Sunday, September 4, 2005

Sunday, September 4, 2005
7:00 AM–6:30 PM
Market Street Foyer

REGISTRATION OPEN

Sunday, September 4, 2005
7:00 AM–8:30 AM

2006 PROGRAM COMMITTEE MEETING, 1ST MEETING

(Garden A/B)

MOLECULAR EPIDEMIOLOGY SPECIAL INTEREST GROUP

(Seacliff A/B)

TRANSGENETIC/IN VITRO MUTAGENESIS SPECIAL INTEREST GROUP

(Seacliff C/D)

Sunday, September 4, 2005
8:30 AM–9:10 AM
Grand Ballroom

PLENARY LECTURE—LAWRENCE A. LOEB

Introduction

Hai Won Chung, President of the Korean Environmental Mutagen Society (KEMS), Seoul National University, Seoul, Korea

GENERATION OF MULTIPLE MUTATIONS IN CANCER

Lawrence A. Loeb, University of Washington, Seattle, WA, United States

9:10 AM–9:15 AM 10TH ICEM ANNOUNCEMENT

Silvio De Flora, University Genoa, Genoa, Italy

Sunday, September 4, 2005
9:15 AM–10:00 AM
Grand Ballroom

PLENARY LECTURE—NADRIAN C. SEEMAN

Introduction

Martina Veigl, President-Elect of the Environmental Mutagen Society (EMS), Case Western Reserve University, Cleveland, OH, USA

#5 NANOTECHNOLOGY AND THE DOUBLE HELIX

Nadrian C. Seeman, New York University, New York, NY, United States

Sunday, September 4, 2005
10:00 AM–10:30 AM
Grand Ballroom Foyer

REFRESHMENT BREAK

Sunday, September 4, 2005
10:30 AM–12:30 PM
Seacliff C/D

CURRENT ISSUES SYMPOSIUM—MUTAGENESIS AND HUMAN DISEASE

ANTIMUTAGENS AND PROSPECTS FOR CHEMOPREVENTION

Chairs: Young-Joon Surh, Seoul National University, Seoul, Korea and
Roderick H. Dashwood, Oregon State University, Corvallis, OR, United States

Sponsored by The Linus Pauling Institute and National Institutes of Health, Office of Dietary Supplements

10:30 AM #6 MOLECULAR TARGETS FOR BIOACTIVE FOOD COMPONENTS

John A. Milner, NIH/NCI, Bethesda, MD, United States

11:00 AM #7 CANCER CHEMOPREVENTION BY DIETARY CHLOROPHYLL AND CHLOROPHYLLIN: RELATIVE EFFICACIES AND ASSOCIATED MECHANISMS

George S. Bailey, Oregon State University, Corvallis, OR, United States

11:30 AM #8 POTENTIAL FOR DIETARY PHYTOCHEMICALS TO MODULATE DEREGULATED SIGNALING: INDOLE-3-CARBINOL AND RELATED AGENTS

Margaret M. Manson, University Leicester, Leicester, United Kingdom

11:50 AM #9 SIGNAL TRANSDUCTION PATHWAYS REGULATING COX-2 EXPRESSION: POTENTIAL MOLECULAR TARGETS FOR CHEMOPREVENTION

Young-Joon Surh, Seoul National University, Seoul, South Korea

12:10 PM #10 HDAC AS A NOVEL TARGET FOR
CHEMOPREVENTION: SULFORAPHANE AND OTHER DIETARY AGENTS

Roderick H. Dashwood, Oregon State University, Corvallis, OR, United States

Sunday, September 4, 2005
10:30 AM–12:30 PM
Grand Ballroom A

CURRENT ISSUES SYMPOSIUM—MUTAGENESIS AND HUMAN DISEASE

ENVIRONMENTAL DNA DAMAGE, REPAIR, AND AGING

Chairs: George M. Martin, University of Washington, Seattle, WA, United States and
Michael Fry, Technion—Israel Institute of Technology, Haifa, Israel

Sponsored by The Ellison Medical Foundation

10:30 AM #11 DNA TRANSACTIONS AND THE BIOLOGY OF AGING

George M. Martin, University of Washington, Seattle, WA, United States

11:00 AM #12 DNA TETRAPLEXES: ROLES IN NORMAL AND PATHOLOGICAL DNA TRANSACTIONS

Michael Fry, Technion—Israel Institute of Technology, Haifa, Israel

11:30 AM #13 DNA REPAIR DEFICIENCIES IN HUMAN PREMATURE AGING

Vilhelm A. Bohr, NIH/NIA, Baltimore, MD, United States

11:50 AM #14 THE ENZYMATIC ACTIVITIES OF THE WERNER SYNDROME PROTEIN ARE DISABLED BY SPECIFIC AMINO ACID POLYMORPHISMS

Lawrence A. Loeb, University of Washington, Seattle, WA, United States

12:10 PM #15 AGING AND CELLULAR RESPONSES TO DNA DAMAGE

Judith Campisi, Lawrence Berkeley National Laboratory, Berkeley, CA, United States

Sunday, September 4, 2005
10:30 AM–12:30 PM
Grand Ballroom B

CURRENT ISSUES SYMPOSIUM—MUTATIONAL MECHANISMS

NEW DEVELOPMENTS IN DNA DAMAGE PROCESSING

Chairs: Errol C. Friedberg, University of Texas, Dallas, TX, United States and Richard D. Wood, University Pittsburgh Cancer Institute, Pittsburgh, PA, United States

10:30 AM #16 DNA POLYMERASE KAPPA: A SPECIALIZED POLYMERASE FOR TRANSLESION DNA SYNTHESIS

Errol C. Friedberg, University of Texas, Dallas, TX, United States

11:00 AM #17 THE POLQ FAMILY AND DNA DAMAGE TOLERANCE IN HUMAN CELLS

Richard D. Wood, University of Pittsburgh Cancer Institute, PA, United States

11:30 AM #18 ROLE OF THE FANCONI ANEMIA CORE COMPLEX IN RESPONSE TO DNA DAMAGE

Weidong Wang, NIH/NIA, Baltimore, MD, United States

11:50 AM #19 NOVEL MOUSE CHROMOSOME INSTABILITY MUTANTS ISOLATED BY FORWARD GENETIC MUTAGENESIS SCREENS

John C. Schimenti, Cornell University, Ithaca, NY, United States

12:10 PM #20 CANCER-ASSOCIATED MUTANTS OF DNA POLYMERASE BETA

Joann B. Sweasy, Yale University, New Haven, CT, United States

Sunday, September 4, 2005
10:30 AM–12:30 PM
Bayview

CURRENT ISSUES SYMPOSIUM—RISK ASSESSMENT

RESPONSES TO LOW DOSES OF ENVIRONMENTAL MUTAGENS

Chairs: Pamela J. Sykes, Flinders Medical Center, Bedford Park, SA, Australia and
K. Sankaranarayanan, Leiden University Medical Center, Leiden, Netherlands

Sponsored by Electric Power and Research Institute (EPRI)

10:30 AM #21 INCORPORATING HORMESIS INTO THE RISK ASSESSMENT PARADIGM

Dennis Paustenbach, ChemRisk, San Francisco, CA, United States

11:00 AM #22 NON-LINEAR SOMATIC INTRACHROMOSOMAL RECOMBINATION IN VIVO

Pamela J. Sykes, Flinders Medical Center, Bedord Park, SA, Australia

11:30 AM #23 SUPPRESSION OF CHEMICAL TUMORIGENESIS AND LIFE SPAN PROLONGATION IN MICE BY LOW DOSE RATE IRRADIATION

Kazuo Sakai, Central Research Institute Electric Power Industry, Tokyo, Japan

11:50 AM #24 ADAPTIVE RESPONSE AND BYSTANDER EFFECTS IN HUMAN AND NON-HUMAN BIOTA

Carmel Mothersill, McMaster University, Hamilton, ON, Canada

12:10 PM #25 RISK ASSESSMENT OF GERM-CELL MUTAGENESIS

K. Sankaranarayanan, Leiden University Medical Center, Leiden, Netherlands

Sunday, September 4, 2005
10:30 AM–12:50 PM
Seacliff A/B

CURRENT ISSUES SYMPOSIUM—MUTAGENESIS AND HUMAN DISEASE

TRANSPLACENTAL EXPOSURE TO NUCLEOSIDE ANALOGS: MITOCHONDRIAL DAMAGE AND FETAL HEALTH

Chairs: Miriam C. Poirier, NIH/NCI, Bethesda, MD and
Simon A. Mallal, Royal Perth Hospital, Perth, Australia

Sponsored by National Cancer Institute, Office of Womens Health

10:30 AM #26 THE HIV PANDEMIC: BENEFITS AND RISKS OF EXPANDED THERAPY FOR MOTHER-TO-CHILD TRANSMISSION

William A. Blattner, Institute of Human Virology, Baltimore, MD, United States

11:00 AM #27 CLINICAL MITOCHONDRIAL DYSFUNCTION IN HIV-UNINFECTED CHILDREN FOLLOWING PERINATAL EXPOSURE TO NUCLEOSIDE

Stephane Blanche, Hospital Necker Enfants Malades, Paris, France

11:30 AM #28 ANTIRETROVIRAL THERAPY (ART)—ASSOCIATED CARDIOTOXICITY IN UNINFECTED BUT ART-EXPOSED INFANTS BORN TO HIV-INFECTED WOMEN: THE PROSPECTIVE NHLBI CHAART-1 STUDY

Steven E. Lipshultz, University of Miami School of Medicine, Miami, FL, United States

11:50 AM #29 INDUCTION AND PERSISTENCE OF MITOCHONDRIAL DNA MUTATIONS IN CHILDREN AND MICE EXPOSED IN UTERO TO ZIDOVUDINE OR COMBIVIR

Vernon E. Walker, Loveless Respiratory Research Institute, Albuquerque, NM, United States

12:10 PM #30 FETAL MITOCHONDRIAL DYSFUNCTION: LESSONS FROM A PRIMATE MODEL

Miriam C. Poirier, NIH/NCI, Bethesda, MD, United States

12:30 PM #31 MITOCHONDRIAL TOXICITY INDUCED BY ANTIRETROVIRAL NUCLEOSIDE ANALOG DRUGS

Simon A. Mallal, Royal Perth Hospital, Perth, Australia

Sunday, September 4, 2005
1:00 PM–3:00 PM
Pacific Concourse

POSTERS ATTENDED AND EXHIBITS OPEN

EXPOSURE, DETECTION, AND TOXICITY

Odd numbered posters will be attended from 1:00 PM–2:00 PM and even numbered posters will be attended from 2:00 PM–3:00 PM.

#32 CHARACTERIZATION OF THE EPIDERM™ HUMAN 3-D SKIN MODEL FOR GENOTOXICITY TESTING. Aardema, MJ¹, Curren, R², Hayden, P³, Munn, G², Gibson, D¹, Hu, T¹. ¹The Procter & Gamble Co, Cincinnati OH, United States, ²Institute for InVitro Sciences, Gaithersburg MD, United States, ³MatTek Corp, Ashland MD, United States.

#33 WITHDRAWN

#34 N-METHYL-N’-NITRO-N-NITROSOGUANIDINE-INDUCED MUTATIONS IN ADULTS AND EMBRYOS OF RPSL TRANSGENIC ZEBRAFISH. Amanuma, K, Nakamura, T, Nagaya, M, Aoki, Y. National Institute for Environmental Studies, Tsukuba, Japan.

#35 SYNTHESIS, CHARACTERIZATION AND ³²P-POSTLABELING ANALYSIS OF DNA ADDUCTS DERIVED FROM THE ENVIRONMENTAL CONTAMINANT 3-NITROBENZANTHRONE. Arlt, VM¹, Osborne, MR¹, Kliem, C², Hull, WE², Mirza, A¹, Bieler, CA², Schmeiser, HH², Phillips, DH¹. ¹Institute of Cancer Research, Sutton, Surrey, United Kingdom, ²German Cancer Research Center, Heidelberg, Germany.

#36 ASSESSMENT OF INITIATING AND PROMOTING ACTIVITY OF POSSIBLE CARCINOGENS BY A NOVEL CELL TRANSFORMATION ASSAY USING V-HA-RAS-TRANSFECTED BHAS CELLS. Asada, S, Sasaki, K, Yamakage, K, Tanaka, N, Umeda, M. Hatano Research Institute, Food and Drug Safety Center, Hadano, Japan.

#37 LOW DOSE EFFECTS IN THE MNRETS INDUCTION BY ACRIDINE ORANGE SUPRAVITAL STAINING AND FLOW CYTOMETRIC METHODS. Asano, N¹, Torous, D², Tometsko, C², Dertinger, S², Morita, T³, Hayashi, M³. ¹Nitto Denko Corp., Osaka, Japan, ²Litron Laboratories, Rochester, NY, United States, ³National Institute of Health Science, Tokyo, Japan.

#38 QUANTITATIVE COMPARISON OF REAL-TIME PCR AND ROLLING CIRCLE AMPLIFICATION. Asur, R, Kulkarni, R, Thomas, RA, Tucker, JD. Wayne State University, Detroit, MI, United States.

#39 AN ANALYSIS OF GENETIC TOXICITY, REPRODUCTIVE AND DEVELOPMENTAL TOXICITY, AND CARCINOGENICITY DATA: I. IDENTIFICATION OF CARCINOGENS USING SURROGATE ENDPOINTS. Matthews, EJ¹, Kruhlak, NL¹, Cimino, MC², Benz, RD¹, Contrera, JF¹. ¹US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff, Rockville, MD, United States, ²US Environmental Protection Agency, Office of Pollution Prevention and Toxics, Risk Assessment Division, Washington, DC United States.

#40 THE IMPACT OF OCCUPATIONAL EXPOSURE TO IRRADIATION IN CZECH NUCLEAR POWER PLANT WORKERS. Beskid, O¹, Dusek, Z¹, Chvatalova, I¹, Schmuczerova, J¹, Stavkova, Z¹, Milcova, A¹, Rossner, P², Rubes, J³, Sram, RJ¹. ¹Institute of Experimental Medicine and Health Institute of Central Bohemia, Prague, Czech Republic, ²National Institute of Public Health, Prague, Czech Republic, ³Veterinary Research Institute, Brno, Czech Republic.

#41 CO-ADMINISTRATION OF ABACAVIR AND LAMIVUDINE IS NEGATIVE IN THE RAT BONE MARROW MICRONUCLEUS TEST. Burman, M, Lynch, AM. Genetic Toxicology, GlaxoSmithKine R&D, Park Road, Ware, Herts, United Kingdom.

#42 EFFECTS OF Sophora flavescens ON REDUCTION OF THE SIDE EFFECTS IN CHEMOTHERAPEUTIC DRUGS. Kim, JC¹, Han, SW¹, Park, EJ², Byun, BH¹. ¹Dept. of Oriental Medicine, Daegu Haany University, Daegu, South Korea, ²Dept. of Food and Nutrition, Kyungnam University, Masan, South Korea.

#43 DETECTION OF ANEUGENIC AND CLASTOGENIC AGENTS USING P53 AS A MARKER OF GENOTOXICITY. Camacho, H, Roy, SK, Eastmond, DA. Environmental Toxicology Graduate Program, University of California at Riverside, Riverside, CA, United States.

#44 ANALYSIS OF MICRONUCLEI IN THE YOUNGEST RETICULOCYTES FROM PERIPHERAL BLOOD OF NASOPHARYNGEAL CANCER PATIENTS UNDERGOING RADIOTHERAPY BY A SINGLE-LASER FLOW CYTOMETER. Sun, LP, Li, DZ, Liu, ZM, Yang, LJ, Liu, JY, Cao, J. Preventive Medical College, Third Military Medical University, Chongqing, China.

#45 IN VITRO EVALUATION OF TINIDAZOLE (TNZ) AND ORNIDAZOLE (ONZ) BY EFFECT BIOMARKERS. López Nigro, MM, Gadano, AB, Carballo, MA. CIGETOX- Citogenética Humana y Genética Toxicológica- Departamento de Bioquímica Clínica- Facultad de Farmacia y Bioquímica- Universidad de Buenos Aires, Buenos Aires, Argentina.

#46 MUTAGENICITY SURVEY OF AIRBORNE PARTICLES PM10 IN THE CZECH REPUBLIC, 1996-2003. Cerna, M, Pastorkova, A, Smid, J. National Institute of Public Health, Prague, Czech Republic.

#47 BIOLUMINESCENT REVERSE MUTATION ASSAY VALIDATION USING E. coli (WP2 uvrA pKM101) AND SALMONELLA STRAINS TA 1535 AND TA1537. Cheung, JR, Osowski, JJ, Aubrecht, J. Pfizer Global Research and Development, Groton, CT, United States.

#48 PROSTATE CANCER CELL SUSCEPTIBILITY TO OXIDATIVE DNA DAMAGE IS INFLUENCED BY CELL ATTACHMENT. Chiang, EC¹, Shen, S², Waters, DJ¹, Bostwick, DG¹. ¹Center on Aging and the Life Course, Purdue University, West Lafayette, IN, United States, ²Gerald P. Murphy Cancer Foundation, West Lafayette, IN, United States.,

#49 ASSAY DESIGN MAY AFFECT GENOTYPING RESULTS FOR THE CYP2D6 C188T POLYMORPHISM. Clark, LS, Read, BD, Nakhle, PJ, Murphy, MP. Gentris Corporation, Morrisville, NC, United States.

#50 FOLPET IS NOT GENOTOXIC IN THE MOUSE DUODENUM AS MEASURED IN THE COMET ASSAY. Clay, P. Syngenta CTL, Macclesfield, Cheshire, United Kingdom.

#51 DEVELOPMENT AND VALIDATION OF THE IN VIVO ALKALINE COMET ASSAY FOR DETECTION OF DNA DAMAGE IN VARIOUS TISSUES OF NMRI MICE. Agurell, E², Vaghef, H¹, Westman, A¹, Jönsson, R¹, Lind, J¹, Andersson, A¹, Hamreby, A-M¹, Czene, S¹, Bolcsfoldi, G¹. ¹AstraZeneca R&D Södertälje, Safety Assessment, Genetic Toxicology, Södertälje, Sweden, ²Medical Products Agency, Uppsala, Sweden.

#52 DIVERSE GENOTOXICANTS AND CYTOTOXIC NON-GENOTOXICANTS EVALUATED WITH A NEW FLOW CYTOMETRY-BASED IN VITRO MICRONUCLEUS SCORING SYSTEM. Dertinger, SD, Avlasevich, S, Bryce, S. Litron Laboratories, Rochester, NY, United States.

#53 EFFECT OF AFMID DEFICIENCY ON THE PHENOTYPE OF Tk MUTANT MICE. Dobrovolsky, VN, Heflich, RH, Doerge, DR, Williams, LD. NCTR/FDA, Jefferson, AR, United States.

#54 CARBENDAZIM INDUCED Tk^-/-
MUTANT COLONIES IN MOUSE LYMPHOMA L5178Y CELLS. HOW MANY COPIES OF CHROMOSOME 11? Doherty, AT, Fellows, M, Hayes, J, Thompson, A, O Donovan, M. AstraZeneca, Macclesfield, Cheshire, United Kingdom.

#55 NICKEL-INDUCED GENETIC EFFECTS IN GERM AND SOMATIC CELLS OF WR MICE. Domschlak, MG¹, Vorobyova, NY², Osipov, AN², Elakov, AL². ¹Institute of Occupational Health Russian Academy of Medical Science, Moscow, Russia, ²Scientific and Industrial Association “Radon”, Moscow, Russia.

#56 COMPARATIVE EVALUATION OF PERIPHERAL BLOOD FLOW CYTOMETRY MICRONUCLEUS TEST IN RATS AND MICE. Elhajouji, A¹, Cammerer, Z¹, Kirsch-Volders, M², Suter, W¹. ¹Novartis Pharma AG, Basel, Switzerland, ²Vrije Universiteit Brussels, Brussels, Belgium.

#57 TOXICOLOGICAL ASSESSMENT OF LOW DOSE EXPOSURE TO THE GENOTOXIC FLAVOUR METHYL EUGENOL. Ellis, JK¹, Carmichael, PL², Gooderham, NJ¹, ¹Imperial College, London, United Kingdom, ²Unilever (SEAC), Sharnbrook, United Kingdom.

#58 INTER-LABORATORY COMPARISON OF MICRONUCLEUS DATA OBTAINED IN RAT BONE MARROW AND PERIPHERAL BLOOD BY FLOW CYTOMETRIC ANALYSIS. Fiedler, RD, Torous, DK. Eastern Michigan University, Ypsolanti, MI, United States.

#59 QUANTITATIVE SENSITIVITY IN AMES ASSAYS OF CIGARETTE SMOKE CONDENSATE. Fowler, KW, Morgan, WT, Bombick, BR, Doolittle, DJ. R. J. Reynolds, Winston-Salem, NC, United States.

#60 IN VIVO GENOTOXICITY AND MUTAGENICITY OF TRACE NUTRIENTS: RESULTS OF SUBCHRONIC EXPOSURE OF MICE TO FESO4, CUSO4 AND VITAMIN C AS EVALUATED BY COMET ASSAY AND MICRONUCLEUS TEST. Franke, SIR¹, Prá, D¹, Erdtmann, B², Da Silva, J³, Henriques, JAP³. ¹PPG em Nutrição Clínica/Curso de Nutrição/DEDFIS - UNISC; PPGBCM/PPGBM - UFRGS, Santa Cruz do Sul; Porto Alegre, RS, Brazil, ²Centro de Biotecnologia - UCS, Caxias do Sul, RS, Brazil, ³Curso de Biologia/Curso de Farmácia, ULBRA, Canoas, RS, Brazil.

#61 GENOTOXIC CONSEQUENCES OF MOPP CHEMOTHERAPY IN GAMETE AND SOMATIC CELLS FROM HODGKIN’S DISEASE PATIENTS. Frias, S, Salas, C, Sanchez, S, Niembro, A, Molina, B, Carnevale, A, Rivera-Luna, R. Instituto Nacional de Pediatria, Mexico D.F., Mexico.

#62 AGE RELATED GENOTOXICITY AND MUTAGENESIS STUDIES. Fucic, A¹, Bubic Spoljar, J², Markovic, D³, Stojkovic, R⁴, Ferencic, Z³, Mildner, B³, Jazbec, AM⁵. ¹Institute for Medical Research and Occupational Health, Zagreb, Croatia, ²PLIVA Research & Development Ltd., Zagreb, Croatia, ³PLIVA Research Institute Ltd, Zagreb, Croatia, ⁴Institute Rudjer Boskovic, Zagreb, Croatia, ⁵Faculty of Forestry, Zagreb, Croatia.

#63 DETECTION OF A NOVEL MUTAGEN 1,3,6-TRINITROPYRENE, AS A MAJOR CONTAMINANT IN SURFACE SOIL IN NAGOYA CITY, JAPAN. Gao, N¹, Yoshida, S¹, Asanoma, M², Watanabe, T³, Hirayama, T³, Nukaya, H⁴, Mizutani, T¹, Takahashi, K¹. ¹Nagoya City University, Nagoya City, Aichi Prefecture, Japan, ²Nagoya City Health Res. Inst., Nagoya City, Aichi Prefecture, Japan, ³Kyoto Pharmaceutical University, Kyoto City, Kyoto Prefecture, Japan, ⁴University of Shizuoka, Shizuoka City, Shizuoka Prefecture, Japan.

#64 ASSESSING LEAD EFFECTS ON FISHER 344 RATS USING ICP-MS AND HISTOLOGY. Gato, WEG, Eversole, RE, Means, JCM. Western Michigan University, Kalamazoo, Mi, United States.

#65 URINARY MUTAGENICITY, URINARY 1-OH-HYDROXYPYRENE LEVELS AND GENETIC POLYMORPHISMS IN WORKERS EXPOSED TO DIESEL EXHAUST. Gil, L, Martinez, V, Ancic, P, Adonis, M. ¹University of Chile, Santiago, Chile.

#66 CO-ADMINISTRATION OF ETHANOL OR AN ALCOHOL DEHYDROGENASE INHIBITOR DRAMATICALLY ENHANCES THE DNA ADDUCT FORMATION BY 1-HYDROXYMETHYLPYRENE IN THE RAT IN VIVO. Ma, L¹, Hollnagel, H¹, Langheinrich, C¹, Stephani, M¹, Kollock, R¹, Seidel, A², Glatt, HR¹. ¹German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany, ²Biochemisches Institut fuer Umweltcarcinogene, Grosshansdorf, Germany.

#67 VITAMINS AS AN ALTERNATIVE TO REDUCE GENOTOXIC RISK OF FLUOROQUINOLONES TREATMENT. González-Avila, M¹, Flores-Lozada, J², Rivera-Sánchez, R², Arriaga-Alba, M². ¹Universidad Politécnica de Pachuca, Pachuca, Hidalgo, Mexico, ²Laboratorio de Investigación Microbiológica, Hospital Juárez de México, Mexico City, D.F., Mexico.

#68 MUTAGENIC ACTIVITY OF AIRBORNE PARTICLES IN CENTRAL METROPOLITAN TOKYO OVER THE PAST 20 YEARS. Goto, S¹, Endo, O², Nakajima, D¹, Aoki, Y¹, Matsushita, H³. ¹National Institute for Environmental Studies, Japan, Tsukuba, Ibaraki, Japan, ²National Institute of Public Health, Japan, Wako, Saitama, Japan, ³University of Shizuoka, Yada, Shizuoka, Japan.

#69 A PERSPECTIVE ON GENOTOXICITY RISK PERCEPTION, ASSESSMENT AND COMMUNICATION. Gray, JA. Chordia Ltd, York, United Kingdom.

#70 BONE MARROW AND PERIPHERAL BLOOD MICRONUCLEUS ANALYSES FOLLOWING REPEATED DOSING OF POSITIVE CONTROL ARTICLES IN MICE AND RATS. Gudi, R, Fall, S, Huston, T, Kendrick, S, Clair, J, Krsmanovic, LJ. BioReliance Invitrogen Bioservices, Rockville, MD, United States.

#71 A RAPID APPROACH FOR ESTIMATING HPRT MUTANT FREQUENCIES AND CHARACTERIZING GENE MUTATIONS IN HUMANS EXPOSED TO GENOTOXICANTS. Guerin, AT, Wickliffe, JK, Hill, CE, Carmical, JR, Ward, JB, Abdel-Rahman, SZ. University of Texas Medical Branch, Galveston, TX, United States.

#72 ANTIMUTAGENIC AND ANTIFUNGAL Impatiens balsamina L. Guevara, AP, Garcia, W. University of the Philippines, Diliman, Quezon City, Philippines.

#73 ESTABLISHMENT OF HUMANIZED IN VITRO GENOTOXICITY TEST SYSTEM: COMBINED SYSTEM USING HUMAN CELL LINES AND HUMAN S9. Hakura, A,¹ Oka, H,² Takasaki, W,³ Sasaki, YF,⁴ Suzuki, S,⁵ Satoh, T,⁶ Honma, M⁶. ¹Eisai Co. Ltd., Kakamigahara, Gifu, Japan, ²Taiho Pharmaceutical Co. Ltd., Tokushima, Tokushima, Japan, ³Sankyo Co. Ltd., Fukuroi, Shizuoka, Japan, ⁴Hachinohe National College of Technology, Hachinohe, Aomori, Japan, ⁵HAB Biomedical Research Institute, Ichikawa, Chiba, Japan, ⁶HAB Biomedical Research Institute, Ichikawa, Chiba, Japan, ⁷National Institute of Health Sciences, Setagaya, Tokyo, Japan.

#74 EVALUATION OF HUMAN RADIATION SENSITIVITY USING FLOW CYTOMETRY OF PHOSPHORYLATED HISTONE H2AX IN CULTURED T LYMPHOCYTES. Hamasaki, K¹, Kusunoki, Y¹, Kodama, Y², Takahashi, N², Nakachi, K¹. ¹Department of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan, ²Department of Genetics, Radiation Effects Research Foundation, Hiroshima, Japan.

#75 DETECTION OF A NOVEL MUTAGEN, 3,6-DINITROBENZO[e]PYRENE, AS A MAJOR CONTAMINANT IN SURFACE SOIL IN OSAKA AND AICHI PREFECTURE, JAPAN. Hasei, T, Watanabe, T, Hirayama, T. Kyoto Pharmaceutical University, Kyoto, Japan.

#76 CARCINOGENIC RISK ESTIMATION OF ORGAN SPECIFIC MUTAGENICITY INDUCED BY PHENACETIN USING gpt DELTA TRANSGENIC RATS. Hayashi, H¹, Shindo, Y¹, Nohmi, T². ¹Toxicology Laboratory, Meiji Seika Kaisha, Ltd., Yokohama, Japan, ²Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo, Japan.

#77 ANTICLASTOGENIC EFFECT OF CHAMOMILE ESSENTIAL OIL EVALUATED WITH THE MICRONUCLEUS TEST. Hernández-Ceruelos, A¹, Cassani, M², Cruz, J², Madrigal-Bujaidar, E². ¹Universidad Autónoma del Estado de Hidalgo, Area Académica de Medicina, Pachuca, Hidalgo, Mexico, ²Laboratorio de Genética, Escuela Nacional de Ciencias Biológicas, I.P.N., Mexico City, D.F., Mexico.

#78 A COMPARISON OF CHO AND HUMAN LYMPHOCYTE CELLS USING CYTOTOXIC CHROMOSOMAL ABERRATION INDUCERS THAT INHIBIT DNA SYNTHESIS. Hilliard, CA, Hill, RB, Armstrong, MJ, Fleckenstein, CM, Galloway, SM. Merck & Co., Inc., West Point, PA, United States.

#79 COLONY SCORING OF THE MICROTITRE MOUSE LYMPHOMA Tk LOCUS ASSAY USING A FLATBED SCANNER. Hou, S¹, Jörgensen-Burman, B-M¹, Kühn, I², Bolcsfoldi, G¹. ¹Department of Genetic toxicology, Safety Assessment, AstraZeneca R&D Södertälje, Södertälje, Sweden, ²Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden.

#80 INHIBITORY EFFECTS OF YAMABUDO-GRAPE (Vitis coignetiae pulliat) ON DNA-ADDUCT FORMATION INDUCED BY HETEROCYCLIC AMINES. Ishida, R, Okamoto, K, Okamoto, G, Arimoto, S. Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan.

#81 EXPOSURE TO SECOND HAND SMOKE IN INFANTS. Jensen, A, Sorensen, M, Stage, M, Bisgaard, H, Loft, S. Universitet of Copenhagen, Copenhagen, Denmark.

#82 ANALYSES OF 8-OH-dG AND 8-OH-GUA AS MARKERS OF OXIDATIVE STRESS. Kasai, H¹, Svoboda, P¹, Yamasaki, S¹, Irie, M², Kawanami, K³, Miyamoto, T³. ¹University of Occupational and Environmental Health, Kitakyushu, Japan, ²Kyushu University, Fukuoka, Japan, ³Nippon Steel Corp., Kimitsu, Japan.

#83 URINARY MUTAGENICITY AND BIOMARKERS OF EXPOSURE TO WOOD SMOKE AMONG CHARCOAL WORKERS IN BRAZIL. Kato, M¹, Carvalho, AB¹, Loomis, D⁴, Rego, G⁵, Gattás, R³, DeMarini, D². ¹Fundacentro-CRBA, Salvador, Bahia, Brazil, ²US Environmental Protection Agency, Research Triangle PArk, NC, United States, ³São Paulo, SP, São PAulo, SP, Brazil, ⁴School of Public Health- UNC-CH, Chapel Hill, NC, United States, ⁵School of Medicine - UFBA, Salvador, Bahia, Brazil.

#84 AN EVALUATION OF THE MUTAGENICITY OF COKE OVEN EMISSIONS USING US EPA’S 2005 SUPPLEMENTAL GUIDANCE FOR ASSESSING CANCER SUSCEPTIBILITY FROM EARLY-LIFE EXPOSURE TO CARCINOGENS. Keshava, C¹, Cimino, M², Dearfield, K³, Flowers, L¹, Kligerman, A⁴, McCarroll, N², Owen, R⁴, Putzrath, R¹, Schoeny, R⁵. ¹National Center for Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, Washington, DC, United States, ²OPPTS, US EPA, Washington, DC, United States, ³OSA, US EPA, Washington, DC, United States, ⁴NHEERL, US EPA, Research Triangle Park, NC, United States, ⁵OW, US EPA, Washington, DC, United States.

#85 GENOTOXICITY EVALUATION OF PEPTIDE COUPLING REAGENTS. Kim, ST¹, Kim, SS², Seid, DA¹. ¹Applied Biosystems, Foster City, United States, ²University of California, Berkeley, United States.

#86 YEAST DEL ASSAY DETECTS CLASTOGENS. Kirpnick, Z¹, Rubitski, E², Homiski, M², Repnevskaya, M¹, Howlett, N³, Aubrecht, J², Schiestl, RH¹. ¹UCLA, Los Angeles, CA, United States, ²Pfizer, Inc., Groton, CT, United States, ³University of Michigan, Ann Arbor, MI, United States.

#87 MUTAGENIC POTENCY STRUCTURE/ACTIVITY RELATIONSHIPS OF AMINO-IMIDAZO-PYRIDINES RELATED TO PhIP AND TMIP FOUND IN COOKED MEATS. Knize, MG¹, Hatch, FT², Tanga, MJ³, Chrisman, W³, Wu, RW¹, Colvin, ME⁴, Felton, JS¹. ¹Lawrence Livermore National Laboratory, Livermore, CA, United States, ²XX, Meredith, NH, United States, ³SRI International, Menlo Park, CA, United States, ⁴University of California, Merced, CA, United States.

#88 ETHYL CARBAMATE IN SOYSAUCE CONSUMED IN KOREA: LEVELS, FORMATION, AND ESTIMATED INTAKE. Kwon, H, Koh, E. Seoul National University, Seoul, South Korea.

#89 GENOTOXICITY OF ACRYLAMIDE AND GLYCIDAMIDE IN HUMAN LYMPHOBLASTOID TK6 CELLS. Koyama, N¹, Sakamoto, H², Sakuraba, M², Koizumi, Y², Takashima, Y², Hayashi, M², Matufuji, H³, Yamagata, K³, Masuda, S¹, Kinae, N¹, Honma, M². ¹University of Shizuoka Graduate School of Nutrirional Sciences, 52-1 Yada Suruga-ku Shizuoka, Japan, ²Division of Genetic and Mutgenesis,National Instituate of Health Sciences, 1-18-1 Kamiyouga,Setagaya-ku,Tokyo, Japan, ³Department of Food Science and Techology, College of Biosciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa, Japan.

#90 AN ANALYSIS OF GENETIC TOXICITY, REPRODUCTIVE AND DEVELOPMENTAL TOXICITY, AND CARCINOGENICITY DATA: II. IDENTIFICATION OF GENOTOXICANTS, REPROTOXICANTS, AND CARCINOGENS USING IN SILICO METHODS WITH EXPERIMENTAL AND VIRTUAL DATABASES. Matthews, EJ, Kruhlak, NL, Benz, RD, Contrera, JF. US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff, Rockville, MD, United States.

#91 DEVELOPING AN IN VITRO PHOTOGENOTOXICITY ASSAY USING HUMAN SKIN. Krul, CAM, Maas, WJM, Steenwinkel, MJST, van Meeuwen, RNC, de Vogel, N. TNO Quality of Life, Zeist, Netherlands.

#92 APPLICATION OF STRUCTURE-BASED ASSESSMENT FOR PRIORITIZING THE CONTROL AND MEASUREMENT OF GENOTOXIC IMPURITIES IN ACTIVE PHARMACEUTICAL INGREDIANTS DURING DRUG DEVELOPMENT. Dobo, K, Cyr, M, Greene, N, Ku, W. Pfizer Global R & D, Groton, CT, United States.

#93 IDENTIFICATION OF LOW-DOSE IONIZING RADIATION BIOSIGNATURES FOR ACUTE EXPOSURES. Kulkarni, R, Bailey, N, Najib, A, Thomas, RA, Tucker, JD. Wayne State University, Detroit, MI, United States.

#94 INCREASED FREQUENCIES OF MICRONUCLEATED RETICULOCYTES IN Aldh2 KNOCKOUT MICE EXPOSED TO ACETALDEHYDE. Kunugita, N¹, Isse, T², Oyama, T², Kitagawa, K³, Ogawa, M², Yamaguchi, T², Kinaga, T², Kawamoto, T². ¹School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan, ²Dept of Environmental Health, University of Occupational and Environmental Health, Kitakyushu, Japan, ³First Department of Biochemistry, Hamamatsu Medical University, Hamamatsu, Japan.

#95 CHROMOSOMAL DAMAGE IN MOTILE AND IMMOTILE MOUSE SPERMATOZOA TREATED IN VITRO WITH GREEN TEA CATECHIN, (-)-EPIGALLOCATECHIN GALLATE (EGCG). Kusakabe, H, Kamiguchi, Y. Asahikawa Medical College, Asahikawa, Japan.

#96 PROSPECTIVE STUDY ON THE RELATIONSHIP BETWEEN ERYTHROCYTE GLYCOPHORIN A GENE MUTATIONS AND CANCER DEVELOPMENT AMONG ATOMIC-BOMB SURVIVORS. Kusunoki, Y¹, Kyoizumi, S², Hayashi, T¹, Hakoda, M², Cologne, JB³, Nakachi, K¹. ¹Department of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan, ²Yasuda Women’s University, Hiroshima, Japan, ³Department of Statistics, Hiroshima, Japan.

#97 ELEVATED DNA-PROTEIN CROSSLINKS IN ERYTHROCYTES OF GERMAN CARP FROM THE LOWER PASSAIC RIVER, NEWARK, NJ. Kuykendall, JR¹, O’Neil, SJ², Jarvi, EJ³. ¹Raabe College of Pharmacy, Ohio Northern University, Ada, OH, United States, ²Idaho State University, Pocatello, ID, United States, ³College of Pharmacy, Ferris State University, Big Rapids, MI, United States.

#98 COMPUTATIONAL MODELING OF HUMAN ARYLAMINE N-ACETYLTRANSFERASE (NAT). Lau, EY, Felton, JS, Lightstone, FC. Lawrence Livermore National Laboratory, Livermore, CA, United States.

#99 COMPARISON OF AMES TEST, CHROMOSOME ABERRATION TEST AND COMET ASSAY FOR IN VITRO PHOTOGENOTOXICITY ASSESSMENT. Lee, M, Hong, M-Y, Kim, J-Y, Lee, YM. Korea Institute of Toxicology, KRICT, Daejeon, South Korea.

#100 CHEMOPREVENTIVE EFFECTS OF ALOE AGAINST GENOTOXICITY INDUCED BY BENZO[a]PYRENE. Lee, BM, Yoo, EJ. Sungkyunkwan University, Suwon, South Korea.

#101 AQUATIC GENOTOXOCITY MONITORING USING MICRONUCLEUS ASSAY IN HUMAN LYMPHOCYTES AND V79 CELLS. Lemos, CT, Oliveira, NCD, Lemos, AO. Divisão de Biologia, Programa de Pesquisas Ambientais, Fundação Estadual de Proteção Ambiental Henrique Luís Roessler - FEPAM, Avenida Dr. Salvador França, 1707, CEP., Porto Alegre, RS, Brazil.

#102 THE BUDDING YEAST S. cerevisiae: A DIAGNOSTIC TOOL FOR THE DETECTION OF MUTAGENIC COMPOUNDS IN THE ENVIRONMENT. Minuzzo, MM, Lettieri, TL. Joint Research Centre of European Commisssion, Ispra (VA) Italy, United States.

#103 EFFECT OF CIGARETTE CONSTRUCTION ON THE IN VITRO TOXICITY OF CIGARETTE SMOKE CONDENSATE. Leverette, RD, Bennett, MB, Hamm, JT, Vulimiri, SV, Yee, SF. A.W. Spears Research Center, Lorillard Tobacco Company, Greensboro, NC, United States.

#104 GENE POLYMORPHISMS OF HOMOCYSTEINE METABOLISM-RELATED ENZYMES IN NUCLEAR FAMILIES OF CHINESE PATIENTS WITH CONGENITAL HEART DEFECTS. Li, Y. Peking University, Beijing, China.

#105 ANTISENSE OLIGONUCLEOTIDES TARGETED ON METALLOTHIONEIN SENSITIZE THE CADMIUM-INDUCED CYTOTOXICITY IN HUMAN NASOPHARYNGEAL CARCINOMA CNE2 CELL LINE. Lin, YC¹, Lin, ZN¹, Liang, JB¹, Ling, WH¹, Yang, XF². ¹School of Public Health, Sun Yat-sen University, Guangzhou, China, ²Center for Disease Control of Guangdong Province, Guangzhou, China.

#106 INCREASED GENE EXPRESSION OF GLUTATHIONEIN-S-TRANSFERASE PI AND ITS RELATION WITH CADMIUM-INDUCED CYTOTOXICITY IN NIH3T3 CELL. Lin, ZN¹, Xu, GN¹, Lin, YC¹, Yang, XF². ¹School of Public Health, Sun Yat-sen University, Guangzhou, China, ²Center for Disease Control of Guangdong Province, Guangzhou, China.

#107 PERSISTENCE OF TRANSLOCATIONS IN STABLE CELLS. Lindholm, C. STUK-Radiation and Nuclear Safety Authority, Helsinki, Finland.

#108 CYTOTOXICAL EFFECT OF CADMIUM ON THE CHEMOTHERAPY SENSITIVITY IN HUMAN NASOPHARYNGEAL CARCINOMA CELL LINE. Ling, WH, Lin, ZN, Lin, YC, Liu, RQ. School of Public Health, Sun Yat-sen University, Guangzhou, China.

#109 EVALUATION OF CELLOMICS MICRONUCLEUS BIOAPPLICATION -AN AUTOMATED SCORING SYSTEM. Lu, S¹, Pomykal, P¹, Li, L¹, Homiski, M², Rubitski, E², Aubrecht, J², Jessen, B¹, Stevens, G¹. ¹WW Safety Sciences La Jolla Laboratories, Pfizer Inc, San Diego, CA, United States, ²WW Safety Sciences Groton Laboratories, Pfizer Inc, Groton, CT, United States.

#110 GENOTOXICITY OF CONTAMINATED SOIL FROM AMMUNITION TESTING GROUNDS. Ma, TH¹, Gong, P², Gebhart, D³, Busby, R³, White, J¹. ¹Department of Biological Sciences, Western Illinois University, Macoomb, IL, United States, ²Analytical Services Inc., Vicksburg, MS, United States, ³U.S. Army Engineer Research and Development Center, Construction and Heritage Conservation Branch, Champaign, IL, United States.

#111 SUITABILITY OF MONKEY AND CANINE PERIPHERAL BLOOD RETICULOCYTES AS TARGET CELLS FOR THE IN VIVO MICRONUCLEUS TEST. Hotchkiss, C¹, Harper, S², Bishop, M³, Moore, M³, Dertinger, S⁴, MacNamee, J⁵, Hayashi, M⁶, MacGregor, J⁷. ¹The Bionetics Corporation, Jefferson, AR, United States, ²FDA-CFSAN, Laurel, MD, United States, ³FDA-NCTR, Jefferson, AR, United States, ⁴Litron Laboratories, Rochester, NY, United States, ⁵Health Canada, Ottawa, Ontario, Canada, ⁶National Institute of Health Sciences, Tokyo, Japan, ⁷Toxicology Consulting Services, Arnold, MD, United States.

#112 IDENTIFICATION OF 4-OXO-2-HEXENAL AS A dG ADDUCT IN A MODEL LIPID PEROXIDATION REACTION AND ITS MUTAGENICITY TO TA 100 AND 104. Maekawa, M¹, Kawai, K¹, Hachisuka, K¹, Takahashi, Y², Nakamura, H², Sawa, R², Kasai, H¹. ¹University of Occupational and Environmental Health, Kitakyushu, Japan, ²Microbial Chemistry Research Center, Tokyo, Japan.

#113 THE MUTAGENIC HAZARDS OF POLYCYCLIC AROMATIC HYDROCARBONS IN SETTLED HOUSE DUST. Maertens, RM¹, Yang, X², Zhu, J², Gagne, R¹, Douglas, GR¹, White, PA¹. ¹Mutagenesis Section, Safe Environments Program, HECSB, Health Canada, Ottawa,ON, Canada, ²Chemistry Research Division, Safe Environments Program, HECSB, Health Canada, Ottawa, ON, Canada.

#114 COMPARISON OF RAT AND HUMAN UDP-GLUCURONOSYLTRANSFERASE 1A1 EXPRESSION ON THE MUTAGENICITY AND CYTOTOXICITY OF THE COOKED-FOOD CARCINOGEN PhIP IN CHO CELLS. Wu, RW, Malfatti, MA, Felton, JS. Lawrence Livermore National Laboratory, Livermore, CA, United States.

#115 UV-C INDUCES CHROMATIN RELAXATION IN P53 DEFICIENT CHO CELLS. Martínez-López, WM-L^1,2,3, Prosper, IP^1,3, Mühlmann-Díaz, MM-D³. ¹Instituo de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay, ²Faculty of Sciences, Montevideo, Uruguay, ³National Commission of Atomic Energy, Buenos Aires, Argentina.

#116 IN VIVO COMET ASSAY ON ISOLATED KIDNEY CELLS AS A TOOL TO DISCRIMINATE GENOTOXIC FROM EPIGENETIC CARCINOGENS OR CYTOTOXIC COMPOUNDS. Marzin, D², Nesslany, F², Zennouche, N¹. ¹Faculty of Pharmacy, Lille, France, ²Institut Pasteur de Lille, Lille, France.

#117 CHANGES IN THE MUTAGENIC AND ESTROGENIC ACTIVITIES OF BISPHENOL A UPON TREATMENT WITH NITRITE. Masuda, S, Terashima, Y, Sano, A, Kuruto, R, Sugiyama, Y, Shimoi, K, Tanji, K, Yoshioka, H, Terao, Y, Kinae, N. University of Shizuoka, Shizuoka, Japan.

#118 GENOTOXICITY OF QUERCETIN IN THE PRESENCE OF OXYGEN SPECIES AND HUMAN LIVER S9 IN HUMAN LYMPHOBLASTOID TK6 OR WTK-1 CELLS. Matsufuji, H¹, Inoue, M¹, Chino, M¹, Honma, M², Hayashi, M², Yamagata, K¹. ¹College of Bioresource Sciences, Nihon University, Fujisawa, Japan, ²National Institute of Health Sciences, Tokyo, Japan.

#119 INDUCTION OF K-ras CODON 12 GGT TO GAT MUTATION BY AZOXYMETHANE IN A RAT MODEL OF COLON CANCER. McKinzie, PB, Delongchamp, RR, Patterson, TA, Parsons, BL. National Center for Toxicological Research, Jefferson, Arkansas, United States.

#120 GAP JUNCTION COMMUNICATION DYMAMICS AND BYSTANDER EFFECTS FROM ULTRA-SOFT X-RAYS. Edwards, GO¹, Chipman, JK¹, Wharton, CW¹, Botchway, SW², Shaikh, W², Hirst, GJ², Meldrum, RA¹. ¹University Of Birmingham, Birmingham, United Kingdom, ²CCLRC, Rutherford Appleton Laboratories, Oxford, United Kingdom.

#121 INCORPORATING CYTOGENETIC CANCER RISK BIOMARKERS INTO OCCUPATIONAL HEALTH SURVEILLANCE PROGRAMS: BULGARIAN EXPERIENCE. Mirkova, ET¹, Lalchev, SG², Alexandrova, EA³. ¹National Center of Public Health Protection, Sofia, Bulgaria, ²Sofia Medical University, Sofia, Bulgaria, ³National Center of Public Health Protection, Sofia, Bulgaria.

#122 EARLY GENOTOXIC EFFECTS AND INDIVIDUAL SUSCEPTIBILITY IN COKE-OVEN WORKERS IN COAHUILA, NORTHERN MEXICO. Montero, R¹, Salinas, J², Camacho, R¹, Araujo, A¹, Mejia, V³, Castorena, F³, Davila, V¹, Serrano, L¹, Albores, A³. ¹I. I. Biomedicas, U.N.A.M., México City, Mexico, ²Jurisdiccion Sanitaria 3, S.S., Sabinas, Coah., Mexico, ³Sección Externa de CINVESTAV-IPN, México City, Mexico.

#123 BENCHMARK DOSE ANALYSIS OF IN VIVO GENOTOXICITY DATA CAN BE USED TO INFORM CANCER RISK ASSESSMENT. Moore, MM¹, Shipp, AM², Heflich, RH¹, Kodell, RL³, Allen, BC². ¹Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR, United States, ²Environ International Corp., Ruston, LA, United States, ³Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, AR, United States.

#124 PERFORMANCE OF IN SILICO ANALYSIS (DEREK AND MULTICASE) FOR PREDICTING THE AMES-TESTING RESULTS OF PHARMACEUTICALS. Muto, S, Morita, T, Uchii, A, Baba, H, Uno, Y. Mitsubishi Pharma Corporation, Kisarazu, Chiba, Japan.

#125 DEPLETION OF MITOCHONDRIAL DNA AFTER IN UTERO EXPOSURE OF MICE TO AZT AND AZT-CONTAINING COMBINATION ANTI-RETROVIRAL THERAPIES. Myers, MB¹, Von Tungeln, LS², Beland, FA², Heflich, RH². ¹University of Arkansas for Medical Sciences, Little Rock, AR, United States, ²National Center for Toxicological Research, Jefferson, AR, United States.

#126 INCREASE IN 8-OXODEOXYGUANOSINE CONTENT OF DNA FROM DROSOPHILA LARVAE IRRADIATED WITH 364 NM LASER-LIGHT. Negishi, T¹, Fujikawa, K², Nakamura, T³, Higashi, S³, Kasai, H⁴, Kawai, K⁴. ¹Okayama University, Okayama, Japan, ²Kinki University, Higashi-Osaka, Japan, ³National Institute for Basic Biology, Okazaki, Japan, ⁴University of Occupational and Environmental Health, Kitakyusyu, Japan.

#127 DETECTION OF MUTAGENIC AND CARCINOGENIC AMINOPHENYLNORHARMAN IN HUMAN URINE SAMPLES. Nishigaki, R¹, Totsuka, Y¹, Kataoka, H², Wakabayshi, K¹, Sugimura, T¹. ¹National Cancer Center Research Institute, Tokyo, Japan, ²Shujitsu University, Okayama, Japan.

#128 COMPARATIVE MOLECULAR ANALYSIS OF p16(INK4A)/ARF EXPRESSION IN SYRIAN HAMSTER CELL IMMORTALIZATION AND MORPHOLOGICAL TRANSFORMATION. O’Donovan, MR¹, Gilham, E², Newbold, RF². ¹AstraZeneca R&D, Macclesfield, United Kingdom, ²Institute of Cancer Genetics and Pharmacogenomics, Brunel University, Uxbridge, United Kingdom.

#129 QUANTIFICATION OF A POTENT MUTAGENIC 4-AMINO-3,3’-DICHLORO-5,4’-DINITROBIPHENYL AND THE RELATED CHEMICALS IN WATER FROM THE WAKA RIVER, WAKAYAMA, JAPAN. Ohe, T¹, Mizuno, T¹, Watanabe, T², Hasei, T², Hirayama, T², Takamura, T³, Wakabayashi, K³. ¹Kyoto Women’s University, Kyoto, Japan, ²Kyoto Pharmaceutical University, Kyoto, Japan, ³National Cancer Center Research Institute, Tokyo, Japan.

#130 A SENSITIVE DETECTION SYSTEM FOR DEMETHYLATING AGENTS: POTENTIAL CARCINOGENS AND CHEMOTHERAPEUTIC AGENTS. Okochi-Takada, E, Wakabayashi, M, Mori, A, Ichimura, S, Sugimura, T, Ushijima, T. National Cancer Center Research Institute, Tokyo, Japan.

#131 TRANSPLACENTAL MITOCHONDRIAL TOXICITY IN PRIMATES EXPOSED TO ZIDOVUDINE (AZT)/LAMIVUDINE (3TC)/NEVIRAPINE (NVP). Orozco, CC¹, Divi, RL¹, Nagashima, K², Harbaugh, SW³, Harbaugh, JW³, Cook, AL³, St. Claire, MC³, Poirier, MC¹. ¹National Cancer Institute, Bethesda, MD, United States, ²Frederick Cancer Research and Development Center, SAIC, Frederick, MD, United States, ³Bioqual Inc., Rockville, MD, United States.

#132 WHAT SHOULD THE TESTING STRATEGY BE WHEN THE TEST MATERIAL IS MORE TOXIC TO FEEDER CELLS THAN TO TARGET CELLS IN THE SYRIAN HAMSTER EMBRYO (SHE) CELL TRANSFORMATION ASSAY? Pant, K, Harvey, JS, San, R. ¹BioReliance, Invitrogen bioservices, Rockville, Maryland, United States, ²GlaxoSmithKline, Ware Hertfordshire, United Kingdom.

#133 EVALUATION OF GENOTOXICITY OF Alternaria alternate GROWN IN DISCOLORED SUN-DRIED RED PEPPER FRUITS. Park, EJ¹, Lee, SM², Byun, BH³, Kyung, KH⁴. ¹Dept. of Food and Nutrition, Masan, Korea, ²Dept. of Sericultural and Entomological Biology, Miryang National University, Miryang, South Korea, ³Dept. of Oriental Medicine, Daegu Haany University, Daegu, Korea, ⁴Dept. of Food Science, Sejong University, Seoul, South Korea.

#134 QUANTIFYING LEVELS OF K-RAS MUTATION IN HUMAN TISSUES AT VARIOUS STAGES OF SPORADIC COLON TUMOR DEVELOPMENT AND PROGRESSION. Parsons, BL¹, Marchant, K², Verkler, TL¹, McKinzie, PB¹, Delongchamp, RR¹, Patterson, TA¹, Broadwater, JR³, Lamps, LW³, Kim, LT². ¹National Center for Toxicological Research USFDA, Jefferson, AR, United States, ²Central Arkansas Veterans Healthcare System, Little Rock, AR, United States, ³University of Arkansas for Medical Sciences, Little Rock, AR, United States.

#135 INTERNAL DOSE OF ³H IN THE RAT SPERMATOCYTES. CHROMOSOME TRANSLOCATIONS IN THE RAT GERM CELLS FOLLOWING FRACTIONATED INTRODUCTION TO TRITIUM WATER. Paskalev, ZD¹, Bairakova, A¹, Apostolova, DB². ¹National Center of Radiobiology and Radiation Protection, Sofia, Bulgaria, ²Clinic of Occupational Diseases, Medical University, Sofia, Bulgaria.

#136 EVALUATION OF GENOTOXIC POTENTIAL OF ARSENIC TRIOXIDE TOXICITY IN BONE MARROW CELLS OF SPRAGUE-DAWLEY RATS. Patlolla, A, Tchounwou, P. Jackson State University, Jackson, MS, United States.

#137 TOXICITY TRENDS IN SUSPENDED MATTER AND SEDIMENTS OF LAKE CHAPALA, MEXICO. Pica-Granados, Y, Huerto-Delgadillo, RI, Hernandez, SH, Trujillo, DG. Mexican Water Technology Institute, Jiutepec, Morelos, Mexico.

#138 VALIDATION OF A DNA REACTIVITY EVALUATION METHOD USING XL-PCR AND TAQMAN® ANALYSIS. Pontén, I, Thalén, M, Bolcsfoldi, G. Genetic Toxicology, AstraZeneca R&D Södertälje, Safety Assessment, Södertälje, Sweden.

#139 STUDY DESIGN EVALUATION OF MOUSE LYMPHOMA ASSAY. Poth, A, Kunz, S, Wollny, HE, Voelkner, W. RCC Cytotest Cell Research, Rossdorf/Hessian, Germany.

#140 IMMUNOHISTOCHEMICAL DETECTION AND SEMIQUANTITATION OF
POLYCYCLIC AROMATIC HYDROCARBON (PAH)-DNA ADDUCTS IN CERVICAL TISSUE COLLECTED IN FOLLOW-UP OF ONCOGENIC HUMAN PAPILLOMAVIRUS (HPV)-INFECTED WOMEN: EFFECT OF SMOKING. Pratt, MM¹, Sirajuddin, P¹, Castle, PE², Schiffman, M², Glass, AG³, Scott, DR³, Rush, BB³, Olivero, OA¹, Poirier, MC¹. ¹Carcinogen-DNA Interactions Section, LCCTP, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States, ²Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States, ³Northwest Kaiser Permanente, Portland, OR, United States.

#141 THALIDOMIDE INDUCES MALFORMATIONS, SOMATIC RECOMBINATION AND INTERFERES THE FERTILITY OF FLIES EXPOSED THROUGH DEVELOPMENT. Ramos-Morales, P, Herrera-Bazan, JJH, Muñoz-Hernandez, A, Muñoz-Moya, JA, Garcia-Martinez, V, Rivas-Martinez, H, Hernandez-Bernal, BR. Lab. Genetica, Fac. Ciencias, Ciudad Universitaria, Mexico, D.F., Mexico.

#142 SEMEN AND FISH ANALYSES OF SPERM FROM INFERTILE COUPLES IN THAILAND. Ratanavalachai, T, Kangsadalampai, S, Chiamchanya, C, Rojpibulsatit, P, Chalok-kongthavorn, P, Gamnarai, N, Sritipsukho, P, Au, W. Thammasat University, Pratumthani, Thailand.

#143 ACRYLAMIDE-INDUCED MULTI-TISSUE GENOTOXICITY IN MICE AND RATS. Recio, L¹, Caspary, W², Torous, D³, Witt, K². ¹Integrated Laboratory Systems, Inc, Genetic Toxicology Program, Research Triangle Park, NC, United States, ²Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, United States, ³Litron Laboratories, Rochester, NY, United States.

#144 CHANGES IN Lentinus edodes DRIED POWDER CONTENTS DURING TIME STORAGE INFLUENCE MODULATION ASSESSMENTS RELATED TO DNA LESIONS AND CHROMOSOME MUTATIONS IN VIVO. Lima, PLAL, Sugui, MMS, Petricio, AIMP, Salvadori, DMFS, Ribeiro, LRR. UNESP, Botucatu, Brazil.

#145 MULTIPLE-ENDPOINT CYTOTOXICITY AND GENOTOXICITY ASSAY IN MOUSE L5178Y CELLS WITH LIMITED COMPOUND REQUIREMENTS. Kehl, M¹, Winters, J¹, Richter, P², Recio, L¹. ¹Integrated Laboratory Systems, Inc, Genetic Toxicology Program, Research Triangle Park, NC, United States, ²Centers for Disease Control and Prevention, Atlanta, GA, United States.

#146 IN VITRO EVALUATION OF COCAINE CHLORHYDRATE CYTOTOXICITY AND GENOTOXICITY USING THE COMET ASSAY. Rojas, M¹, Monroy, C², Cortés, A², Groot, H². ¹Universidad del Rosario, Bogotá, Colombia, ²Universidad de los Andes, Bogotá, Colombia.

#147 CHROMOSOMAL TRANSLOCATIONS IN CURED ALL (ACUTE LYMPHOBLASTIC LEUKEMIA) AND NON-HODGKIN’S LYMPHOMA PATIENTS: LATE EFFECTS OF CANCER THERAPY. Camparoto ML¹, Brassesco MS¹, Tone LG², Sakamoto-Hojo ET³. ¹Departamento de Genetica, Faculdade de Medicina de Ribeirão Preto, USP, Ribeirão Preto, SP, Brazil, ²Departamento de Pediatria e Puericultura-HC, FMRP, USP, Ribeirão Preto, SP, Brazil, ³Departamento de Biologia, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, USP, Ribeirão Preto, SP, Brazil.

#148 THE DISAPPEARANCE OF THE PHOSPHORYLATED FORM OF H2AX (?H2AX) MONITORS DNA DOUBLE STRAND BREAKS REPAIR (DSBS) ONLY AT LOW LEVELS OF DNA DAMAGE. Salles, B, Bouquet, F, Muller, C. IPBS CNRS/Univ, Toulouse, France.

#149 THE EFFECT OF ENDOGENOUS AND SYNTHETIC FEMALE SEX HORMONES ON DNA. Braz, MG, Salvadori, DMF. UNESP, Botucatu, SP, Brazil.

#150 MICRONUCLEI AND GLOBIN ADDUCTS IN MICE AFTER INHALATION OF TOLUENE DIISOCYANATE (TDI) AND METHYLENE DIPHENYL DIISOCYANATE (MDI) IN VIVO. Sandvik, H¹, Santonen, T¹, Säkkinen, K¹, Hautamäki, M¹, Tornaeus, J¹, Ahonen, N¹, Jarventaus, H¹, Korpi, A², Pasanen, A-L¹, Rosenberg, C¹, Norppa, H¹. ¹Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland, ²Department of Environmental Sciences, University of Kuopio, Kuopio, Finland.

#151 DETECTION OF OXIDATIVE DNA DAMAGE IN LYMPHOCYTES OF PATIENTS WITH ALZHEIMER’S DISEASE. Sardas, S, Kadioglu, E, Isik, E, Aslan, S, Karakaya, AE. Gazi University, Ankara, Turkey.

#152 DIFFERENCES IN SENSITIVITY BETWEEN CHO-K1 AND CHO-WBL CELLS TO GENOTOXIC COMPOUNDS. Sawant, SG, Bunch, R, Yamada, J, Hernandez, R, Baker, D, Manoukian, R, Cosenza, ME, Afshari, CA, Dunn, RT. Amgen inc., Thousand Oaks, CA, United States.

#153 OXIDATIVE STRESS CAUSED BY GLUTATHIONE SYNTHESIS INHIBITOR BUTHIONINE SULFOXIMINE RESULTS IN GENOME REARRANGEMENTS IN MICE. Reliene, R, Schiestl, RH. UCLA, Los Angeles, CA, United States.

#154 A SEARCH FOR A POSITIVE CONTROL FOR THE IN VIVO/IN VITRO RAT PERIPHERAL BLOOD CHROMOSOMAL ABERRATION TEST. Schisler, MR, Gollapudi, BB. The Dow Chemical Company, Midland, MI, United States.

#155 THE ASSOCIATION OF MALE AGE AND METAL CONTENT OF HUMAN SPERM AND SEMINAL PLASMA MEASURED BY PROTON-INDUCED-X-RAY-EMISSION (PIXE). Schmid, TE¹, Grant, P³, Marchetti, F¹, Weldon, RH², Eskenazi, B², Wyrobek, AJ¹. ¹Biosciences Directorate, Lawrence Livermore, CA, United States, National Laboratory, Livermore, CA, United States, ²School of Public Health, University of California in Berkeley, Berkeley, CA, United States, ³Center for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, Livermore, CA, United States.

#156 INHIBITION OF FRIED MEAT-INDUCED DNA DAMAGE: A DIETARY INTERVENTION STUDY IN HUMANS. Shaughnessy, DT¹, Gangarosa, L², Schliebe, B², DeMarini, DM³, Xu, Z-L⁴, Umbach, DM⁵, Sandler, RS², Taylor, JA¹. ¹Laboratory of Molecular Carcinogenesis, NIEHS, Research Triangle Park, NC, United States, ²Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ³Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, NC, United States, ⁴Epidemiology Branch, NIEHS, Research Triangle Park, NC, United States, ⁵Biostatistics Branch, NIEHS, Research Triangle Park, NC, United States.

#157 CAN PERIPHERAL BLOOD LYMPHOCYTES PROVIDE A WINDOW TO ASSESS THE EXTENT OF GENOTOXICITY WITHIN THE PROSTATE? Shen, S¹, Cooley, DM¹, Schlittler, D¹, Chiang, E¹, Bostwick, DG³, Morris, JS⁴, Glickman, LT¹, Waters, DJ². ¹Purdue University, West Lafayette, IN, United States, ²Gerald P Murphy Cancer Foundation, West Lafayette, IN, United States, ³Bostwick Laboratories, Richmond, VA, United States, ⁴University of Missouri, Columbia, MO, United States.

#158 MOLECULAR EPIDEMIOLOGY OF GASTRIC CANCER IN COLOMBIA. Arboleda, YY, Acosta, CP, Alvarez, RE, Rodriguez, LJ, Urbano, AL, Maca, NN, Muñoz, SL, Gonzales, FE, Castro, LI, Adrada, JC, Sierra-Torres, CH. Laboratorio de Genetica Humana, Facultad Ciencias de la Salud, Universidad del Cauca, Popayan, Colombia.

#159 PREDICTING MUTAGENICITY IN THE MOUSE LYMPHOMA ASSAY USING SAR MODELLING. Sjögren, M, Bolcsfoldi, G. Safety Assessment, AstraZeneca R&D, Stockholm, Sweden.

#160 ARSENIC-INDUCED HORMESIS: THE CASE FOR NON-LINEAR LOW-DOSE RISK ASSESSMENT. Snow, ET. Deakin University, Burwood, Victoria, Australia.

#161 GENOTOXICITY OF DEET (N,N-DIETHYL-META-TOLUAMIDE) IN Vicia faba ROOT TIP CELLS AND HUMAN LYMPHOCYTES. Sozen, E, Tuylu, BA, Karacaoglan, C. Anadolu University, Eskisehir, Turkey.

#162 ASSESSMENT OF THE MITOTIC INDEX BY FLOW CYTOMETRY: IMPACT ON THE PERFORMANCE OF THE HUMAN LYMPHOCYTE CHROMOSOME ABERRATION ASSAY. Sanok, K, Gunther, W, O’Lone, S, Wiersch, C, Spellman, R, Muehlbauer, P. Pfizer Global R&D, Groton, CT, United States.

#163 MOLECULAR CHARACTERIZATION OF CISPLATIN AND TRANSPLATIN-INDUCED BASE SUBSTITUTIONS AND DELETION MUTATIONS IN NEWLY ESTABLISHED gpt DELTA L1 CELLS. Takeiri, A¹, Mishima, M¹, Tanaka, K¹, Shioda, A¹, Harada, A¹, Watanabe, K¹, Deki, T¹, Masumura, K², Nohmi, T². ¹Fuji Gotemba Research Labs., Chugai Pharmaceutical Co., Ltd., Shizuoka, Japan, ²Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo, Japan.

#164 OPTIMIZATION OF mRNA TARGET DETECTION BY ROLLING CIRCLE AMPLIFICATION (RCA) IN SOLUTION. Thomas, RA, Asur, R, Gajapathy, S, Tucker, JD. Wayne State University, Detroit, MI, United States.

#165 PERFORMANCE AND POWER OF FLOW CYTOMETRIC MICRONUCLEUS SCORING. Torous, D¹, Asano, N², Hayashi, M⁴, Dertinger, S¹, Morita, T³, Tometsko, C¹, Sugunan, S¹. ¹Litron Laboratories, Rochester, NY, United States, ²Toxicological Research Center, Nitto Denko Corp., Osaka, Japan, ³Div. of Safety Information on Drug, Food and Chemicals, National Institute of Health Sciences, Tokyo, Japan, ⁴Div. of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo, Japan.

#166 STRUCTURES OF DNA ADDUCTS DERIVED FROM N-NITROSOTAUROCHOLIC ACID. Totsuka, Y¹, Takamura, T¹, Enomoto, S¹, Nishigaki, R¹, Kawahara, N², Masumura, K², Nohmi, T², Sugimura, T¹, Wakabayashi, K¹. ¹National Cancer Center Research Institute, Tokyo, Japan, ²National Institute of Health Sciences, Tokyo, Japan.

#167 ENZYMATIC POST-LABELING ASSAY QUANTITATION OF NOVEL DNA ADDUCTS USING ACCELERATOR MASS SPECTROMETRY. Kim, S, Sumbad, R, Tran, A-T, Herderson, PT. Lawrence Livermore National Laboratory, Livermore, CA, United States.

#168 A STUDY ON IN VITRO GENOTOXIC ACTIVITY OF (+) USNIC ACID AND (-)-USNIC ACID WITH CBMN ASSAY IN HUMAN LYMPHOCYTES. Tuylu, BA. Anadolu University, Eskisehir, Turkey.

#169 THE FLEMISH HEALTH AND ENVIRONMENT BIOMONITORING PROGRAM: DIFFERENCES IN CLINICAL PARAMETERS AT BIRTH BETWEEN NEONATES BORN FROM WOMEN RESIDING IN AREAS DIFFERING IN POLLUTION PRESSURE. Van De Mieroop, E¹, Koppen, G², Bruckers, L³, Bilau, M⁴, Brits, E², Baeyens, W⁵, van Larebeke, N⁴, Schoeters, G², Neelen, V¹. ¹Provincial Institute for Hygiene, Antwerp, Belgium, ²Flemish Institute of Technological Research, Mol, Belgium, ³Limburgs Universitair Centrum, Diepenbeek, Belgium, ⁴Ghent University, Ghent, Belgium, ⁵Vrije Universiteit Brussel, Brussel, Belgium.

#170 BIOMONITORING FOR GENOTOXIC EFFECTS HAS A LOW SENSITIVITY IN TERMS OF CANCER RISKS ASSOCIATED WITH LIFELONG EXPOSURES STARTING IN UTERO. van Larebeke, NAF. Ghent University, Ghent, Belgium.

#171 DOSE RESPONSE ASSESSMENT OF SIMULATED SOLAR LIGHT ON THE LEVELS OF P53 MUTATION IN NORMAL-APPEARING SKIN. Verkler, TL, Delongchamp, RR, Miller, BJ, Howard, PC, Parsons, BL. National Center for Toxicological Research, USFDA, Jefferson, AR, United States.

#172 INFLUENCE OF IMMOBILIZATION STRESS ON DNA DAMAGE LEVEL IN SPLEEN CELLS OF DIFFERENT AGE MICE. Vorobyova, NY, Osipov, AN. Institute of Chemistry Physics RAS, Moscow, Russia.

#173 TESTING OF 51 MARKETED PHARMACEUTICALS USING THE GREENSCREEN GENOTOXICITY ASSAY. Walmsley, RM¹, Billinton, N¹, Van Gompel, J². ¹Gentronix Ltd, Manchester, United Kingdom, ²J&J, Beers, Belgium.

#174 A METHOD TO DISTINGUISH BETWEEN THE INDUCTION OF NEW MUTANTS AND SELECTION OF PRE-EXISTING MUTANTS IN THE MOUSE LYMPHOMA ASSAY. Wang, J¹, Heflich, RH², Moore, MM². ¹Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, United States, ²Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR, United States.

#175 USE OF TRANSCRIPTIONAL COUPLING AND KEGG PATHWAY ANALYSIS OF GLOBAL GENE EXPRESSION TO REVEAL TRANSCRIPTIONAL CHANGES BETWEEN STATIONARY- AND LOG-PHASE Salmonella typhimurium LT2. Ward, WO¹, Swartz, C¹, Porwollik, S², Hanley, NM¹, Warren, SH¹, McClelland, M², DeMarini, DM¹. ¹EPA, Research Triangle Park, NC, United States, ²Sidney Kimmel Cancer Center, San Diego, CA, United States.

#176 IN VITRO EVALUATION OF PHOTOCYTOTOXICITY AND PHOTOGENOTOXICITY FOR NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS). Watanabe, Y, Hasegawa, T, Miida, Y, Okazaki, A, Hashimoto, K, Takasaki, W. Sankyo Co., LTD., Fukuroi, Shizuoka, Japan.

#177 RECENT ADVANCES IN THE PREDICTION OF GENOTOXICITY USING DEREK FOR WINDOWS. Williams, RV¹, Naven, RT¹, Hayashi, M², Kamata, E². ¹Lhasa Limited, Leeds, United Kingdom, ²National Institute of Health Sciences, Tokyo, Japan.

#178 DIFFERENTIAL INDUCTION OF MICRONUCLEI IN ERYTHROCYTES OF ACRYLAMIDE-TREATED Cyp2E1-NULL AND WILD-TYPE MICE: EVIDENCE CONSISTENT WITH A GLYCIDAMIDE-MEDIATED EFFECT. Witt, KL¹, Recio, L³, Tice, RR³, Kissling, GE¹, Torous, DK², Ghanayem, BI¹. ¹National Institute of Environmenal Health Sciences, Research Triangle Park, NC, United States, ²Litron Laboratories, Rochester, NY, United States, ³ILS, Inc., Research Triangle Park, NC, United States.

#179 IN UTERUS ALCOHOL EXPOSURE ALTERED THE MITOCHONDRIAL PROTEOME OF THE FOETAL BRAIN. Xu, YJ, Li, Y. Peking University, Beijing, China.

#180 SIMULTANEOUS DETERMINATION OF 8-OH-dG AND 8-GUA (FREE BASE), MARKERS OF OXIDATIVE STRESS, AND CREATININE, A STANDARDIZATION COMPOUND, IN URINE. Yamasaki, S, Kasai, H. University of Occupational and Environmental Health, Kitakyushu, Japan.

#181 GERMLINE MUTATION, DNA DAMAGE AND EPIGENETIC MODIFICATIONS IN RESPONSE TO EXPOSURE TO PARTICULATE AIR POLLUTION IN AN INDUSTRIAL LOCATION. Polyzos, A¹, Kovalchuk, O², Somers, CM³, Rowan-Carroll, A¹, Berndt, ML¹, Williams, A¹, Quinn, JS⁴, Douglas, GR¹, Yauk, CL¹. ¹Health Canada, Ottawa, ON, Canada, ²University of Lethbridge, Lethbridge, AB, Canada, ³University of Regina, Regina, SK, Canada, ⁴McMaster University, Hamilton, ON, Canada.

#182 ENHANCED APOPTOTIC EFFECT OF CYCLOPHOSPHAMIDE IN VITRO IN HUMAN COLORECTAL CANCER CELLS INCUBATED WITH RAT S9. Yu, RL, Puskorius, RL, Zubrickas, KR, Mauthe, RJ. Pfizer, Inc., Ann Arbor, MI, United States.

#183 INDUCTION OF CELL CYCLE ARREST AND APOPTOTIC CELL DEATH BY THE PLANT-DERIVED DNA DAMAGE CHEMICAL CRYPTOLEPINE IN HUMAN LUNG ADENOCARCINOMA A549 CELLS. Zhu, H, Gooderham, NJ. Imperial College London, London, United Kingdom.

LB1 POPULATION RISK FACTOR IN GALLBLADER CANCER: EVALUATION BASED IN THE ANALYSIS OF THE HAPLOTYPE B OF mt DNA. Aguilar, XA¹, Taboada, G¹, Rada, A¹, Navia Ma del, Pilar², Arrieta, G³. ¹Instituto de Genética, Facultad de Medicina, UMSA, La Paz, Bolivia, ²Instituto de Investigación en Salud y Desarrollo, UMSA, La Paz, Bolivia, ³Servicio de Cirugía. Hospital Obrero Nº1, La Paz, Bolivia.

LB2 GENE EXPRESSION PROFILES DISTINGUISH LARGE AND SMALL COLONY THYMIDINE KINASE MUTANTS OF L5178Y MOUSE LYMPHOMA CELLS. Fuscoe, JC^1,2, Han, T^1,2, Wang, J³, Chen, T³, Moore, MM³. ¹Center for Functional Genomics, National Center for Toxicological Research, U.S. FDA, Jefferson, AR, United States, ²Division of Systems Toxicology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR, United States, ³Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR, United States.

LB3 INHIBITION OF PARP ACTIVITY INDUCES AN ATR- AND CHK1-DEPENDENT S-PHASE ARREST. Horton, JK, Stefanick, DF, Kedar, PS, Wilson, SH. Laboratory of Structural Biology, NIEHS, Research Triangle Park, NC, United States.

LB4 A MODEL V79 CELL LINE TRANSFECTED WITH MURINE GLUTATHIONE-S-TRANSFERASE THETA (mGSTT1) TO EVALUATE DNA DAMAGE INDUCED BY SELECTED MUTAGENS. Hu, Y¹, Tennant, AH¹, Townsend, AJ², Kligerman, AD¹. ¹ Environmental Carcinogenesis Division, NHEERL, US EPA, Research Triangle Park, NC, Untied States, ² Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, United States.

LB 5 HETEROLOGOUS EXPRESSION SYSTEM OF MOUSE HEAVY METAL TRANSCRIPTION FACTOR MTF-1 IN YEAST. Jin, YH, Al-Refai, H, Freedman, JH. Nicholas School of the Environment and Earth Sciences, Duke University, Durham, NC, United States.

LB6 COMPARATIVE INVESTIGATION OF IN VITRO INDUCTION OF DNA DAMAGE AND MICRONUCLEI BY PRO-MUTAGENS IN HUMAN-DERIVED HEPATOMA HepG2 CELLS. Kawaguchi, S¹, Okutani, S¹, Kinae, N², Honma, M³, Hayashi, M³, Sasaki, YF¹. ¹Hachinohe National College of Technology, Aomori, Japan, ²University of Shizuoka, Shizuoka, Japan, ³ National Institute of Health Sciences, Tokyo, Japan.

LB7 USE OF GENOTOXICITY DATA FOR DETERMINING THE MODE OF ACTION FOR CANCER CAUSING AGENTS. Keshava, C.¹, Chu, M¹, Cimino, MC¹, Dearfield, KL², Keshava, N¹, Kligerman, AD³, McCarroll, NE¹, Moore, MM⁴, Owen, R³, Putzrath, RM¹, Schoeny, R¹. ¹U.S. Environmental Protection Agency, Washington, DC; United States, ²U.S. Department of Agriculture, Washington, DC; United States, ³U.S. Environmental Protection Agency, Research Triangle Park, NC; United States, ⁴U.S. Food and Drug Administration, NCTR, Jefferson, AR, United States.

LB8 INVOLVEMENT OF BER PROTEINS IN TRINUCLEOTIDE REPEAT EXPANSION EXACERBATION IS LESION-SPECIFIC. Kovtun, IV, McMurray, CT. Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, United States.

LB9 CHARACTERIZATION OF THE MECHANISM OF MICRONUCLEUS FORMATION. Kumaravel, TS, Clements, J. Department of Genetic and Molecular Toxicology, Covance Laboratories Ltd., Harrogate, United Kingdom.

LB10 RESVERATROL INHIBITS PHORBOL ESTER-INDUCED EXPRESSION OF COX-2 AND ACTIVATION OF NF-?B IN MOUSE SKIN BY BLOCKING IB KINASE- ß ACTIVITY. Kundu, JK, Shin, YK, Kim, Y-C, and Surh, Y-J. National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul, South Korea.

LB11 REDUCED HEMATOPOIETIC RESERVES IN DNA INTERSTRAND CROSSLINK REPAIR DEFICIENT-Ercc1^-/- MICE. Lalai, AS^1, Prasher, JM2, Heijmans-Antonissen, C2, Ploemacher, RE2, Hoeijmakers, JHJ1, Touw, IP2, Niedernhofer, LJ³. ¹ Dept. of Cell Biology and Genetics, Erasmus Medical Center, Rotterdam, The Netherlands, ²Dept. of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands, ³Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States.

LB12 BASIC PRINCIPLES OF MUTAGENICITY TESTS FOR THE DETECTION OF ENVIRONMENTAL POLLUTANTS WITH PARTICULAR EMPHASIS ON PLANT BIOASSAY. ZhuLei.Tianjin University, Tianjin, China.

LB13 EXAMINATION OF MISMATCH REPAIR VARIATION IN Trypanosoma cruzi: THE GENETIC BASIS AND INFLUENCE ON SEQUENCE DIVERSITY. Machado-Silva, A¹, Cerqueira, G¹, Augusto-Pinto, L¹, DaRocha, WD¹, Pena, SDJ¹, El-Sayed, N³, Teixeira, SMR¹, Machado, CR¹, McCulloch, R². ¹Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, ²Wellcome Centre for Molecular Parasitology, Glasgow University, Glasgow, Scotland, ³The Institute for Genomic Research (TIGR), Rockville, MD, United States.

LB14 APOPTOSIS IN LYMPHOCYTES FOLLOWING EXPOSURE TO LOW DOSES OF GAMMA- AND NEUTRON RADIATION. Rossouw, MS^1,4; Slabbert, JP²; Blackhurst, D ³; Meehan, KA ⁴. ¹Department of Radiation Oncology, Tygerberg Hospital, Cape Town, South Africa, ²Department of Radiation Biology, iThemba Labs, Somerset West, South Africa, ³ Faculty of Medicine, University of Cape Town, Cape Town, South Africa, ⁴Faculty of Applied Sciences, Cape Peninsula University of Technology, Cape Town, South Africa.

LB15 MORPHOLOGICAL CHARACTERISATION AND ANALYSIS OF ⁶⁰Co GAMMA AND p(66)Be NEUTRON RADIATION-INDUCED APOPTOSIS IN CHO-K1 CELLS. Smit, KA¹, Slabbert, JP², Meehan, KA¹. ¹Faculty of Applied Sciences, Cape Peninsula University of Technology, Cape Town, South Africa, ²iThemba LABS, Somerset West, Cape Town, South Africa.

LB16 THE LEUKOCYTE APOPTOSIS ASSAY: A PREDICTOR OF INHERENT RADIOSENSITIVITY. Meehan, KA¹,Erasmus, WL¹, Abbert, JP², Crompton, N³. ¹Cape Peninsula University of Technology, Cape Town, South Africa, ²iThemba LABS, Somerset West, South Africa, ^3.Cornerstone University, Grand Rapids, MI, Unites States.

LB17 INDUCTION OF PSEUDO-MICRONUCLEI IN RAT SKIN MICRONUCLEUS TEST ON A VITAMIN D3 ANALOGUE. Mishima, M, Takeiri, A, Tanaka, K, Harada, A, Watanabe, K. Fuji Gotemba Research Laboratory, Chugai Pharmaceutical Co., Ltd.

LB18 DOUBLE-STRAND BREAK FORMATION FOLLOWING INTERSTRAND CROSSLINKS REQUIRES XPF IN HUMAN CELLS. Mogi, S^{1, 2}, Oh, DH^{1, 2}.
¹Department of Dermatology, University of California at San Francisco, San Francisco, CA, United States, ²Dermatology Research Unit, VA Medical Center, San Francisco, CA, United States.

LB19 ARTEMIS NUCLEASE SHOWS SPECIFICITY FOR DOUBLE-STRAND BREAKS WITH 3’ PHOSPHOGLYCOLATE TERMINI. Povirk, LF¹, Zhou, T¹, Zhou, R¹, Yannone, SM². ¹Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, Unites States, ²Life Sciences Division, Lawrence Berkeley Laboratory, Berkeley, CA, Unites States.

LB20 MOLECULAR MAPPING OF COMMON FRAGILE SITE FRA6E AND EVALUATION OF ITS REPLICATIVE PATTERN. Graziotto, R¹, Palumbo, E¹, Rampin, M¹, Taramell, R², Bensimon, A³, Russo, A^{1 1}Dipartimento di Biologia, Università degli Studi di Padova, Padova, Italy; ²Dipartimento di Biotecnologie e Scienze Molecolari, Università degli Studi dell’Insubria, Varese, Italy; ³Institute Pasteur, Paris, France.

LB21 INTERACTION OF DNA POLYMERASES WITH N3-METHYLADENINE AND STRUCTURAL ANALOGS 3-DEAZAADENINE AND 3-METHYL-3-DEAZADENINE. Settles S, Gold B. University of Nebraska Medical Center; Eppley Institute for the Research in Cancer, Omaha, NE, United States.

LB22 HOST CELL REACTIVATION OF PLASMIDS CONTAINING OXIDATIVE DNA LESIONS IN COCKAYNE AND UV-SENSITIVE SYNDROME CELLS. Spivak, G, Hanawalt, PC. Department of Biological Sciences, Stanford University, Stanford, CA, United States.

LB23 YEAST SCF^Met30 REGULATES RESPONSE TO HEAVY METAL STRESS. Yen, JL, Su, NY, Kaiser, P. Department of Biological Chemistry, UCI, Irvine, CA, United States.

Sunday, September 4, 2005
3:00 PM–5:00 PM
Bayview

CURRENT ISSUES SYMPOSIUM—MUTATIONAL MECHANISMS

A GENOMIC VIEW OF MUTATION

Chair: Lynn S. Ripley, UMDNJ, Newark, NJ, United States and
Norman Arhheim, University of Southern California, Los Angeles, CA, United States

3:00 PM #184 A GENOMIC VIEW OF FRAMESHIFTS IN HUMAN EXONS

Lynn S. Ripley, UMDNJ, Newark, NJ, United States

3:30 PM #185 A GENOME-WIDE VIEW OF THE RATE AND SPECTRUM OF SPONTANEOUS MUTATIONS

Michael Lynch, Indiana University, Bloomington, IN, United States

4:00 PM #186 MALE GERMLINE MUTATIONS:
MUTATION RATES AT SPECIFIC HOTSPOTS

Norman Arhheim, University of Southern California, Los Angeles, CA, United States

4:20 PM #187 A NOVEL METHOD TO QUANTIFY EXTREMELY RARE RANDOM GENOMIC MUTATIONS

Jason H. Bielas, University of Washington School of Medicine, Seattle, WA, United States

4:40 PM #188 TANDEM REPEAT MUTATION AND RAPID EVOLUTION

John W. Fondon III, University of Texas, Dallas, TX, United States

Sunday, September 4, 2005
3:00 PM–5:00 PM
Seacliff A/B

CURRENT ISSUES SYMPOSIUM—RISK ASSESSMENT

LEGAL AND ETHICAL ISSUES ASSOCIATED WITH GENETIC TESTING

Chairs: Errol Zeiger, Chapel Hill, NC , United States and
Dafna Feinholtz, Col. Jardines en la Montana, Mexico

3:00 PM ETHNICITY, GENETIC VARIABILITY, AND RACE

Richard R. Sharp, Baylor College of Medicine, Houston, TX, United States

3:30 PM #189 TREATING GENETIC INFORMATION DIFFERENTLY FROM OTHER MEDICAL INFORMATION

Henry T. Greely, Stanford University School of Law, Palo Alto, CA, United States

4:00 PM #190 A WORKING DILEMMA: HOW OCCUPATIONAL HEALTH POLICY PREVENTS THE ETHICAL USE OF GENETIC KNOWLEDGE

Geoffrey P. Lomax, California Department of Health Sciences, Sacramento, CA, United States

4:20 PM #191 GENETICALLY BASED TOXIC TORT SUITS

Gary E. Marchant, Arizona State University, Tempe, AZ, United States

4:40 PM #192 ETHICS OF GENETIC TESTING:
INCORPORATION OF A GENDER PERSPECTIVE

Dafna Feinholz, Comision Nacional de Bioetica, Col. Jardines en la Montana, Mexico

Sunday, September 4, 2005
3:00 PM–5:00 PM
Seacliff C/D

CURRENT ISSUES SYMPOSIUM—MUTATIONAL MECHANISMS

NONCOVALENT CHEMICAL-DNA INTERACTIONS AND GENOTOXICITY

Chairs: Ronald D. Snyder, Schering-Plough Research Institute, Lafayette, NJ, United States and
Christian Bailly, INSERM, IRCL, Lille, France

3:00 PM #193 CHEMISTRY AND BIOLOGY OF NONCOVALENT DNA INTERACTIONS

Christian Bailly, INSERM, IRCL, Lille, France

3:30 PM #194 DNA TOPOLOGY AFFECTS THE RESPONSE OF HUMAN TOPOISOMERASES TO ANTICANCER DRUGS

Neil Osheroff, Vanderbilt University School of Medicine, Nashville, TN, United States

4:00 PM #195 CHINESE HAMSTER V79 CELL-BASED INVESTIGATIONS INTO THE RELATIONSHIP BETWEEN NON-COVALENT DNA INTERACTION AND GENOTOXICITY

Ronald D. Snyder, Schering-Plough Research Institute, Lafayette, NJ, United States

4:20 PM #196 3D DOCKING MODEL FOR PREDICTING DNA INTERCALATION ACTIVITY

Larry B. Hendry, Accelerated Pharmaceuticals, Augusta, GA, United States

4:40 PM #197 MECHANISMS AND IMPLICATIONS OF RECOMBINOGENIC AND ANEUPLOIDOGENIC EFFECTS OF TOPOISOMERASE II INHIBITORS

Lynn R. Ferguson, University of Auckland School of Medicine, Auckland, New Zealand

Sunday, September 4, 2005
3:00 PM–5:00 PM
Grand Ballroom B

CURRENT ISSUES SYMPOSIUM—MUTATIONAL MECHANISMS

OXIDATIVE STRESS RESPONSES

Chairs: Susumu Nishimura, University Tsukuba, Ibaraki, Japan and
Arthur P. Grollman, State University at Stony Brook, New York, NY, United States

3:00 PM #198 POSTREPLICATIVE PROTECTION AGAINST INDUCTION OF MUTATIONS BY 8-Oxo-dG-INDUCED MUTAGENESIS IN MAMMALIAN CELLS

Masaaki Moriya, State University at Stony Brook, New York, NY, United States

3:30 PM #199 IN SITU ANALYSIS OF CELLULAR RESPONSES TO OXIDATIVE BASE DAMAGE AND STRAND BREAKS IN MAMMALIAN CELLS

Akira Yasui, Institute of Development, Aging and Cancer, Sendai, Japan

4:00 PM #200 OXIDATIVE DAMAGE TO DNA: IS IT ONLY 8-Oxo-dG?

Steven R. Tannenbaum, Massachusetts Institute of Technology, Cambridge, MA, United States

4:20 PM #201 INVOLVEMENT OF MUTY IN PREVENTING CANCER

Jeffrey H. Miller, University of California, Los Angeles, CA, United States

4:40 PM OXOGUANINE AND CARCINOGENESIS: HUMANS VS. MICE

Susumu Nishimura, Banyu Tsukuba Research Institute, Ibaraki, Japan

Sunday, September 4, 2005
3:00 PM–5:00 PM
Grand Ballroom A

CURRENT ISSUES SYMPOSIUM—DNA REPAIR

RECOMBINATION AND DOUBLE-STRAND-BREAK REPAIR

Chairs: James E. Haber, Brandeis University, Waltham, MA, United States and Stephen C. West, London Research Institute, Herts, United Kingdom

3:00 PM #202 RECOMBINATION REPAIR AND A TREATMENT FOR BRCA2 TUMOURS

Thomas Helleday, University of Sheffield, Sheffield, United Kingdom

3:30 PM #203 DNA DOUBLE-STRAND BREAK REPAIR IN DROSOPHILA

Jeff J. Sekelsky, University of North Carolina, Chapel Hill, NC, United States

4:00 PM #203A “RECOMBOMICE” SHED LIGHT ON HOMOLOGOUS RECOMBINATION
IN VIVO

Beven P. Engelward, Massachusetts Institute of Technology, Cambridge, MA, United States

4:20 PM #204 MULTIPLE MECHANISMS TO REPAIR BROKEN YEAST CHROMOSOMES

James E. Haber, Brandeis University, Waltham, MA, United States

4:40 PM #205 REGULATION AND MECHANISM OF DOUBLE-STRAND BREAK REPAIR IN MAMMALIAN CELLS

Stephen C. West, London Research Institute, Herts, United Kingdom

Sunday, September 4, 2005
5:15 PM–7:15 PM
Bayview

CURRENT ISSUES SYMPOSIUM—ENVIRONMENTAL MUTAGENESIS/CARCINOGENESIS

CASE STUDIES OF ENVIRONMENTAL MUTAGEN CONTAMINATION DISASTERS AROUND THE WORLD

Chairs: William Au, University Texas, Galveston, TX, United States and
Lance R. Brooks, Department of Homeland Security, Washington, DC, United States

Sponsored by US Department of Homeland Security

5:15 PM #206 NATIONAL EXPOSURE MEASUREMENT FOR DECISIONS TO PROTECT PUBLIC HEALTH FROM ENVIRONMENTAL EXPOSURES

Dana B. Barr, Centers for Disease Control, Atlanta, GA, United States

5:45 PM #207 HEALTH CONSEQUENCES OF MUSTARD GAS EXPOSURE

Brian J. Davey, Organization for the Prohibition of Chemical Weapons, The Haag, Netherlands

6:15 PM #208 PREVENTING CHEMICAL ACCIDENTS: LESSONS FROM BHOPAL

Gerald Poje, US Chemical Safety Hazard Investigation Board, Trenton, NJ, United States

6:35 PM #209 WORLD TRADE CENTER ATTACK: HEALTH EFFECTS NOW AND LATER

Mark A. Maddaloni, US EPA, New York, NY, United States

6:55 PM #210 RADIATION EXPOSURE AND HEALTH RISK IN KAZAKHSTAN FROM ATOMIC BOMB TESTINGS

Rakhmetkaji I. Bersimbaev, Kazhak National University, Almaty, Kazakhstan

Sunday, September 4, 2005
5:15 PM–7:15 PM
Seacliff C/D

CURRENT ISSUES SYMPOSIUM—DNA REPAIR

TRANSCRIPTIONAL ENCOUNTERS WITH DNA DAMAGE

Chairs: Paul W. Doetsch, Emory University, Atlanta, GA, United States and
Priscilla K. Cooper, Lawrence Berkeley National Laboratory, Berkeley, CA, United States

5:15 PM #211 TRANSCRIPTIONAL MUTAGENESIS IN BACTERIAL AND MAMMALIAN SYSTEMS

Paul W. Doetsch, Emory University, Atlanta, GA, United States

5:45 PM #212 ASSEMBLY OF REPAIR FACTORS FOR TRANSCRIPTION-COUPLED REPAIR

Leon H. Mullenders, Leiden University Medical Center, Leiden, Netherlands

6:15 PM #213 TRANSCRIPTION ARREST AT DNA DAMAGE SITES: IMPLICATIONS FOR TRANSCRIPTION-COUPLED REPAIR

Silvia Tornaletti, Stanford University, Stanford, CA, United States

6:35 PM #214 TFIIH TRANSCRIPTION FACTOR IN DNA REPAIR

Jean-Marc Egly, CNSR/INSERM/ULP, Strasbourg, France

6:55 PM #215 FUNCTIONAL ANALYSIS OF CSA AND CSB PROTEINS IN TRANSCRIPTION-COUPLED REPAIR

Kiyoji Tanaka, Osaka University, Osaka, Japan

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