ICEM - 2005 Current Issues Symposia

The Current Issues Symposia have been organized into six categories. Sessions are listed alphabetically under each category. Refer to the Program Index for a quick listing of sessions and categories.

Symposia Categories

DNA Repair
Environmental Mutagenesis/Carcinogenesis
Mutagenesis and Human Disease
Mutational Mechanisms
Risk Assessment
Student/Faculty Programs

DNA Repair

Sunday, September 4, 2005
3:00 PM–5:00 PM
Grand Ballroom A

RECOMBINATION AND DOUBLE-STRAND-BREAK REPAIR

Chairs: James E. Haber, Brandeis University, Waltham, MA, United States and Stephen C. West, London Research Institute, Herts, United Kingdom

3:00 PM #202 RECOMBINATION REPAIR AND A TREATMENT FOR BRCA2 TUMOURS: Thomas Helleday, University of Sheffield, Sheffield, United Kingdom
3:30 PM #203 DNA DOUBLE-STRAND BREAK REPAIR IN DROSOPHILA: Jeff J. Sekelsky, University of North Carolina, Chapel Hill, NC, United States
4:00 PM #203A “RECOMBOMICE” SHED LIGHT ON HOMOLOGOUS RECOMBINATION IN VIVO: Beven P. Engelward, Massachusetts Institute of Technology, Cambridge, MA, United States
4:20 PM #204 MULTIPLE MECHANISMS TO REPAIR BROKEN YEAST CHROMOSOMES: James E. Haber, Brandeis University, Waltham, MA, United States
4:40 PM #205 REGULATION AND MECHANISM OF DOUBLE-STRAND BREAK REPAIR IN MAMMALIAN CELLS: Stephen C. West, London Research Institute, Herts, United Kingdom

Sunday, September 4, 2005
5:15 PM–7:15 PM
Seacliff C/D

TRANSCRIPTIONAL ENCOUNTERS WITH DNA DAMAGE

Chairs: Paul W. Doetsch, Emory University, Atlanta, GA, United States and
Priscilla K. Cooper, Lawrence Berkeley National Laboratory, Berkeley, CA, United States

5:15 PM #211 TRANSCRIPTIONAL MUTAGENESIS IN BACTERIAL AND MAMMALIAN SYSTEMS: Paul W. Doetsch, Emory University, Atlanta, GA, United States
5:45 PM #212 ASSEMBLY OF REPAIR FACTORS FOR TRANSCRIPTION-COUPLED REPAIR: Leon H. Mullenders, Leiden University Medical Center, Leiden, Netherlands
6:15 PM #213 TRANSCRIPTION ARREST AT DNA DAMAGE SITES: IMPLICATIONS FOR TRANSCRIPTION-COUPLED REPAIR: Silvia Tornaletti, Stanford University, Stanford, CA, United States
6:35 PM #214 TFIIH TRANSCRIPTION FACTOR IN DNA REPAIR: Jean-Marc Egly, CNSR/INSERM/ULP, Strasbourg, France
6:55 PM #215 FUNCTIONAL ANALYSIS OF CSA AND CSB PROTEINS IN TRANSCRIPTION-COUPLED REPAIR: Kiyoji Tanaka, Osaka University, Osaka, Japan

Monday, September 5, 2005
10:30 AM–12:30 PM
Grand Ballroom A

CELL CYCLE AND HOW CELLS SENSE THEIR ENVIRONMENT

Chairs: Peter J. Stambrook, University of Cincinnati, Cincinnati, OH, United States and
Ronald A. Laskey, MRC Research Centre, Cambridge, United Kingdom

10:30 AM #218 CONTROL OF DNA REPLICATION BY GEMININ AND MCM3 ACETYLASE: Ronald A. Laskey, MRC Research Centre, Cambridge, United Kingdom
11:00 AM #219 DYNAMICS OF DNA DOUBLE-STRAND BREAKS, RECOMBINATION, AND CHROMOSOME TRANSLOCATIONS: Roland Kanaar, Erasmus University, Rotterdam, Netherlands
11:30 AM #220 GENOME INTEGRITY VIA SIGNALING NETWORKS: LESSONS FROM MODEL ORGANISMS: Yolanda Sanchez, University of Cincinnati Medical Center, Cincinnati, OH, United States
11:50 AM #221 CANCER SUSCEPTIBILITY AND BRCA2 FUNCTIONS: Ashok R. Venkitaraman, MRC Research Centre, Cambridge, United Kingdom
12:10 PM #222 PHOSPHOSERINE/THREONINE-BINDING DOMAINS: MOLECULAR INTEGRATORS OF PROTEIN KINASE SIGNALING NETWORKS: Michael B. Yaffe, MIT, Cambridge, MA, United States

Monday, September 5, 2005
10:30 AM–12:30 PM
Grand Ballroom B

INTERACTIVE COMPETITION AMONG DNA REPAIR PATHWAYS

Chairs: Jac A. Nickoloff, University of New Mexico, Albuquerque, NM, United States and
John B. Hays, Oregon State University, Corvallis, OR, United States

10:30 AM #228 DNA MISMATCH REPAIR AND NUCLEOTIDE EXCISION REPAIR RESPONSES TO “MISMATCHED” UV PHOTOPRODUCTS: John B. Hays, Oregon State University, Corvallis, OR, United States
11:00 AM #229 KINASE-INDEPENDENT FUNCTION FOR DNA-DEPENDENT PROTEIN KINASE IN DOUBLE-STRAND BREAK REPAIR BY HOMOLOGOUS RECOMBINATION: Jac Nickoloff, University New Mexico, Albuquerque, NM, United States
11:30 AM #230 FACTORS FROM MULTIPLE REPAIR PATHWAYS PARTICIPATE IN THE UNCOUPLING OF INTERSTRAND CROSS-LINKS: Randy J. Legerski, University of Texas, Houston, TX, United States
11:50 AM #231 A GLOWING REPORT: USE OF FLUORESCENT PROBES TO STUDY THE COORDINATION OF RECOMBINATION AND DNA REPLICATION IN E. coli K-12: Steven J. Sandler, University of Massachusetts, Amherst, MA, United States
12:10 PM #232 THE MANY FACES OF XPG: COORDINATING ROLES IN NUCLEOTIDE AND BASE EXCISION REPAIR AND TRANSCRIPTION-COUPLED REPAIR: Priscilla K. Cooper, Lawrence Berkeley National Laboratory, Berkeley, CA, United States

Tuesday, September 6, 2005
10:30 AM–12:30 PM
Grand Ballroom A

CHROMATIN DYNAMICS: INFLUENCE ON GENOME FUNCTION AND DNA DAMAGE RESPONSE

Chairs: Genevieve Almouzni, Curie Institute, Paris, France and
Gary Felsenfeld, NIH, Bethesda, MD, United States

10:30 AM #456 CHROMATIN ASSEMBLY FACTORS, REPLICATION-FORK ARRESTS, AND DNA- DAMAGE RESPONSE: Genevieve Almouzni, Curie Institute, Paris, France
11:00 AM #457 CHROMATIN BOUNDARIES, EPIGENETIC SIGNALS, AND THE REGULATION OF GENE EXPRESSION: Gary Felsenfeld, NIH, Bethesda, MD, United States
11:30 AM #458 HISTONE PHOSPHORYLATION LINKS ATP- DEPENDENT CHROMATIN REMODELING WITH DNA DAMAGE REPAIR: Haico van Attikum, Miescher Institute Biomedical Research, Basel, Switzerland
11:50 AM #459 INO80 CHROMATIN REMODELING AND DNA REPAIR: Xuetong Shen, University of Texas M.D. Anderson Cancer Center, Science Park–Research Division, Smithville, TX, United States
12:10 PM #460 ROLE OF HISTONE H4 LYSINE 16 ACETYLATION IN MAMMALIAN CELLS: Asifa Akhtar, EMBL, Heidelberg, Germany

Wednesday, September 7, 2005
10:30 AM–12:30 PM
Bayview

APOPTOSIS: MECHANISMS AND THERAPEUTIC TARGETS

Chairs: Bernd Kaina, University Mainz, Mainz, Germany and
Mats Ljungman, University of Michigan, Ann Arbor, MI, United States

10:30 AM #672 DNA DAMAGE-TRIGGERED APOPTOSIS: CRITICAL LESIONS AND PATHWAYS: Bernd Kaina, University Mainz, Mainz, Germany
11:00 AM #673 ROLE OF APOPTOSIS IN CANCER THERAPY AND TISSUE TOXICITY: Andrei V. Gudkov, Cleveland Clinic, Cleveland, OH, United States
11:30 AM #674 REGULATION OF DIFFERENTIATION AND APOPTOSIS BY GENOTOXIC STRESS: Jean Y.J. Wang, University of California, San Diego, CA, United States
11:50 AM #675 TRANSCRIPTION AS A THERAPEUTIC APOPTOSIS-INDUCING TARGET: Mats Ljungman, University of Michigan, Ann Arbor, MI, United States
12:10 PM #676 DNA DAMAGE AND REPLICATION INVOLVED IN UV-INDUCED APOPTOSIS IN DNA REPAIR DEFICIENT HUMAN CELLS: Carlos F. Menck, University Sao Paulo, Sao Paulo, Brazil

Wednesday, September 7, 2005
10:30 AM–12:30 PM
Grand Ballroom A

ENVISIONING DNA DAMAGE AND REPAIR RESPONSES: STRUCTURAL BIOLOGY FROM ATOMS TO CELLS

Chairs: John A. Tainer, The Scripps Research Institute, La Jolla, CA, United States and
Roland Kanaar, Erasmus University, Rotterdam, Netherlands

10:30 AM #677 MULTI-PROTEIN REPAIR MACHINES: FROM MIRACLES TO MOLECULES: John A. Tainer, The Scripps Research Institute, La Jolla, CA, United States
11:00 AM #678 SUPRAMOLECULAR ASSEMBLIES FOR CELLULAR DNA REPAIR: Claire Wyman, Erasmus University, Rotterdam, Netherlands
11:30 AM #679 NONHOMOLOGOUS END-JOINGING BY CELL-FREE EXTRACTS: Gilbert Chu, Stanford University Medical Center, Stanford, CA, United States
11:50 AM #680 STRUCTURE AND MECHANISM OF RecBCD: Dale B. Wigley, London Research Institute, Hertfordshire, United Kingdom
12:10 PM #681 MANAGING DNA STRAND BREAKS: CRYSTAL STRUCTURES AND CATALYTIC SELECTIVITIES OF DNA LIGASES: Tom Ellenberger, Harvard Medical School, Boston, MA, United States

Thursday, September 8, 2005
1:00 PM–3:00 PM
Bayview

MODELS AND MECHANISMS FOR PROCESSING DNA DAMAGE

Chairs: John M. Essigmann, MIT, Cambridge, MA, United States and
Robert H. Schiestl, UCLA, Los Angeles, CA, United States

1:00 PM #730 GENOTOXICITY AND REPAIR OF MODIFIED DNA BASES POSSIBLY RESPONSIBLE FOR SPONTANEOUS MUTAGENESIS: John M. Essigmann, MIT, Cambridge, MA, United States
1:30 PM #731 GENETIC AND ENVIRONMENTAL EFFECTS OF NON-HOMOLOGOUS END JOINING: Robert H. Schiestl, UCLA, Los Angeles, CA, United States
2:00 PM #732 TRANSCRIPTION PAST DNA ADDUCTS: BIOCHEMICAL AND COMPUTER MODELING STUDIES: David A. Scicchitano, New York University, New York, NY, United States
2:20 PM #733 REGULATION OF HUMAN NUCLEOTIDE EXCISION REPAIR BY TUMOR SUPPRESSOR GENES: James M. Ford, Stanford University Medical School, Stanford, CA, United States
2:40 PM UV-DDB-BASED UBIQUITIN LIGASE AND NUCLEOTIDE EXCISION REPAIR: Vesna Rapic Otrin, University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States

Thursday, September 8, 2005
1:00 PM–3:00 PM
Grand Ballroom A

POST-TRANSLATIONAL MODIFICATION OF DNA REPAIR ENZYMES

Chairs: Alan D. D’Andrea, Harvard Medical School, Boston, MA, United States and
Jesper Q. Svejstrup, London Research Institute, Herts, United Kingdom

1:00 PM #734 FUNCTIONAL ASPECTS OF SUMOYLATION OF HUMAN THYMINE DNA GLYCOSYLASE IN BASE EXCISION REPAIR: Roland Steinacher, University of Basel, Basel, Switzerland
1:30 PM #735 ACETYLATION OF DNA BASE EXCISION REPAIR PROTEINS IN MAMMALIAN CELLS: Sankar Mitra, University of Texas, Galveston, TX, United States
2:00 PM #736 UBIQUITINATION OF DAMAGE RECOGNITION FACTORS INVOLVED IN NUCLEOTIDE EXCISION REPAIR: Kaoru Sugasawa, RIKEN Institute, Saitama, Japan
2:20 PM #737 REGULATION OF THE FANCONI ANEMIA PATHWAY BY MONOUBIQUITINATION: Alan D. D’Andrea, Harvard Medical School, Boston, MA, United States
2:40 PM #738 UBIQUITINATION AND DEGRADATION OF RNA POLYMERASE II DURING DNA DAMAGE: Jesper Q. Svejstrup, London Research Institute, Herts, United Kingdom

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Environmental Mutagenesis/Carcinogenesis

Sunday, September 4, 2005
5:15 PM–7:15 PM
Bayview

CASE STUDIES OF ENVIRONMENTAL MUTAGEN CONTAMINATION DISASTERS AROUND THE WORLD

Chairs: William Au, University Texas, Galveston, TX, United States and
Lance R. Brooks, Department of Homeland Security, Washington, DC, United States

Sponsored by US Department of Homeland Security

5:15 PM #206 NATIONAL EXPOSURE MEASUREMENT FOR DECISIONS TO PROTECT PUBLIC HEALTH FROM ENVIRONMENTAL EXPOSURES: Dana B. Barr, Centers for Disease Control, Atlanta, GA, United States
5:45 PM #207 HEALTH CONSEQUENCES OF MUSTARD GAS EXPOSURE: Brian J. Davey, Organization for the Prohibition of Chemical Weapons, The Haag, Netherlands
6:15 PM #208 PREVENTING CHEMICAL ACCIDENTS: LESSONS FROM BHOPAL: Gerald Poje, US Chemical Safety Hazard Investigation Board, Trenton, NJ, United States
6:35 PM #209 WORLD TRADE CENTER ATTACK: HEALTH EFFECTS NOW AND LATER: Mark A. Maddaloni, US EPA, New York, NY, United States
6:55 PM #210 RADIATION EXPOSURE AND HEALTH RISK IN KAZAKHSTAN FROM ATOMIC BOMB TESTINGS: Rakhmetkaji I. Bersimbaev, Kazhak National University, Almaty, Kazakhstan

Monday, September 5, 2005
10:30 AM–12:30 PM
Seacliff A/B

ENVIRONMENTAL CONTAMINANT EXPOSURE AND MUTAGENESIS IN WILDLIFE

Chairs: Christopher M. Somers, University Regina, SK, Canada and
Frederik-Jan van Schooten, Maastricht University, Maastricht, Netherlands

10:30 AM #223 INTEGRATING TOXICOLOGY, MUTAGENESIS, AND POPULATION GENETICS: John W. Bickham, Texas A&M University, College Station, TX, United States
11:00 AM #224 ENVIRONMENTAL RADIATION: GLOBAL DISTRIBUTION AND GENETIC RISKS TO WILDLIFE: Douglas R. Boreham, McMaster University, Hamilton, ON, Canada
11:30 AM #225 ASSESSING THE POPULATION-LEVEL IMPACTS OF GENOTOXIC SUBSTANCES IN AQUATIC SYSTEMS: Paul A. White, Health Canada, Ottawa, ON, Canada
11:50 AM #226 URBAN WILDLIFE AS SENTINELS FOR MUTAGENESIS: AN UNDER-UTILIZED RESOURCE?: Frederik-Jan van Schooten, Maastricht University, Maastricht, Netherlands
12:10 PM #227 URBAN POLLUTION: DOGS AS SENTINEL ANIMALS FOR NEURODEGENERATION AND NEUROCARCINOGENESIS: Lilian Calderon-Garciduenas, Instituto Nacional de Pediatria, Mexico City, Mexico and Department Biomedical Pharmaceutical Sciences, University of Montana, Missoula, MT, United States

Monday, September 5, 2005
3:00 PM–5:00 PM
Grand Ballroom A

GENOTOXICOLOGY OF AQUATIC SYSTEMS

Chairs: Gisella A. Umbuzeiro, CETESB, Sao Paolo, Brazil and
Yasunobu Aoki, NIES, Tsukuba, Ibaraki, Japan

3:00 PM #426 DEVELOPMENT OF IN VIVO MUTAGENICITY ASSAY SYSTEM USING rpsL TRANSGENIC ZEBRAFISH FOR MONITORING ENVIRONMENTAL MUTAGENS: Yausnobu Aoki, NIES, Tsukuba, Ibaraki Japan
3:20 PM #427 RELEVANCE OF THE SALMONELLA ASSAY IN WATER QUALITY EVALUATION: INDICATION OF AZO DYES AS IMPORTANT AQUATIC CONTAMINANTS: Gisella A. Umbuzeiro, CETESB, Sao Paolo, Brazil
3:40 PM #428 GENOTOXIC AND ECOTOXICOLOGICAL ASSESSMENT FOR DIAGNOSIS OF AQUATIC ECOSYSTEMS: Vera M. Vargas, FEPAM, Porto Alegre, Brazil
4:00 PM #429 GENOTOXICITY BIOMARKERS IN FISH AND BLUE MUSSELS: RESULTS FROM BEEP CRUISES: Claudia Bolognesi, NIRC, Genova, Italy
4:15 PM #430 GENOTOXICTY AND ACUTE TOXICITY ASSESSMENT IN AQUATIC ENVIRONMENTS: Richard M. Walmsley, Gentronix, Ltd., Manchester, UK
4:30 PM #431 GENOTOXICITY OF MICROCYSTIN-LR: IMPLICATION OF REACTIVE OXYGEN SPECIES: Metka Filipic, National Institute of Biology, Ljubljana, Slovenia
4:45 PM #432 EVALUATION OF THE TERATOGENIC AND MUTAGENIC POTENTIAL OF THALIDOMIDE IN THE SMALL FISH MODEL JAPANESE MEDAKA: Don G. Ennis, University of Louisiana, Lafayette, LA, United States

Monday, September 5, 2005
3:00 PM–5:00 PM
Seacliff C/D

MUTAGENIC CONSEQUENCES OF ENVIRONMENTAL EXPOSURES

Chairs: Tetsuya Kamataki, Hokkaido University, Hakodate, Japan and Emilio Rojas, UNAM, Mexico City, Mexico

3:00 PM #440 GENE AND ENVIRONMENT INTERACTION: GENETIC POLYMORPHISM OF CYP2A6 AS A DETERMINANT OF TOBACCO RELATED CANCER RISK: Tetsuya Kamataki, Hokkaido University, Hakodate, Japan
3:20 PM #441 ENVIRONMENTAL TRACE ELEMENTS ASSOCIATED WITH CANCER RISK IN LUCRECIA-RN/BRAZIL: Carlos F.S. Castro, Catholic University at Brasília, Taguatinga, Brazil
3:40 PM #442 GENOTOXIC CONSEQUENCES OF MEXICO CITY ATMOSPHERIC POLLUTION: Emilio Rojas, UNAM, Mexico City, Mexico
4:00 PM #443 4-OXO-2-HEXENAL IN COOKED FOODS AND DNA ADDUCT FORMATION IN MOUSE ORGANS AFTER ORAL ADMINISTRATION: Kazuaki Kawai, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
4:15 PM #444 BIOLOGICAL PROPERTIES OF AMINOPHENYLNORHARMAN FORMED FROM NORHARMAN AND ANILINE: Yukari Totsuka, National Cancer Center Research Institute, Tokyo, Japan
4:30 PM #445 PHOTOTOXICITY INCLUDING PHOTOMUTAGENICITY OF THIRTEEN SELECTED POLYCHLORINATED BIPHENYLS (PCBS) IN Salmonella typhimurium TA102 AND HUMAN SKIN CELLS: Lei Wang, Jackson State University, Jackson, MS, United States
4:45 PM #446 ENHANCEMENT OF DNA REPAIR BY RADIO-PROTECTORS: IN VIVO STUDIES WITH ANIMAL MODELS: C.K.K. Nair, Bhabha, Atomic Research Centre, Mumbai, India

Tuesday, September 6, 2005
10:30 AM–12:30 PM
Seacliff C/D

ENVIRONMENTAL AND GENETIC FACTORS INFLUENCING THE RISK OF COMMON NONCANCER DISEASE

Chairs: Harvey Mohrenweiser, University California, Irvine, CA, United States and Irene M. Jones, Lawrence Livermore National Laboratory, Livermore, CA, United States

10:30 AM #461 CARDIOVASCULAR DISEASE/HYPERTENSION: GENETIC SUSCEPTIBILITY AND EXPOSURE FACTORS: Daniel T. O’Connor, University California, San Diego, La Jolla, CA, United States
11:00 AM #462 ENVIRONMENT AND GENES IN THE ETIOLOGY OF PARKINSONISM: Caroline M. Tanner, Parkinson’s Institute, Sunnyvale, CA, United States
11:30 AM #463 ROLE OF EXPOSURE AND GENETICS IN INFLAMMATORY/AUTOIMMUNE DISEASE SUCH AS MULTIPLE SCLEROSIS: Lisa F. Barcellos, University California, Berkeley, CA, United States
11:50 AM GENETICS AND EXPOSURE IN THE RISK OF ASTHMA AND RESPIRATORY DISEASE: John R. Balmes, University of California, San Francisco, CA, United States
12:10 PM #464 CHALLENGES IN THE STUDY OF GENE BY ENVIRONMENT INTERACTION IN RISK OF COMMON DISEASES: Harvey Mohrenweiser, University California, Irvine, CA, United States

Tuesday, September 6, 2005
10:30 AM–12:30 PM
Bayview

ENVIRONMENTAL MUTAGENS IN AIR

Chairs: Radim J. Sram, Institute of Experimental Medicine, Prague, Czech Republic and
Larry D. Claxton, US EPA, Research Triangle Park, NC, United States

10:30 AM #465 OVERVIEW OF THE MUTAGENICITY OF URBAN AIR: Larry D. Claxton, US EPA, Research Triangle Park, NC, United States
11:00 AM #466 BIOMARKERS OF URBAN AIR-ASSOCIATED MUTAGENICITY: Radim J. Sram, Institute of Experimental Medicine, Prague, Czech Republic
11:30 AM #467 ADDUCTS AND OXIDATIVE DAMAGE OF URBAN AIR: Peter B. Farmer, University of Leicester, Leicester, United Kingdom
11:50 AM #468 AIR POLLUTION AND RISKS FOR CANCER, REPRODUCTIVE EFFECTS, AND CARDIOVASCULAR DISEASE: Joellen Lewtas, University Washington, Seattle, WA, United States
12:10 PM #469 AIR POLLUTION AND CHRONIC HEALTH EFFECTS: THE BAD AND THE WORSE: Lilian Calderón-Garcidueñas, Instituto Nacional de Pediatria, Mexico City, Mexico and Department of Biomedical Pharmaceutical Sciences, University of Montana, Missoula, MT, United States

Tuesday, September 6, 2005
10:30 AM–12:30 PM
Grand Ballroom B

MUTAGENS AND CARCINOGENS FROM COOKED FOOD

Chairs: James S. Felton, Lawrence Livermore National Laboratory, Livermore, CA, United States and Nigel J. Gooderham, Imperial Cancer Research Institute, London, United Kingdom

10:30 AM #470 METABOLISM AND GENOTOXICITY OF HETEROCYCLIC AMINES: James S. Felton, Lawrence Livermore National Laboratory, Livermore, CA, United States
11:00 AM #471 CARCINOGENICITY OF MUTAGENS/CARCINOGENS FROM COOKED FOOD: Hitoshi Nakagama, National Cancer Center Research Institute, Tokyo, Japan
11:30 AM #472 HETEROCYCLIC AMINES IN COOKED MEATS IN THE SINGAPORE CHINESE DIET: Adeline Seow, University of Singapore, Singapore
11:50 AM #473 IMPACT OF CHEMOPREVENTION ON THE METABOLISM AND GENOTOXICITY OF HETEROCYCLIC AMINES: Nigel J. Gooderham, Imperial Cancer Research Institute, London, United Kingdom
12:10 PM #474 RISK ASSESSMENT OF ACRYLAMIDE IN FOODS: Jan Alexander, National Institute Public Health, Oslo, Norway

Wednesday, September 7, 2005
10:30 AM–12:30 PM
Grand Ballroom B

ANIMAL MODELS FOR ENVIRONMENTAL CARCINOGENESIS AND PREVENTION

Chairs: Toby G. Rossman, New York University, Tuxedo, NY, United States and
Silvio De Flora, University Genoa, Genoa, Italy

Sponsored by US EPA, Office of Research and Development

10:30 AM #668 IDENTIFICATION OF HUMAN CANCER MODIFIER GENES USING MOUSE MODELS: Allan Balmain, University California, San Francisco, CA, United States
11:00 AM INFILTRATIVE IMMUNE REGULATION OF TUMOR ANGIOGENESIS: Douglas Hanahan, University California, San Francisco, CA, United States
11:30 AM #669 TRANSPLACENTAL CARCINOGENESIS BY ENVIRONMENTAL AGENTS: Michael P. Waalkes, NIEHS, Research Triangle Park, NC, United States
11:50 AM #670 THE HAIRLESS MOUSE MODEL FOR COCARCINOGENESIS AND CHEMOPREVENTION: Toby G. Rossman, New York University, Tuxedo, NY, United States
12:10 PM #671 PREVENTION OF TOBACCO AND UV CARCINOGENESIS: Silvio De Flora, University Genoa, Genoa, Italy

Thursday, September 8, 2005
10:30 AM–12:30 PM
Grand Ballroom A

ENVIRONMENTAL FACTORS ASSOCIATED WITH HUMAN CANCER

Chairs: Martina L. Veigl, Case Western Reserve University, Cleveland, OH, United States and
Young-In Kim, University Toronto, Toronto, ON, Canada

ENVIRONMENTAL MUTAGENS IN WATER, SOIL, AND SEDIMENT

Chairs: Takeshi Ohe, Kyoto Women’s University, Kyoto, Japan and
Kirby C. Donnelly, Texas A&M University, College Station, TX, United States

10:30 AM #698 EPIDEMIOLOGY OF DRINKING WATER: Kenneth Cantor, NIH/NCI, Bethesda, MD, United States
11:00 AM #699 MUTAGENS IN DRINKING WATER: Michael J. Plewa, University of Illinois, Urban, IL, United States
11:30 AM #700 MUTAGENS IN SURFACE WATERS: Tetsushi Watanabe, Kyoto Pharmaceutical University, Kyoto, Japan
11:50 AM #701 MUTAGENIC HAZARDS OF AQUATIC SEDIMENTS: Guosheng Chen, Health Canada, Ottawa, ON, Canada
12:10 PM #702 GENOTOXICITY OF SOILS: Kirby C. Donnelly, Texas A&M University, College Station, TX, United States

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Mutagenesis and Human Disease

Sunday, September 4, 2005
10:30 AM–12:30 PM
Seacliff C/D

ANTIMUTAGENS AND PROSPECTS FOR CHEMOPREVENTION

Chairs: Young-Joon Surh, Seoul National University, Seoul, Korea and
Roderick H. Dashwood, Oregon State University, Corvallis, OR, United States

Sponsored by The Linus Pauling Institute and National Institutes of Health, Office of Dietary Supplements

10:30 AM #6 MOLECULAR TARGETS FOR BIOACTIVE FOOD COMPONENTS: John A. Milner, NIH/NCI, Bethesda, MD, United States
11:00 AM #7 CANCER CHEMOPREVENTION BY DIETARY CHLOROPHYLL AND CHLOROPHYLLIN: RELATIVE EFFICACIES AND ASSOCIATED MECHANISMS: George S. Bailey, Oregon State University, Corvallis, OR, United States
11:30 AM #8 POTENTIAL FOR DIETARY PHYTOCHEMICALS TO MODULATE DEREGULATED SIGNALING: INDOLE-3-CARBINOL AND RELATED AGENTS: Margaret M. Manson, University Leicester, Leicester, United Kingdom
11:50 AM #9 SIGNAL TRANSDUCTION PATHWAYS REGULATING COX-2 EXPRESSION: POTENTIAL MOLECULAR TARGETS FOR CHEMOPREVENTION: Young-Joon Surh, Seoul National University, Seoul, South Korea
12:10 PM #10 HDAC AS A NOVEL TARGET FOR CHEMOPREVENTION: SULFORAPHANE AND OTHER DIETARY AGENTS: Roderick H. Dashwood, Oregon State University, Corvallis, OR, United States

Sunday, September 4, 2005
10:30 AM–12:30 PM
Grand Ballroom A

ENVIRONMENTAL DNA DAMAGE, REPAIR, AND AGING

Chairs: George M. Martin, University of Washington, Seattle, WA, United States and
Michael Fry, Technion—Israel Institute of Technology, Haifa, Israel

Sponsored by The Ellison Medical Foundation

10:30 AM #11 DNA TRANSACTIONS AND THE BIOLOGY OF AGING: George M. Martin, University of Washington, Seattle, WA, United States
11:00 AM #12 DNA TETRAPLEXES: ROLES IN NORMAL AND PATHOLOGICAL DNA TRANSACTIONS: Michael Fry, Technion—Israel Institute of Technology, Haifa, Israel
11:30 AM #13 DNA REPAIR DEFICIENCIES IN HUMAN PREMATURE AGING: Vilhelm A. Bohr, NIH/NIA, Baltimore, MD, United States
11:50 AM #14 THE ENZYMATIC ACTIVITIES OF THE WERNER SYNDROME PROTEIN ARE DISABLED BY SPECIFIC AMINO ACID POLYMORPHISMS: Lawrence A. Loeb, University of Washington, Seattle, WA, United States
12:10 PM #15 AGING AND CELLULAR RESPONSES TO DNA DAMAGE: Judith Campisi, Lawrence Berkeley National Laboratory, Berkeley, CA, United States

Sunday, September 4, 2005
10:30 AM–12:50 PM
Seacliff A/B

TRANSPLACENTAL EXPOSURE TO NUCLEOSIDE ANALOGS: MITOCHONDRIAL DAMAGE AND FETAL HEALTH

Chairs: Miriam C. Poirier, NIH/NCI, Bethesda, MD and
Simon A. Mallal, Royal Perth Hospital, Perth, Australia

Sponsored by National Cancer Institute, Office of Womens Health

10:30 AM #26 THE HIV PANDEMIC: BENEFITS AND RISKS OF EXPANDED THERAPY FOR MOTHER-TO-CHILD TRANSMISSION: William A. Blattner, Institute of Human Virology, Baltimore, MD, United States
11:00 AM #27 CLINICAL MITOCHONDRIAL DYSFUNCTION IN HIV-UNINFECTED CHILDREN FOLLOWING PERINATAL EXPOSURE TO NUCLEOSIDE: Stephane Blanche, Hospital Necker Enfants Malades, Paris, France
11:30 AM #28 ANTIRETROVIRAL THERAPY (ART)—ASSOCIATED CARDIOTOXICITY IN UNINFECTED BUT ART-EXPOSED INFANTS BORN TO HIV-INFECTED WOMEN: THE PROSPECTIVE NHLBI CHAART-1 STUDY: Steven E. Lipshultz, University of Miami School of Medicine, Miami, FL, United States
11:50 AM #29 INDUCTION AND PERSISTENCE OF MITOCHONDRIAL DNA MUTATIONS IN CHILDREN AND MICE EXPOSED IN UTERO TO ZIDOVUDINE OR COMBIVIR: Vernon E. Walker, Loveless Respiratory Research Institute, Albuquerque, NM, United States
12:10 PM #30 FETAL MITOCHONDRIAL DYSFUNCTION: LESSONS FROM A PRIMATE MODEL: Miriam C. Poirier, NIH/NCI, Bethesda, MD, United States
12:30 PM #31 MITOCHONDRIAL TOXICITY INDUCED BY ANTIRETROVIRAL NUCLEOSIDE ANALOG DRUGS: Simon A. Mallal, Royal Perth Hospital, Perth, Australia

Monday, September 5, 2005
10:30 AM–12:30 PM
Bayview

MITOCHONDRIAL DNA DAMAGE AND HUMAN DISEASE

Chairs: Susan P. LeDoux, University South Alabama, Mobile, AL, United States and
Yusaku Nakabeppu, Kyushu University, Kyushu, Japan

Sponsored by The Ellison Medical Foundation

10:30 AM MITOCHONDRIA AND APOPTOSIS: PASO DOBLE: Douglas R. Green, La Jolla Institute Allergy and Immunology, San Diego, CA, United States
11:00 AM #233 TWO DISTINCT PATHWAYS FOR CELL DEATH TRIGGERED BY ACCUMULATION OF 8- OXOGUANINE IN NUCLEAR AND MITOCHONDRIAL GENOMES: Yusaku Nakabeppu, Kyushu University, Kyushu, Japan
11:30 AM #234 DISEASES FROM MUTATIONS IN THE GENE FOR THE MITOCHONDRIAL DNA POLYMERASE: William C. Copeland, NIEHS, Research Triangle Park, NC, United States
11:50 AM #235 MITOCHONDRIA, OXIDATIVE STRESS, IRON, AND TELOMERASE: WHAT IS THE CONNECTION?: Bennett Van Houten, NIEHS, Research Triangle Park, NC, United States
12:10 PM #236 ENHANCING MITOCHONDRIAL DNA REPAIR: A NOVEL THERAPEUTIC STRATEGY: Glenn L. Wilson, University of South Alabama, Mobile, AL, United States

Monday, September 5, 2005
10:30 AM–12:30 PM
Seacliff C/D

MOLECULAR EPIDEMIOLOGY OF CHILDREN’S ENVIRONMENTAL HEALTH

Chairs: Nina T. Holland, University of California, Berkeley, United States and
Mathuros Ruchirawat, Chulabhorn Institute, Bangkok, Thailand

10:30 AM #237 ENVIRONMENTAL EXPOSURES AND THE MOLCULAR EPIDEMIOLOGY OF CHILDHOOD LEUKEMIA: Patricia A. Buffler, University of California, Berkeley, CA, United States
11:00 AM #238 CHILDREN’S ENVIRONMENTAL HEALTH IN DEVELOPING COUNTRIES: Mathuros Ruchirawat, Chulabhorn Institute, Bangkok, Thailand
11:30 AM #239 ASSESSING FETAL, INFANT, AND CHILDHOOD EXPOSURES TO ENVIRONMENTAL TOXICANTS: Dana B. Barr, Centers for Disease Control, Atlanta, GA, United States
11:50 AM #240 AFLATOXINS, CHILD GROWTH, AND IMMUNITY IN WEST AFRICA: FROM DISEASE MECHANISMS TO DISEASE PREVENTION: Paul C. Turner, Leeds University, Leeds, United Kingdom
12:10 PM #241 GENETIC AND IMMUNOLOGICAL BIOMARKERS IN MINORITY POPULATIONS: Nina T. Holland, University of California, Berkeley, CA, United States

Wednesday, September 7, 2005
10:30 AM–12:30 PM
Seacliff C/D

NUTRIGENOMICS: A SYSTEMS BIOLOGY APPROACH TO STUDYING GENE-DIET INTERACTIONS

Chairs: Lynn R. Ferguson, University Auckland Medical School, Auckland, New Zealand and
Michael Fenech, CSIRO, Adelaide, SA, Australia

Sponsored by National Institutes of Health, Office of Dietary Supplements

10:30 AM #682 NUTRITIONAL GENOMICS: THE NEXT FRONTIER IN THE POST-GENOMIC ERA: James Kaput, UC Davis Centre of Excellence in Nutrigenomics, Davis, CA, United States
11:00 AM #683 SEEING THE TREES IN THE FOREST: REDUCING THE DIMENSIONALITY OF COMPLEX DATASETS: Kevin Dawson, UC Davis Centre of Excellence in Nutrigenomics, Davis, CA, United States
11:30 AM #684 FOLATE, MTHFR POLYMORPHISMS AND GENOME INSTABILITY: Michael Fenech, CSIRO, Adelaide, SA, Australia
11:50 AM HUMAN DIVERSITY AND GENETIC EPIDEMIOLOGY: Jose M. Ordovas, USDA, Tufts University, Boston, MA, United States
12:10 PM #685 UNCOUPLING GENE-DIET INTERACTIONS IN INFLAMMATORY BOWEL DISEASE: Lynn R. Ferguson, University Auckland Medical School, Auckland, New Zealand

Thursday, September 8, 2005
1:00 PM–3:00 PM
Seacliff C/D

EPIGENETIC MECHANISMS LEADING TO HUMAN DISEASE

Chair: W. David Sedwick, Case Western Reserve University, Cleveland, OH, United States and
Jeffrey M. Besterman, MethylGene, Montreal, QC, Canada

1:00 PM #722 EPIGENETICS, EVOLUTION, AND HEALTH: Randy L. Jirtle, Duke University, Durham, NC, United States
1:30 PM #723 EPIGENETIC REPROGRAMMING: MECHANIMS AND CONSEQUENCES: Victor V. Lobanenkov, NIH/NIAID, Bethesda, MD, United States
2:00 PM HYPERMETHYLATION AND MECHANISMS OF GENE SILENCING IN CANCER: James G. Herman, Johns Hopkins University, Baltimore, MD, United States
2:20 PM #724 MECHANISMS UNDERLYING DRUG-INDUCED EPIGENETIC HETEROTYPES IN CANCER CELLS: Martina Veigl, Case Western Reserve University, Cleveland, OH, United States
2:40 PM #725 EPIGENETIC REGULATION BY MG98 AND MGCD0103: FROM BENCH TO CLINIC: Jeffrey M. Besterman, MethylGene, Montreal, QC, Canada

Thursday, September 8, 2005
1:00 PM–3:00 PM
Grand Ballroom B

INHERITED DEFECTS, MUTAGENESIS, AND DNA REPAIR IN HUMAN NEUROLOGICAL DISEASE

Chairs: Cynthia T. McMurray, Mayo Clinic, Rochester, MN, United States and Keith W. Caldecott, University Sussex, Brighton, United Kingdom

1:00 PM #726 CHROMOSOMAL SINGLE-STRAND BREAK REPAIR AND NEURODEGENERATIVE DISEASE: Keith W. Caldecott, University Sussex, Brighton, United Kingdom
1:30 PM WHEN DNA REPAIR BECOMES MUTAGENIC: OGG1 AND MSH2/MSH3 COOPERATE TO CAUSE CAG EXPANSION EVENTS AND NEURONAL TOXICITY IN HUNTINGTON’S DISEASE: Cynthia T. McMurray, Mayo Clinic, Rochester, MN, United States
2:00 PM #727 DOUBLE-STRAND DNA BREAK REPAIR: IMPLICATIONS FOR OXIDATIVE DNA DAMAGE, NEURONS, AND AGING: Michael R. Lieber, University of Southern California, Los Angeles, CA, United States
2:20 PM #728 UBIQUITIN-ACTIVATING ENZYME E1 CORRECTS THE IMPAIRMENT IN NUCLEOTIDE EXCISION REPAIR IN TERMINALLY DIFFERENTIATED CELLS: Thierry Nouspikel, Stanford University, Stanford, CA, United States
2:40 PM #729 ATAXIA TELANGIECTASIA: LINKING ATM AND DNA DAMAGE TO NEURODEGENERATION: Peter J. McKinnon, St. Jude Childrens Research Hospital, Memphis, TN, United States

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Mutational Mechanisms

Sunday, September 4, 2005
10:30 AM–12:30 PM
Grand Ballroom B

NEW DEVELOPMENTS IN DNA DAMAGE PROCESSING

Chairs: Errol C. Friedberg, University of Texas, Dallas, TX, United States and Richard D. Wood, University Pittsburgh Cancer Institute, Pittsburgh, PA, United States

10:30 AM #16 DNA POLYMERASE KAPPA: A SPECIALIZED POLYMERASE FOR TRANSLESION DNA SYNTHESIS: Errol C. Friedberg, University of Texas, Dallas, TX, United States
11:00 AM #17 THE POLQ FAMILY AND DNA DAMAGE TOLERANCE IN HUMAN CELLS: Richard D. Wood, University of Pittsburgh Cancer Institute, PA, United States
11:30 AM #18 ROLE OF THE FANCONI ANEMIA CORE COMPLEX IN RESPONSE TO DNA DAMAGE: Weidong Wang, NIH/NIA, Baltimore, MD, United States
11:50 AM #19 NOVEL MOUSE CHROMOSOME INSTABILITY MUTANTS ISOLATED BY FORWARD GENETIC MUTAGENESIS SCREENS: John C. Schimenti, Cornell University, Ithaca, NY, United States
12:10 PM #20 CANCER-ASSOCIATED MUTANTS OF DNA POLYMERASE BETA: Joann B. Sweasy, Yale University, New Haven, CT, United States

Sunday, September 4, 2005
3:00 PM–5:00 PM
Bayview

A GENOMIC VIEW OF MUTATION

Chair: Lynn S. Ripley, UMDNJ, Newark, NJ, United States and
Norman Arhheim, University of Southern California, Los Angeles, CA, United States

3:00 PM #184 A GENOMIC VIEW OF FRAMESHIFTS IN HUMAN EXONS: Lynn S. Ripley, UMDNJ, Newark, NJ, United States
3:30 PM #185 A GENOME-WIDE VIEW OF THE RATE AND SPECTRUM OF SPONTANEOUS MUTATIONS: Michael Lynch, Indiana University, Bloomington, IN, United States
4:00 PM #186 MALE GERMLINE MUTATIONS: MUTATION RATES AT SPECIFIC HOTSPOTS: Norman Arhheim, University of Southern California, Los Angeles, CA, United States
4:20 PM #187 A NOVEL METHOD TO QUANTIFY EXTREMELY RARE RANDOM GENOMIC MUTATIONS: Jason H. Bielas, University of Washington School of Medicine, Seattle, WA, United States
4:40 PM #188 TANDEM REPEAT MUTATION AND RAPID EVOLUTION: John W. Fondon III, University of Texas, Dallas, TX, United States

Sunday, September 4, 2005
3:00 PM–5:00 PM
Seacliff C/D

NONCOVALENT CHEMICAL-DNA INTERACTIONS AND GENOTOXICITY

Chairs: Ronald D. Snyder, Schering-Plough Research Institute, Lafayette, NJ, United States and
Christian Bailly, INSERM, IRCL, Lille, France

3:00 PM #193 CHEMISTRY AND BIOLOGY OF NONCOVALENT DNA INTERACTIONS: Christian Bailly, INSERM, IRCL, Lille, France
3:30 PM #194 DNA TOPOLOGY AFFECTS THE RESPONSE OF HUMAN TOPOISOMERASES TO ANTICANCER DRUGS: Neil Osheroff, Vanderbilt University School of Medicine, Nashville, TN, United States
4:00 PM #195 CHINESE HAMSTER V79 CELL-BASED INVESTIGATIONS INTO THE RELATIONSHIP BETWEEN NON-COVALENT DNA INTERACTION AND GENOTOXICITY: Ronald D. Snyder, Schering-Plough Research Institute, Lafayette, NJ, United States
4:20 PM #196 3D DOCKING MODEL FOR PREDICTING DNA INTERCALATION ACTIVITY: Larry B. Hendry, Accelerated Pharmaceuticals, Augusta, GA, United States
4:40 PM #197 MECHANISMS AND IMPLICATIONS OF RECOMBINOGENIC AND ANEUPLOIDOGENIC EFFECTS OF TOPOISOMERASE II INHIBITORS: Lynn R. Ferguson, University of Auckland School of Medicine, Auckland, New Zealand

Sunday, September 4, 2005
3:00 PM–5:00 PM
Grand Ballroom B

OXIDATIVE STRESS RESPONSES

Chairs: Susumu Nishimura, University Tsukuba, Ibaraki, Japan and
Arthur P. Grollman, State University at Stony Brook, New York, NY, United States

3:00 PM #198 POSTREPLICATIVE PROTECTION AGAINST INDUCTION OF MUTATIONS BY 8-Oxo-dG-INDUCED MUTAGENESIS IN MAMMALIAN CELLS: Masaaki Moriya, State University at Stony Brook, New York, NY, United States
3:30 PM #199 IN SITU ANALYSIS OF CELLULAR RESPONSES TO OXIDATIVE BASE DAMAGE AND STRAND BREAKS IN MAMMALIAN CELLS: Akira Yasui, Institute of Development, Aging and Cancer, Sendai, Japan
4:00 PM #200 OXIDATIVE DAMAGE TO DNA: IS IT ONLY 8-Oxo-dG?: Steven R. Tannenbaum, Massachusetts Institute of Technology, Cambridge, MA, United States
4:20 PM #201 INVOLVEMENT OF MUTY IN PREVENTING CANCER: Jeffrey H. Miller, University of California, Los Angeles, CA, United States
4:40 PM OXOGUANINE AND CARCINOGENESIS: HUMANS VS. MICE: Susumu Nishimura, Banyu Tsukuba Research Institute, Ibaraki, Japan

Thursday, September 8, 2005
10:30 AM–12:30 PM
Bayview

NEW FRONTIERS IN GERM-CELL RESEARCH

Chairs: Carole L. Yauk, Health Canada, Ottawa, ON, Canada and
Carol D. Swartz, US EPA, Research Triangle Park, NC United States

10:30 AM #703 LONG-TERM EFFECTS OF EXPOSURE TO RADIATION: Yuri E. Dubrova, University of Leicester, Leicester, United Kingdom
11:00 AM #704 MOLECULAR MECHANISMS OF PATERNALLY TRANSMITTED CHROMOSOMAL DAMAGE: Francesco Marchetti, Lawrence Livermore National Laboratory, Livermore, CA, United States
11:30 AM #705 TRANS GENERATIONAL EPIGENETIC ACTIONS OF ENDOCRINE DISRUPTORS ON THE MALE GERM LINE: Michael K. Skinner, Washington State University, Pullman, WA, United States
11:50 AM #706 THE CONSERVED PROTEIN-CODING TRANSCRIPTOME OF MAMMALIAN MALE GERM CELLS: Michael Primig, Biozentrum and Swiss Institute of Bioinformatics, Basel, Switzerland
12:10 PM #707 ROLE OF EPIGENETIC CHANGES IN RADIATION-INDUCED TRANSGENERATION CARCINOGENESIS: Olga Kovalchuk, University of Lethbridge, Lethbridge, AB, Canada

Thursday, September 8, 2005
10:30 AM–12:30 PM
Grand Ballroom B

TRANSLESION DNA SYNTHESIS

Chairs: Fumio Hanaoka, Osaka University, Osaka, Japan and
Helle D. Ulrich, London Research Institute, Herts, United Kingdom

10:30 AM #713 TRANSLESION DNA SYNTHESIS IN 3D: Wei Yang, NIH/NIDDK, Bethesda, MD, United States
11:00 AM #714 INTERPLAY BETWEEN DNA POLYMERASES AND ACCESSORY FACTORS DURING LESION BYPASS AND MUTAGENESIS: Robert P. Fuchs, CNRS, Illkirch, France
11:30 AM #715 LAGGING-STRAND DNA SYNTHESIS AND GENOMIC STABILITY IN YEAST: Motoshi Suzuki, Nagoya University School of Medicine, Nagoya, Japan
11:50 AM #716 CONTROL OF DNA DAMAGE TOLERANCE BY UBIQUITIN AND SUMO: Helle D. Ulrich, London Research Institute, Herts, United Kingdom
12:10 PM #717 BIOCHEMICAL PROPERTIES OF DNA POLYMERASE ETA: Fumio Hanaoka, Osaka University, Osaka, Japan

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Risk Assessment

Sunday, September 4, 2005
10:30 AM–12:30 PM
Bayview

RESPONSES TO LOW DOSES OF ENVIRONMENTAL MUTAGENS

Chairs: Pamela J. Sykes, Flinders Medical Center, Bedford Park, SA, Australia and
K. Sankaranarayanan, Leiden University Medical Center, Leiden, Netherlands

Sponsored by Electric Power and Research Institute (EPRI)

10:30 AM #21 INCORPORATING HORMESIS INTO THE RISK ASSESSMENT PARADIGM: Dennis Paustenbach, ChemRisk, San Francisco, CA, United States
11:00 AM #22 NON-LINEAR SOMATIC INTRACHROMOSOMAL RECOMBINATION IN VIVO: Pamela J. Sykes, Flinders Medical Center, Bedord Park, SA, Australia
11:30 AM #23 SUPPRESSION OF CHEMICAL TUMORIGENESIS AND LIFE SPAN PROLONGATION IN MICE BY LOW DOSE RATE IRRADIATION: Kazuo Sakai, Central Research Institute Electric Power Industry, Tokyo, Japan
11:50 AM #24 ADAPTIVE RESPONSE AND BYSTANDER EFFECTS IN HUMAN AND NON-HUMAN BIOTA: Carmel Mothersill, McMaster University, Hamilton, ON, Canada
12:10 PM #25 RISK ASSESSMENT OF GERM-CELL MUTAGENESIS: K. Sankaranarayanan, Leiden University Medical Center, Leiden, Netherlands

Sunday, September 4, 2005
3:00 PM–5:00 PM
Seacliff A/B

LEGAL AND ETHICAL ISSUES ASSOCIATED WITH GENETIC TESTING

Chairs: Errol Zeiger, Chapel Hill, NC , United States and
Dafna Feinholtz, Col. Jardines en la Montana, Mexico

3:00 PM ETHNICITY, GENETIC VARIABILITY, AND RACE: Richard R. Sharp, Baylor College of Medicine, Houston, TX, United States
3:30 PM #189 TREATING GENETIC INFORMATION DIFFERENTLY FROM OTHER MEDICAL INFORMATION: Henry T. Greely, Stanford University School of Law, Palo Alto, CA, United States
4:00 PM #190 A WORKING DILEMMA: HOW OCCUPATIONAL HEALTH POLICY PREVENTS THE ETHICAL USE OF GENETIC KNOWLEDGE: Geoffrey P. Lomax, California Department of Health Sciences, Sacramento, CA, United States
4:20 PM #191 GENETICALLY BASED TOXIC TORT SUITS: Gary E. Marchant, Arizona State University, Tempe, AZ, United States
4:40 PM #192 ETHICS OF GENETIC TESTING: INCORPORATION OF A GENDER PERSPECTIVE: Dafna Feinholz, Comision Nacional de Bioetica, Col. Jardines en la Montana, Mexico

Wednesday, September 7, 2005
10:30 AM–12:30 PM
Seacliff A/B

TOXICO-INFORMATICS: EMERGING CAPABILITIES FOR IMPROVED PUBLIC DATA ACCESS AND EXPLORATION

Chairs: Ann M. Richard, US EPA, Research Triangle Park, NC, United States and
Andrew Worth, Institute for Health and Consumer Protection, Ispra, Italy

Sponsored by National Institute of Environmental Health Sciences and US EPA National Center for Computational Toxicology

10:30 AM #686 TOXICO-CHEMOINFORMATICS:EMERGING CAPABILITIES FOR IMPROVED PUBLIC DATA ACCESS AND EXPLORATION: Ann M. Richard, US EPA, Research Triangle Park, NC, United States
11:00 AM #687 OPEN-SOURCE TECHNOLOGIES FOR DATABASE PROCESSING AND ANALYSIS: Marc C. Nicklaus, NIH/NCI, Bethesda, MD, United States
11:30 AM #688 A STANDARDIZED GENETIC TOXICITY DATABASE FOR IMPROVED (Q)SAR IN COLLABORATION WITH US FDA: Chihae Yang, Leadscope, Inc., Columbus, OH, United States
11:50 AM #689 QSAR AND TOXICITY DATABASES WITHIN THE EUROPEAN UNION: Andrew Worth, Institute for Health and Consumer Protection, Ispra, Italy
12:10 PM #690 BUILDING A TOXICOGENOMICS KNOWLEDGE BASE: Michael D. Waters, NIEHS, Research Triangle Park, NC, United States

Thursday, September 8, 2005
10:30 AM–12:30 PM
Seacliff A/B

RISK ASSESSMENT AND GENETIC TOXICOLOGY

Chairs: Lutz Müller, Hoffmann-La Roche, Basel, Switzerland and
Kerry L. Dearfield, US EPA, Washington, DC, United States

Sponsored by Johnson & Johnson Pharmaceutical Research & Development

10:30 AM #708 INCORPORATION OF MOLECULAR ENDPOINTS INTO QUANTITATIVE CANCER RISK ASSESSMENTS: R. Julian Preston, US EPA, Research Triangle Park, NC, United States
11:00 AM #709 RISK FROM LOW DOSE EXPOSURE TO GENOTOXINS—STRATEGY AND EXAMPLES FROM GENOTOXIC IMPURITIES IN DRUG SUBSTANCES: Lutz Müller, Hoffmann-La Roche, Basel, Switzerland
11:30 AM #710 RISK ASSESSMENT OF METALS: COBALT AS AN EXAMPLE: Micheline Kirsch-Volders, Free University of Brussels, Brussels, Belgium
11:50 AM #711 GERM CELL RISK ASSESSMENT OF ACRYLAMIDE: Kerry L. Dearfield, USDA, Washington, DC, United States
12:10 PM #712 PATHOGEN INACTIVATION BY PHOTOCHEMICAL TREATMENT OF PLATELETS: GENOTOXICITY TESTING AND RISK ASSESSMENT: Güenter Speit, University of Ulm, Ulm, Germany

Thursday, September 8, 2005
1:00 PM–3:00 PM
Seacliff A/B

DECISION-MAKING WITH GENETIC TOXICITY DATA

Chairs: David J. Kirkland, Covance Laboratories, Ltd., North Yorkshire, United Kingdom and
Marilyn J. Aardema, Procter & Gamble, Cincinnati, OH, United States

Student/Faculty Programs

Tuesday, September 6, 2005
10:30 AM–12:30 PM
Seacliff A/B

SCIENCE EDUCATION IN THE UNIVERSITY: NEW TEACHING METHODS

Chairs: James M. Gentile, Research Corporation, Tucson, AZ, United States and
Jo Handelsmann, University Wisconsin, Madison, WI, United States