Poster Sessions
David DeMarini, Program Chair
SESSION I: Saturday, March 17, 2001, 5:00 - 7:30 pm
- Mutational Mechanism
- Mutation Spectra
- Gene Expression
- New Technologies
- Transgenics
- Adducts
- Biomonitoring
- Metals
- Germ Cells
- Micronucleus
SESSION II: Sunday, March 18, 2001, 4:00 - 6:30 pm
- DNA Repair
- Gene Expression
- Genetic Susceptibility
- Comet
- Cytogenetics
- Carcinogenesis
- Environmental Studies
- Test Development
SESSION III: Tuesday, March 20, 2001, 1:00 - 3:30 pm
- Genomic Instability
- Mutational Mechanisms
- DNA Repair
- Transgenics
- Antimutagenesis
- Micronucleus
- Bacterial Studies
- Biomonitoring
SESSION I: Saturday, March 17, 2001, 5:00 - 7:30 pm
(Use your Internet browser's "Find" function to locate your name or title in the list below.)
Mutational Mechanism
Poster Number Abstract Number Title Authors
1 132 Detection of mutation in Chinese hamster ovary cells using a fluorescent reporter McGarrity LJ, Dobrovolsky VN, Morris SM, Heflich RH
2 222 Site-Specific Mutagenesis Studies of Acetylaminofluorene DNA Adduct Positioned in NarI Restriction Enzyme Site -- Effects of Adducts Structure, Host Cell and Sequence Context Tan X, Suzuki N, Grollman AP, Shibutani S
3 56 Accumulation of Somatic Mutations in Proliferating T cell Clones in Children with Leukemia Finette BA, Homans AC, Rivers J, Messier T, Albertini RJ
4 209 Identification of Functional Interactions between DNA Intercalating Agents and Topoisomerase II using the V79 Micronucleus Assay Snyder RD
5 75 Mutation induction in neonatal mice treated with antiretroviral nucleoside analog drugs Heflich RH, Von Tungeln LS, Hamilton LP, Dobrovolsky VN, Bishop ME, Gamboa da Costa G, Beland FA
6 79 Mutation load over the life of the mouse is age and tissue specific but not obviously related to rates of cell proliferation Hill KA, Halangoda A, Heinmoller PW, Chitaphan CC, Sommer SS
7 25 Error-prone repair of carcinogen-induced DNA depurinating damage induces preneoplastic mutations in SENCAR mouse skin Chakravarti D, Mailander PC, Higginbotham S, Rogan EG, Cavalieri EL
8 237 DNA Damage Responses - Sequential Occurrence of p53 Induction, Apoptosis and Micronucleus Formation Induced by Topoisomerase II Inhibitors in TK6 Cells Wang L, Eastmond DA
9 161 Radiation induced DNA damage and tetranucleotide instability in a model system for human lung cancer Oh DS, Slebos RJC, Taylor JA
Mutation Spectra
Poster Number Abstract Number Title Authors
10 41 Alternate Pathway to Lung Cancer Indicated by KRAS and TP53Mutations in Nonsmokers Exposed to Indoor Smoky Coal Emissions Demarini DM, Landi S, Tian D, Hanley NM, Roop BC, Gao W, Mumford JL
11 124 Mutations induced by (-)-anti-11R,12S-dihydrodiol, 13S,14R-epoxide of dibenzo[a,l]pyrene in the coding region of the hprt gene in chinese hamster V-79 cells Mahadevan B, Dashwood WM, Doehmer J, Baird WM
12 198 Frequency and Types of Hprt Lymphocyte Mutations in PMS2-deficient mice Shaddock JG, Dobrovolsky VN, Mittelstaedt RA, Bendre S, Heflich RH, Parsons BL
13 186 Mutation Spectrum of 1,2-Dibromo-3-Chloropropane, an Endocrine Disruptor, in the lac Transgenic Big Blue Rat2 Fibroblast Cell Line Ryu JC, Kim YJ
14 180 Function analysis of Saccharomyces cerevisiae genes by using single gene deletion mutants and proteome analysis Rogowska A, Fey SJ, Mose Larsen P
15 98 Application of the short-extension nested PCR mutation assay for genotoxicity testing in mitochondrial DNA: effects of bleomycin Khaidakov M, Manjanatha MG, Aidoo A
16 81 Mutagenic and Recombinagenic Effects of Two Methylating Agents in Bacteria Hoffmann GR, Crowley DJ, Theophiles PJ
17 20 Molecular description of three macro-deletions and an Alu-Alu recombination-mediated duplication in the HPRT gene in four patients with Lesch-Nyhan disease Brooks EM, Branda RF, Nicklas JA, O'Neill JP
Gene Expression
Poster Number Abstract Number Title Authors
18 87 Ultraviolet light-induced gene expression by cDNA microarray analysis Huang JC, Guo YL, Li C, Huang W
19 187 Studies on endocrine disrupting activity, gene expression profile and DNA damage of phthalate analogues Ryu JC, Kim HT
20 29 Study of the Effects of P53 in Human Lymphoblast Cells Following Ionizing Radiation using 7K cDNA Microarrays Chuang YE, Liber HL, Staudt LM, Mitchell JB
21 96 CELL TRANSFORMATION AND GENE EXPRESSION INDUCED BY METAL WORKING FLUID IN BALB/C-3T3 CELLS Keshava N, Lin F, Huffman D, Chen ZY, Ong T
22 57 Gene expression analysis after radiation exposure Ford BN, Thorleifson E, Wilkinson D
23 225 Baseline expression of DNA repair-related genes differs among healthy mouse tissues Tomascik-Cheeseman LM, Coleman MA, Marchetti F, Mascio-Kegelmeyer L, Nelson D, Nath J, Wyrobek AJ
24 68 CYP1B1 expression as a risk factor for breast cancer Goth-Goldstein R, Erdmann C, Russell M
New Technologies
Poster Number Abstract Number Title Authors
25 236 A highthroughput genotoxicity assay exploiting the transcriptional response to DNA damage in the microbial eukaryote, Saccharomyces cerevisiae Walmsley RM, Barker MG, Billinton N, Knight A
26 217 Visualization of Frameshift Mutations in Mice Lacking Different Mismatch Repair Capabilities Stringer JR, Hersh MN
27 164 Detection of spontaneous mouse H-ras mutation by genotypic selection; PNA enrichment of target sequence and analysis by MutEx/ACB-PCR Parsons BL, Mittelstaedt RA, Heflich RH
28 153 Comprehensive analysis of protein levels of drug resistant and sensitive yeast strains Nawrocki A, Fey SJ, Goffeau A, Roepstorff P, Mose Larsen P
29 185 IDENTIFICATION OF SINGLE NUCLEOTIDE POLYMORPHISMS IN HUMAN FEN1 AND PCNA BY HETEROZYGOUS SEQUENCING PROTOCOL Ruttan CC, Yurkowski S, Glickman BW
Transgenics
Poster Number Abstract Number Title Authors
30 141 Extent of CpG methylation is not proportional to the in vivo spontaneous mutation frequency at transgenic loci in Big Blu rodents Monroe JJ, Manjanatha MG, Skopek TR
31 143 Mutant Spectra in Gene A of PhiX174 Bacteriophage carried in a transgenic mouse embryonic cell line, PX-2, exposed to N-Nitroso-N-ethylurea (ENU) Montgomery BA, Valentine CR
32 148 Mutation Frequency and Sequence Specificity in Parasite-Infected Big Blue Transgenic Mice Mortona O, Nannenga B, Tenclay S, Gentile GJ, Gentile JG
33 107 Studies on the Mutagenic Activity of Smokeless Tobacco in lacZ Mouse Oral Tissues Kosinska W, von Pressentin MDM, Chen M, Guttenplan JB
34 108 Transgenic p53 knockout mice as an alternative model for carcinogen bioassay: Results with cyclophosphamide Krishna G, Urda G, Tefera W, Reindel J
35 110 Induction of micronuclei by alkylating agents in p53 hemizygous and wild type mice Krsmanovic LS, Gudi R, Jacobson-Kram D
36 117 Exposure schemes and p53 status affect Radiation-induced in vivo loss of heterozygosity Liang L, Mendonca MS, Shao C, Deng L, Stambrook PJ, Tischfield JA
37 240 Comparisons of Single Burst Assay revertant frequencies in livers and spleens of phiX174 am3, cs70 transgenic neonatal and adult mice injected with ethylnitrosourea Weaver RP, Malling HV
38 130 Characterization of Mutations Induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the Colon of gpt delta Transgenic Mouse Masumura K, Matsui K, Yamada M, Ishida K, Watanabe M, Wakabayashi K, Nohmi T
39 221 Agents which reduce somatic intrachromosomal recombination below spontaneous frequency in the pKZ1 recombination mutagenesis model Sykes PJ, Hooker AM, McCallum BD, Morley AA
40 220 DNA Damage in Human Transitional Cell Carcinoma (TCC) cells following exposure to N-hydroxy-4-acetylaminobiphenyl, the proximate carcinogenic metabolite of the human bladder carcinogen 4-aminobiphenyl Swaminathan S, Burger MS, Torino JL, Oberley TD
Adducts
Poster Number Abstract Number Title Authors
41 238 Induction of IlacI mutations in Big Blue Rat2 cells treated with para-benzoquinone: Role of DNA adducts Wang Y, Wu W, Sprung CN, Bodell WJ
42 229 Dose-Response Relationship of Hemoglobin Adducts in Female Rats and Mice Exposed to 1,3-Butadiene Upton PB, Ranasinghe A, Meng Q, Walker VW, Henderson RF, Swenberg JA
43 174 Genotoxicity of Naturally-Occurring Indole Compounds Reddy MV, Laws GM, Armstrong MJ, Barnum JE, Sina JF, Storer RD, Galloway SM
44 89 DNA Adducts Detected by the 32P-Postlabeling Assay in JP-8 Exposed Rat Hepatocytes Jackman S, Grant GM, Stenger DA, Kolanko CJ, Nath J
45 65 7H-Benzo{c}fluorene, a candidate carcinogenic PAH with major health implications Goldstein L, Goth-Goldstein R, Russell M, Singh R, Weyand EH
Biomonitoring
Poster Number Abstract Number Title Authors
46 157 METABOLIC POLYMORPHISMS AND FREQUENCY OF CHROMOSOMAL ABERRATIONS Norppa H, Lindholm C, Ojajärvi A, Salomaa S, Hirvonen A
47 140 CYTOGENETIC MONITORING OF LOW LEVEL OCCUPATIONAL EXPOSURE TO BENZENE: NEED OF MOLECULAR CHROMOSOMAL ABERRATION ASSAYS FOR PREDICTING CANCER RISK Mirkova ET, Lalchev SG, Alexandrova EA
48 215 BIOMONITORING OF OCCUPATIONAL EXPOSURE TO ACRYLONITRILE Sram RJ, Beskid O, Binkova B, Chvatalova I, Rossner PJR, Rossner P
49 239 Possible influence of chronic exposure on the frequencies of hprt mutant lymphocytes in workers exposed to low levels of butadiene Ward JB, Abdel-Rahman SZ, Barker PJ, Stock TH, Morandi M, Ammenheuser MM
50 228 Evaluation of the Ability of Three Somatic Biomarkers to Detect Low Dose Radiation Exposure in Chernobyl Cleanup Workers Tucker JD, Langlois RG, Nelson DO, Mendelsohn ML, Pleshanov P, Jones IM
51 173 Chromosome Translocation Frequencies for Biological Dosimetry in Chernobyl Clean Up Workers Ramsey MJ, Cofield JW, Nelson DO, Jones IM, Tucker JD
52 179 An examination of chromosome damage in residents of Slavutych, Ukraine and radiation workers at Chornobyl Rodgers BE, Baker LK
53 194 The Frequency of t(14;18) in Blood Lymphocytes Is Stable over a 2 Year Period in Adults Scheerer JB, Xi L, Knapp GW, Bigbee WL, Fuscoe JC
Metals
Poster Number Abstract Number Title Authors
54 181 Transformation of human osteosarcoma (HOS) cells by low concentrations of arsenite is associated with mutation and gene amplification Rossman TG, Mure K, Lopez LC, Uddin AN
55 188 DIFERENT RESPONSES OF p53 TO THE CHALLENGE WITH ARSENIC Salazar AM, Acuña MC, Menéndez D, Trejo C, Herrera LA, Dueñas A, Ostrosky-Wegman P
56 200 Metabolism of sodium arsenite by various mammalian cells Sharma R, Peng B, Kligerman AD, Mass MJ
57 7 Effect of exposure protocol and heat shock protein expression on arsenite induced genotoxicity in MCF-7 breast cancer cells Barnes JA, Collins BW, Dix DJ, Allen JW
58 224 An Evaluation of the Relative Genotoxicity of Arsenite, Arsenate, and Four Methylated Metabolites In Vitro Using the Alkaline Single Cell Gel Assay (ASCG) Tennant AH, Styblo M, Mass MJ, Kligerman AD
59 129 Proximate or ultimate genotoxic forms of arsenic: methylated arsenic(III) species that react directly with DNA Mass MJ, Roop B, Tennant A, Kundu B, Brock K, Pimentel M, Thomas D
60 36 Sodium arsenite and UV induced mutations at the TK locus Danaee H, Liber HL, Nelson HN, Ebie KN, Kelsey KT
61 118 Induction of Oxyradicals by Arsenic: Implication for Mechanism of Genotoxicity Liu SX, Hei TK,Center for radiological Res., Columbia University. New york, NY. 10032 Liu SX, Hei TK
62 131 Dietary folate deficiency enhances arsenic-induced micronucleus formation in mice McDorman EW, Collins BW, Allen JW
63 246 Genotoxicity of Particulate Hexavalent Chromium in a Human Bronchial Cell Model Wise SS, Elmore LW, Antonucci PG, Holt SE, "Wise, sr. JP"
64 94 Genotoxic effects of Cr+, Cr4+ and Cr3+ in the Drosophila wing spot assay Katz AJ, Shi XL, Chiu A, Chiu N, Beaubier J
65 93 Use of genotoxicity assays to predict the carcinogenicity of nickel-containing materials Kaspin LC, Verma A, Thakore K, Metwally ME, Landolph JR
66 52 Role of Iron in the Mutagenesis of Natural and Synthetic Aluminosilicate Fibers Fach E, Long JF, Waldman WJ, Williams MV, Dutta PK
Germ Cells
Poster Number Abstract Number Title Authors
67 252 Age and Insert Site Dependence of Spontaneous Mutation Frequency at a DNA Repeat Locus Transgene in Individual Mouse Sperm Zhang Y, Monckton DG, Siciliano MJ, Connor TH, Meistrich ML
68 232 Radiation effects on semen quality and chromosomal damage in sperm of seminoma survivors Velazquez-Wong AC, Sloter E, Salamanca-Gomez F, Meistrich ML, Wyrobek AJ
69 193 RT-PCR ANALYSIS OF MOUSE OOCYTES AND CUMULUS CELLS SHOW DIFFERENTIAL EXPRESSION OF KU80 Schahin-Reed D, Mabery SL, Marchetti F, Wyrobek AJ
70 182 Stable variants of sperm aneuploidy among healthy men show associations between germinal and somatic aneuploidy Rubes J, Vozdova M, Rezacova O, Robbins WA, Rerreault SD, Wyrobek AJ
71 80 Validation of a multicolor FISH assay to detect chromosomal aberrations in mouse sperm using reciprocal translocation carriers Hill F, Marchetti F, Liechty M, Bishop J, Hozier J, Stubbs L, Wyrobek AJ
72 192 Human F9 germline mutations reveal dramatic variation in the sex ratio of mutation with mutation type, an advanced maternal age effect, high mosaicism, and a universal core mutation pattern indicative of predominantly endogenous mechanisms Scaringe WA, Xuemin L, Halangoda A, Hill KA, Sommer SS
Micronucleus
Poster Number Abstract Number Title Authors
73 142 ALTERATIONS OF XENOBIOTIC METABOLIZING ENZYMES DUE TO THE INFECTION BY TAENIA TAENIFORMIS METACESTODE IN RAT LIVER Montero R, Serrano L, Plancarte A
74 212 TREATMENT-INDUCED HYPO- AND HYPERTHERMIA AS AN ENDPOINT TO DEFINE MAXIMUM TOLERATED DOSE (MTD) IN A STANDARD MOUSE AND RAT BONE MARROW MICRONUCLEUS TEST (MNT) Spencer PJ, Hammond TA, Gollapudi BB
75 226 Transferability of a Flow Cytometric Micronucleus Assay: An Interlaboratory Study Torous DK, Hall NE, Dertinger SD, Tometsko CR
76 102 Simultaneous detection of Apoptosis, Necrosis and Micronuclei in a microscale MNT in vitro screening assay with L5178Y tk+/- cells Kirchner S, Albertini S, Chètelat AA, Gocke E, Muster W
77 183 In Vitro Micronucleus Test Results: Studies With and Without Cytochalasin-B Utilizing Varied Treatment and Harvest Times Rubitski EE, Homiski ML, Masucci ME, Provost N, Thiffeault CJ, Mauthe RJ
78 49 DIFFERENTIAL SENSITIVITY OF CHINESE HAMSTER V79 AND CHINESE HAMSTER OVARY (CHO) CELLS IN THE IN VITRO MICRONUCLEUS (MN) SCREENING ASSAY Erexson GL, Periago MV, Spicer CS
79 66 IN VITRO MUTAGENIC EVALUATION OF CANNABIDIOL (CBD), A MARIHUANA COMPOUND, ON HUMAN LYMPHOCYTES BY THE MICRONUCLEUS AND COMET ASSAY TESTS Gomes L, Gattás GJF
SESSION II: Sunday, March 18, 2001, 4:00 - 6:30 pm
(Use your Internet browser's "Find" function to locate your name or title in the list below.)
DNA Repair
Poster Number Abstract Number Title Authors
1 206 Effects on cultured mammalian cells of p,p'-DDE at relevant environmental concentrations Simonetti JP, Berner J, Williams KJ
2 196 Characterization and Mutagen Sensitivity of a Human Abasic Endonuclease Overexpressing CHO AA8 Cell Line Schild LS, Brookman KW, Christian AT, Thompson LH, Wilson III DM
3 166 Understanding factors which affect double-strand break formation and repair Pluth JM, Cooper B, Rydberg B, Cooper PK
4 122 DNA repair gene expression in mouse oocyte, zygote, and two-cell embryo Mabery SL, Schahin-Reed D, Marchetti F, Coleman MA, Wyrobek AJ
5 128 Database mining and gene-specific PCR to identify DNA repair genes expressed in early development Marsh BJ, Mabery S, Coleman MA, Wyrobek AJ
6 126 Localization of double strand break repair proteins during the early stages of mouse development Marchetti F, Hwang M, Wyrobek AJ
7 2 Reproducibility of the Cytogenetic Adaptive Response in Human Lymphoblastoid Cells Attix CM, Sorensen KJ, Wyrobek AJ, Tucker JD
8 35 Recovery of Preferential Repair Cosentino L, Heddle JA
9 219 Biochemical Reconstruction of a DNA Repair Pathway from Schizosaccharomyces pombe Styers ML, Alleva JL, Doetsch PW
10 10 Novel systems for assessing the repair of DNA damage induced by platinum antitumor compounds Beljanski V, Villanueva JM, Marzilli LG, Doetsch PW
11 137 INDUCTION OF ADAPTIVE RESPONSE IN MURINE LEUKOCYTES BY GAMMA RADIATION EXPOSURE IIN VIVO Mendiola-Cruz MT, Morales-Ramirez P
12 150 Post-treatment loss of BPDE-DNA adducts as a measure of DNA repair in human lymphoblasts Motykiewicz G, Faraglia B, Senie RT, Santella RM
13 190 Repair rates of R-band, G-band, and C-band DNA Sanders MH, Bates S, Wilbur BS, Holmquist GP
14 83 A human gene mapping to 11p15 complements the DNA post replicative repair defective CHO mutant UV-1 Holmes AA, Vannais D, Waldren CA, Stamato T
Gene Expression
Poster Number Abstract Number Title Authors
15 213 Glutathione S-transferase theta and mu (GSTT1 and GSTM1) gene expression in patients with aplastic anemia and myelodysplastic syndrome Spivey AC, Osgood CJ, Stacey MW
16 85 Utilization of Affymetrix Mu11K GeneChips to Examine Gene Expression Changes Caused by Mitomycin C (MMC) in L5178Y TK+/- Mouse Lymphoma Cells Hu T, Gibson DP, Torontali SM, Carr GJ, Tiesman JP, Aardema MJ
17 211 APPLICATION OF cDNA MICROARRAY ANALYSIS TO DISCRIMINATE DNA-REACTIVE VERSUS NON-REACTIVE MUTAGENS IN THE IN VITRO MOUSE LYMPHOMA FORWARD MUTATION ASSAY Sparrow BR, Kan L, Linscombe VA, Charles GD, Gollapudi BB
18 197 INDUCTION OF GENE EXPRESSION BY 2-DEOXY-5-AZACYTIDINE IN MISMATCH REPAIR DEFECTIVE COLON CANCER CELL LINES Sedwick WD, Leahy P, Strickfaden SM, Veigl ML
19 231 CONSTITUTIVE REVERSAL OF A MISMATCH REPAIR DEFECT IN CLONES FROM EPIGENETICALLY SILENCED COLON CANCER CELL LINES Veigl ML, Strickfaden SM, Ma AH, Georgy MF, Chen WD, Markowitz SM, Sedwick WD
20 39 Analysis of Transcript Profiles Induced by Genotoxicants in Mouse Lymphoma Cells Deahl JT, Flick LM, Li Q, Watson DE, Newton RK
21 88 Comparative Analysis of Gene Expression Changes in Mouse Tissues, Mouse Lymphoma Cells, and Mouse Fibroblast cells following Mitomycin C Treatment Islaih M, Flick LM, Deahl JT, Reid-Hubbard JL, Watson DE, Newton RK
22 115 Transcript profiling of a carcinogen/non-carcinogen pair in a 14 week rat study Li B, Flick L, Phelps JB, Newton RK, Li Q, Sullivan J, Watson DE
23 175 Gene Expression Changes Induced by Genotoxic Agents in the Human TK6 Cell Line Reid-Hubbard JL, Li B, Newton RK, Watson DE
Genetic Susceptibility
Poster Number Abstract Number Title Authors
24 22 Biological Effect of Myeloperoxidase and Glutathione S-transferase Polymorphisms and Their Role in Lung Cancer Risk Cajas-Salazar N, Zwischenberger J, Alpard S, Au WW
25 113 FANCONI ANEMIA FANCG/XRCC9 PARTICIPATES IN SENSITIVITY OF CHO CELLS TO MULTIPLE TYPES OF DNA DAMAGING AGENTS Lamerdin JE, Dias J, George JW, Souza B, Christian AT, Liu N, Thompson LH
26 97 TUMORIGENIC POTENTIAL OF METAL WORKING FLUID INDUCED IN BALB/C-3T3 TRANSFORMED CELLS Keshava N, Lin F, Chen ZY, Huffman D, Ong T
27 138 DIFFERENT INDIVIDUAL SUSCEPTIBILITY TO METRONIDAZOLE IN HUMANS Menendez D, Rojas E, Herrera L, Lopez MC, Sordo M, Ostrosky-Wegman P
28 23 RAD6 gene is involved in Bleomycin tolerance induced by Heat Shock in Saccharomyces cerevisiae Candreva EC, Keszenman DJ, Nunes E
Comet
Poster Number Abstract Number Title Authors
29 203 Extent of DNA Damage in Prostate of Elderly Dogs is Abrogated by Selenomethionine Supplementation Shen S, Cooley DM, Glickman LT, Oteham C, Combs Jr GF, Waters DJ
30 171 The Relative Potency of Estrogen Metabolites in Induction of DNA Strand Breaks in Human Cells Quintana PJE, Rabanal C, de Peyster A
31 73 GENOTOXIC RESPONSE OF CALIFORNIA SEA LION (ZALOPHUS CALIFORNIANUS) LYMPHOCYTES TO BPDE AND H2O USING THE COMET ASSAY Hastings-Smith DA, El-Zein R, Ward Jr. JB
32 58 DNA damage in gastric mucosa cells and leukocytes of patients with gastric disease infected or not by the Helicobacter pylori Freire-Maia DV, Ladeira MSP, Salvadori DMF, Achiles P, Padulla P, Rodrigues MAM
33 67 Single cell gel (Comet) assay of transitional cells from patients with history of urothelial neoplasm Gontijo AMMC, Elias FN, de Oliveira MLCS, Salvadori DMF, de Camargo JLV
34 32 Comet assay and micronucleus test after 4-week oral treatment of mice with melphalan or azathioprine Cinelli S, Argentino storino A, Lascialfari A, Cordelli E, Ranaldi R, Pacchierotti F
35 51 AZT-Induced DNA Damage Detected by the Comet Assay Escobar PA, Olivero OA, Day BW, Tice RR, Romkes M, Day RD, Bigbee WL
35.5 191 SINGLE VERSUS TRIPLE DOSING IN THE COMET ASSAY Sasaki YF, Kamaya A, Sekihasi K, Kawamura K, Ikka T, Tsuda S
Cytogenetics
Poster Number Abstract Number Title Authors
36 146 DNA LESION FATE DURING THE SISTER CHROMATID EXCHANGE EVENT Morales-Ramirez P, Rodriguez-Reyes R
37 24 CHROMOSOMAL ABERRATIONS IN MICE BONE MARROW PRODUCED BY IMIPRAMINE AND DESIPRAMINE Cardenas Y, Madrigal E, Becerril A
38 12 Smoking during pregnancy: Induced chromosome aberrations in mothers and newborns Bennett LM, Ramsey MJ, Harger GF, Bigbee WL, Tucker JD
39 40 Use of the TK6 Mutation Assay to Investigate Cytotoxicity-Associated False Positive Chromosome Aberration Results Deluca JG, Dysart GR, McGettigan KK, Mittal LV, Galloway SM
40 5 Detection of hyperdiploidy in rat interphase hepatocytes following treatment in vivo with vinblastine sulfate using fluorescence in situ hybridization (FISH) Balakrishnan S, Payawal JH, Hasegawa LS, Schuler MJ, Eastmond DA
41 3 Genetic and Acquired Susceptibility to Environmental Disease Au WW, Anwar WR, Salama AS, Heo MY
42 125 DNA AND CHROMOSOME DAMAGE BY CHLOROHYDROXYFURANONES IN MAMMALIAN CELLS Mäki-Paakkanen J, Laaksonen M, Komulainen H, Vartiainen T, Hakulinen P, Munter T, Kronberg L
43 26 Polyploidy (Endoreduplication) and Structural Chromosome Aberrations Induced in Chinese Hamster Ovary Cells by Two Similar Anthraquinone Mixtures Disperse Blue 23 (DB23) and Disperse Blue X (DBX) Chen H, Sharma R, Tice R, Dressler W
44 144 Non-Random Distribution of Chromosomal Rearrangements in Karyotypically Unstable Human Cells Moore SR, Parks KK, Ritter LE, Grosovsky AJ
45 244 Molecular Prognostic Indicators of Uveal Melanoma: Correlation of DNA Sequence Copy Number Aberrations with Patient Follow-up White JS, McLean IW, Nath J, Becker RL, Director-Myska AE
Carcinogenesis
Poster Number Abstract Number Title Authors
46 169 Redbook 2000: FDA Guidance for Genetic Toxicity Testing of Food Ingredients Prival MJ, Benz RD, Bigger CA, Blakey DH, Elespuru RK, Jagannath DR, MacGregor JT
47 178 Telomerase Activity in Radiation Induced Myeloid Leukemic Cells Rithidech KR, Gordon CR, Cronkite EP
48 86 Protective effect of baicalin on hepatocyte apoptosis induced by TNF-a and ActD in rat hepatocyte in vitro Hu CH
49 16 BETA-catenin mutations in multiple target organs following treatment of F344 rats with dietary phytochemicals and 1,2-dimethylhydrazine (DMH) or 2-amino-3-methylimidazo[4,5-f ]quinoline (IQ) Blum CA, Xu M, Orner GA, Michels A, Bailey GS, Dashwood RH
50 216 ASSESSMENT OF THE EPA/IARC DATABASE ON GENETIC AND RELATED EFFECTS (GRE) IN SHORT TERM TESTS Stack HF, Jackson MA, Waters MD
51 248 The carcinogenic activity associated with topoisomerase II-mediated DNA damage in the mouse skin tumorigenesis model Xiao H, Yang JM, Liu LF
Environmental Studies
Poster Number Abstract Number Title Authors
52 172 GENETIC CHARACTERIZATION OF MEX2000 Drosophila STOCK FROM MEXICO CITY; GENOTOXIC EFFECTS INDUCED BY ETHYL-NITROSOUREA (ENU) Ramos-Morales P, Muñoz MA, Muñoz HA, Ordaz MG, Rivas MH, Hernandez BB, Arellano AO
53 31 Use of the L5178Y TK+/- Mouse Lymphoma Forward Mutation Assay to Measure Photomutagenicity Cifone MA, Sernau RC
54 30 Effect of a 60Hz electromagnetic field on the frequency of Bleomycin-induced HGPRT gene mutation and 1,2,4-benzenetriol-induced sister chromatid exchanges in CHO cells Chung HW, Kang SJ, Lee YJ
55 245 Field applications of a traditional laboratory model system, the mouse (Mus musculus domesticus) Wickliffe JK, Rodgers BE, Chesser RK, Gaschak SG, Zhichevsky I, Phillips CJ, Baker RJ
56 27 Estimation of Absorbed Radiation Dose from Internally Deposited Radionuclides Chesser RK, Zinner B
57 195 Effect of the dechlorinating agent, ascorbic acid, on the mutagenicity of chlorinated water samples Schenck KM, Speth TF, Sivaganesan M
58 109 Role of Insoluble Metal Ions in Airborne Particulate Induced Disease Kristovich R, Long JF, Waldman WJ, Williams MV, Dutta PK
59 136 Genetic Damage Indicators in Fish Exposed to Varying Stream Conditions in an Agricultural Watershed Meier JR, Chang LW, Daniel FB, Franson SE, Wernsing P
60 92 QUANTITATIVE CYTOTOXIC AND GENOTOXIC ANALYSIS OF DRINKING WATER DISINFECTION BY-PRODUCTS Kargalioglu Y, Minear RA, Chadaga AR, Wagner ED, Plewa MJ
61 99 Community Participatory-based Reproductive Epidemiology Using DBCP Exposure as a Model Kim PJ, Rodriguez J, Lim KL, Robbins WA
62 21 Mutation Analysis of P53 and RAS Genes In Liver Tumors From European Flounder (Platichthys flesus) and Dab (Limanda limanda) Browning CA, Jenkins GJS, Lyons BP, Parry JM
Test Development
Poster Number Abstract Number Title Authors
63 72 Measurement of stabilised topoisomerase cleavage complexes using the TARDIS assay Harvey JS, Burman M, Lynch AM, Rees RW
64 46 Development of an in vitro p53 mutagenicity assay Elespuru RK, Chung NG
65 243 Minisatellite Change as a Biomarker of Mutagenic Effects in Somatic Cells White PA, Parfett CL, Gingerich J, Bayley J, Berndt L, Douglas GR, Blakey D
66 241 EVALUATING THE USE OF THE IN VIVO RAT SKIN MICRONUCLEUS ASSAY FOR DETECTION OF GENOTOXIC AGENTS FOLLOWING TOPICAL APPLICATION Weiner SK, Schuler MJ, Ku WW, Guzzie PJ
67 156 Further evaluation of a skin in vivo micronucleus test Nishikawa T, Haresaku M, Fukushima A, Nakamura T, Adachi K, Hayashi M
68 152 AN IN VITRO CHINESE HAMSTER OVARY (CHO) CELL CULTURE SYSTEM FOR TESTING DNA DAMAGE Nath RG, Dowty HV, Luo F-Q, Gutt S, Hall C, Binder RL
69 134 Detection of rare K-ras point mutation using Allele-specific Competitive Blocker PCR McKinzie PB, Parsons BL
70 254 IDENTIFICATION OF A CELL SENESCENCE GENE FOR OVARIAN CANCER BY COMPLEMENTATION ANALYSIS Zhawar VK, Satyasree G, Rane N, Sandhu AK, Kaur GP, Athwal RS
71 247 Development of a Multiple-Endpoint Assay to Measure Growth Repression of Tumor Cells Woods E, Berhow M, Mehta P, Wagner ED, Plewa MJ
72 28 Rolling Circle Amplification Used to Detect Single-Base Changes and Gene Expression Levels in Single Cells Christian AT, Pattee MS, Sorensen KJ, Attix CM, Reed BE, Tucker JD
73 210 Measurement of mutation load using the p53 gene in human cells from paraffin-embedded tissues Sommer SS, Heinmoller E, Schlake G, Chen J, Li X, Hill KA, Liu Q
74 53 Determinants of DNA Yield and Quality from Buccal Cell Samples Collected with Mouthwash Feigelson HS, Calle EE, Rodriguez C, Jacobs EJ, Robertson AS, Thun MJ
75 47 DEVELOPMENT OF A MINIATURIZED MICROPLATE MN ASSAY WITH HUMAN LYMPHOCYTES AND MOUSE LYMPHOMA L5178Y CELL LINE: A COMPARATVE STUDY Elhajouji A, Poetter F, Suter W
SESSION III: Tuesday, March 20, 2001, 1:00 - 3:30 pm
(Use your Internet browser's "Find" function to locate your name or title in the list below.)
Genomic Instability
Poster Number Abstract Number Title Authors
1 204 FORWARD VERSUS REVERSE MUTATIONS INDUCED BY N-ETHYL-N-NITROSOUREA IN MOUSE EMBRYONIC PREMELANOCYTES Shibuya T, Sui H, Matsumoto H, Satoh M, Hara T
2 214 Niacin Deficiency Causes Genomic Instability in Rat Bone Marrow In Vivo! Spronck JC, Kirkland JB
3 145 Camptothecin, a topoisomerase I inhibitor, induces genomic instability Moore BK, Grosovsky AJ
4 84 Effect of c-myc over-expression and loss of msh-2 expression on somatic intrachromosomal recombination Hooker AM, Morley AA, Sykes PJ
5 62 The effect of sulindac treatment on genomic instability in a mismatch repair-defective cell line: efficacy versus cytotoxicity Glaab WE, Hill RB, Galloway SM, Skopek TR
Mutational Mechanisms
Poster Number Abstract Number Title Authors
6 119 RNA POLYMEARASE II AS A SENSOR AND INTEGRATOR OF CELLULAR STRESS Ljungman M, O'Hagan H, Yanamadala S, Tenbroeke ML
7 147 Transcriptional Mutagenesis in Mammalian Cells Morey NJ, Meadows KL, Doetsch PW
8 101 Regulation of rrg1+ Expression by Glucose in Schizosaccharomyces pombe Kim MJ, Park SD
9 91 DNA HYPERMETHYLATION AND LOSS OF EXPRESSION OF THE p16 TUMOR SUPPRESSOR GENE IN CADMIUM TRANSFORMED BALB/c-3T3 CELLS Joseph P, Lei Y, Muchnok T, Ong T
10 43 Frequencies of Hprt and Tk mutant lymphocytes in Tk+/- animals treated with different classes of mutagens Dobrovolsky VN, Shaddock JG, VonTungeln LS, Beland FA, Heflich RH
11 189 Mild hyperthermia impairs carboplatin resistance in human ovary tumour cells Salvo A, Bracesco N, Candreva EC, Nunes E
12 135 Investigating the impact of variations in nitric oxide (NO) delivery among commonly used NO-donors McQueen ET, Abu-Shakra A
13 154 Mitotic gene conversion without crossing-over at an endogenous human locus Neuwirth EAH, Quintana PJE, Grosovsky AJ
14 253 P27kip1 gene is haplo-insufficient in the colon mutagenesis of mice Zhang S, Holcroft J, Lin W, Lloyd R, Bowden G, de Boer JG, Glickman BW
15 63 Functional Characterization of the bypass DNA polymerase Pol eta, using random mutagenesis Glick E, Loeb LA
DNA Repair
Poster Number Abstract Number Title Authors
16 121 Defective processing of hydrogen peroxide-induced oxidative DNA damage in premature cataract prone mouse lens epithelial cells Lohani A, Kumaravel TS, Mambo E, Egwuagu C, Evans MK
17 159 ATM, NBS1, and RPA are involved in cellular responses to UV-induced DNA damage Oakley GG, Johnson BR, Robison J, Dixon K
18 199 Somatic mutations at Aprt and Hprt loci of mice deficient in mismatch repair Shao C, Yin M, Deng L, Liskay RM, Doetschman TC, Stambrook PJ, Tischfield JA
19 249 ROLE OF MMR PROTEINS IN INDUCTION OF P53 AND APOPTOSIS THROUGH TRANSCRIPTION BLOCKAGE Yanamadala S, Ljungman M
20 64 Evidence in E. coli that 3-Methyladenine Lesions can be Processed by Both Base and Nucleotide Excision Repair Gold B, Shah D, Kelly J, Zhang Y, Dande P, Soto AM, Marky L
21 120 Assessing the repair of biologically significant levels of DNA adducts in human cells Lloyd DR, Hanawalt PC
22 123 RPA Foci in Irradiated Cells as an Indicator of Unrepaired DNA Damage MacPhail SH, Olive PL
23 116 Expression of hMMS2 antisense in human cells decreases the frequency of recombination and increases the frequency of induced mutations Li Z, Xiao W, McCormick JJ, Maher VM
24 100 Rad22 protein, a Rad52 Homologue in Schizosaccharomyces pombe, binds to DNA double-strand breaks Kim WJ, Kim MJ, Park SD
25 127 Generation of DNA repair-deficient CHO cells expressing ADH4, the esophageal alcohol dehydrogenase Marietta CA, Brooks PJ
26 170 Characterization of the promoter region of the Chinese hamster apurinic/apyrimidinic endonuclease gene (chAPE1) Purohit S, Arenaz P
27 218 Functional Interactions of the Bacteriophage PBS-2 Uracil-DNA Glycosylase Inhibitor Protein (UGI) with the Human Immunodeficiency Virus Vpr and Uracil-DNA Glycosylase Complex Studebaker AW, Chen R, Mansky LM, Williams MV
28 70 Random Mutagenesis of Human 3-Methyladenine DNA Glycosylase Guo H
29 133 G2/M Checkpoint Control McGowan CH, Melchionna R, Chen XB, Blassina A, Ensch-Simon I
Transgenics
Poster Number Abstract Number Title Authors
30 6 Development of an in vitro assay to detect mutation induction in the lacZ transgene of Muta Mouse cultured splenocytes Ballantyne M, Marshall RR, Wolfreys AM, Ellis G
31 54 Transgenic shuttle vector assays for assessing overall mutagenesis during normal and malignant cell development in vivo Felix K, Potter M, Janz S
32 48 DEVELOPMENT OF A lac- SELECTION ASSAY FOR DETECTION OF MUTAGENESIS IN VERTEBRATE SYSTEMS Ennis DG, Higginbotham RH
33 8 Transmission of Mutations in Transgenes to the Offspring of ENU-Treated Big Blue™ Transgenic Male Mice Barnett LB, Tyl RW, Shane BS, Shelby MD, Lewis SE
34 55 Mutagenicity of 3-chloro-p-toluidine (3-CHL) and 5-chloro-p-toluidine (5-CHL) in the liver of Big Blue™ transgenic mice Fin J, Ganesh L, Deboer JG, Shane BS
35 45 The Development and Characterization of Epithelial Cell Lines From Muta Mouse Douglas GR, White PA, Gingerich J, Parfett C, Bayley J, Shwed P, Blakey D
36 9 Protective Effect of Dietary-restriction Through Development on Induced Mutant Frequency After an Acute Dose of N-Methyl-N-nitrosourea or N-Ethyl-N-nitrosourea Bavinton HB, Heddle JA
37 13 Improved Protocol for the Big Blue™ Transgenic Mutagenesis System Bielas JH
38 202 QUANTITATIVE AND MOLECULAR ANALYSIS OF C MUTATIONS IN MAMMARY AND BONE MARROW TISSUES OF BIG BLUE™ RATS EXPOSED TO 7,12-DIMETHYLBENZ(A)ANTHRACENE (DMBA) Shelton SD, Desai MP, Manjanatha MG
39 251 Conjugated linoleic acid inhibits 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutations in Big Blue transgenic rats Yang H, de Boer JG, Glickman BW
Antimutagenesis
Poster Number Abstract Number Title Authors
40 38 Differential cytoprotection of amifostine against DNA damage induced by idarubicin de Campos Nebel M, Larripa IB, Gonzalez Cid MB
41 76 Genotoxic and antigenotoxic effect of chamomile essential oil in somatic and germ cells Hernández-Ceruelos CA, De la Cruz-Maya C, Madrigal-Bujaidar E
42 15 Modulation of biochemical and mutagenic effects of 7,12-dimethylbenz[a]anthracene (DMBA) and bleomycin (BLM) by dietary antioxidants Bishop ME, Desai VG, Lyn-Cook LE, Khadaikov M, Manjanatha MG, Aidoo A
43 184 Antimutagenicity and Tumor-Suppressive Properties of Commercial Corn Processing By-Products Rundell MS, Muellner M, Berhow M, Vaughn S, Wagner ED, Plewa MJ
44 176 GENETIC TOXICOLOGY TESTING OF NATURAL PRODUCTS BEING DEVELOPED AS CANCER CHEMOPREVENTIVE AGENTS Riccio ES, Lee PS, Bakke JP, Kirsten NL, Crowell JA, Mirsalis JC
45 163 Effect of White Tea on Intestinal Tumor Progression in the APC Min Mouse Orner GA, Blum CA, Dashwood W-M, Dashwood RH
46 165 Evidence that chlorophyllin (CHLN) may behave as an inhibitor or a promoter of radiation-induced genetic damage in somatic cells of Drosophila Pimentel E, Cruces MP, Zimmering S
47 151 Excess mutagenesis in mismatch repair deficient cells is reduced by dietary antioxidants Mure K, Rossman TG
48 201 Effect of the Antimutagens Vanillin and Cinnamaldehyde on the Spontaneous Mutation Spectra of Salmonella TA104 Shaughnessy DT, Setzer RW, DeMarini DM
49 155 The Effect of Dietary Restriction During Development in utero on the Frequency of Spontaneous Somatic Mutations Newell LE, Heddle JA
Micronucleus
Poster Number Abstract Number Title Authors
50 61 Why Is The In Vitro Micronucleus Assay Missing Some Clastogens? A Case Study Gibson DP, Murphy VA, Cruze CA, Aardema MJ
51 60 In vivo micronucleus assay - control values for children of 0-7 years age Fucic A, Lasan R, Hitrec V
52 33 Staurosporine Induces Micronuclei in Chinese Hamster Ovary (WBL)Cells That Are Kinetochore Positive Cocco RE, Soelter SG, Janssen DL, Bunch RT
53 42 The aryl hydrocarbon receptor antagonist 3'-methoxy-4'-nitroflavone protects mice from benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage Dertinger SD, Nazarenko DA, Gasiewicz TA
54 106 The frequency of Micronuclei, Plasma Malondialdehyde and Blood Serotonin Among Children At Risk Of Exposure To Saw Dust Korraa SS, Iskander N, Shalaby H
55 78 The in vitro micronucleus assay in hamster and human cells: (i) Cytotoxicity-associated positive results and (ii) Assessment of optimal sampling time Hill RB, Greenwood SK, Galloway SM
56 11 Metronidazole and Its Metabolizes Induce MicronucleiI and Increase Cell Proliferation in Cells With Nonfunctional P53 Bendesky A, Menendez D, Ostrosky-Wegman P
Bacterial Studies
Poster Number Abstract Number Title Authors
57 168 BEWARE OF POSITIVE RESULTS IN AN AMES SCREENING ASSAY WHEN TESTING COMPOUNDS AT PRECIPITATED DOSES Preston RF, Gallagher CJ, Erali MD, Kordik C, Luo C, Oldham JW, Dufrain RJ
58 114 Characterization of a DNA Damage-inducible gene from a fluorescent Pseudomonas sp. strain YP Lee JS, Park Y, Park JK, Park SD
59 160 Metabolic activation of aminophenylnorharman and aminomethylphenylnorharman in umu tester strains Oda Y, Totsuka Y, Wakabayashi K, Shimada T
60 112 Regulation of nfsA expression by SoxS in Escherichia coli Lambert IB, Paterson ES, Boucher S
61 233 MUTAGENIC SYNERGY BETWEEN ORGANOPHOSPHORUS ESTER INSECTICIDES AND AROMATIC AMINES Wagner ED, Marengo M, Anderson M, Plewa MJ
62 111 Mutagenicity in Salmonella and DNA Damage in the CHO/Comet Assay Induced by Nitrohalomethanes, a Novel Class of Drinking Water Dinsinfection By-Products Kundu B, Warren SH, DeMarini DM, Richardson SD, Wagner ED, Plewa MJ
63 69 Genotoxicity of 1,3-Dichloropropane, 2,2-Dichloropropane, and 1,1-Dichloropropene in Salmonella and E. coli Prophage-Induction Assays Granville CA, Warren SH, Huggins-Clark G, George SE, Claxton LD, DeMarini DM
64 105 In Vivo Genotoxicity and Bioavailability of 2,4,6-Trinitrotoluene Amended Soil Kohan MJ, Bordelon NR, Brooks LR, Huggins-Clark G, Donnelly KC, George SE
65 103 DIRECT COMPARISON OF PLATE INCORPORATION AND PREINCUBATION METHODS FOR INITIAL MICROBIAL MUTAGENESIS SCREENING Kirsten NL, Quillen F, Noble C, Sina JF
66 19 Relationship Between FTC 'Tar' and Urine Mutagenicity in Smokers of Tobacco-burning or Eclipse Cigarettes Bowman DL, Bombick BR, Avalos JT, Davis RA, Morgan WT, Doolittle DJ
67 17 Comparative studies on the genotoxic and cytotoxic potential of mainstream smoke condensate from menthol and non-menthol cigarettes which burn or primarily heat tobacco Bombick BR, Avalos JT, Putnam KP, Bowman DL, Morgan WT, Bombick DW, Doolittle DJ
68 4 A Comparison of the Effectiveness of Salmonella Strains for Detecting Mutagenicity of A Cigarette Smoke Condensate Avalos JT, Lawlor TE, Fowler KW, Bombick BR, Doolittle DJ
Biomonitoring
Poster Number Abstract Number Title Authors
69 77 INCREASED TRANSLOCATION FREQUENCY OF CHROMOSOMES 7, 11 AND 14 IN LYMPHOCYTES FROM PATIENTS WITH NEUROCYSTICERCOSIS Herrera LA, Rodriguez U, Gebhart E, Ostrosky-Wegman P
70 82 FACTORS AFFECTING MICRONUCLEUS FREQUENCY IN EXFOLIATED BUCCAL AND UROTHELIAL CELLS OF ADULTS AND CHILDREN Holland NT, Hubbard A, Schumacher L, Gunn L, Golden D, Duramad P, Smith MT
71 207 Effects of age on structural chromosomal abnormalities in sperm from healthy men Sloter E, Eskenazi B, Kidd S, Moore II D, Hill F, Nath J, Wyrobek AJ
72 223 PAH-DNA ADDUCTS, GSTM1, AND XRCC1 IN A BREAST CANCER CASE-CONTROL STUDY Tang DT, Cho S, Chen S, Rundle A, Perera FP
73 205 RISK FACTORS FOR DEVELOPMENT OF CERVICAL CANCER IN VENEZUELA AND THE U.S Sierra-Torres CH, Robazetti SC, Arrastia CD, Tyring SK, Au WW
74 230 Is the high rate of esophageal cancer in Linxian, China associated with the formation of polycyclic aromatic hydrocarbon (PAH)-DNA adducts in human esophageal tissue? van Gijssel HE, Poirier MC, Divi RL, Olivero OA, Roth MJ, Dawsey SM, Taylor PR
75 167 Nucleoside Analog-Induced Mitochondrial Toxicity: Manifestations in the Clinic and in a Transplacental Erythrocebus patas Monkey Model Poirier MC, Gerschenson M, Nguyen VT, Divi RL, Olivero OA, Sable C, St. Claire MC
76 250 People Exposed to Lead and the Comet Assay Yañez CM, Torres MM, Sicard DM, Groot-Restrepo H
