Poster Sessions
James Tucker, Program Chair
SESSION I: Sunday, April 9, 2000, 5:00 - 7:30 pm
Test Results: Drosophila, Plants, Fish
Test Results: Micronucleus/Cytogenetics
Mutagenic Mechanisms
Test Results: Mammalian Cells
Human Biomonitoring/Studies
Molecular Studies
Genetic Susceptibility
DNA Adducts
Oxidative Damage
Mutational Spectra
SESSION II: Monday, April 10, 2000, 4:00 - 6:30 pm
Risk Assessment
Transgenics: Test Results
Environmental Studies
Test Development
Germ Cell Studies
Test Results: Other
Cytogenetics
Test Results: Bacteria
SESSION III: Wednesday, April 12, 2000, 1:00 - 3:30 pm
New Technologies/Systems
SAR/Computer Modeling
Metabolic Activation/Photo-Activation
Animal Studies
DNA Repair, Genetic Studies
Cancer Genes
Transgenics
Anti-Cancer Effects
Cell Cycle
Apoptosis
Carcinogenesis
Genomic Instability
SESSION I: Sunday, April 9, 2000, 5:00 - 7:30 pm
(Use your Internet browser's "Find" function to locate your name or title in the list below.)
Poster
No. Title Author
Test Results: Drosophila, Plants, Fish
1 Evaluation of Genetic Damage in Fish Exposed to Pesticides in Field Aquatic Microcosms Chang LW (1)
2 EVALUATION OF THE GENETIC TOXICITY OF THE INSECTICIDE DIELDRIN Díaz-Barriga S (1)
3 GENOTOXICITY OF PRIMAQUINE - AN EFFECTIVE DRUG FOR THE NEW STRAIN OF MALARIA Ma TH (1)
4 Indicators of Genetic Damage in Model Stream Fish Using Controlled Laboratory Exposures Meier JR (1)
Test Results: Micronucleus/Cytogenetics
5 Computerized automated morphometric assay including frequency estimation of pentachlorophenol induced nuclear anomalies (micronucleus) in catfish Heteropneustes fossilis Ali MN ()
6 Combination of MN test with FISH using (TTAGGG)n telomeric probe as centromere detection system in Chinese Hamster V79 cell line for Aneuploidy versus Clastogenicity discrimination Elhajouji A (1)
7 EFFECT OF CHLOROPHYLLIN ON THE MN-PCE INDUCTION IN PERIPHERAL BLOOD OF MICE EXPOSED TO CHROMIUM TRIOXIDE in vivo García-Rodriguez MC (1)
8 Genotoxic effect of imipramine and desipramine evaluated by micronuleus test Hernández-Ceruelos A (2)
9 A microscale MNT in vitro screening assay with L5178Y tk+/- mouse lymphoma cells to predict the outcome of GLP-assays detecting clastogenic activity Kirchner S (1)
10 THE HISTORICAL VEHICLE AND POSITIVE CONTROL MICRONUCLEUS (MN) DATA IN MICE AND RATS Krishna G (1)
11 Erythrocyte And Spermatid Micronucleus Analyses In Mice Chronically Exposed To Potassium Bromate (KBrO3) In Drinking Water Lori A (1)
12 Detection of genotoxicity of phenyl ethyl carbamates of recent chemistry synthesis Márquez-Becerra P (1)
13 Comparison of the Induction of Micronuclei (MN) in the lymphocytes of 4 Mammalian Species Following In Vitro Exposure to Sodium Arsenite Peng B ()
14 International Data Base Comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes. Effect of laboratory protocol, scoring criteria, and host factors on the baseline frequency of micronuclei The HUman MicroNucleus project HUMN ()
15 Genotoxic effects of the DNA topoisomerase II inhibitor merbarone in human lymphoblastoid TK6 cells: a comparison with ICRF-187 and etoposide Wang L (1)
Mutagenic Mechanisms
16 Mutation and Repair in Quiescent and Proliferating Mammalian Cells Bielas JH (1)
17 CHARACTERIZATION OF A LOSS OF HETEROZYGOSITY CANCER HAZARD IDENTIFICATION ASSAY Chen T (1, 2)
18 A Novel Approach That Validates Adaptive Mutagenesis Chrenek MA (1)
19 EFFECT OF N-METHYL-N-NITROSOUREA ON THE FREQUENCY OF ILLEGITIMATE V(D)J RECOMBINASE-MEDIATED GENE REARRANGEMENTS Fuscoe JC (1)
20 Enhanced DNA Incorporation of AZT and Synergistic Effects of AZT and DdI in Inducing HPRT and TK Mutations in Human Cells Meng Q (1)
21 Antimutagens and their Potential in the Prevention of Antibiotic Resistance Development Pillai SP (1,2)
22 USING GENETICALLY MODIFIED CHO CELLS TO STUDY THE MUTAGENESIS OF HETEROCYCLIC AMINES FROM COOKED FOODS Wu RW (1)
Test Results: Mammalian Cells
23 DISTRIBUTION OF COLONIES IN THE L5178Y TK+/- MOUSE LYMPHOMA ASSAY Cifone MA (1)
24 The phytoestrogen, coumestrol induces mutations at the Thymidine kinase locus in human lymphoblastoid cells Domon OE (1)
25 MICRONUCLEUS (MN) AND cII MUTANT FREQUENCY (MF) IN TRANSGENIC BIG BLUE™ RODENT CELLS TREATED WITH THE EPOXIDE METABOLITES OF 1,3-BUTADIENE (BD) Erexson GL (1)
26 Comparative Studies of Sister Chromatid Exchanges and DNA Damage Analysis in Human Lymphocytes Exposed to Military Jet Propulsion Fuels and Additives Jackman SM (1)
27 Induction of DNA Damage in Human Lymphocytes and Rat Hepatocytes Exposed to Jet Propulsion Fuels as Measured by the Single Cell Gel Electrophoresis Assay (SCGE) Jackman SJ (1)
28 COMET ASSAY ANALYSIS OF FOUR RAT NASAL CARCINOGENS IN TARGET AND NON-TARGET CELLS Mayer C (1)
29 Are aneugens mutagenic in the mouse lymphoma TK assay? O'Donovan MR (1)
30 Assesment of Diazepam and Griseofulvin in the Mitotic Spindle Assay Provost N (1)
Human Biomonitoring/Studies
31 IRON SALTS AND DEFEROXAMINE IN CELLS FROM A THALASSAEMIC PATIENT AND NORMAL INDIVIDUALS IN THE COMET ASSAY Anderson D (1)
32 Determination of heterocyclic aromatic amine levels in human milk samples by a rapid solid-phase extraction method Debruin LS (1)
33 Detection of Genome Damages in Workers Employed in Pesticide Production by Comet Assay Garaj-Vrhovac V (1)
34 GENOTOXICITY OF PESTICIDES IN BLOOD LYMPHOCYTES OF OCCUPATIONALY EXPOSED WORKERS Korraa SS ()
35 GENOTOXICITY OF GLUTARALDEHYDE AMONG HOSPITAL WORKERS AT ENDOSCOPY UNITS Korraa SS (1)
36 DNA breaks induced by in vivo Metronidazole treatment Menéndez D (1)
37 Chromosomal translocations in highly exposed DDT sprayers Ostrosky-Wegman P (1)
38 CHROMOSOME ABERRATIONS IN PERIPHERAL BLOOD LYMPHOCYTES AMONG CIGARETTE SMOKERS IN COLOMBIA Sierra MS (1)
39 DETECTION OF ONCOGENE PROTEINS IN HUMAN BIOLOGICAL FLUIDS Spruill MD (1)
40 Relationship of occupational butadiene exposure to frequencies of hprt mutant lymphocytes Ward JB (1)
Molecular Studies
41 Altered Gene Expression in Cultured Primary Rat Hepatocytes Exposed to Methapyrilene and Pyrilamine Harris AJ (1)
42 Detection of sunlight induced DNA damage, the role of UV-A and UV-B Jenkins GJS (1)
43 Use of Multiplex-Touchdown PCR for Detecting Loss of Heterozygosity (LOH) in Radiation Induced Mouse Acute Myeloid Leukemic (AML) Cells Rithidech K (1)
44 The use of catalytic topoisomerase II inhibitors to probe mechanisms of chemical-induced clastogenicity in Chinese hamster V79 cells Snyder RD (1)
Genetic Susceptibility
45 SELECTION FOR HPRT MUTANT T-LYMPHOCYTES IN HUMANS RECEIVING PURINE ANALOGUE MEDICATIONS Ardell SK (1)
46 Use of biomarkers to understand genetic susceptibility to environmental cancer Au WW (1)
47 INFLUENCE OF MYELOPEROXIDASE GENOTYPE ON THE FREQUENCY OF CHROMOSOMAL ABERRATIONS IN LUNG CANCER PATIENTS Cajas-Salazar N (1)
48 Novel polymorphisms in three genes involved in DNA repair Ford BN (1)
49 Cytogenetic biomarkers in occupational exposure to diisocyanates: influence of genetic polymorphisms of metabolic enzymes Norppa H (1)
50 Modulation of benzo[a]pyrene-induced genotoxicity by polymorphic GSTM1 and mEH genes Sierra-Torres CH (1)
51 DNA Repair Gene-Gene Interaction and Breast Cancer Risk Smith TS (1)
52 Heritable Biochemical Effects In Mouse Kidney Cells Following Paternal F0 Irradiation Are Modulated In F3 Offspring After Additional Exposure To Radiation Vance MM (1)
DNA Adducts
53 Benzo[a]pyrene treatment of aquaria raised offspring of the estuarine fish Fundulus heteroclitus, collected from a PCB contaminated site, results in decreased hepatic DNA adducts compared to reference site Kohan M (1)
54 Regulation of global genomic repair of BPDE adducts by p53 in mammalian cells Lloyd DR (1)
55 RESPONSE OF FANCONI ANEMIA CELLS ON EXPOSURE TO (-)ANTI-(11R,12S,13S,14R)-DIHYDRODIOL EPOXIDE Mahadevan B (1)
56 Mutagenicity and DNA-binding formed by soluble organic fraction of diesel particulate derived polycyclic aromatic hydrocarbons (PAHs) Savela K (1)
Oxidative Damage
57 Oxidative Mutagenesis induced by nitric oxide and hydrogen peroxide in the G12 transgenic Chinese hamster cells Abu-Shakra A (1)
58 A Study on the Mechanism of DNA damage induced by benzene metabolite, 1,2,4-benzenetriol, with the alkaline COMET assay Chung HW (1)
59 DNA DAMAGE EVALUATION IN DIFFERENT ORGANS OF GGT-DEFICIENT MICE Valverde M (1)
Mutational Spectra
60 SEQUENCE ANALYSIS OF MUTATIONS INDUCED BY N-ETHYL-N-NITROSOUREA IN THE TK AND HPRT GENES OF MOUSE LYMPHOMA CELLS Chen T (1,2)
61 COMPARISON OF MUTAGENIC SPECIFICITY INDUCED BY BENZIDINE AND BENZIDINE CONGENERS IN SALMONELLA TYPHIMURIUM his GENES Chung KT (1)
62 ASSOCIATION BETWEEN MUTATION SPECTRUM AND PERSISTENT DNA ADDUCT PROFILE IN SALMONELLA FOR BENZO[a]PYRENE OR DIBENZO[a,l]PYRENE Demarini DM (1)
63 7,12-Dimethylbenz[a]anthracene-induced mutagenesis in Tk+/- mice Dobrovolsky VN (1)
64 Specificity of mutations induced by the food-associated heterocyclic amine PhIP at the HPRT locus in colon cancer cell lines defective in mismatch repair Glaab WE (1)
65 The Pattern of Mutation in the Factor IX Gene in Different Populations Supports Primarily Endogenous Influences upon Recent Germline Mutations Li X (1)
66 Sequence Specificity of hpt Lymphocyte Mutation in Rats Fed the Hepatocarcinogen 2-Acetylaminofluorene Mittelstaedt RA (1)
67 DIFFERENCES IN THE SPECTRA OF IN VIVO SOMATIC AND GERMINAL HPRT MUTATIONS IN HUMANS O'Neill JP (1)
68 F9 non-CpG Mutation Hotspots Specific to Latin American Populations Scaringe WA (1)
69 Induction of lacI mutations in Big Blue Rat2 cells treated with either N-(2-hydroxyethyl)-N-nitrosourea or N-methyl-N-nitrosourea Sprung CN (1)
70 Mutational spectra of background somatic mutations at the hypoxanthine-guanine phosphoribosyltransferase locus in T lymphocytes in human fetuses Yoshioka M (1)
SESSION II: Monday, April 10, 2000, 4:00 - 6:30 pm
(Use your Internet browser's "Find" function to locate your name or title in the list below.)
Poster
No. Title Author
Risk Assessment
1 Genetic Damage and the Linear-No-Threshold Hypothesis Brooks AL (1)
2 Comparative Potency Ranking of Ozonation and Chlorination Disinfection By-Products Harrington-Brock K (1)
3 IMPLICATIONS OF THE GENETIC AND RELATED EFFECTS INDUCED BY 1,3-BUTADIENE (BD) AND ITS OXIDATIVE METABOLITES Jackson MA (1)
4 Plasma drug levels compared to genotoxicity in adult Cynomolgus (Macaca fascicularis) monkeys exposed to 3'-azido-3'-deoxythymidine (AZT) Olivero OA (1)
5 The Environmental Mutagen Information Center - An On-going Thirty-Year Effort Owens ET (1)
6 Assessing Research on the Biological Effects of Low Dose Radiation Wassom JS (1)
Transgenics: Test Results
7 The frequency and pattern of mutation in forebrain, cerebellum, liver and kidney of Big Blue(r) mice with chronic ethanol consumption Farwell KD (1)
8 Azathioprine does not induce gene mutations in non-target organs for tumorigenicity Harvey JS (1)
9 UVB-Induced Point Mutations and Deletions in the Skin of gpt-delta Transgenic Mice Horiguchi M (1,2)
10 Evaluation of mutant frequencies in liver tumors of lacI transgenic mice treated with oxazepam (OXP) Hursey J (1)
11 N-NITROSODI-N-PROPYLAMINE INDUCES ORGAN SPECIFIC MUTAGENESIS WITH SPECIFIC EXPRESSION TIMES IN LACZ TRANSGENIC MICE Itoh S (1)
12 Genotoxicity Assessment of Atrazine in the Big Blue Rat2 lacI Transgenic Cell Line Ryu JC (1)
13 MUTANT FREQUENCY AND TYPES OF LACI MUTATIONS IN THE BONE MARROW OF BIG BLUE R RATS EXPOSED TO 7,12-DIMETHYLBENZ(a)ANTHRACENE (DMBA) Shelton SD (1)
14 Transplacental mutagenesis of mainstream cigarette smoke in Big Blue(r) transgenic rats Shih PMT (1)
15 Assessment of the mutagenicity of three non-DNA reactive hepatocarcinogens at the cII locus in Big Blue™ transgenic mice Singh VK (1)
Environmental Studies
16 Simple, Rapid and Sensitive Method of Detection of Genotoxicity of Environmental Samples Employing umu-lux microplate-luminescence System Goto S (1)
17 MAMMALIAN CELL GENOTOXICITY OF DRINKING WATER DISINFECTION BY-PRODUCTS USING SINGLE CELL GEL ELECTROPHORESIS Kargalioglu Y (1)
18 Mutagenic Properties of River Waters Flowing Through Big City Areas in North America Ohe T (1)
19 Evaluation of Estrogenic Activities and DNA strand Breaks of Seven Phthalate Esters Ryu JC (1)
20 Effect of land treatment on the mutagenicity of Milwaukee harbor sediment Schenck KM (1)
21 MICROBIAL SPECIES- AND STRAIN-SPECIFIC DETECTION BY PCR USING MINOR DIFFERENCES IN THE 16S rRNA GENE SEQUENCES Tapp RA (1)
22 COMPARATIVE CYTOTOXICITY OF DRINKING WATER DISINFECTION BY-PRODUCTS IN MAMMALIAN AND BACTERIAL CELLS Vankerk D (1)
23 GENOTOXIC SYNERGY BETWEEN ORGANOPHOSPHORUS ESTER INSECTICIDES AND AROMATIC AMINES Wagner ED (1)
Test Development
24 A rapid assay for rho- mutations in the yeast Saccharomyces cerevisiae Barclay BJ (1)
25 Necrosis, Apoptosis, Cytostasis and DNA damage in human lymphocytes measured simultaneously within the Cytokinesis-block Micronucleus Assay - description of method and results for hydrogen peroxide Fenech M (1)
26 MOUSE LYMMPHOMA FORWARD MUTATION ASSAY (MLA): COMPARATIVE EVALUATION OF TREATMENT TIME, CLONING METHOD, AND EXPRESSION PERIOD Gollapudi BB (1)
27 Evaluation of a Mouse lymphoma TK locus screening test Gustafsson F (1)
28 Comparison of manual and automated (MicroFlow™) scoring of rat and mouse peripheral blood micronucleated reticulocytes (MN-RETs) induced by methotrexate and adozelesin Harbach PR (1)
29 Practical interpretation of the revised OECD guidelines for genotoxicity testing. The recommendations of the Industrial Genotoxicity Group Jones E (1)
30 Development of simplified spot-test procedure of yeast-based steroid hormone receptor gene trascription assay Jung HK (1)
31 Use of Temperature to Enhance the Sensitivity of the Drosophila Wing Spot Assay Katz AJ (1)
32 VALIDATION OF AN ICH/OECD-COMPLIANT PHOTOACTIVATED BACTERIAL MUTATION ASSAY Kraycer JA (1)
33 UDS in Mouse Liver - Assay Development Proudlock RJ (1)
34 Accelerated Screening of Combinatorial Chemistry Compounds Using a Modified Ames Assay Todd MD (1)
35 Flow cytometric analysis of micronuclei in rat bone marrow Torous DK (1)
Germ Cell Studies
36 Heritable Effects From Paternal F0 Irradiation of Type B Spermatogonia in Four Generations of Offspring Baulch JE (1)
37 MICE ARE LESS SUSCEPTIBLE THAN HUMANS TO INDUCTION OF GERM CELL ANEUPLOIDY BY NOVP CANCER CHEMOTHERAPY AS MEASURED BY SPEPM-FISH Bishop JB (1)
38 GERMLINE MOLECULAR MUTATION ASSAY IN DROSOPHILA MELANOGASTER Clark KB (1,2)
39 A new FISH assay to detect chromosome structural aberrations in mouse sperm Hill FS (1)
40 ANALYSIS OF MUTATIONAL EFFECT OF INCORPORATED RADIONUCLIDES Lee WR (1)
41 Does DNA damage accumulate during the post-meiotic phase of spermatogenesis and increase the risk of chromosomal abnormalities in offspring? Marchetti F (1)
42 EFFECT OF MUTAGEN-INDUCED CELL LETHALITY ON THE DOSE-RESPONSE RELATIONSHIP Perantie DC (1)
43 Investigation of Chromosome Damage in Sperm of Men Treated With Anti-Retroviral Drugs Robbins WA (1)
44 Bleomycin induces specific-locus mutations but not dominant-lethal mutations in male mice Russell LB (1)
45 Associations between chromosomal abnormalities and semen quality in healthy men Sloter E (1,2)
46 No Association Between Freezing Human Sperm Over Time and Comet Assay Measurements Tareen NG (1)
47 An Approach to Detect Mutations in Single Sperm at Human Expanded Myotonic Dystrophy CTG Repeats in a Transgenic Mouse Model Zhang Y (1)
Test Results: Other
48 CYTOTOXICITY STUDIES INTO THE ROLE OF pH-DEPENDENT AUTOXIDATION OF PHENYLHYDROQUINONE IN ORTHO-PHENYLPHENOL INDUCED URINARY BLADDER CARCINOGENESIS IN MALE F344 RATS Balakrishnan S (1)
49 Mutagenicity Assessment of Quinacrine Hydrochloride Clarke JJ (1)
50 UPDATE ON THE SYRIAN HAMSTER EMBRYO (SHE) CELL TRANSFORMATION ASSAY: RESULTS FOR THE PREDICITON ON NTP CARCINOGENS AND FROM THE ILSI/HESI PROGRAM ON ALTERNATIVE CARCINOGENESIS MODELS Gibson DP (1)
51 Use of the comet assay in industrial genotoxicity screening: technical considerations Hartmann A (1)
Cytogenetics
52 TRANSLOCATION PERSISTENCE IN HUMAN PERIPHERAL BLOOD LYMPHOCYTES FOLLOWING LOW DOSES OF IONIZING RADIATION: EFFECT ON BIODOSIMETRY Cofield JW (1)
53 Sidestream cigarette smoke induces cytogenetic damage in ApoE null mice Dertinger SD (1)
54 Characterization of Structural and Numerical Chromosome Aberrations in Uveal Melanoma Cell Lines using Spectral Karyotyping Director-Myska AE (1)
55 A Characterization of the Gene Dosage Aberrations of Uveal Melanoma Using Comparative Genomic Hybridization White JS (1,3)
56 A simple method for more accurate calculation of cell growth for the in vitro chromosome aberration assay Galloway SM (1)
57 Late-Arising First-Division Metaphases Have Higher Frequencies of X-Ray-Induced Chromosome Aberrations than do Early-Arising Metaphases in Human Lymphocytes Hoffmann GR (1)
58 Non-random chromosomal break point in lymphocytes from human population with low-dose radiation exposure Hsieh WA (1)
59 Antagonistic influence of Selenium (Se) on clastogenic changes caused by arsenic in cultured CHO cells Kochar T (1)
60 DNA DAMAGE CAUSED BY THE INCORPORATION OF 99mTc-RADIOPHARMACEUTICALS IN MURINE LYMPHOCYTES Pedraza-López M (1)
61 CHROMOSOME ABERRATIONS, SCES AND MUTAGENICITY IN CHO CELLS EXPOSED TO COFFEE SUBSTITUTE EXTRACTS Ramsey MJ (1)
62 CHARACTERIZATION OF UROTSA CELLS MAINTAINED IN SERUM-FREE MEDIUM Rossi MR (1,3)
63 INFLUENCE OF TEST CONCENTRATION AND TREATMENT PROTOCOL ON THE INDUCTION OF MICRONUCLEI AND CHROMOSOMAL ABERRATIONS IN CULTURED HUMAN LYMPHOCYTES BY THE PHYTOESTROGEN COUMESTROL Schuler MJ (1)
64 Transient reductions in telomerase activity are associated with chromosome instability in immortal telomerase-positive cell lines Schwartz JL (1)
65 Effects of ionizing radiation on the germ cells of Stage I Seminoma (SIS) patients Velazquez-Wong AC (1,2)
66 ANTIGENOTOXIC EFFECT OF ASCORBIC ACID ON NEUTRON REACTOR DAMAGE IN Drosophila melanogaster Zambrano AF (1)
Test Results: Bacteria
67 Vaporization of mutagenic antineoplastic agents at 23o and 37o C using a desiccator technique Connor TH ()
68 EFFECT OF GLUCOSE CONCENTRATION, AGAR SOURCE AND CONCENTRATION AND "SALTS" Composition on the ON RECOVERY OF Salmonella typhimurium REVERTANTS Evans KL ()
69 The Ames Salmonella Assay - State of the Art Majeska JB (1)
70 A microsupension screening version of the Ames test to predict the outcome of GLP assays for gene mutations Muster W (1)
71 S. typhimurium TA2638a, an alternative to TA102 for routine mutagenicity testing? Rydén E (1)
SESSION III: Wednesday, April 12, 2000, 1:00 - 3:30 pm
(Use your Internet browser's "Find" function to locate your name or title in the list below.)
Poster
No. Title Author
New Technologies/Systems
1 DT-PCR with near infrared fluorescence labeled primers: direct mutation characterization without sequencing Chen JZ (1)
2 Automatic Analysis of Slides Processed in the Comet Assay Frieauff W (1)
3 cDNA Microarray Analysis of ATM-dependent Gene Expression in the Developing Nervous System Rolig RL (1)
4 Analysis of sequence alterations in a defined DNA region: Comparison of temperature-modulated heteroduplex analysis (TMHA) and denaturing gradient gel electrophoresis (DGGE) Skopek TR (1)
SAR/Computer Modeling
5 EVALUATION OF THE TOPKAT COMPUTER-BASED SYSTEM FOR PREDICTING CARCINOGENICITY OF CHEMICALS Prival MJ (1)
6 Modeling of the Human P450 1A2 Active Site; Implications for Bioactivation of the Heterocyclic Aromatic Amine Food Mutagens Sasaki JC (1)
7 WINDOWS™ 32-BIT SOFTWARE FOR THE EPA/IARC GENETIC ACTIVITY PROFILE DATABASE Stack HF (1)
8 Evaluation of DEREK as a pre-screen for genotoxicity Vanparys PAH (1)
Metabolic Activation/Photo-Activation
9 Metabolic differences in Ames tester strains: molecular characterization of a nitroreductase protein that is present in Salmonella typhimurium TA1535 but absent in TA1538 Boroumandi S (1)
10 A new set of plasmids containing oxygen-insensitive nitroreductases, nfsA and nfsB, and their use in the construction of new, highly-sensitive Salmonella typhimurium and Escherichia coli tester strains Carroll C (1)
11 Benzo[a]pyrene toxicity is modulated by 3'-methoxy-4'-nitroflavone through aryl hydrocarbon receptor-dependent and independent mechanisms Dertinger SD (1)
12 NEW E. coli STRAINS EXPRESSING HUMAN OR RAT P450 ENZYMES -- APPLICATION TO PROBLEMS IN MOLECULAR TOXICOLOGY AND MUTATION RESEARCH Josephy PD (1)
13 COUMARIN HYDROXYLASE ACTIVITY IS INDUCED BY THE METACESTODE FORMS OF Taenia taeniformis IN RAT LIVER Montero R (1)
14 INVOLVEMENT OF HUMAN P450S IN THE METABOLIC ACTIVATION OF HETEROCYCLIC AMINES USING UMU TESTER STRAINS Oda Y ()
15 LYOPHILIZATION OF POST-MITOCHONDRIAL SUPERNATANTS (S9) AND MICROSOMES DERIVED FROM SPRAGUE DAWLEY RAT LIVER HOMOGENATES Rundell JO ()
Animal Studies
16 INFLUENCE OF CALORIE RESTRICTI0N ON LYMPHOCYTE hpt MUTANT FREQUENCY IN RATS MAINTAINED ON NIH-31 AND SEMIPURIFIED AIN-93M DIETS Aidoo A (1)
17 DNA DAMAGE IN LEUKOCYTES AND TESTICULAR CELLS IN MALE MICE AFTER CHRONIC OR ACUTE TREATMENTS WITH SODIUM ARSENATE Alvarez-Barrera L (1)
18 DISTRIBUTION OF HPRT MUTATIONS AMONG IN VIVO T-CELL CLONES IN THE MOUSE Judice SJ (1)
19 Comparison of the in vivo mutagenicity of N-ethyl-N-nitrosourea at the Hprt locus in splenic lymphocytes of B6C3F1 mice exposed transplacentally or as adults Sussman HE (1,2)
20 FURTHER ASSESSMENT OF THE IMMATURE RAT MODEL TO ASSESS MICRONUCLEUS INDUCTION IN BONE MARROW, LIVER, AND COLON Weiner SK (1)
DNA Repair, Genetic Studies
21 Retroviral-mediated transfer of DNA repair genes into xeroderma pigmentosum cells. Complementation of DNA repair functions at nucleotide resolution in the human P53 gene Bouziane M (1)
22 Increased level of chromosomal aberrations induced by hydroxyurea treatment during the G2 phase of Fanconi Anemia cells groups A to D Frias S (1)
23 Double strand break repair gene sequence variation (SNPs) in control and cancer samples Kyle VL (1)
24 Ataxia Telangiectasia Cell Extracts Exhibit A Decrease In Fidelity of Double-strand Break Repair Li Y (1)
25 Double mutant Rad 54 and DNA PK mouse cells used to elucidate the roles of homologous recombination and non homologous end joining in DNA double strand break repair and chromosome repair Pluth JM (1)
26 EFFECTS OF A MISMATCH-REPAIR-GENE KNOCKOUT ON MUTATIONAL AND REPRODUCTIVE ENDPOINTS IN THE MOUSE Russell LB (1)
27 Characterizing DNA Repair Gene Single Nucleotide Polymorphisms by Heterozygote Sequencing Protocol (HSP) Ruttan CC (1)
28 Parallel expression analyses of DNA repair genes in adult mouse tissues using cDNA microarrays Tomascik cheeseman LM (1,2)
29 INVESTIGATION OF CYTOTOXICITY, G2/M CHECKPOINT ARREST AND APOPTOSIS FOLLOWING DEOXYAZACYTIDINE REVERSAL OF EPIGENETIC SUPPRESSION IN AN hMLH1 DEFICIENT COLON CANCER CELL LINE Veigl ML ()
Cancer Genes
30 EXTENT OF ADDUCTION OF BENZO[Ia]PYRENE-INDUCED HEPATIC AND LUNG DNA ADDUCTS IN MICE CO-TREATED WITH PENTACHLOROPHENOL MAY BE ASSOCIATED WITH TRP53 GENE FUNCTION Bordelon NR (1)
31 Analysis of lymphocyte micronucleus frequencies and their TP53 contents in chronic gamma-irradiated human subjects Chang WP (1)
32 Measurement of a p53-mutation load in individual human tissues: A systematic approach using immunohistochemistry and whole genome amplification Heinmoller E (1)
33 ALTERATIONS OF CANCER-RELATED GENES IN TUMOR CELL LINES DERIVED FROM CADMIUM-TRANSFORMED BALB/c-3T3 CELLS Joseph P (1)
34 ASSOCIATION BETWEEN TUMORS DEVELOPED FROM BERYLLIUM-TRANSFORMED CELLS AND CHANGES IN CANCER-RELATED GENES Joseph P (1)
35 CANCER RESISTANCE AND ALTERED LONGEVITY IN MICE WITH ATRUNCATED p53 GENE Venkatachalam S ()
Transgenics
36 Establishment of transgenic zebrafish for the detection of mutations caused by compounds in aquatic environments Amanuma K (1)
37 Mutagenesis of ethylnitrosourea (ENU) at the lacI locus in a transgenic fish (Oryzias latipes) Shih PMT (1)
38 Evaluation of a lambda transgenic fish model for in vivo mutation analyses Winn RN (1)
39 A DIFFERENCE IN MUTATIONAL RESPONSE DETECTED BETWEEN TRANSGENES AND ENDOGENOUS GENES DURING CHRONIC MUTAGEN EXPOSURE Cosentino L (1,2)
40 Tissue and sequence context influences on the spectrum of spontaneous deletions and insertions in the Big Blue lacI transgene Halangoda A (1)
41 Frameshift Mutation and Mismatch Repair: In situ Detection at the Single-Cell Level in Mice Hersh MN (1)
42 Profile of the frequency and pattern of spontaneous mutation with age in Big Blue mice Hill KA (1)
43 Lack of lacZ transcription in MutaMouse and pUR288 plasmid mouse Martus HJ (1)
44 DIFFERENTIAL RESPONSES OF RAT MAMMARY EPITHELIAL AND FIBROBLAST CELL LINES TO N-ETHYL-N-NITROSOUREA McDiarmid HM (1)
45 CARCINOGEN-INDUCED LOSS OF HETEROZYGOSITY IN MICE HETEROZYGOUS AT APRT Robbins SB (1)
46 Parameters that increase or decrease mutation frequency: age, tissue type, genotype, antioxidants and carcinogenesis Sommer SS (1)
47 Methylnitrosourea (MNU), a non-hepatocarcinogenic agent, causes mutations in the liver following cell proliferation induced by a partial hepatectomy Zhang X (1)
48 Lower spontaneous lacZ mutant frequency in Muta™mouse male germ cells than in somatic tissues Douglas GR ()
49 Development of a lacI- Selection Assay for Detection of Mutagenesis in Mammalian Systems Ennis DG (1)
50 High plating density improves the Big Blue assay without loss of sensitivity: Comprehensive comparison of Big Blue screening and selectable systems Heinmoller PW (1)
51 LAMBDAIcII gene is useful for sequence analysis in the transgenic mouse mutation assays Suzuki T (1)
52 CHARACTERIZATION OF THE cII LOCUS IN THE MUTA™MOUSE TRANSGENIC SYSTEM Swiger RR (1)
53 Mutations Identified by a Forward Assay of Bacteriophage PhiX174 in a Transgenic Mouse Cell Line Valentine CR (1)
Anti-Cancer Effects
54 Modulation of 7,12-dimethylbenz[a]anthracene (DMBA)-induced mutant frequency and endogenous antioxidant enzyme activity by dietary vitamins Bishop M (1)
55 Antigenotoxicity of Quercetin and its Glycosides against Oxidative DNA Damage Heo MY (1)
56 Effects of lycopene on benzo(a)pyrene-induced mutagenesis in lacZ mouse prostate, lung and colon Kosinska W (1)
57 REDUCTION OF SPONTANEOUS MUTATION IN MISMATCH REPAIR DEFICIENT HUMAN COLON CANCER CELL LINES BY DIETARY ANTIOXIDANTS Mure K (1)
58 SEPARATION AND CHEMICAL IDENTIFICATION OF ANTIMUTAGENS AND CANCER CELL GROWTH SUPPRESSORS FROM SOYBEAN PROCESSING PRODUCTS AND BY-PRODUCTS Plewa MJ (1)
59 ANTIMUTAGENIC EFFECT OF CINNAMALDEHYDE DUE TO INHIBITION OF MUTATIONS AT GC SITES BUT NOT AT AT SITES IN SALMONELLA TA104 Shaughnessy DT (1)
60 The in vivo induction of adaptive response in rats using ionizing radiation Sorensen KS (1)
61 Modulation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutagenesis by conjugated linoleic acid in the mammary gland and colon in Big Blue rats Yang HY (1)
62 Genotoxicity Evaluation of Apomorphine HCl: Comparison of the in vitro and in vivo studies Youssef AF (1)
Cell Cycle
63 Genotoxic effects of arsenite may be mediated by up-regulation of Cyclin D Vogt BL (1)
Apoptosis
64 Respirable quartz and kaolin induction of apoptosis in rat pulmonary macrophage NR8383 cells Gao N (1)
65 DECREASED APOPTOSIS IN TUMOR CELLS AND TRANSFORMED CELLS INDUCED BY CADMIUM CHLORIDE AND BERYLLIUM SULPHATE Keshava N (1)
Carcinogenesis
66 N-ACETYL-L-CYSTEINE PARADOXICALLY REDUCES TUMOR MULTIPLICITY BUT EXACERBATES SKIN MALIGNANCIES IN TRANSGENIC MICE TREATED TOPICALLY WITH BENZO(A)PYRENE Martin KR (1)
67 ANALYSIS OF K-IRAS AND P53 MUTATIONS IN MESOTHELIOMAS FROM HUMANS AND RATS EXPOSED TO ASBESTOS Ni Z (1,2)
Genomic Instability
68 Instability of CTG repeats from human disease genes in the model organism Escherichia coli Bichara M ()
69 Inactivation of an autosomal locus in mouse embryonic stem cells Bolante Cervantes R (1)
70 Requirement of Wild-Type p53 Protein for Maintenance of Chromosomal Integrity Honma M (1)
