Environmental Mutagen Society
EMS 2003:
From Mechanisms to Risk Assessment
May 10 - 14, 2003
Fontainebleau Hilton Resort
Miami Beach, Florida
Meeting Program
David A. Eastmond, Program Chair
| Saturday 5/10/03 |
Sunday 5/11/03 |
Monday 5/12/03 |
Tuesday 5/13/03 |
Wednesday 5/14/03 |
Saturday, May 10, 2003
| 8:00am - 10:30am |
Executive Board Meeting | Imperial II |
| 8:30am - 5:00pm |
New Developments in Molecular Epidemiology Short Course Course Organizer, Fred F. Kadlubar, U.S. FDA/NCTR |
Monaco |
| The Short Course has been cancelled (April 7, 2003) |
||
| 10:45am - 12:00pm |
ICEM Strategic Steering Committee Meeting | Imperial III |
| 1:00pm - 5:00pm |
EMS Council Meeting | Imperial II |
| 3:30pm - 7:00pm |
Registration | Fountainebleau Gallerie |
| 6:30pm - 9:00pm |
Student Poster Session {Sponsored by Eli Lilly} |
Versailles Gallerie |
| Welcoming Reception {Sponsored by the Genetic Toxicology Association and Pfizer} |
||
Sunday, May 11, 2003
| 7:00am - 8:30am |
Breakfast Meetings | |
| 2004 Program Committee (First Meeting) | Imperial I | |
| Finance Committee | Voltaire | |
| Hollaender Committee | Lafayette | |
| Membership and Professional Development Committee | Pasteur | |
| Student and Young Investigator Breakfast | Le Mans | |
| 7:30am - 5:00pm |
Registration | Fountainebleau Gallerie |
| 8:30am - 9:15am |
Plenary Lecture: Molecular Epidemiologic Approaches
to Evaluating the Effects of Prenatal and Postnatal Environmental Exposures |
Fontainebleau A |
| 9:20am - 12:10pm |
DNA Damage Checkpoint Signaling Symposium Chairpersons, Mats Ljungman, University of Michigan, and Peter J. Stambrook, University of Cincinnati |
Fontainebleau B |
| 9:20am | Introduction: DNA Damage Checkpoint Signaling - Who’s on First? Mats Ljungman, University of Michigan |
|
| 9:50am | Activation of and Signaling by the ATM Kinase After DNA Damage Michael B. Kastan, St. Jude Children's Research Hospital |
|
| 10:20am | Break | |
| 10:40am | Analysis of the ATR-Mediated DNA Damage and Replication Checkpoints in Xenopus Egg Extracts Karlene Cimprich, Stanford University |
|
| 11:10am | Convergence of the p53 and MAP Kinase Genotoxic Stress Signaling Pathways in Cell Cycle Control Al Fornace, National Cancer Institute |
|
| 11:40am | Fanconi Anemia Pathway in the DNA Damage Response Alan D'Andrea, Harvard University | |
| 9:20am - 12:10pm |
Embryonic and Fetal Exposure and Children's Health Symposium Chairpersons, James D. Tucker, Wayne State University, and Radim J. Sram, Institute of Experimental Medicine, Czech Republic |
Fontainebleau A |
| 9:20am | Physiologic and Genetic Risk Factors for Paternally Transmitted Chromosomal Abnormalities Andrew J. Wyrobek, Lawrence Livermore National Laboratory |
|
| 9:50am | Impact of Environmental Pollution on Pregnancy Outcome Radim J. Sram, Institute of Experimental Medicine, Czech Republic |
|
| 10:20am | Break | |
| 10:40am | Cigarette Smoking During Pregnancy: Genetic Susceptibility and Cytogenetic Consequences in Mothers and
Newborns James D. Tucker, Wayne State University |
|
| 11:10am | Genetic Polymorphisms and Down Syndrome: Maternal Risk and Fetal Survival S. Jill James, U.S. FDA/NCTR |
|
| 11:40am | Clinical Consequences of Intrauterine Mutagen Exposures David K. Manchester, University of Colorado | |
| 1:30pm - 4:20pm |
Advances in Somatic Mutation Models Symposium Chairpersons, Suzanne Morris and Daniel A. Casciano, U.S. FDA/NCTR |
Brittany/Champagne |
| 1:30pm | Introduction Daniel A. Casciano, U.S. FDA/NCTR |
|
| 1:35pm | Relevance of Model Somatic Mutation Systems to Humans Richard J. Albertini, University of Vermont |
|
| 2:00pm | Hprt and Tk Mutation in Model Systems Robert H. Heflich, U.S. FDA/NCTR |
|
| 2:30pm | The Aprt Model for Genomic Instability and Loss of Heterozygosity Jay Tischfield, Rutgers University |
|
| 3:00pm | Break | |
| 3:20pm | Application of the Pink-Eyed Unstable p(un) Mouse for Detection of Genotoxicity In Vivo Jiri Aubrecht, Pfizer | |
| 3:50pm | PhiX and Other Transgenic Mutation Systems Heinrich V. Malling, NIEHS | |
| 1:30pm - 4:20pm |
Children's Susceptibility to Environmental
Agents Symposium Chairpersons, Nina T. Holland, University of California, Berkeley and William Suk, NIEHS |
Fontainebleau A |
| 1:30pm | Children's Health and the Environment William Suk, NIEHS |
|
| 2:00pm | Emerging Environmental Threats to Children's
Health - The Situation in Developing Countries Kalpana Balakrishnan, Deemed University, Chennai, India |
|
| 2:30pm | Functional Genomics and Pesticide Exposure in
Children and Pregnant Women Nina T. Holland, University of California, Berkeley |
|
| 3:00pm | Break | |
| 3:20pm | Molecular Epidemiology of Childhood Leukemia Martyn T. Smith, University of California, Berkeley |
|
| 1:30pm - 4:20pm |
Potential Modifiers of Carcinogenesis at Low Doses Symposium Chairpersons, R. Julian Preston, U.S. EPA and Antone L. Brooks, Washington State University |
Fontainebleau B |
| 1:30pm | Bystander Effects: Radiation and Chemicals Charles R. Geard, Columbia University |
|
| 2:00pm | Molecular Responses to Low Dose Ionizing Radiation David A. Boothman, Case Western Reserve University |
|
| 2:30pm | Genomic Instability: Radiation and Chemicals Jeffrey L. Schwartz, University of Washington |
|
| 3:00pm | Break | |
| 3:20pm | Gene Expression Approaches: New Ideas Thomas J. Vasicek, Lynx Therapeutics |
|
| 3:50pm | Risk Assessment Models for Radiation and Chemicals Suresh H. Moolgavkar, Fred Hutchinson Cancer Research Center | |
| 4:30pm - 7:00pm |
Exhibits and Posters Session 1 | Fontainebleau C and D |
| {Odd numbered posters to be attended 4:30 PM - 5:45 PM; Even numbered posters to be attended from 5:45 PM - 7:00 PM} | ||
Monday, May 12, 2003
| 7:00am - 8:30am |
Breakfast Meetings | |
| Exhibitor's Breakfast | Voltaire | |
| Genomics Group | Imperial II | |
| Molecular Epidemiology Group | Imperial IV | |
| Risk Assessment Group | Imperial I | |
| Transgenic and In Vivo Mutagenesis Group {Sponsored by Boehringer Ingelheim Pharmaceuticals Inc.} |
Lafayette | |
| 7:30am - 5:00pm |
Registration | Fountainebleau Gallerie |
| 8:30am - 11:20am |
Genomic Instability Symposium Chairpersons, William F. Morgan, University of Maryland, and Robert H. Schiestl, University of California, Los Angeles |
Fontainebleau B |
| 8:30am | Transgenerational Effects of Paternal Exposure to Ionizing Radiation Janet E. Baulch, University of California, Davis |
|
| 9:00am | Analyses of Meiotic Recombination and Germline Mutation in Mice Carole L. Yauk, Health Canada, Ottawa |
|
| 9:30am | Effects of Carcinogens and Cancer Predisposing Mutations on the Frequency of DNA Deletions Robert H. Schiestl, University of California, Los Angeles |
|
| 10:00am | Break | |
| 10:20am | Cis-Acting Mechanisms for Genomic Instability Andrew J. Grosovsky, University of California, Riverside |
|
| 10:50am | The Origin of Mutations In Vivo and in Stem Cells Peter J. Stambrook, University of Cincinnati | |
| 8:30am - 11:20am |
Toxico- and Medical Genomics Symposium Chairpersons, Michael D. Waters, NIEHS, and C. Sid Aaron, Pharmacia |
Fontainebleau A |
| 8:30am | Toxicogenomic Classification of Toxic Effects Raymond Tennant, NIEHS |
|
| 9:00am | Liver Gene Expression Profiles From Chronic and Acute TCDD, PCB153 or PCB126 Treated Rats Renae L. Malek, The Institute for Genomic Research |
|
| 9:30am | Microarray Analysis in Mechanistic Toxicologic Research Roger G. Ulrich, Rosetta Inpharmatics/Merck |
|
| 10:00am | Break | |
| 10:20am | The ILSI/HESI Genomics Studies Jiri Aubrecht, Pfizer |
|
| 10:50am | Proteomic Analysis of Cancers Emanuel F. Petricoin, III, U.S. FDA-NCI | |
| 11:30am - 12:15pm |
Plenary Lecture: A Mutator Phenotype in Cancer Lawrence A. Loeb, University of Washington, Seattle, WA |
Fontainebleau A |
| 1:30pm - 4:30pm |
Assembly and Regulation of DNA Repair Machines Symposium Chairpersons, Larry H. Thompson, Lawrence Livermore National Laboratory, and John A. Tainer, Scripps Research Institute |
Fontainebleau A |
| 1:30pm | Overview Larry H. Thompson, Lawrence Livermore National Laboratory |
|
| 1:45pm | Role and Regulation of DNA-PK in DNA Double-Strand Break Repair Susan Lees-Miller, University of Calgary, Canada |
|
| 2:10pm | Biochemical Reconstitution and In Situ Visualization of Nonhomologous End-Joining Complexes William S. Dynan, Medical College of Georgia |
|
| 2:35pm | Rad50/Mre11/NBS1 Complex in Human Disease Checkpoint Implementation and Repair James P. Carney, University of Maryland |
|
| 3:00pm | Break | |
| 3:20pm | Structural Biochemistry and Interaction Architecture of Mre11 Nuclease and Rad50-ATPase in DNA
Recombination and Repair John A. Tainer, Scripps Research Institute |
|
| 3:45pm | Mismatch Repair Machinery and ATP-hydrolysis: Implications for Repeat Expansions in Humans Cynthia T. McMurray, Mayo Clinic |
|
| 4:10pm | Nuclear Localization of Mre11, Rad50, and Nbs1 Immunoreactivity in Human Brain Neurons Ahn J, Marietta CA, Brooks PJ |
|
| 4:20pm | Nijmegen Breakage Syndrome Cells Exhibit Increased Mis-rejoining of DNA Double-strand Breaks Pluth JM, Yamazaki V, Cooper BA, Rydberg BE, Kirchgessner CU, Cooper PK |
|
| 1:30pm - 4:30pm |
Abstract | Platform Session 1: DNA Damage and Response Chairpersons, Allen T. Christian, Lawrence Livermore National Laboratory, and Elizabeth T. Snow, Deakin University |
Le Mans/Bordeaux |
| 1:30pm | 7 | Gene Expression Profiles and Genetic Damage
in BPDE-Exposed TK6 Cells Akerman GS, Domon OE, Culp SJ, MacGregor JT, Rosenzweig B, Sistare FD, Morris SM |
|
| 1:50pm | 202 | Classification of chemical carcinogens by gene
expression profiling: discrimination of genotoxic versus non-genotoxic carcinogens van Agen E, Kleinjans JCS, van Delft JHM |
|
| 2:10pm | 188 | Coordinated Regulation of Gene Expression by
Low Dose Arsenic Snow ET, Sykora P, Schuliga M, Hu Y |
|
| 2:30pm | 252 | Histopathology of Exposure to Low Doses of Ionizing Radiation in a Population of Bats Meehan K, Truter E, Parker MI |
|
| 2:50pm | 118 | Ionizing Radiation-induced Sperm DNA Lesions are Repaired in the Egg by Double-strand Break Repair
Pathways Marchetti F, Essers J, Kanaar R, Wyrobek AJ |
|
| 3:10pm | Break | ||
| 3:30pm | 204 | Apoptotic Nucleases Initiate Leukemogenic Translocations Vaughan AT, Betti CJ, Villalobos MJ, Diaz MO |
|
| 3:50pm | 212 | Relationship Between Toenail Concentration of Selenium and the Level of Genotoxic Stress within the
Aging Prostate Waters DJ, Shen S, Cooley DM, Bostwick DG, Qian J, Glickman LT, Morris JS |
|
| 4:10pm | 222 | Effect of Smoking Habit on the Frequency of Micronuclei in Human Lymphocytes: Results from the Human
MicroNucleus Project Zeiger E, Bonassi S, Chang WP, Holland N, Kirsch-Volders M, Fenech M |
| 1:30pm - 4:30pm |
Mode of Action in Risk Assessment Symposium |
Fontainebleau B |
| 1:30pm | Mode of Action in Risk Assessment Kerry L. Dearfield, U.S. EPA |
|
| 1:45pm | Is the Dose-Response Linear or Nonlinear for Genotoxic Effects? R. Julian Preston, U.S. EPA |
|
| 2:10pm | Follow-up Test Strategies for Determining Mode of Action Warren W. Ku, Pfizer |
|
| 2:35pm | Follow-up Strategies for Determining Relevance of Genotoxicity Sheila M. Galloway, Merck |
|
| 3:00pm | Break | |
| 3:20pm | Non-Linear Modes of Action: A Case Study Matthew S. Bogdanffy, Dupont |
|
| 3:45pm | Physiologically Based Pharmacokinetic (PBPK) Modeling and Mode of Action in Dose-Response Analysis Hugh A. Barton, U.S. EPA |
|
| 4:10pm | An FDA Perspective on Mode of Action in Mutagenicity and Carcinogenicity Risk Assessment James T. MacGregor, U.S. FDA | |
| 4:30pm - 7:00pm |
Exhibits and Poster Session 2 | Fountainebleau C and D |
| {Odd numbered posters to be attended 4:30 PM - 5:45 PM; Even numbered posters to be attended from 5:45 PM - 7:00 PM} | ||
Tuesday, May 13, 2003
| 7:00am - 8:30am |
Breakfast Meetings | |
| EMS Executive Board | Imperial Boardroom | |
| Awards and Honors Committee | Imperial I | |
| DNA Repair Group | Voltair | |
| Germ Cells/Aneuploidy/Human Genetic Diseases Group | Imperial III | |
| New Technologies Group | Lafayette | |
| 7:30am - 1:00pm |
Registration | Fountainebleau Gallerie |
| 8:30am - 9:15am |
Plenary Lecture: Contaminants, Genes and Health: Lessons from Wildlife Louis J. Guillette, Jr., University of Florida, Gainesville, FL |
Fontainebleau A |
| 9:20am - 10:50am |
Business Meeting/Awards Presentation | Fontainebleau A |
| 10:50am - 1:15pm |
Exhibits and Poster Session 3 | Fountainebleau C and D |
| {Odd numbered posters to be attended 10:50 AM - 12:00 PM; Even numbered posters to be attended from 12:00 PM - 1:15 PM} | ||
| 1:15pm - 7:30pm |
Free afternoon | |
| 7:30pm - 10:30pm |
Dessert Cruise | |
Wednesday, May 14, 2003
| 7:00am - 8:30am |
Breakfast Meetings | ||
| 2004 Program Committee (Second Meeting) | Imperial Boardroom | ||
| Education and Student Affairs Committee | Monaco | ||
| 7:30am - 12:00pm |
Registration | Fountainebleau Gallerie | |
| 8:30am - 9:10am |
Nucleotide Excision Repair and the Identification of DNA Lesions in Malignant Melanoma: Epidemiology
and Fish Stories Richard B. Setlow, Brookhaven National Laboratory, Upton, NY |
Fontaine Room | |
| 9:15am - 11:30am |
Excision Repair Symposium Chairpersons, Joann B. Sweasy, Yale University, and Samuel H. Wilson, NIEHS |
Fontaine Room | |
| 9:15am | Overview of Base Excision Repair Samuel H. Wilson, NIEHS |
||
| 9:45am | Nucleotide Excision Repair: Solved and Unsolved Problems Richard D. Wood, University of Pittsburgh |
||
| 10:15am | Break | ||
| 10:30am | Transcription-Coupled DNA Repair in Human Cells: Mechanisms and Interactions Priscilla Cooper, Lawrence Berkeley Laboratory |
||
| 11:00am | DNA Repair in Chromatin: An Overview Michael J. Smerdon, Washington State University | ||
| 9:15am - 11:30am |
Computational/Predictive Toxicology Symposium {Sponsored by Novartis} Chairpersons, Nigel Greene, Pfizer, and R. Daniel Benz, U.S. FDA |
Brittany/Champagne | |
| 9:15am | Computational Toxicology Advances: Emerging Capabilities for Data, Exploration and SAR Model
Development Ann M. Richard, U.S. EPA |
||
| 9:45am | Using Computational Biology Techniques to Bridge the Experimental Divide Felice Lightstone, Lawrence Livermore National Laboratory |
||
| 10:15am | Break | ||
| 10:30am | The Application of In Silico Tools for Toxicity Prediction in Drug Discovery and Development Nigel Greene, Pfizer |
||
| 11:30am | Are In Vitro, Animal, and Clinical Testing Still Necessary? R. Daniel Benz, U.S. FDA | ||
| 9:15am - 11:30am |
Abstract | Platform Session 2: Environmental Agents and Mutation Chairpersons, Toby G. Rossman, New York University, and Ofelia A. Olivero, National Cancer Institute |
Le Mans /Bordeaux /Burgundy |
| 9:15am | 164 | Arsenite Induces Delayed Mutagenesis, Gene Amplification, and Transformation in Human Osteosarcoma
(HOS) Cells at Extremely Low Concentrations Rossman TG, Mure K, Uddin AN, Styblo M, Lopez LC |
|
| 9:35am | 155 | Role of Mismatch Repair in Chromium(VI) Toxicity and Potential Implications for Chromium Carcinogenesis
and Risk Assessment Peterson E, Reynolds M, Messer J, Zhitkovich A |
|
| 9:55am | 195 | Effect of Low Dose Radiation on Somatic Intrachromosomal Recombination In Vivo and In Vitro Sykes PJ, Bhat M, Cormack J, Morley AA, Hooker AM |
|
| 10:15am | Break | ||
| 10:30am | 206 | Assessment of Depleted Uranium (DU) Mutagenicity at the hprt Locus in F344 Rats Walker DM, Hahn FF, Lewis J, Barr EB, Walker VE |
|
| 10:50am | 232 | Sentinel Mice Detect Heritable DNA Mutations Induced by Air Pollution Somers CM, Quinn JS |
|
| 11:10am | 240 | Chromosomal Aberrations Induced by Ambient and Indoor Air Pollution Bocskay K, Orjuela M, Warburton D, Perera F | |
| 11:35am - 12:20pm |
Keynote Lecture: Identification of Pathways That Maintain Genome Stability Richard Kolodner, University of California, San Diego, CA |
Fontaine Room |
| 1:30pm - 6:30pm |
Colon Cancer Satellite Meeting | Fontainebleau A |
| 1:40pm - 2:25pm |
Plenary Lecture: Role of New Technologies in the Regulatory Process Paul Gilman, Science Advisor, U.S. EPA, Washington, DC |
Fontaine Room |
| 2:30pm - 4:45pm |
Abstract | Platform Session 3: DNA Repair and Mutagenesis Chairpersons, Gerald M. Adair, University of Texas, and Kathleen A. Hill, City of Hope |
Le Mans /Bordeaux /Burgundy |
| 2:30pm | 3 | Effects of MSH3 Gene Deletion on Targeted Homologous Recombination in ERCC1 Wild-type
or ERCC1 Knock-out Cell Lines Adair GM, Robison T, Bolt A, Della-Coletta L, Nairn RS |
|
| 2:50pm | 26 | siRNA Depletion of BRCA1 and BRCA2 in Fanconi Anemia Cells Bruun D, Folias AE, Akkari YM, Cox YT, Olson SB, Moses RE |
|
| 3:10pm | 213 | Recruitment of the DNA Binding Protein RAD18 to Sites of Stalled Replication Forks is Required for DNA
Damage Tolerance in Human Cells Watson NB, Burke T, Stefan M, Zacharias W, McGregor WG |
|
| 3:30pm | Break | ||
| 3:50pm | 103 | The K289M DNA Polymerase Beta Cancer-Associated Mutant Misincorporates Nucleotides Lang T, Sweasy JB |
|
| 4:10pm | 9 | DNA Repair and Mutagenesis in Young Mice Heterozygous for Various BER Genes Allen D, Huamani J, MacInnes MA, Chen DJ, Sobol RW, Wilson SH, Tebbs R, Walter CA |
|
| 4:30pm | 75 | Spacing Between Spontaneous Multiple Mutations Suggests a Coordinate Event and Multiple Mutations are
Elevated in p53-Deficient Mice, Especially in the Liver and Spleen Hill KA, Wang J, Farwell KD, Sommer SS | |
| 2:30pm - 4:50pm |
Environmental Mutagens and Carcinogens: An Update Symposium Chairpersons, Patricia Ostrosky, National Autonomous University of Mexico, Mexico City, and George R. Douglas, Health Canada |
Fontaine Room |
| 2:30pm | Aflatoxin Mutations and Liver Cancer John M. Essigman, Massachusetts Institute of Technology |
|
| 3:00pm | Arsenic and Cancer: Are Humans Really That Sensitive? Allan H. Smith, University of California, Berkeley | |
| 3:30pm | Break | |
| 3:50pm | The Role of Infectious Diseases in Carcinogenesis Patricia Ostrosky, National Autonomous University of Mexico, Mexico City |
|
| 4:20pm | Mutations Induced by Urban Air and Drinking Water: Do They Leave a Mutational Signature in Human
Tumors? David M. DeMarini, U.S. EPA | |
| 5:15pm - 6:45pm |
EMS Council Meeting | Imperial Boardroom |
This page was last changed on 08-APR-2003.
