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Short Courses |
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Short Courses
The 9th ICEM will begin on Saturday morning, September 3, with committee meetings and four Short Courses. The Short Courses will run concurrently from 8:00 AM–12:20 PM. Short Courses require a separate registration fee.
Short Course Registration: Registered participants in the 9th ICEM may enroll in one of the short courses offered on Saturday morning. Four Short Courses will be held on Saturday, September 3. Separate registration is required to attend a Short Course. The Short Courses will run concurrently, allowing you to register for only one Short Course. Please mark the appropriate space on the Registration Form if you will be attending a Short Course.
Saturday, September 3, 2005
Saturday, September 3, 2005
8:00 AM–12:30 PM
Bayview
Applied and Regulatory Genetic Toxicology
Chair: Paul A. White, Health Canada, Ottawa, Ontario, Canada
Sponsored by Health Canada
This course will provide an overview of genetic toxicology test batteries, genetic toxicology tests approved for regulatory purposes, and regulatory guidelines for interpreting genetic toxicology test data. Detailed information will be provided on all of the major genetic toxicology tests, including how they are conducted and how the results are interpreted. The use of genetic toxicology data in industry and governmental regulatory agencies will be discussed.
- Welcome and Introduction
- Paul A. White, Health Canada, Ottawa, ON, Canada
- Overview of Test Batteries, Approved Regulatory Tests, and Regulatory Guidelines
- Paul A. White, Health Canada, Ottawa, ON, Canada
- Use of Genetic Toxicology Testing in the Assessment of Existing Chemical Substances under the Canadian Environmental Protection Act
- Kathy Hughes, Health Canada, Ottawa, ON, Canada
- Framework for the Use of Genetic Toxicity Test Results for the Regulation of Chemical Products
- Kerry L. Dearfield, USDA, Washington, DC, United States
- Genetic Toxicology Testing in the Agrochemical Industry and Its Role in Product Safety Assessment and Mechanistic Research
- Bhaskar Gollapudi, The Dow Chemical Company, Midland, MI, United States
- Genetic Toxicology Testing and Product Safety Assessment in the Pharmaceutical Industry
- Robert J. Mauthe, Pfizer Global R&D, Ann Arbor, MI, United States
Saturday, September 3, 2005
8:00 AM–12:30 PM
Seacliff A/B
Emerging Issues in Molecular Epidemiology
Chairs:
Stefano Bonassi, INRC, Genoa, Italy
Marianne Berwick, University New Mexico,
Albuquerque, NM, USA
The recent availability of high-throughput techniques for population studies has provided the potential for discovering genetic risks of disease in individuals and modeling gene-environment interactions. This course addresses issues regarding various genetic biomarkers, such as the use of SNPs and gene-expression profiles in the study of human populations, as well as the potential of banking biological sampling. Statistical methods for analyzing data from new molecular endpoints will be presented, along with new perspectives on the classic disciplines of biodosimetry and exposure assessment.
- How Molecular Epidemiology Is Changing with New Techniques
- John S. Witte, University California, San Francisco, CA, United States
- Association Studies in Molecular Epidemiology
- Marianne Berwick, University New Mexico, Albuquerque, NM, United States
- SNPs and Microarrays in Population Studies
- Martyn T. Smith, University California, Berkeley, CA, United States
- Statistical Methods in Molecular Epidemiology
- Sandrine Dudoit, University California, Berkeley, CA, United States
- Biodosimetry: From Chromosomes to Gene Expression Profiling
- James D. Tucker, Wayne State University, Detroit, MI, United States
- Tissue Repositories: Issues and Challenges, A View from the Trenches
- Vann E. Schaffner, University New Mexico, Albuquerque, NM, United States
- Exposure Biomarkers: A Role for DNA Adducts
- Peter B. Farmer, University Leicester, Leicester, United Kingdom
Saturday, September 3, 2005
8:00 AM–12:30 PM
Seacliff C
New Developments and Applications of the Comet Assay
Chairs: N.P. Singh, University Washington, Seattle,
WA, United States and
Peggy Olive, BC Cancer Research Centre, Vancouver, BC, Canada
Sponsored by Integrated Laboratory Systems, Inc.
This course will cover the various primary applications of the Comet (or single cell gel electrophoresis) assay. For each major area of interest, instructors will review innovative applications, proper study design, the types of mechanistic data that can be obtained by modifying the assay, data analysis, and study interpretation.
Organizers and/or Instructors:
- Brian Burlinson, GlaxoSmithKlein, Herts, United Kingdom
- Andrew R. Collins, University Oslo, Oslo, Norway
- Maria Dusinska, Institution Preventive and Clinical Medicine, Bratislava, Slovakia
- Andreas Hartmann, Novartis, Basel, Switzerland
- Makoto Hayashi, NIHS, Tokyo, Japan
- Günter Speit, University Ulm, Ulm, Germany
- Raymond R. Tice, NIEHS, Research Triangle Park, NC,
United States
Lecture Topics:
- Assessment of DNA Repair Competency in Mammalian Cells (e.g., Lesion-specific Pathways, use of FISH)
- Human Biomonitoring (e.g., Classes of DNA Damage, Occupational, Environmental Exposures)
- Genetic Ecotoxicology (Aquatic, Terrestrial)
- Genetic Toxicology (Screening/Regulatory Applications, In Vitro/In Vivo Test Methods, Cytotoxicity, Validation)
- Question-and-Answer Panel
- Optional Lecture—Practical Aspects of the Comet Assay
Saturday, September 3, 2005
8:00 AM–12:30 PM
Seacliff D
Quality Assurance (QA) in Government and Industry Laboratories
Chair: Thomas J. Hughes, US EPA, Research Triangle Park, NC, United States
Sponsored by Celanese
This course will provide an overview of QA and Quality Control (QC) relevant to U.S. government, industrial, and pharmaceutical laboratories. Regulations on the use of rodents in toxicology, including Institutional Animal Care and Use Committee (IACUC) functions, will be given. Good Laboratory Practice (GLP) Regulations will be reviewed, including management of GLP studies at Contract Research Organizations (CROs). QA practices for paper and electronic records in government and the pharmaceutical industry will be described, including techniques to validate computer software and programs for record keeping.
- Relationships Among QC, Peer-Review, and QA Procedures at the US EPA
- Thomas J. Hughes, US EPA, Research Triangle Park, NC, United States
- Regulations and Guidelines for Use of Animals in Toxicological Research
- James W. Allen, US EPA, Research Triangle Park, NC, United States
- Overview of GLP Regulations and QA
- Patricia O’Brien Pomerleau, CIIT Centers for Health Research, Research Triangle Park, NC, United States
- Management of GLP Studies at Contract Research Organizations (CROs)
- Thomas R. Barfknecht, Celanese Ltd., Dallas, TX, United States
- QA and Data Management Techniques at the US EPA
- Ron Rogers, US EPA, Research Triangle Park, NC, United States
- Computer Systems and Quality Assurance
- John Haw, Cary, NC, United States
- Final Questions and Answers
Final Questions and Answers
