The Emerging Issues Symposia will consist of invited speakers and presentations selected from the abstract submissions. If you wish to be considered for a presentation in one of these sessions, please select the presentation type of “platform” during your abstract submission. There are ten (10) Emerging Issues Symposium sessions. These sessions have been organized into five (5) categories. Each session is listed alphabetically under each category. Refer to the Program Index for a quick listing of sessions and categories.

• DNA Repair
• Environmental Mutagenesis/Carcinogenesis
• Mutagenesis and Human Disease
• Mutational Mechanisms
• Risk Assessment

DNA Repair

Tuesday, September 6, 2005
3:00 PM–5:00 PM
Seacliff C/D

ENDOGENOUS DNA DAMAGE: COMPARISON WITH ENVIRONMENTAL GENOTOXICANTS

Chairs: P.J. Brooks, NIH, Bethesda, MD, United States and
David H. Phillips, Institute of Cancer Research, Sutton, United Kingdom

3:00 PM #647 WHAT MEASURING DNA DAMAGE DOES AND DOES NOT TELL US ABOUT CAUSES OF CANCER AND MUTATION

David H. Phillips, Institute of Cancer Research, Sutton, United Kingdom

3:20 PM #648 TOXICOGENOMICS OF ENDEMIC NEPHROPATHY, AN ENVIRONMENTAL DISEASE

Arthur P. Grollman, SUNY Stony Brook, Stony Brook, NY, United States

3:40 PM #649 BIOLOGICAL EFFECTS OF 8, 5’- CYCLOPURINES: A UNIQUELY TOXIC FORM FOR ENDOGENOUS OXIDATIVE DNA DAMAGE

P.J. Brooks, NIAAA, NIH, Bethesda, MD, United States

4:00 PM #650 MEASUREMENT OF IN VIVO OXIDATIVE DNA DAMAGE BY LIQUID CHROMOTOGRAPHY/MASS SPECTOMETRY

Miral Dizdaroglu, National Institute of Standards and Technology, Gaithersburg, MD, United States

4:15 PM #651 GENOTOXICITY OF ARSENIC AND CADMIUM: OXIDATIVE DNA DAMAGE, DNA REPAIR, ZINC FINGER PROTEINS AND P53

Tanja Schwerdtle, Technical University of Berlin, Berlin, Germany

4:30 PM #652 SPONTANEOUS DNA DAMAGE DUE TO MITOCHONDRIAL METABOLISM TRIGGERS CHECKPOINT ACTIVATION IN REPAIR DEFICIENT Saccharomyces cerevisiae

Wolfram Siede, University of North Texas Health Science Center, Fort Worth, TX, United States

4:45 PM #653 GENOME INSTABILITY CAUSED BY ENDOGENOUS NUCLEOTIDE LESIONS

Tatsuo Nunoshiba, Tohoku University, Sendai, Japan

Environmental Mutagenesis/Carcinogenesis

Monday, September 5, 2005
3:00 PM–5:00 PM
Grand Ballroom A

GENOTOXICOLOGY OF AQUATIC SYSTEMS

Chairs: Gisella A. Umbuzeiro, CETESB, Sao Paolo, Brazil and
Yasunobu Aoki, NIES, Tsukuba, Ibaraki, Japan

3:00 PM #426 DEVELOPMENT OF IN VIVO MUTAGENICITY ASSAY SYSTEM USING rpsL TRANSGENIC ZEBRAFISH FOR MONITORING ENVIRONMENTAL MUTAGENS

Yausnobu Aoki, NIES, Tsukuba, Ibaraki Japan

3:20 PM #427 RELEVANCE OF THE SALMONELLA ASSAY IN WATER QUALITY EVALUATION: INDICATION OF AZO DYES AS IMPORTANT AQUATIC CONTAMINANTS

Gisella A. Umbuzeiro, CETESB, Sao Paolo, Brazil

3:40 PM #428 GENOTOXIC AND ECOTOXICOLOGICAL ASSESSMENT FOR DIAGNOSIS OF AQUATIC ECOSYSTEMS

Vera M. Vargas, FEPAM, Porto Alegre, Brazil

4:00 PM #429 GENOTOXICITY BIOMARKERS IN FISH AND BLUE MUSSELS: RESULTS FROM BEEP CRUISES

Claudia Bolognesi, NIRC, Genova, Italy

4:15 PM #430 GENOTOXICTY AND ACUTE TOXICITY ASSESSMENT IN AQUATIC ENVIRONMENTS

Richard M. Walmsley, Gentronix, Ltd., Manchester, UK

4:30 PM #431 GENOTOXICITY OF MICROCYSTIN-LR: IMPLICATION OF REACTIVE OXYGEN SPECIES

Metka Filipic, National Institute of Biology, Ljubljana, Slovenia

4:45 PM #432 EVALUATION OF THE TERATOGENIC AND MUTAGENIC POTENTIAL OF THALIDOMIDE IN THE SMALL FISH MODEL JAPANESE MEDAKA

Don G. Ennis, University of Louisiana, Lafayette, LA, United States

Monday, September 5, 2005
3:00 PM–5:00 PM
Seacliff C/D

MUTAGENIC CONSEQUENCES OF ENVIRONMENTAL EXPOSURES

Chairs: Tetsuya Kamataki, Hokkaido University, Hakodate, Japan and Emilio Rojas, UNAM, Mexico City, Mexico

3:00 PM #440 GENE AND ENVIRONMENT INTERACTION: GENETIC POLYMORPHISM OF CYP2A6 AS A DETERMINANT OF TOBACCO RELATED CANCER RISK

Tetsuya Kamataki, Hokkaido University, Hakodate, Japan

3:20 PM #441 ENVIRONMENTAL TRACE ELEMENTS ASSOCIATED WITH CANCER RISK IN LUCRECIA-RN/BRAZIL

Carlos F.S. Castro, Catholic University at Brasília, Taguatinga, Brazil

3:40 PM #442 GENOTOXIC CONSEQUENCES OF MEXICO CITY ATMOSPHERIC POLLUTION

Emilio Rojas, UNAM, Mexico City, Mexico

4:00 PM #443 4-OXO-2-HEXENAL IN COOKED FOODS AND DNA ADDUCT FORMATION IN MOUSE ORGANS AFTER ORAL ADMINISTRATION

Kazuaki Kawai, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan

4:15 PM #444 BIOLOGICAL PROPERTIES OF AMINOPHENYLNORHARMAN FORMED FROM NORHARMAN AND ANILINE

Yukari Totsuka, National Cancer Center Research Institute, Tokyo, Japan

4:30 PM #445 PHOTOTOXICITY INCLUDING PHOTOMUTAGENICITY OF THIRTEEN SELECTED POLYCHLORINATED BIPHENYLS (PCBS) IN Salmonella typhimurium TA102 AND HUMAN SKIN CELLS

Lei Wang, Jackson State University, Jackson, MS, United States

4:45 PM #446 ENHANCEMENT OF DNA REPAIR BY RADIO-PROTECTORS: IN VIVO STUDIES WITH ANIMAL MODELS

C.K.K. Nair, Bhabha, Atomic Research Centre, Mumbai, India

Mutagenesis and Human Disease

Monday, September 5, 2005
3:00 PM–5:15 PM
Seacliff A/B

ADVANCES IN HUMAN BIOMONITORING

Chairs: Beatrice Pool-Zobel, University Jena, Jena, Germany and
Lucia R. Ribeiro, School of Medicine, Botucatu-UNESP, Brazil

3:00 PM #418 ENVIRONMENTAL COLON CARCINOGENESIS: ASSESSING THE BALANCE OF EXPOSURE AND SUSCEPTIBILITY IN COLONOCYTES AND PERIPHERAL LEUCOCYTES—
A BIOMICS APPROACH

Beatrice Pool-Zobel, University Jena, Jena, Germany

3:20 PM #419 RELEVANCE OF BIOMARKERS OF INDIVIDUAL SUSCEPTIBILITY IN MOLECULAR EPIDEMIOLOGY STUDIES

Maria Dusinska, Slovak Medical University, Bratislava, Slovakia

3:40 PM #420 EFFECTS OF DIETARY COMPONENTS ON GENOMIC STABILITY IN HUMANS: RESULTS OF INTERVENTION TRIALS

Siegfried Knasmuller, University Vienna, Vienna, Austria

4:00 PM #421 ADVANCING AGE AMONG HEALTHY NONSMOKING MALES IS ASSOCIATED WITH REDUCED SPERM MOTILITY AND INCREASED FREQUENCIES OF SPERM WITH DNA FRAGMENTATION, CHROMOSOMAL ABNORMALITIES AND GENE MUTATIONS

Andrew J. Wyrobek, Lawrence Livermore National Laboratory, Livermore, CA, United States

4:15 PM #422 DIETARY AND SMOKING HABITS INFLUENCE ANTI-B[a]P-DNA ADDUCTS IN ENVIRONMENTALLY LOW EXPOSED HUMANS

Sofia Pavanello, University of Padova, Italy

4:30 PM #423 GENOTYPE AND PHENOTYPE OF GLUTATHIONE-S-TRANSFERASE PI IN PLACENTA OF MEXICAN WOMEN LIVING AT THE US-MEXICO BORDER AND RELATION TO PLACENTAL PAH-DNA ADDUCT LEVELS

Penelope J.E. Quintana, San Diego State University, San Diego, CA, United States

4:45 PM #424 CYTOGENIC BIOMARKERS AND HUMAN CANCER RISK

Hannu Norppa, Finnish Inst. of Occupational Health, Helsinki, Finland

5:00 PM #425 INVESTING IN GENETIC TOXICOLOGY RESEARCH IN AFRICA

Wagida A. Anwar, Ain Shams University, Cairo, Egypt

Mutational Mechanisms

Monday, September 5, 2005
3:00 PM–5:15 PM
Bayview

MICROBIAL INFECTION AND MALIGNANCY

Chairs: Patricia Ostrosky-Wegman, UNAM, Mexico City, Mexico and
Julie Parsonnet, Stanford University, CA, United States

3:00 PM MICROBES AND MALIGNANCY

Julie Parsonnet, Stanford University, Stanford, CA, United States

3:20 PM #433 ADULT STEM CELL THERORY OF THE MULTI-STAGE, MULTI-MECHANISM MODEL OF CARCINOGENESIS: ROLE OF INFLAMATION ON THE PROMOTION OF INITIATED STEM CELLS

James E.Trosko, Michigan State University, East Lansing, MI, United States

3:40 PM #434 TUMOR VIRUSES AND THE “INTRACELLULAR IMMUNE SYSTEM”: ROLES OF TUMOR SUPPRESSOR PATHWAYS IN CONTROLLING VIRAL INFECTION

Patrick S. Moore, University of Pittsburgh, Pittsburgh, PA, United States

4:00 PM #435 HCMV-INDUCED GENETIC INSTABILITY: BRAIN TUMOR CASE-CONTROL STUDY

Randa El-Zein, M.D. Anderson Cancer Center, University of Texas, Houston, TX, United States

4:15 PM #436 EXPOSURE TO WOOD SMOKE AND GENETIC SUSCEPTIBILITY FOR CERVICAL NEOPASIA AMONG HPV-INFECTED WOMEN IN COLUMBIA

Carlos H. Sierra-Torres, Universidad del Cauca, Popayan, Columbia

4:30 PM #437 BIOREGULATION OF MICROBES FOR THE ATTENUATION OF MICROBE-ASSOCIATED MALIGNANCY

Ki Baik Hahm, Ajou University School of Medicine, Suwon, South Korea

4:45 PM #438 MECHANISMS OF INFECTION-INDUCED CARCINOGENESIS

Patricia Ostrosky-Wegman, UNAM, Mexico City, Mexico

5:00 PM #439 CYCLIN D-RB PATHWAY IS ALTERED DURING CONTINUOUS EXPOSURE OF MOLT-3 HUMAN LYMPHOBLASTOID CELLS TO THE ANTIRETROVIRAL DRUG ZIDOVUDINE (AZT)

Ofelia A. Olivero, National Cancer Institute, NIH, Bethesda, MD, United States

Monday, September 5, 2005
3:00 PM–5:00 PM
Grand Ballroom B

SPONTANEOUS MUTAGENESIS AND HYPERMUTATION

Chairs: Nancy Maizels, University of Washington, Seattle, WA, United States and Karen M. Vasquez, University of Texas M.D. Anderson Cancer Center, Science Park–Research Division, Smithville, TX, United States

3:00 PM #447 BIOCHEMICAL BASIS OF SOMATIC HYPERMUTATION

Myron F. Goodman, University of Southern California, Los Angeles, CA

3:20 PM #448 RECOMBINOGENIC DNA STRUCTURES IN IMMUNOGLOBULIN GENE DIVERSIFICATION AND ONCOGENESIS

Nancy Maizels, University of Washington, Seattle, WA, United States

3:40 PM #449 NON-B DNA STRUCTURE-INDUCED GENETIC INSTABILITY

Karen M. Vasquez, University of Texas M.D. Anderson Cancer Center, Science Park–Research Division, Smithville, TX, United States

4:00 PM #450 SPINDLE CHECKPOINT-DEPENDANT PHOSPHORYLATION OF BLM AND CHORMOSOME STABILITY

Yi Wang, Baylor University, Houston TX, United States

4:15 PM #451 SPONTANEOUS MUTAGENESIS IN MICE WITH A TARGETED DISRUPTION OF THE MutYH GENE

Teruhisa Tsuzuki, Kyushu University, Fukuoka, Japan

4:30 PM #452 ROLE OF THE CHECKPOINT IN POST-REPLICATION REPAIR PATHWAY

Mihoko K. Kai, Stanford University School of Medicine, Stanford, CA, United States

4:45 PM #453 NUCLEOTIDE EXCISION REPAIR TRIGGERS H2AX PHOSPHORYLATION INDEPENDANT OF DNA DOUBLE STRANDS BREAKS

Eli Hefner, University of California, San Francisco, CA, United States

Tuesday, September 6, 2005
3:00 PM–5:00 PM
Grand Ballroom A

DNA DAMAGE AND MUTATIONAL SPECIFICITY

Chairs: Kathleen A. Hill, University Western Ontario, ON, Canada and
Gerald P. Holmquist, City of Hope, Duarte, CA, United States

3:00 PM #640 NUCLEOTIDE EXCISION REPAIR RATES OF R-BAND, G-BAND AND C-BAND DNA IN MAMMALIAN CELLS

Gerald P. Holmquist, City of Hope, Duarte, CA, United States

3:20 PM #641 ISSUES IN MUTAGENESIS EMERGING FROM IN VIVO ANALYSIS OF GERMLINE AND SOMATIC SPONTANEOUS MUTATIONS IN HUMAN AND MOUSE

Kathleen A. Hill, University of Western Ontario, ON, Canada

3:40 PM #642 DNA ADDUCTS, MUTANT FREQUENCIES, TYPES OF MUTATIONS AND MICROARRAY GENE EXPRESSION PROFILES INDUCED BY ARISTOLOCHIC ACID IN KIDNEY AND LIVER OF BIG BLUE TRANSGENIC RATS

Nan Mei, National Center for Toxicological Research, US FDA, Jefferson, AR, United States

4:00 PM #643 TRACING NUCLEOSIDE INCORPORATION AND ESTROGEN-DEPENDANT DNA OXIDATION IN MCF-7 BREAST CANCER CELLS USING ACCELERATOR MASS SPECTROMETRY

Paul T. Henderson, Lawrence Livermore National Laboratory, Livermore Livermore, CA, United States

4:15 PM #644 DNA LESIONS INDUCED BY ULTRAVIOLET A AND B RADIATION IN HUMAN CELLS: COMPARATIVE ANALYSIS IN THE OVERALL GENOME AND THE P53 TUMOR SUPPRESSOR GENE

Ahmad Besaratinia, City of Hope, Duarate, CA, United States

4:30 PM #645 DYNAMIC MITOCHONDRIAL DNA RESPONSES TO OXIDATIVE DAMAGE IN HUMAN CANCER CELLS

Junjian Z. Chen, McGill University Health Center, Montreal, Quebec, Canada

4:45 PM #646 INHIBITION EFFECTS OF GREEN VEGETABLE OR FRUITS AGAINST 8-OH-dG INDUCED BY NITROPHENANTHRENE DERIVATIVES IN VITRO AND IN VIVO

Nobuyuki Sera, Fukuoka Institute of Health and Environmental Sciences, Fukuoka, Japan

Tuesday, September 6, 2005
3:00 PM–5:00 PM
Bayview

GENE EXPRESSION AND GENOMIC CHANGES

Chairs: Cynthia A. Afshari, Amgen, Thousand Oaks, CA, United States and Keiji Wakabayashi, Cancer Prevention Basic Research Project, Kyoto, Japan

3:00 PM #654 CAN THE APPLICATION OF GENOMICS IMPACT THE DISCIPLINE OF GENETIC TOXICOLOGY?

Cinthia A. Afshari, Amgen, Inc., Thousand Oaks, CA, United States

3:20 PM #655 ENDOGENOUS AND EXOGENOUS ORIGINS OF ABERRANT DNA METHYLATION

Toshikazu Ushijima, National Cancer Center Research Institute, Tokyo, Japan

3:40 PM #656 GENE ALTERATIONS AND CHANGES OF GENE EXPRESSION IN COLON CARCINOGENESIS OF ANIMALS

Keiji Wakabayashi, Cancer Prevention Basic Research Project, Kyoto, Japan

4:00 PM #657 PRELIMINARY VALIDATION OF A HIGH-THROUGHPUT MAMMALIAN IN VITRO GENOTOXICITY SCREENING ASSAY: GREENSCREEN TK

Paul W. Hastwell, GlaxoSmithKline, Hertfordshire, UK

4:15 PM #658 CELL DIFFENTIATION AND DOMINANT SIGNALING PATHWAY SIGNATURES IN THE MOLECULAR CLASSIFICATION OF HUMAN BREAST CANCER CELL LINES

Cindy A. Wilson, University of California Los Angeles, Los Angeles, CA United States

4:30 PM #659 EFFECT OF P53 GENOTYPE ON GENE EXPRESSION PROFILES IN MURINE LIVER

Suzanne M. Morris, FDA/NCTR, Jefferson, AR, United States

4:45 PM #660 PhIP-INDUCED GLOBAL CHANGES IN GENOME EXPRESSION IN HUMAN PROSTATE CELLS

Chitra F. Manohar, Lawrence Livermore National Laboratory, Livermore, CA, United States

Tuesday, September 6, 2005
3:00 PM–5:00 PM
Grand Ballroom B

NEW TECHNOLOGIES IN MUTATIONAL ANALYSIS FOR GENOMIC AND GENETIC TOXICOLOGY STUDIES

Chairs: Rosalie K. Elespuru, US FDA, Rockville, MD, United States and
Matthew E. Hurles, Wellcome Trust Sanger Institute, Cambridge, United Kingdom

3:00 PM HIGH-THROUGHPUT DNA SEQUENCE ANALYSIS

Daixing Zhou, Solexa Inc., Hayward, CA, United States

3:20 PM #661 NEW ASSAYS FOR GERMLINE MUTATION: IDENTIFYING DE NOVO CHROMOSOMAL REARRANGEMENTS IN SPERM GENOMES

Matthew E. Hurles, Wellcome Trust Sanger Institute, Cambridge, United Kingdom

3:40 PM #662 MEASUREMENT OF SOMATIC MUTATION LOAD IN HUMAN SOLID TISSUES

Steve S. Sommer, City of Hope, Duarte, CA, United States

4:00 PM #664 STATISTICAL ISSUES ASSOCIATED WITH MICROARRAY-BASED GENOME PROFILING

Ru Fang Yeh, University of California, San Francisco, CA, United States

4:15 PM #665 GENOTYPING SELECTION:
MONITORING P53 MUTATIONS DURING TUMOR DEVELOPMENT

Barbara L. Parsons, NCTR, Jefferson, AR, United States

4:30 PM SEARCHING FOR CAUSES OF HUMAN GENETIC DISEASE

Rosalie K. Elespuru, US FDA, Rockville, MD, United States

4:45 PM GENE EXPRESSION PROFILING USING HIGH-DENSITY MICROARRAYS

Alexander Kohlmann, Roche Molecular Systems, Pleasanton, CA, United States

Risk Assessment

Tuesday, September 6, 2005
3:00 PM–5:00 PM
Seacliff A/B

COMPUTATIONAL TOXICOLOGY: AN ALTERNATIVE TO ANIMALS

Chairs: R. Daniel Benz, US FDA, Rockville, MD, United States and
Philip N. Judson, Lhasa, University of Leeds, Leeds, United Kingdom

3:00 PM #633 AN INTRODUCTION TO COMPUTATIONAL TOXICOLOGY

R. Daniel Benz, US FDA, Rockville, MD, United States

3:20 PM #634 PREDICTIVE TOXICOLOGY METHODOLOGY AND PERFORMANCE

Edwin J. Matthews, US FDA, Rockville, MD, United States

3:40 PM #635 PREDICTING PHARMACEUTICAL EFFICACY USING 3-D DESCRIPTORS

Josep R. Prous, Prous Science, Barcelona, Spain

4:00 PM #636 USE OF SAR/QSAR IN EUROPE

Philip N. Judson, Lhasa, University of Leeds, Leeds, United Kingdom

4:15 PM #637 MC4PC PREDICTION OF THE GENETIC TOXICITY POTENTIAL OF ORGANIC MOLECULES

Gilles Klopman, MultiCASE, Beachwood, OH, United States

4:30 PM #638 PREDICTING MAXIMUM RECOMMENDED DAILY DOSE

Naomi Kruhlak, US FDA, Rockville, MD, United States

4:45 PM #639 PREDICTING ABSORPTION, DISTRIBUTION, METABOLISM AND EXCRETION (ADME)

Michael B. Bolger, SimulationsPlus, Lancaster, CA, United States