International Workshop on Genotoxicity Test Procedures:
March 25-26, 1999 Washington, D.C.

Provisional Programme

David Kirkland, Program Chair

For More Information

David Kirkland, Program Chair
Covance Laboratories Europe
Otley Road, Harrogate
North Yorks HG3 1PY
UNITED KINGDOM
Phone: +44-1423-500011
FAX: +44-1423-568473
Email: dkirkland@hazle.co.uk

Wednesday, March 24, 1999

18.00 Organisers meet for IWGTP, check the rooms, facilities, etc.

Thursday, March 25, 1999

Morning Session
07.30 Registration open

08.30 Welcome and opening address
Jim MacGregor, FDA

08.40 The IWGTP, reasoning, objectives, procedural announcements
David Kirkland, Covance

09.00 -
10.00 Genotoxicity and cytoxicity
Chair: Makoto Hayashi, NIHS

09.00 Appropriate levels of cytoxicity; experience with submissions for new pharmaceuticals
Lutz Müller, BfArM

09.10 Appropriate levels of cytoxicity; new data for the in vitro chromosomal aberration test
Sheila Galloway, Merck

09.30 Discussion

09:55 Concluding Comments
Toshio Sofuni, NIHS

10.00 The role of experts on statistics in the IWGTP
David Lovell, Pfizer UK

10.30 Coffee Break

11.00 First group sessions
Setting agenda and time-tables

Mouse Lymphoma Assay Martha Moore

In Vivo Micronucleus Test Makoto Hayashi

In Vitro Micronucleus Test Micheline Kirsch-Volders

Comet Assay Ray Tice

Transgenic Mutation Assays John Heddle

Photochemical Genotoxicity Elmar Gocke

DNA Adducts / DNA Binding Assays David Phillips

12.30 Lunch

Afternoon Session

13.30 Continuing group discussions
The easy-to-solve issues

16.30 Coffee Break

16.50 Plenary session, individual group reports (10-15 min. each)
Chair: Leonard Schechtman, FDA

18.30 Reception

Friday, March 26, 1999

Morning Session
08.30 Continuing group discussions
Contentious issues

12.30 Lunch

Afternoon Session

13.30 Continuing group discussions
Generation of a SOP

15.30 Coffee Break

16.00 Plenary session, individual group reports (15 minutes concluding reports for every group)
Chair: Toshio Sofuni