY PHOTOCHEMICAL TREATMENT OF PLATELETS: GENOTOXICITY TESTING AND RISK ASSESSMENT

Güenter Speit, University of Ulm, Ulm, Germany

Thursday, September 8, 2005
10:30 AM–12:30 PM
Grand Ballroom B

CURRENT ISSUES SYMPOSIUM—MUTATIONAL MECHANISMS

TRANSLESION DNA SYNTHESIS

Chairs: Fumio Hanaoka, Osaka University, Osaka, Japan and
Helle D. Ulrich, London Research Institute, Herts, United Kingdom

10:30 AM #713 TRANSLESION DNA SYNTHESIS IN 3D

Wei Yang, NIH/NIDDK, Bethesda, MD, United States

11:00 AM #714 INTERPLAY BETWEEN DNA POLYMERASES AND ACCESSORY FACTORS DURING LESION BYPASS AND MUTAGENESIS

Robert P. Fuchs, CNRS, Illkirch, France

11:30 AM #715 LAGGING-STRAND DNA SYNTHESIS AND GENOMIC STABILITY IN YEAST

Motoshi Suzuki, Nagoya University School of Medicine, Nagoya, Japan

11:50 AM #716 CONTROL OF DNA DAMAGE TOLERANCE BY UBIQUITIN AND SUMO

Helle D. Ulrich, London Research Institute, Herts, United Kingdom

12:10 PM #717 BIOCHEMICAL PROPERTIES OF DNA POLYMERASE ETA

Fumio Hanaoka, Osaka University, Osaka, Japan

Thursday, September 8, 2005
1:00 PM–3:00 PM
Seacliff A/B

CURRENT ISSUES SYMPOSIUM—RISK ASSESSMENT

DECISION-MAKING WITH GENETIC TOXICITY DATA

Chairs: David J. Kirkland, Covance Laboratories, Ltd., North Yorkshire, United Kingdom and
Marilyn J. Aardema, Procter & Gamble, Cincinnati, OH, United States

Sponsored by Covance, Inc.

1:00 PM #718 LESSONS FROM ANALYSES OF PREDICTION OF CARCINOGENICITY FROM GENOTOXICITY RESULTS

David J. Kirkland, Covance Laboratories, Ltd., North Yorkshire, United Kingdom

1:30 PM #719 ROLE OF IN VIVO TRANSGENIC MUTATION MODELS IN GENOTOXICITY TESTING

George R. Douglas, Health Canada, Ottawa, ON, Canada

2:00 PM #720 FDA POSITION ON INTERPRETATION OF POSITIVE GENOTOXICITY DATA

David Jacobson-Kram, US FDA, Rockville, MD, United States

2:20 PM #721 USE OF GENETIC TOXICOLOGY DATA IN ESTABLISHING A CARCINOGENIC MODE OF ACTION

Rita Schoeny, US EPA, Washington, DC, United States

2:40 PM #721A COMPARISON OF GENOTOXIC EFFECTS USING THE COMETASSAY IN TISSUES OF FEMALE Cyp2E1^-/-AND WILD-TYPE MICE TREATED WITH ACRYLAMIDE:
EVIDENCE CONSISTENT WITH A GLYCIDAMIDE-MEDICATED EFFECT

Leslie Recio, Integrated Laboratory Systems, Research Triangle Park, NC, United States

Thursday, September 8, 2005
1:00 PM–3:00 PM
Seacliff C/D

CURRENT ISSUES SYMPOSIUM—MUTAGENESIS AND HUMAN DISEASE

EPIGENETIC MECHANISMS LEADING TO HUMAN DISEASE

Chair: W. David Sedwick, Case Western Reserve University, Cleveland, OH, United States and
Jeffrey M. Besterman, MethylGene, Montreal, QC, Canada

1:00 PM #722 EPIGENETICS, EVOLUTION, AND HEALTH

Randy L. Jirtle, Duke University, Durham, NC, United States

1:30 PM #723 EPIGENETIC REPROGRAMMING:
MECHANIMS AND CONSEQUENCES

Victor V. Lobanenkov, NIH/NIAID, Bethesda, MD, United States

2:00 PM HYPERMETHYLATION AND MECHANISMS OF GENE SILENCING IN CANCER

James G. Herman, Johns Hopkins University, Baltimore, MD, United States

2:20 PM #724 MECHANISMS UNDERLYING DRUG-INDUCED EPIGENETIC HETEROTYPES IN CANCER CELLS

Martina Veigl, Case Western Reserve University, Cleveland, OH, United States

2:40 PM #725 EPIGENETIC REGULATION BY MG98 AND MGCD0103: FROM BENCH TO CLINIC

Jeffrey M. Besterman, MethylGene, Montreal, QC, Canada

Thursday, September 8, 2005
1:00 PM–3:00 PM
Grand Ballroom B

CURRENT ISSUES SYMPOSIUM—MUTAGENESIS AND HUMAN DISEASE

INHERITED DEFECTS, MUTAGENESIS, AND DNA REPAIR IN HUMAN NEUROLOGICAL DISEASE

Chairs: Cynthia T. McMurray, Mayo Clinic, Rochester, MN, United States and Keith W. Caldecott, University Sussex, Brighton, United Kingdom

1:00 PM #726 CHROMOSOMAL SINGLE-STRAND BREAK REPAIR AND NEURODEGENERATIVE DISEASE

Keith W. Caldecott, University Sussex, Brighton, United Kingdom

1:30 PM WHEN DNA REPAIR BECOMES MUTAGENIC: OGG1 AND MSH2/MSH3 COOPERATE TO CAUSE CAG EXPANSION EVENTS AND NEURONAL TOXICITY IN HUNTINGTON’S DISEASE

Cynthia T. McMurray, Mayo Clinic, Rochester, MN, United States

2:00 PM #727 DOUBLE-STRAND DNA BREAK REPAIR: IMPLICATIONS FOR OXIDATIVE DNA DAMAGE, NEURONS, AND AGING

Michael R. Lieber, University of Southern California, Los Angeles, CA, United States

2:20 PM #728 UBIQUITIN-ACTIVATING ENZYME E1 CORRECTS THE IMPAIRMENT IN NUCLEOTIDE EXCISION REPAIR IN TERMINALLY DIFFERENTIATED CELLS

Thierry Nouspikel, Stanford University, Stanford, CA, United States

2:40 PM #729 ATAXIA TELANGIECTASIA: LINKING ATM AND DNA DAMAGE TO NEURODEGENERATION

Peter J. McKinnon, St. Jude Childrens Research Hospital, Memphis, TN, United States

Thursday, September 8, 2005
1:00 PM–3:00 PM
Bayview

CURRENT ISSUES SYMPOSIUM—DNA REPAIR

MODELS AND MECHANISMS FOR PROCESSING DNA DAMAGE

Chairs: John M. Essigmann, MIT, Cambridge, MA, United States and
Robert H. Schiestl, UCLA, Los Angeles, CA, United States

1:00 PM #730 GENOTOXICITY AND REPAIR OF MODIFIED DNA BASES POSSIBLY RESPONSIBLE FOR SPONTANEOUS MUTAGENESIS

John M. Essigmann, MIT, Cambridge, MA, United States

1:30 PM #731 GENETIC AND ENVIRONMENTAL EFFECTS OF NON-HOMOLOGOUS END JOINING

Robert H. Schiestl, UCLA, Los Angeles, CA, United States

2:00 PM #732 TRANSCRIPTION PAST DNA ADDUCTS: BIOCHEMICAL
AND COMPUTER MODELING STUDIES

David A. Scicchitano, New York University, New York, NY, United States

2:20 PM #733 REGULATION OF HUMAN NUCLEOTIDE EXCISION REPAIR BY TUMOR SUPPRESSOR GENES

James M. Ford, Stanford University Medical School, Stanford, CA, United States

2:40 PM UV-DDB-BASED UBIQUITIN LIGASE AND NUCLEOTIDE EXCISION REPAIR

Vesna Rapic Otrin, University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States

Thursday, September 8, 2005
1:00 PM–3:00 PM
Grand Ballroom A

CURRENT ISSUES SYMPOSIUM—DNA REPAIR

POST-TRANSLATIONAL MODIFICATION OF DNA REPAIR ENZYMES

Chairs: Alan D. D’Andrea, Harvard Medical School, Boston, MA, United States and
Jesper Q. Svejstrup, London Research Institute, Herts, United Kingdom

1:00 PM #734 FUNCTIONAL ASPECTS OF SUMOYLATION OF HUMAN THYMINE DNA GLYCOSYLASE IN BASE EXCISION REPAIR

Roland Steinacher, University of Basel, Basel, Switzerland

1:30 PM #735 ACETYLATION OF DNA BASE EXCISION REPAIR PROTEINS IN MAMMALIAN CELLS

Sankar Mitra, University of Texas, Galveston, TX, United States

2:00 PM #736 UBIQUITINATION OF DAMAGE RECOGNITION FACTORS INVOLVED IN NUCLEOTIDE EXCISION REPAIR

Kaoru Sugasawa, RIKEN Institute, Saitama, Japan

2:20 PM #737 REGULATION OF THE FANCONI ANEMIA PATHWAY BY MONOUBIQUITINATION

Alan D. D’Andrea, Harvard Medical School, Boston, MA, United States

2:40 PM #738 UBIQUITINATION AND DEGRADATION OF RNA POLYMERASE II DURING DNA DAMAGE

Jesper Q. Svejstrup, London Research Institute, Herts, United Kingdom

Thursday, September 8, 2005
3:30 PM–5:30 PM
Marina Room

EMS COUNCIL MEETING

Thursday, September 8, 2005
6:30 PM–10:30 PM
San Francisco City Hall

BANQUET (MUST HAVE TICKET)

Transportation departs at 6:30 PM from Market Street Lobby.

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