Highlights of Past EMS Meetings
1970
Washington,
DC |
1971
Washington,
DC |
1972
Cherry Hill, New
Jersey |
1973
Asilomar,
California |
1974
Washington,
DC |
1975
Miami Beach,
Florida |
1976
Atlanta,
Georgia |
1977
Colorado Springs,
Colorado |
1978
San Francisco,
California |
1979
New Orleans,
Louisiana |
1980
Nashville,
Tennessee |
1981
San Diego,
California |
1982
Boston,
Massachusetts |
1983
San Antonio,
Texas |
1984
Montreal,
Quebec |
1985
Las Vegas,
Nevada |
1986
Baltimore,
Maryland |
1987
San Francisco,
California |
1988
Charleston,
South Carolina |
1989
Cleveland,
Ohio |
1990
Albuquerque,
New Mexico |
1991
Orlando,
Florida |
1992
Reno,
Nevada |
1993
Norfolk,
Virginia |
1994
Portland,
Oregon |
1995
St. Louis,
Missouri |
1996
Victoria,
British Columbia |
1997
Minneapolis,
Minnesota |
1998
Anaheim,
California |
1999
Washington,
DC |
2000
New Orleans,
Louisiana |
2001
San Diego,
California |
2002
Anchorage,
Alaska |
2003
Miami Beach,
Florida |
2004
Pittsburgh,
Pennsylvania |
|
1st Annual Meeting
Washington, DC
March 22 - 25, 1970
(Sunday to Wednesday) |
| Site |
Sheraton Park Hotel |
| Administrative Officer |
Not mentioned |
Registration Fees
(on-site) |
Members $10 Non-members $15 Students $3 Wives $2 |
| Program Committee |
R.B. Freese, Chair, C.W. Edington, Leo Friedman, M.S. Legator, F.J. de Serres |
| Approximate Number of Attendees |
|
| Approximate Size of EMS Membership |
|
| Opening Address |
H. Bentley Glass, Academic Vice President State University of NY at Stony Brook |
| Keynote Presentation |
None |
| Workshops |
None |
Symposium:
Selected Methods of Mutagen Testing
(Title of presentation) |
Chairman: Alexander Hollaender, Oak Ridge National Lab; Speakers: F.J. de Serres (Detection of
point mutations and deletions with the adenine-3 system of Neurospora), Marvin Legator (Host-mediated assay)
Günther Röhrborn and Samuel S. Epstein (Dominant lethal tests in mice), P.W. Neurath, D.A. Low and W.D. Selles
(Automation of chromosome analysis) |
Symposium:
Correlations and Population Monitoring
(Title of
presentation) |
Chairman: Hans Falk, National Institute of Environmental Health Sciences;
Speakers: James A.
Miller (The mutagenicity of chemical carcinogens and their metabolites), Harold Kalter (Correlation of teratogenic and
mutagenic agents), J.E. Cleaver (Xeroderma pigmentosum: A disease caused by a deficiency in a DNA repair mechanism),
James Crow (Population monitoring) |
Symposium:
Basic Aspects of Mutagenesis
(Title of presentation) |
Chairman: Ernest Freese, National Institute of Neurological Diseases and Stroke; Speakers: John
W. Drake (Analysis of molecular mechanisms of mutation in a bacterial phage system), R.F. Kimball (The Relation of
repair processes to chemical mutagenesis), Mathew Meselson (Genetic recombination at the molecular level), Warren W.
Nichols (The role of chromosome breaks in genetic damage and mutation) |
Symposium:
Nitroso Compounds
(Title of presentation) |
Chairman: Samuel S. Epstein, Children's Cancer Research Foundation;
Speakers: William Lijinsky
(Chemistry and biology of nitrosamines), Perry R. Stout (The ecology of nitroso compounds) |
Symposium:
Cyclamates
(Title of presentation) |
Chairman: Charles J. Kensler, Arthur D. Little Company; Speakers: Leon Golberg (Metabolism of
cyclamates in animals and man), Sidney Green (Cytogenetic and dominant-lethal effects of cyclohexylamine), Jacqueline
Verrett (Teratogenic effects of cyclamate and its metabolites in the chick embryo), Paul Nees and P.H. Derse (Fatal
effects from a single administration of cyclamate to pregnant swine in the first trimester) |
| Poster Sessions |
None |
Platform Presentations
28 Short Talks
(Number of papers per session
title) |
Effects of Environmental Agents on Non-mammalian Systems (14);
Chairman: Fritz Sobels, Department
of Radiation Genetics, State University of Leiden, The Netherlands; Speakers: Hans J. Rhaese; Robert B. Webb; F. Mukai and
I. Hawryluk; Bernard Heinemann; F.J. de Serres and H.V. Malling; H.V. Malling and F.J. de Serres; T.M. Rizki; Luolin S. Browning;
William T. Lee and Gary A. Sega, Claes Ramel; G. Ficsor and Gayle M. Nii; G. Ficsor, F.C. Janca and C. van Hook IV |
| Effects of Environmental Agents on Mammalian Systems (14);
Chairman: George Yerganian, Children's
Center Research Foundation; Speakers: D.J. Kilian, M. Benge and H. Edwards; James E. Trosko and Miriam Isoun; E.H.Y. Chu
and E.G. Bailiff; Fa-ten Kao and Theodore T. Puck; K.S. Lavappa; George Yerganian and Henry J. Gagnon; C.B. Jacobson and C. Polge;
Luis Arias-Bernarl and C.B. Jacobson; Claire Dick, C.G. Biava and G.H. Berryman; Claire Dick and C.G. Biava; Kyle W. Petersen and
F.H.J. Figge; W.M. Generoso, Sandra K. Stout and Sandra W. Huff; Allyn A. Bregman |
| Additonal Events/Features |
Free evening (Tuesday) |
| "4" full days, meeting ended 5:15 PM on Wednesday |
| Reception: Sponsor not specified |
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|
2nd Annual
Meeting Washington, DC
March 21-24,
1971 (Sunday to Wednesday) |
| Site |
Sheraton Park Hotel, Esplanade |
| Conference Co-ordinator |
Mrs. Marion Zeiger |
Registration Fees
(on-site) |
Members $15 Non-members $20 Students $5 Spouse $3 |
| Program Committee |
M.S. Legator, Chairman, Ilse-Dore Adler, W.G. Flamm, F. Kelly, V.W. Mayer, E. Zeiger |
| Approximate Number of Attendees |
200 |
| Approximate Size of EMS Membership |
443 |
| Number of Student Travel Award Winners |
|
| Student Winners Who Became Regular Members |
|
| Opening Address |
Speakers: Alexander Hollaender, ORNL; Rene Dubos, The Rockefeller Univ |
| Keynote presentation |
None |
| Workshops |
None |
Symposia:
Genetic Load
(Title of speaker's presentation) |
Chairman: F. Vogel;
Speakers: W.J. Schull, Univ of Michigan (The concept of genetic
load); F. Vogel, Institute for Anthropology and Human Genetics, Univ of Heidelberg (Possible increase of the genetic load
due to chemical mutagens); H.E. Sutton, Univ of Texas (Possibilities of monitoring populations for mutations by
large-scale examinations of biochemical markers) |
Symposium:
Possible Contributions of Genetics to Toxicology
(Title of
speaker's presentation) |
Chairman: A. Hemming;
Speakers: Joseph Brogelleca, Medical College of Virginia (Basic
concepts in the design of toxicological tests); Harold Peck, Merck Institute (Toxicity testing of drugs and other
chemicals); Bert N. La Du, Jr., New York Univ School of Medicine (Possible contributions of genetics to
toxicology) |
Symposium:
Potential Mutagens in the Environment
(Title of speaker's
presentation) |
Chairman: L. Fishbein;
Speakers: John Wassom and H.V. Malling, ORNL (Environmental Mutagen
Information Center); L. Fishbein and W.G. Flamm, NIEHS (Potential environmental mutagens); K. Petersen and F. Sauro,
Cell Biology Branch, FDA (Dominant-lethal effects of trifluoropromazine) |
| Results of a Collaborative Cytogenetic Study |
Collaborators: Ilse-Dore Adler, Children’s Cancer Research Foundation; B. Adler, Hazelton Univ; M.C.
Benge, Dow Chemical Company; S. Hoo, Hazelton Univ; D. Mensik, Dow Chemical Company; K. Palmer, FDA; F. Sauro, FDA;
Protocol: Ilse-Dore Adler and M.C. Benge,
Results: K. Palmer and S. Hoo |
| Report of the Cytogenetic Standardization Committee |
Results: Warren W. Nichols, Institute for Medical Research, Camden, New Jersey |
Panel Discussion:
The Role of Nonmammalian Systems in Determining Potential Genetic
Hazards to Man |
Moderator: J.W. Drake;
Participants: F.J. de Serres, ORNL; S. Abrahamson, Univ of Wisconsin; C.
Kensler, Arthur D. Little Company; W.L. Russell, ORNL; J. Renwick, London School of Hygiene and Tropical Medicine; F. Vogel,
Institute for Anthropology and Human Genetics, Univ of Heidelberg |
| Poster Sessions |
None |
Platform Presentations
22 Contributed Short Talk Papers
(No central
themes provided for each session) |
Contributed papers, first session;
Chairman: F.J. de Serres;
Speakers: B.E. Matters and Schmid;
R.B. Cumming and Marva F. Walton; W.L. Russell and R.B. Cumming; W.M. Generoso; J.H. Moutschen; U.H. Ehling and A. Neuhauser;
E.H.Y. Chu and H.V. Malling, J. Schoneich; Ilse-Dore Adler and Samuel S. Epstein; Sandra K. Stout, W.M. Generoso, and Sandra A.
Huff; G.E. Cosgrove and W.M. Generoso; Robert S. Ledley; Jack Schubert, Sylvia F. Pan, and Niel Wald; C.B. Jacobson and C.
Polge |
| Contributed papers, second session;
Chairman: W.G. Flamm,
Speakers: Daniel Roth and Maria L.
Manjon; A.H. Sparrow, L.A. Schairer, and A.G. Underbrink; Luolin S. Browning; David Brusick; Vernon W. Mayer; H.V. Malling,
E.H.Y. Chu and D. Wild; Bernard Heinemann; John W. Drake, Diane F. Smith, and Warren E. Williams
|
| Additional Events/Programs |
Two free evenings |
| Cocktail Party: evening of last day |
| Reception: No sponsor specified |
| Abstracts included in Program |
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|
3rd Annual
Meeting Cherry Hill, New Jersey
March 26 - 29,
1972 (Sunday to Wednesday) |
| Site |
The Cherry Hill Inn |
| Administrative Officer |
Not mentioned |
Registration Fees
(on-site) |
Members $15 Non-members $20 Students $5 Spouse $3 |
| Program Committee |
Warren W. Nichols and Charles J. Kensler |
| Approximate Number of Attendees |
|
| Approximate Size of EMS Membership |
|
| Student Award Winners Still with Society |
No Student Awards Given |
| Workshops |
None |
Symposia
(Title of speaker's presentation) |
Repair Mechanisms and Antimutagens;
Chairman: Charles J. Kensler;
Speakers: Repair
Mechanisms, R.B. Setlow, Oak Ridge National Lab, and P. Howard-Flanders, Yale University; Antimutagens, A. Novick, University of
Oregon, and R.B. Cumming, Oak Ridge National Lab. |
| New Techniques in Mutagenicity Testing;
Chairman: Charles G. Smith;
Speakers: T.C. HSU,
Anderson Hospital (New staining techniques and fluorescence), E.H.Y. Chu, Oak Ridge National Lab (Host mediated systems
utilizing mammalian and human cells), C.R. Shaw, Anderson Hospital (Applications of isoenzymes to mutagenicity
testing), D. Goodman, Rutgers University (Automated techniques capable of detecting human protein
Variations) |
| Poster Sessions |
None |
Platform Presentations
21 Contributed Short Talk Papers
(No central
themes provided for each session) |
Contributed papers, first session;
Chairman: Alexander Hollaender;
Speakers: O.P. Kamra and R.
Rajaraman; B. Birshtein, R. Baumal, P. Coffino, M. Kuehl and M.D. Scharff; P. Sarvella and F. Gordon; F.A. Andersen and S. Person;
W.L. Russell and E.M. Kelly; G.A. Sega and R.B. Cumming |
| Contributed papers, second session;
Chairman: Ernest Freese;
Speakers: K. Norlen-Nilsson and
B.A. Kihlman; D. Rotter and S. Mittler; R.A. Gerdes; R.H. Smith; M.M. Nawar and H.V. Malling; J.A. Styles |
| Contributed papers, third session;
Chairman: Warren W. Nichols;
Speakers: H. Ginsberg; V.A.
Ray, H.E. Holden, D.S. Salsburg, J.H. Ellis, Jr.; L.J. Just and M.H. Voyer; L. Mezger-Freed; H.I. Kohn; C. Clive, W.G. Flamm, M.R.
Machesko and N.J. Bernheim; J.L.R. Chandler and R. Fahrig; P.A. Gee, G.A. Sega and W.R. Lee; R.L. Capizzi, W.J. Smith, R. Field
and B. Papirmeister; H. Rozmiarek, R.L. Capizzi, B. Papirmeister, W.H. Fuhrman and W.J. Smith |
Platform Presentations
2 Contributed Major Papers
(Title of
presentation) |
Contributed papers, first session;
Chairman: Alexander Hollaender;
Speaker: James Neel,
University of Michigan (Strategies on the study of spontaneous and induced mutations in man) |
| Contributed papers, second session;
Chairman: Ernest Freese;
Speaker: D.J. Kilian, Dow
Chemical Company (Mutagenic evaluation of industrial compounds) |
| Additional Events/Programs |
Three Luncheons provided for attendees |
| Award Dinner: 1st EMS Award Given to Dr. Charlotte Auerbach |
| Reception: No sponsor specified |
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|
6th Annual
Meeting Miami Beach, Florida
March 9 - 12,
1975 (Friday to Monday) |
| Site |
The Deauville Hotel |
| Administrative Officer |
Richard J. Burk, Jr. |
Registration Fees
(on-site) |
Members $20 Non-Members $25 Students $5 Spouses $2 |
| Program Committee |
J.W. Drake, Chairman, W.G. Flamm |
| Approximate Number of Attendees |
|
| Approximate Size of EMS Membership |
446 |
| Student Award Winners Still with Society |
Student awards not yet determined |
Keynote/Special Presentation:
|
Speakers: Albert C. Kolbye, Bureau of Foods, FDA |
| Workshops |
None |
Symposium:
The Utility of Mutagenicity Screening Tests for the Assessment of
Carcinogenicity
(Title of presentation) |
Chairman: W. Gary Flamm, NCI;
Speakers: F.J. de Serres, NIEHS (Problem overview); H.S.
Rosenkranz, Columbia Univ (Mutagenicity and chemical carcinogens
); D.J. Brusick, Litton Bionetics (In vitro
metabolism
of chemical carcinogens to mutagens); H. Stich, Univ of British Columbia (Repair of genetic damage induced by chemical
carcinogens); M. Carstadt, Office of Technology Assessment, Congress of the US (Legislative aspects) |
A Joint EMS/RRS Symposium:
Risk Estimates and Problems of Decision Making in Regulatory
Processes
(Title of presentation) |
Chairman: S.S. Abrahamson, Dept of Zoology, Univ of Wisconsin;
Speakers: H. Eldon Sutton, Dept of
Zoology, Univ of Texas, Austin (Philosophy and review of committee T7 report); C. Langley, NIEHS (Population
considerations in risk estimation); W.L. Russell, Biology Division, ORNL (Risk estimates based on mammalian studies);
Panel Discussion: Chairman: S.S. Abrahamson;
Panelists: S.S. Epstein, Dept of Pharmacology, Case Western Reserve
Univ.; D. Hoel, NIEHS; H. Blumenthal, Division of Toxicology, Bureau of Foods, FDA; J. Buckley, EPA |
Symposium:
Molecular Dosimetry of Chemical Mutagens
(Title of
presentation) |
Chairman: W.R. Lee; Louisiana State Univ;
Speakers: W.R. Lee (Determining molecular dose to the
germ line following exposure of the organism to chemical mutagens); C.S. Aaron, Louisiana State Univ (Selection of
appropriate target molecules for determining molecular dose to the germ line); G.A. Sega, ORNL (Measurement of molecular
dose and DNA repair in mammalian germ cells); R.B. Cumming, ORNL (The potential use of molecular dosimetry data for
extrapolation to human genetic risk );
Panel Discussion |
Symposium:
Utility of Mutagenicity Tests in Safety Evaluation
(Title of
presentation) |
Chairman: Verne A. Ray, Pfizer Pharmaceuticals
Speakers: S. Green, FDA; R. McConnell, Searle
Lab |
Special report:
Report of the Cytogenetic Standardization Committee |
Results: Warren W. Nichols, Institute for Medical Research, Camden, New Jersey |
| Poster Sessions |
none presented |
Platform Presentations I
36 Short Talks
(No central themes provided
for each session) |
Session I: Chairman: H.E. Brockman, Illinois State Univ;
Co-Chairman: D. Brusick, Litton
Bionetics |
| Session II: Chairman: R. Valencia, WARF Institute;
Co-Chairman: M. Farrow, Wyeth Lab |
| Session III: Chairman: D. Clive, Burrough Wellcome;
Co-Chairman: L. Jacobs, Univ of
Wisconsin |
Platform Presentations II
31 Short Talks
(No central themes provided
for each session) |
Session IV: Chairman: A. Mitchell, Stanford Research Institute;
Co-Chairman: F. Mukai, NYU
Medical Center |
| Session V: Chairman: J. Heddle, York Univ;
Co-Chairman: B. Strauss, Univ of Chicago |
| Session VI: Chairman: L. Valcovic, NIEHS;
Co-Chairman: N. Mitra, NIEHS |
| Additional Activities/Features |
Reception: Sponsor not specified |
| Free evening: Saturday |
| Abstracts included in Program |
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|
7th Annual
Meeting Atlanta, Georgia
March 12 - 15,
1976 (Friday to Monday) |
| Site |
The Marriott Motor Hotel |
| Administrative Officer |
Richard J. Burk, Jr. |
Registration Fees
(on-site) |
Members $20 Non-Members $25 Students $5 Spouses $2 |
| Program Committee |
J.W. Drake, Chairman |
| Approximate Number of Attendees |
|
| Approximate Size of EMS Membership |
441 |
| Number of Student Travel Award Winners |
|
| Student Winners Who Became Regular Members |
Not Known |
| Keynote/Special Presentation: |
None |
| Workshops |
None |
Symposium:
Current Progress in Chromosomal Aberration Research
(Title of
presentation) |
Chairman: W.M. Generoso, ORNL;
Speakers: M.A. Bender, Brookhaven National Lab (Induced DNA
lesions, DNA repair, and chromosomal aberration formation); W.M. Generoso (Inducibility by chemical mutagens of chromosome
aberrations in male and female germ cells of mice ); J.G. Brewen, ORNL (Are chromosome aberrations a reliable index of
genetic damage?) |
A Joint EMS/Society of Toxicology Symposium:
The Low Dose Extrapolation
Dilemma
(Title of presentation) |
Chairman: J.W. Drake, Univ of Illinois, Urbana;
Speakers: D.W. Gaylor, National Center for
Toxicological Research (The use of models for low-dose extrapolation); C.S. Weil, Carnegie-Mellon Univ (Restraints for
consideration before extrapolation) |
Second Annual Industrial Symposium:
Genetic Safety Evaluation of Industrial
Chemicals
(Title of presentation) |
Chairman: V.A. Ray, Pfizer Pharmaceutical;
Speakers: D. Brusick, Litton Bionetics, Inc. (An
approach to the problem); L.G. Scharpf, Jr., Monsanto Industrial Chemical Co. (Safety evaluation of nitrilotriacetic
acid); L. Goldberg, Chemical Industry Institute of Toxicology (The role of CIIT
) |
Symposium:
Mutagenic Mechanisms in Eucaryotes
(Title of presentation) |
Chairman: L. Prakash, Univ of Rochester;
Speakers: L. Prakash (Repair capacity and mutagenesis
in yeast); L. Siminovitch, Univ of Toronto, Toronto (Isolation and characterization of mutants of mammalian somatic
cells); L.A. Chasin, Columbia Univ. (A search for mitotic recombination in cultured mammalian cells) |
| Poster Sessions |
none presented |
Platform Presentations Session I
21 Short Talks
(Papers per session
title) |
Fundamental Mechanisms (11);
Chairman: L.S. Ripley, Univ of Illinois;
Co-Chairman: F. Sherman,
Univ of Rochester |
| System Development: Microbial and Mammalian (10);
Chairman: K.C. Bora, Environmental Health Directorate,
Canada; Co-Chairman: E. Zeiger, FDA |
Platform Presentations Session II
23 Short Talks
(Papers per session
title) |
Suspect Compounds (12); Chairman: W.R. Lower, Univ of Missouri;
Co-Chairman: F. Hollingsworth,
Georgia Mental Health Institute |
| System Development: Mammalian (11);
Chairman: E.R. Soares, NIEHS
Co-Chairman: G. Sega,
ORNL |
Platform Presentations Session III
16 Short Talks
(Papers per session
title) |
System Development: Plant and Insect (7);
Chairman: R.C. Sparrow, Brookhaven National Lab
Co-Chairman: A.H. Sparrow, Brookhaven National Lab |
| System Development: Somatic Cell Culture and Sister-Strand Exchange (9);
Chairman: S.E. Bloom, Cornell
Univ; Co-Chairman: D. Matheson, Litton Bionetics, Inc. |
| Additonal Activities/Features |
Reception: Sponsor not specified |
| Two free evenings |
| Abstracts included in Program |
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| 8th Annual
Meeting Colorado Springs, Colorado February 13 -
17, 1977 [days of the week] |
| |
|
| Administrative Officer |
|
Registration Fees
(pre-registered / on-site) |
Members $nn Non-members $nn Students $nn Spouses $nn |
| Program Committee |
|
| Approximate Number of Attendees |
|
| Approximate Size of EMS Membership |
|
| Student Award Winners Still with Society |
Student awards not yet determined |
| Opening Address |
|
| Keynote Presentation |
|
| Workshops |
|
Symposia
(Title of speaker's presentation) |
; Chairman: ; Speakers: |
| ; Chairman: ; Speakers: |
| ; Chairman: ; Speakers: |
| ; Chairman: ; Speakers: |
| ; Chairman: ; Speakers: |
| Poster Sessions |
|
Platform Presentations
nn Short Talks (Number of papers per session
title) |
(nn); Chairman: ; Speakers: |
| (nn); Chairman: ; Speakers: |
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|
9th Annual
Meeting San Francisco, California
March 9 - 13,
1978 (Thursday to Monday) |
| Site |
Sheraton Palace Hotel |
| Administrative Officer |
Richard J. Burk, Jr. |
Registration Fees
(on-site) |
Members $30 Non-Members $40 Students $5 Spouses $2 |
| Program Committee |
D.J. Brusick, Chairman |
| Approximate Number of Attendees |
358 |
| Approximate Size of EMS Membership |
532 |
| Student Award Winners Still with Society |
Student awards not yet determined |
Keynote/Special Presentation:
|
None |
| Workshops |
None |
Symposium:
The Somatic Mutation Hypothesis of Neoplasia Induction: A 1978
Assessment
(Title of presentation) |
Chairman: E. Huberman, ORNL;
Speakers: B. Ames, Univ of California at Berkeley (Mutagenic
potency and carcinogenesis); E. Huberman (Mutagenesis and malignant cell transformation of cells in culture by chemical
carcinogens); J. Robbins,(XP and carcinogenicity) |
A Joint EMS/Society of Toxicology Symposium:
Scientific and Regulatory Aspects of
Short-Term Mutagenesis/Carcinogenesis Assays
(Subject matter for discussion) |
Background and introduction to short-term tests;
Speaker: Verne A. Ray, Pfizer, Inc.;
Regulatory aspects of short-term tests;
Speakers: E. Bingham, OSHA; R.M. Hehir, CPSE; A.C. Kolbye Jr., FDA; and C.R.
Morris, FDA; Validation programs for short-term tests;
Speaker: V. Dunkel, NCI. |
Symposium:
New Methods for the Detection of Somatic and Germ Cell Mutations in
Mammals
(Title of presentation) |
Chairman: L.R. Valcovic, NIEHS;
Speakers: R. Doherty, Univ of Rochester School of Medicine
(Human in vivo hemoglobin somatic mutation assay); R.J. Feuers, National Center for Toxicological Research (A
biochemical approach to detect induced germ cell mutations in mammals); A. Wyrobek, Lawrence Livermore Lab (Genetic factors
in the induction of sperm abnormalities in mice and humans) |
Symposium:
Mutagenesis Studies of Commercially Important Chemicals (A Comprehensive
Overview of the Findings and Resultant Impacts on the Economy and Industry)
(Title of presentation) |
Chairman: G.W. Newell, Stanford Research Institute;
Speakers: G.W. Newell (Captan - the wide
spectrum fungicide); D. Stoltz, Toxicological Research Division, Health Protection Branch, Ottawa, Canada (Saccharin -
everyone’s sweetener); D. Matheson, Litton Bionetics, Inc. (Tris-(2,3-dibromopropyl) phosphate: A flame retardant
chemical) |
| Poster Sessions |
Two sessions; Subject matter and number of posters not provided in Program |
Platform Presentations 1
37 Contributed Short Papers
(No topic
provided for any session; sessions run concurrently) |
Session I: Chairman: J. Epler, ORNL;
Co-Chairman: T-M. Ong, NIEHS |
| Session II: Chairman: A. Sivak, Arthur D. Little Co.;
Co-Chairman: G.H. Strauss, Univ of
Vermont |
| Session III: Chairman: S. Green, Howard Univ.;
Co-Chairman: J. Bishop, NCTR. |
Platform Presentations 2
38 Contributed Short Papers
(No topic
provided for any session; sessions run concurrently) |
Session IV: Chairman: D. DeMarini, Illinois State Univ;
Co-Chairman: V. Mayer, FDA |
| Session V: Chairman: V.A. Ray, Pfizer, Inc.;
Co-Chairman: B.K. Vig, Nevada Mental Health
Institute |
| Session VI: Chairman: J. Brown, Dynapol;
Co-Chairman: R. Valencia, Univ of Wisconsin |
Platform Presentations 3
36 Contributed Short Papers
(No topic
provided for any session; sessions run concurrently) |
Session VII: Chairman: S.R. Haworth, EG&G Mason;
Co-Chairman: D. Jagganath, Litton Bionetics,
Inc. |
| Session VIII: Chairman: E. Jacobson, Bureau of Radiological Health, FDA;
Co-Chairman: W.G.
Thilly, MIT |
| Session IX: Chairman: J.T. Hill, Monsanto Co.;
Co-Chairman: D. Matheson, Litton Bionetics,
Inc. |
| Additonal Activities/Features |
Reception: Co-Sponsored by: Microbiological Associates, A Division of Whittaker Corporation |
| Two free evenings |
| Free morning and afternoon on Monday, the final day; meeting started at 8:00 PM that day |
| Abstracts included in Program |
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|
10th Annual
Meeting New Orleans, Lousiana
March 8 - 12,
1979 (Thursday to Monday) |
| Site |
Monteleone Hotel |
| Administrative Officer |
Richard J. Burk, Jr |
Registration Fees
(on-site) |
Members $30 Non-Members $40 Students $5 Spouses $2 |
| Program Committee |
M.M. Mendelsohn, Chairman |
| Approximate Number of Attendees |
443 |
| Approximate Size of EMS Membership |
729 |
Keynote/Special Presentation:
|
None |
| Workshops: |
None |
Symposium:
Sister Chromatid Exchange
(Title of presentation) |
Chairman: A.V. Carrano, Lawrence Livermore Lab;
Speakers: S. Wolff, Univ of California, San
Francisco (The formation of SCEs); A.V. Carrano (Sister chromatid exchange: Relation to single gene mutation, acute and
chronic exposure in vivo, and human population monitoring); E.L. Schneider, National Institute on Aging (Sister
chromatid exchange in vitro,
in vivo and in
utero) |
Symposium:
Repair in Eukaryotes
(Title of presentation) |
Chairman: V. Maher, Michigan State Univ;
Speakers: B.S. Baker, Univ of California, San Diego
(On the function of mutagen synthesis loci in
Drosophila melanogaster); W. Generoso, ORNL (Repair and induction of
chromosome aberrations in germ cell of mice); J.J. McCormick, Michigan State Univ (Evidence that DNA excessive repair
processes in human fibroblasts can eliminate potentially cytotoxic and mutagenic lesions); M.W. Lieberman, Washington Univ
(Nucleosome rearrangement in human chromatin during UV-induced DNA repair synthesis) |
Industrial Symposium:
Mutagens and Carcinogens in Food
(Title of
presentation) |
Chairman: M.J. Prival, Food and Drug Administration;
Speaker: M.J. Prival (Mutagenic testing
of "Generally Recognized As Safe" [GRAS] additives in food); G.W. Newell, National Academy of Sciences, National Research
Council (In vitro and in vivo mutagenicity of selected pesticides); S.R. Tannenbaum, MIT (Nitrate, nitrite and
nitrosamines: Intake vs. endogenous formation); T. Sugimura, National Cancer Center Research Institute, Tokyo
(Mutagens in cooked foods and their implication for cancer prevention) |
A Joint EMS/Society of Toxicology Symposium:
Animal Models in Human Risk
Estimation
(Title of presentation) |
Chairman: J.J. McPhillips, Astra Pharmaceutical, Products;
Speaker: M.A. Bender, Brookhaven
National Lab (Animal models for mutagenesis); E.M. Johnson, Daniel Baugh Institute, Thomas Jefferson Univ (Model systems
for assessment of teratogenetic effects in humans: Nature of the problem); J.H. Weisberger and G.M. Williams, The Naylor Dana
Institute for Disease Prevention, American Health Foundation (Decision points in carcinogenesis testing);
General
Discussion |
Posters:
32 Posters pre-registered |
One session, odd and even numbered manned at different times; Posters not classified into subject
areas |
Platform Presentations Session 1
53 Short Talks
(Number of papers per
session title) |
Chemical Mutagens (12); Chaired by: A.D. Burrell, IBM Corporation, and V.F. Simmon, SRI
International |
| Metabolic Activation (13);
Chaired by: J.S. Felton, Lawrence Livermore Lab, and J. Patrick O'Neill,
ORNL |
| Human Studies (14); Chaired by: R.J. Albertini, Univ of Vermont, and H. Rappaport, Carnegie-Mellon
Univ |
| Mechanisms and Interpretation of Mutagenicity (14);
Chaired by: J.B. Favor, Georgia Institute of
Technology, and P.B. Selby, ORNL |
Platform Presentations Session II
53 Short Talks
(Number of papers per
session title) |
Mutagens in the Human Environment (13);
Chaired by: M.L. Meltz, SW Foundation for Research and
Education, and T.K. Rao, ORNL |
| Testing Methods (13): Microbiological and Whole Animal;
Chaired by: B.S. Hass Argonne National Lab, and
J.T. MacGregor, Western Regional Research Center, USDA |
| Mechanisms of Mutagenesis (13);
Chaired by: H.E. Brockman, Illinois State Univ, and M.A. Conkling,
NIEHS |
| Germ Cell Effects (14); Chaired by: G.A. Sega, ORNL and A.J. Wyrobek, Lawrence Livermore Lab |
Platform Presentations Session III
40 Short Talks
(Number of papers
per session title) |
Chemical Mutagens (13); Chaired by: D.B. Couch, Chemical Industry Institute of Toxicology and D.F.
Krahn, E.I. du Pont de Nemours & Company |
| Chemical Mutagens: Energy Related
In Vitro Mammalian Tests (13);
Chaired by: J.P. Crowley,
Battelle Columbus Lab, and L.H. Thompson, Lawrence Livermore Lab |
| SCE and Other Cytogenetic Endpoints (14);
Chaired by: A.D. Bloom, College of Physicians and Surgeons,
Columbia Univ, and A.F. McFee, Comparative Animal Research Lab |
| Additonal Events/Features |
Reception: Co-Sponsored by: Microbiological Associates & ToxiGenics, Inc., Divisions of Whittaker
Corporation |
| Three free evenings |
| Last day (Monday) program coincides with start of Society of Toxicology meeting; EMS registration badges
accepted for first day of SOT meeting |
| "Five" day meeting, with first and last days both partial days (12:00 to 5:00PM on Thursday, 8:30 to
10:30AM on Monday) |
| Abstracts included in Program |
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|
11th Annual
Meeting Nashville, Tennessee March 16 - 19,
1980 [days of the week] |
| |
|
| Administrative Officer |
|
Registration Fees
(pre-registered / on-site) |
Members $nn Non-members $nn Students $nn Spouses $nn |
| Program Committee |
|
| Approximate Number of Attendees |
|
| Approximate Size of EMS Membership |
|
| Student Award Winners Still with Society |
|
| Opening Address |
|
| Keynote Presentation |
|
| Workshops |
|
Symposia
(Title of speaker's presentation) |
; Chairman: ; Speakers: |
| ; Chairman: ; Speakers: |
| ; Chairman: ; Speakers: |
| ; Chairman: ; Speakers: |
| ; Chairman: ; Speakers: |
| Poster Sessions |
|
Platform Presentations
nn Short Talks (Number of papers per session
title) |
(nn); Chairman: ; Speakers: |
| (nn); Chairman: ; Speakers: |
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|
12th Annual
Meeting San Diego, California
March 5 - 8,
1981 (Thursday to Sunday) |
| Site |
Town and Country Hotel |
| Administrative Officer |
Richard J. Burk, Jr. |
Registration Fees
(on-site) |
Members $30 Non-members $40 Students $5 Spouses $2 |
| Program Committee |
Not Listed, though Verne Ray would have chaired committee |
| Approximate Number of Attendees |
|
| Approximate Size of EMS Membership |
|
| Student Award Winners Still with Society |
None Known |
| Keynote Presentation |
None |
| Workshops |
None |
An SOT/EMS Joint Symposium:
Mechanisms of DNA Repair
(Title of
Presentation) |
Speakers: Steven Aust, Stuart M. Linn, M. Lieberman, Avery A. Sandberg, J.J. McCormick
(Introduction); Stuart M. Linn, University of California, Berkeley (The enzymology of DNA repair); Michael
Lieberman, Washington University School of Medicine (The distribution of DNA repair within the genome); Avery A. Sandberg,
Roswell Park Memorial Inst, (Reflection of DNA damage in human chromosomes); J. Justin McCormick, Michigan State Univ
(The relationship of DNA damage to mutagenesis and carcinogenesis) |
Symposium:
New Developments in Genetic Toxicology
(Title of
Presentation) |
Presiding: A. Hollaender, Associated Universities Inc.;
Speakers: Bruce Ames, University of
California, Berkeley (Potency calibrations of mutagenesis and carcinogenesis); Heinrich Malling, NIEHS (Single cell gene
mutation systems in mammals); Theodore Puck, University of Colorado Medical Center (Use of human-CHO hybrids in analysis of
mutagen action) |
Symposium:
Metabolic Activation
(Title of Presentation) |
Presiding: D.J. Brusick, Litton Bionetics, Inc.;
Speakers: D.J. Brusick (Cell-free S-9
microsomal enzyme activation: An assessment of the system); Eliezer Huberman, Oak Ridge National Lab (Activation of
chemicals to mutagens for mammalian cells in intact hepatocytes); Daniel Nebert, National Institute of Child Health &
Human Development (Pharmacokinetics of carcinogens/mutagens in the intact animal: Complexity not seen in cell-free or cell
culture systems) |
An Industrial Symposium:
Genetic Hazard Evaluation
(Title of
Presentation) |
Presiding: George Hoffman, National Academy of Sciences;
Speakers: James Crow, University of
Wisconsin (Assessing the human mutation burden); Liane B. Russell, Oak Ridge National Lab (The use of mouse mutagenesis
studies for predicting the induction of inherited human disorders); Richard Albertini, University of Vermont (An approach
to direct mutagenicity testing in man) |
Poster Sessions
74 Posters pre-registered
(Number of posters per
topic) |
Session 1): Repair (11), Screening Chemicals (13) |
| Session 2): SCEs (3), Complex Mixtures (14), Plant Systems (3), Sperm Abnormality
(3), Mechanisms (3) |
| Session 3): Screening Chemicals (13), Assay Development (11) |
Platform Presentations Session 1:
62 Short Talks
(Number of
papers per session title) |
Mutagenic Screening I: Bacterial Assays (13);
Presiding: J.B. Guttenplan, NY University Dental
Center, and L.D. Kier, EHL Monsanto |
| Sister Chromatid Exchange Analysis I (11);
Presiding: S. Galloway, Litton Bionetics, and H.
Holden, Pfizer |
| Mechanisms I (13); Presiding: R.B. Cumming, Oak Ridge National Lab, and K. Mortelmans, SRI
International |
| Complex Mixtures I (12); Presiding: J.L. Epler, Oak Ridge National Lab, and M.A. Pereira, US EPA,
HERL |
| Assay Development (13); Presiding: D.E. Amacher, Pfizer, and J.B. Bishop, National Center for Tox
Research |
Platform Presentations Session 2:
50 Short Talks
(Number of
papers per session title) |
Mutagenic Screening II: Mammalian Cell Assays (13);
Presiding: A.D. Burrell, IBM, and George R.
Douglas, Dept of National Health & Welfare, Ottawa, Canada |
| Chromosome Analyses (12) Presiding: R.W. Naismith, Penn St & Pharmacon, and M.F. Salamone,
York University |
| Statistical Treatment of In Vitro and In Vivo Test Data (7);
Presiding: J.D. Irr,
E.J. Dupont de Nemours & Company |
| Mammalian Germ Cell Analysis (13);
Presiding: C.A. Schreiner, Mobil Oil Co., and P.B. Selby, Oak
Ridge National Lab |
| Cell Transformation Assays (5);
Presiding: K.A. Traul, Bio/Dynamics, Inc. |
Platform Presentations Session 3:
59 Short Talks
(Number of
papers per session title) |
Mutagenic Screening III: Prokaryotic and Eukaryotic Cell Assays (13);
Presiding: H.E. Brockman,
Illinois State U, and S.R. Haworth, EG&G Mason Research Institute |
| Sister Chromatid Exchange Analysis II (11)
Presiding: J.H. Carver, Battelle Columbus Lab, and A.J.
Kligerman, CIIT |
| Mechanisms II (11); Presiding: R.K. Elespuru, Frederick Cancer Research Center, and F.W. Larimer,
Oak Ridge National Lab |
| Complex Mixtures II (6); Presiding: T. Ong, NIOSH |
| DNA Repair Systems (12); Presiding: M.O. Bradley, Merck Institute of Therapeutic Research, and
D.A. Casciano, NCTR |
| Plant Systems (6); Presiding: M.J. Plewa, University of Illinois |
| Additional Events/Programs |
Two Free evenings, all scheduled programs ended at 5:00 PM Friday and at 6:00 PM Saturday |
| Reception; Co-Sponsored by Microbiological Associates, A subsidiary of Whittaker
Corporation |
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|
13th Annual Meeting
Boston, Massachusetts
February 26 - March 1,
1982 (Friday to Monday) |
| Site |
Boston Park Plaza |
| Administrative Officer |
Richard J. Burk, Jr. |
Registration Fees
(pre-registered/on-site) |
Members $40/$55 Non-members $50/$70 Students $5/$10 Spouses
$2/$4 |
| Program Committee |
G. Newell, Chair, D. Brusick, R. Elespuru, W.G. Flamm, B. Glickman, G. Hoffman, M. Plewa, D.
Taub |
| Approximate Number of Attendees |
|
| Approximate Size of EMS Membership |
|
| Student Award Winners Still with Society |
None Known |
| Keynote Presentation |
None |
| Workshops: |
Procedural Modifications in the
Salmonella Histidine Reversion Assay;
Presiding: H.I. Adler, Oak
Ridge National Lab, and T.K. Rao, Oak Ridge National Lab |
| An Interlaboratory Evaluation of the Ames Strains: The Genetic Drift Study;
Presiding: D. Anderson,
BIBRA, Surrey, UK; Results from a 39 laboratory comparative study |
Workshop:
Recent Advances in Mammalian Cell Mutagenesis
(Title of
presentation) |
Presiding: A.D. Mitchell, SRI International;
Speakers: R. Langerbach, EPA, RTP (Cell-mediate activation in V79 cell mutagenesis); D. Casciano, National Center
for Toxicological Research (Hepatocyte-mediated activation for CHO cell mutagenesis); L.H. Thompson, Lawrence Livermore Lab
(Repair-deficient mutants of CHO cells for improved assays of chromosomal aberations, SCE, cell killing land specific locus
mutations); Juan San Sebastian, ORNL (Examination of multiple endpoint mutagenesis using CHO cells); M. Moore, EPA, RTP
(Are small colonies in the L5178Y mouse lymphoma TK+/- assay significant mutational events?)
| | A Society of Toxicology/EMS Joint Debate: |
There is a Role Today for Mutagenicity Testing in the Safety Evaluation of Chemicals;
Presiding: W.G.
Flamm, FDA, and P.E. Voytek, EPA; Rapporteur: M.L. Mendelsohn, Lawrence Livermore Lab;
Speakers: For the
Proposition -- D.J. Brusick, Litton Bionetics, V.A. Ray, Pfizer Pharm;
Against the Proposition -- A.C. Kolbye, Jr.,
FDA, R.B. Cumming, Oak Ridge National Lab |
Symposia:
New Vistas in Molecular Mutagenesis
(Title of presentation) |
Presiding: Jeff F. Lemontt, Integrated Genetics, Inc., Framingham, MA;
Speakers: W.A. Haseltin,
Harvard Medical School (New methods for detection of damage to human DNA); G.C. Walker, MIT (Analysis of structure and
function of E. coli genes); Barry Glickman, NIEHS (A role for DNA in mutagenesis) |
Industrial Symposium:
Somatic Mutation in Cancer
(Title of presentation) |
Presiding: R.I. Demara, Univ of Wisconsin;
Speakers: R.I. Demara (Somatic mutation in
malignant transformation); J.C. Barrett, NIEHS, RTP (Cell transformation, mutation and cancer); J.J. Mulvihill, NCI,
Bethesda (Clinical genetics of human cancer) |
| Round Table Discussions |
Safety Assessment, Prioritization, and Ranking of Mutagens/Carcinogens;
Presiding: M.S. Legator, Univ of
Texas Med Branch, Galveston; Presenters: M.S. Legator (The role of genetic toxicology in a decision-tree concept);
G. Williams, American Health Foundation, Valhalla (Application of genotoxicity and carcinogenicity data to the assessment of
carcinogenic potency for safety evaluations); John Van Ryzin, Columbia Univ, NYC (Mathematical models for risk assessment
in extrapolation of data from animals to man) |
| Regional and Independent Mutagen Societies;
Presiding: D.J. Brusick, Litton Bionetics; An open
discussion by various regional mutagen societies |
| Status of National and International Programs;
Presenters: Angela Auletta, US EPA (The Gen-Tox
program); F. de Serres, NIEHS (International Commission for Protection Against Environmental Mutagens and Carcinogens
[ICPEMC]); and S. Abrahamson and F.T. Hatch, Univ of Wisconsin and Lawrence Livermore Lab (The International Conference on
Environmental Mutagens) |
Poster Sessions
92 posters pre-registered
(Number of posters per
topic) |
Session 1): Mechanisms (9), Method Development (10), Plant Systems (1), Activation (3), Cell Transformation
(3), Statistical and Data Base Treatment (2), Mutagenic Evaluation: Microbial Systems (8), Mutagenic Evaluation: Whole Animal and
Plant Systems (9) |
| Session 2): SCEs (6), Complex Mixtures (8), Repair (9), Mutagenic Evaluation: Procaryotic and Eucaryotic Cell
Assays (24) |
Platform Presentations Session 1:
49 Short Talks
(Number of papers
per session title) |
Mechanisms 1. Prokaryotes & Eukaryotes (13);
Presiding: P.K. LeMotte, Harvard, and E. Eisenstadt,
Harvard |
| Activation (13); Presiding: L.C. Blair, Univ Illinois, and G.F. Strniste, Los Alamos National
Lab |
| Statistical Treatment and Data Bases (12);
Presiding: J.B. Bishop, National Center for Toxicology
and, R.R. Tice, Brookhaven Natl Lab |
| Method Development: Whole Animal Systems (11);
Presiding: B.L. Gledhill, Lawrence Livermore and,
J.T. MacGregor, USDA, West Region |
Platform Presentations Session 2:
34 Short Talks
(Number of papers
per session title) |
Mechanisms II. Eukaryotes (Mammalian) (13);
Presiding: G.A. Sega, Oak Ridge National Lab, and D.A.
Kaden, M.I.T |
| Mutagenic Evaluation: Whole Animal and Plant (10);
Presiding: W.G. Thilly, M.I.T., and P.B. Shelby, Oak
Ridge National Lab |
| Method Development: Mammalian Cell Systems (11);
Presiding: P.L. Olive, John Hopkins Oncology Cent, and
J.L. Ivett, NC State |
Platform Presentations Session 3:
36 Short Talks
(Number of papers
per session title) |
SCEs (13); Presiding: L.G. Littlefield, Oak Ridge Assoc Univ, and R.G. Moon, Univ Utah Research
Institute |
| Complex Mixtures (11); Presiding: M.J. Plewa, Univ Illinois, and D.R. Stoltz, Health Protection Branch,
Ottawa |
| Method Development: Human Systems (12);
Presiding: T.H. Connor, Univ Texas Med Branch, and T-M. Ong,
NIOSH |
Platform Presentations Session 4:
41 Short Talks
(Number of papers
per session title) |
DNA Repair (13); Presiding: M.G. Farrow, Hazelton Labs Inc., and D.H. Blakey, National Health &
Welfare, Ottawa, Canada |
| Complex Mixtures II (11); Presiding: T.K. Rao, Oak Ridge National Lab, and M.F. Salamone, Ontario
Ministry of the Environment |
| Microbial Screening & Method Development (11);
Presiding: K. Mortelmans, SRI International, and D.W.
Matheson, Stauffer Chemical Company |
| Mutagenic Evaluations: Prokaryotes & Eukaryotes Cell Assays (6);
Presiders V.M. Maher, Michigan
State University, and M.M. Moore, EPA Research Triangle Park |
| Additional Events/Features |
Social Events coffee: Social get-together for an hour and one-half in the morning; a time to meet and
exchange ideas with other attendees and an member of the local committee |
| "Brown Bag" lunch discussion: Rap session with EMS officers; A "round table" get-together |
| Reception: Co-Sponsored by Microbiological Associates, A subsidiary of Whittaker Corporation |
| Four day meeting, no free evenings, started on Friday afternoon and ended Monday late
afternoon |
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|
14th Annual Meeting
San Antonio, Texas
March 3 - 6, 1983
(Wednesday to Sunday) |
| Site |
Hyatt Regency |
| Administrative Officer |
Richard Burk, Jr |
Registration Fees
(pre-registered / on-site) |
Members $40/$55 Non-Members $50/$70 Student Members $5/$10 Spouses
$2/$4 |
| Program Committee |
Richard J. Albertini, Chairman, J. Patrick O’Neill, Andrew Sivak, Alice Tu, Diane Taub;
Local
Arrangements: Martin Meltz |
| Approximate Number of Attendees |
|
| Approximate Size of EMS Membership |
|
| Student Award Winners Still with Society |
Not Known |
Keynote/Special Presentation:
Radiation Research Society Special Session |
RAS oncogenes in retroviruses and human carcers;
Introduction: E.R. Epp;
Presenter E.M. Scolnick,
Merck Sharp & Dohme |
| Workshops |
Genetic Toxicology Standard Test Methods. Is There a Need?;
Presiding: Robert W. Naismith, Pharmakon
Research International, Inc. |
| Application of CHO Cells in Industrial Toxicology;
Presiding: Albert Li, Monsanto Company |
Radiation Research Society Symposium
(Title of presentations) |
DNA Base Damage; Presiding: S.S. Wallace, New York Medical College;
Speakers: T.P. Brent, St Jude
Children’s Hospital (Repair of alkylated DNA by N-glycosylases); S.S. Wallace (Repair of radiolysis products of
thymine); S. Mitra, ORNL (Adaptive response of bacteria mammalian cells to N-methyl-N’-nitro-N-guanidine) |
EMS/RRS Joint Symposium:
Comparative and Interactive Genetic Effects of Ionizing
Radiations and Chemicals
(Title of presentations) |
Presiding Alexander Hollaender, Associated Universities, Inc.;
Speakers: R.H. Haynes, York Univ
(Comparative cellular effects of radiations and chemicals); J. Williams, George Washington Univ Medical School
(Interactions between chemicals and irradiation: Analysis of dose patterns and persistence); A. Upton, New York Univ
(Comparative and interactive effects of low dose exposure to radiation and chemicals in humans) |
Public Policy Issues Symposium: Cigarette Smoking & Public Health
(Title of
presentations) |
Presiding M.D. Shelby, Chairman, Public Policy Committee, NTP;
Speakers: D. DeMarini, ORNL
((Laboratory evidence for the mutagenicity and carcinogenicity of cigarette smoke); L. Garfinkel, American Cancer Society,
Inc. (Cigarette smoking and mortality rates, epidemiological and pathological evidence); J. Grabowski, National Institute of
Drug Abuse (Cigarette smoking: Behavior and psychology); E.M. Lewit, New Jersey Medical School (Economics of
cigarettes) |
Host Area Symposium: Functional Organization of Eukaryotic Chromosomes
(Title of
presentations) |
Presiding M.E. Gaulden, Univ of Texas Health Science Center at Dallas;
Speakers: M. E. Gaulden
(Introduction); W.T. Garrard, Univ of Texas Health Science Center at Dallas (Relationship between nucleosome structure
and function); H. Juarez-Salinas and M.E. Jacobson, North Texas State Univ and Texas College of Osteopathic Medicine
(Chemical mutagen-induced DNA damage and poly-ADP ribosylation of chromosomal protein); P. Tucker, Univ of Texas Health
Science Center at Dallas (Structure of genes that change position during development) |
Poster Sessions
102 Posters pre-registered
(Number of posters per
topic) |
Session 1): 54 posters, Animal Systems (11), Mammalian and Plant Systems: Cytogenetics & SCEs (13),
Eukaryotes: Mechanisms & Methods (28) |
| Session 2): 48 posters, Environmental Mutagens & Complex Mixtures (9), Prokaryotes: Mechanisms &
Methods (25), DNA Damage & Repair (14) |
Platform Presentations Session 1
34 Short Talks
(Number of papers per
session title) |
Prokaryotes: Mechanisms & Methods (11);
Presiding: N.E. McCarroll, Hazleton Lab America, Inc. &
T.K. Rao, Northrop Services, Inc. |
| Complex Mixtures (12); Presiding: A.P. Li, Monsanto Company & R.G. Stahl, The Univ of Texas School
of Public Health |
| Human Systems (11); Presiding: Lorraine M. Cherry, Univ of Texas M.D. Anderson Hospital and Tumor
Institute, & Irene M. Jones, Lawrence Livermore Natl Lab |
Platform Presentations
51 Short Talks
(Number of papers per session
title) |
Plant Systems: Mechanisms & Methods (12);
Presiding: R. Schoeny, Univ of Cincinnati & D.L.
Weaver, Univ of Illinois |
| Animal Systems: Mechanisms & Methods (13);
Presiding: P.A. Foureman, Univ of Wisconsin & R.
Schlegel, UC School of Public Health Berkeley |
| Mammalian Cells: Cytogenetics & SCEs (13);
Presiding: M.W. Heartlein, Univ of Tennessee, Oak Ridge
Graduate School of Biomdical Sciences & J.L. Schwartz, Harvard School of Public Health |
| Transformation/Statistical Treatment & Data Base (13);
Presiding: G.V. Johnson, Univ of Illinois
& S.A. Weiss, Southwest Foundation for Research & Education |
Platform Presentations
39 Short Talks
(Number of papers per session
title) |
Prokaryotes: Mutagenic Evaluations (14);
Presiding: R.K. Elespuru, NCI-Frederick Cancer Research
Facility & A Mulholand, Ethyl Corporation |
| Animal Systems: Cytogenetics & SCEs(11);
Presiding: J.L. Ivett, Brookhaven National Lab & B.L.
Harper, Univ of Texas Medical Branch |
| Eukaryotes: Mechanism & Methods (14);
Presiding: Ann E. Aust, Michigan State Univ. & Andrea
Back, Microbiological Associates |
Platform Presentations
39 Short Talks
(Number of papers per session
title) |
Eukaryotes: Mutagenic Evaluations (13);
Presiding: M. L. Alexander, Southwest Texas State Univ. &
D.L. Morris, Univ of Texas Medical Branch |
| Animal Systems: Germinal Mutations (13);
Presiding: D. Grahn, Argonne Natl Lab & P.B. Selby,
ORNL |
| DNA Damage & Repair (13);
Presiding: G.T. Bowdan, Univ of Arizonia & J.W. Hamilton, Cornell
Univ |
| Regional Group Update |
Presiding: Co-Chairmen, EMS Regional Affiliates Committee, Anthony V. Carrano, Lawrence Livermore Natl
Lab & Dale W. Matheson, Stauffer Chemical Company; Speakers: Six unspecified presenters representing regional
groups |
| Additional Events/Programs |
Social Events Coffee: Social get-together for a couple hours in the morning; a time to meet and exchange
ideas with other attendees |
| "Brown Bag" lunch discussion; Rap session with EMS officers; A "round table" get-together |
| Reception: Co-Sponsored by Microbiological Associates, A subsidiary of Whittaker Corporation |
| Special Outing: An evening on the 10,000 acre Gallagher Ranch with a Texas BBQ |
| Abstracts included in program booklet |
(return to the top of this page)
|
7th Annual
Meeting Montreal, Quebec, Canada
February 19-23,
1984 (Sunday to Thursday) |
| Site |
Le Centre Sheraton |
| Administrative Officer |
Richard Burk, Jr |
Registration Fees
(pre-registered / on-site) |
Members $55/$70 Non-Members $65/$80 Student Members $10/$20 Spouses
$5/$10 |
| Program Committee |
Liane B. Russell, Chairman, Virginia Dunkel, Rosalie Elespuru, Sheila Galloway, Elizabeth Jacobson,
Michael Prival; Local Arrangements: Francine Denizeau, Earle R. Nestmann |
| Approximate Number of Attendees |
425 |
| Approximate Size of EMS Membership |
|
| Number of Student Travel Award Winners |
10 |
| Student Winners Who Became Regular Members |
Virginia Stewart Houk, Christopher P. Selby, Leon Stankowski, Jr |
| Keynote/Special Presentations |
None scheduled |
| Plenary/Public Lectures |
None scheduled |
| Workshops |
Update on ASTM Efforts in Reviewing Standards for Toxicology Tests;
Presiding: Robert W. Naismith,
Pharmakon Research International, Inc |
| Application of CHO Cells in Industrial Toxicology;
Presiding: Albert Li, Monsanto Company |
Workshops:
Deliberations of ASTM Task Groups of Genetic Toxicology |
Ames test subgroup; Presiding: L.D. Claxton, EPA, RTP |
| Dominant-Lethal Test Subgroup;
Presiding: S. Green, FDA, Washington |
| Subgroup on Drosophila Bioassays;
Presiding: C.S. Aaron, Allied Chemical Corp |
| Subgroup on Micronucleus Tests;
Presiding: J.T. MacGregor, Western Regional Research Center, USDA,
Berkeley |
Workshop:
Reports on National and International Programs in Environmental Mutagenesis and
Carcinogenesis
(Title of presentations) |
Presiding: Fred J. de Serres, NIEHS;
Speakers: Fritz Sobels, State Univ of Leiden, The
Netherlands (Current activities of the international commission for protections against environmental mutagens and
carcinogens); A. Auletta, US EPA, Washington (Report on phase II of the US-EPA Gene-Tox program); F.J. de Serres
(Evaluation of short-term test for carcinogenicity in the international program for chemical safety) |
Symposium:
Genetic Events Leading to Activation of Oncogenes
(Title of
presentations) |
Presiding: Wen K. Yang, ORNL;
Speakers: S.A. Aaronson, NCI (Transforming genes of retroviruses
and human cancer cells); H. Robinson, Worcester Foundation for Experimental Biology, Shrewsbury, MA (Viral genes and host
genes in avian leucoksis virus-induced cancers); C. Croce, Wister Institute for Anatomy and Biology, Philadelphia
(Oncogenes in malignancy) |
Symposium:
Molecular Analysis of Specific-locus Mutations in Eukaryotes, Mutagenic
Processess and Gene Structure
(Title of presentations) |
Presiding: E.G. Bernstine, Integrated Genetics;
Speakers: F. Sherman, The Univ of Rochester, NY
(Common to weird mutations of the CYC1 gene in yeast); R. Levis, Univ California, Berkeley (Transposable element
insertions in the white locus of Drosophila); N.A. Jenkins, N.G. Copeland and L.B. Russell, Univ of Cincinnati and ORNL
(Insertional mutagenesis by murine retroviral DNAs) |
Host Area Symposium: Cellular Changes in Chemical and Radiation
Carcinogenesis
(Title of presentations) |
Presiding John Heddle, Ludwig Institute for Cancer Research, Toronto;
Speakers: M.C. Paterson,
Atomic Energy of Canada Ltd., Chalk River (New Insight into the molecular defect in xeroderma pigmentosum); J.A. Heddle
(Towards the detection of mutant cells in somatic tissues); E. Farber, Univ of Toronto (Multistep nature of cancer
development with chemicals); W.R. Bruce, Ludwig Institute for Cancer Research, Toronto (Cancer prevention-a strategy based
on short-term assays) |
Poster Sessions
90 Posters preregistered
(number of posters per
topic) |
Session 1): Chromosome Damage (13), SCEs (9), Prokaryotes: DNA Damage, Mutagenic Mechanisms and Assay
Development (11); Mutagenic Evaluations: Fungi, Plants, and Mammalian Cells (12) |
| Session 2): DNA Damage and Repair (12), Prokaryotic Mechanisms (10), Mammalian Cells: Mutagenic Mechanisms
(13); Miscellaneous Problems (10) |
Platform Presentations
Session 1
51 Short Talks
(number of papers per
session title) |
Mammalian Somatic Cells: Testing (13);
Presiding: M.G. Farrow, Hazleton Lab America Inc., Vienna, VA
& B. Myhr, Litton Bionetics Inc, Kensington, MD |
| Complex Mixtures (13); Presiding: J.H. Carver, Chevron Environmental Health Center Inc., Richmond,
California & J. Felton, Lawrence Livermore Natl Lab |
| Non-Mammalian Eukaryotes (13);
Presiding: M.J. Plewa, Univ of Illinois, Urbana & L. Prakash, Univ
of Rochester School of Medicine. |
| DNA Damage and Repair (12);
Presiding: F. Denizeau, Univ du Quebec a Montreal & B. W. Glickman,
NIEHS, RTP |
Platform Presentations
Session 2
50 Short Talks
(number of papers per
session title) |
Prokaryotic Test System (13);
Presiding: R.K. Elespuru, NCI-Frederick Cancer Research Facility &
D.E. Levine, Univ California, Berkeley |
| SCE: Applications and Mechanisms (11);
Presiding: M.K. Conner, Graduate School of Public Health, Univ
of Pittsburgh & S.M. Morris, National Center for Toxicological Research, Jefferson, AR |
| Mammalian Somatic Cells: Mechanisms (13);
Presiding: A.V. Carrano, Lawrence Livermore Natl Lab &
J.P. O'Neill, Univ of Vermont School of Medicine, Burlington. |
| Mammalian Germ Line and in vivo Somatic Mutations (13);
Presiding: V.L. Sawin, Shell Development
Company, Houston & Paul B. Selby, ORNL |
Platform Presentations
Session 3
36 Short Talks
(number of papers per
session title) |
Mammalian Somatic Cells: Method Development (13);
Presiding:W.W. Au, ORNL & P.L. Olive, B.C. Cancer
Research Center, Vancouver |
| Activation, Metabolism (11);
Presiding: H.E. Holden, Pfizer Central Research, Groton, CT & R.C. von
Borstal, The Univ of Alberta, Edmonton, Canada |
| Human Population Monitoring: Theoretical Analyses (12);
Presiding: L.G. Littlefield, Oak Ridge
Associated Universities & E. Whorton Jr., Univ of Texas Medical Branch, Galveston |
| Regional Group Update |
Presiding: David Brusick, Litton Bionetics, Inc.; Speakers: Six unspecified presenters
representing regional groups |
| Additional Events/Features |
Social Events coffee: Social get-together for an hour and one-half in the morning; a time to meet and
exchange ideas with other attendees and an member of the local committee. |
| "Brown Bag" lunch discussion: Rap session with EMS officers; A "round table" get-together |
| Reception: Co-Sponsored by: Microbiological Associates, A subsidiary of Whittaker Corporation (second
sponsor not specified) |
| Two free evenings: (Sunday, Wednesday) |
| Special outing: An evening (Tuesday) of French-Canadian dinning and folklore, and iced maple sugar at
La Cabane A Sucre |
| Five day meeting, starting Sunday afternoon at 1:30 PM; ending Thursday at noon.
No evening sessions on any
day |
| Abstracts included with program |
(return to the top of this page)
|
16th Annual
Meeting Las Vegas, Nevada
February 25 - March 1,
1985 (Monday to Friday) |
| Site |
Sahara Hotel |
| Administrative Officer |
Richard J. Burk, Jr. |
Registration Fees
(pre-registered / on-site) |
Members $75/$90 Non-members $85/$90 Students $15/$25 Spouses
$5 |
| Program Committee |
M. Shelby, Chair, D. DeMarini, F. de Serres, M. Moore, D. Pagano, T.K. Rao, B. Tainer, M. Waters, P.
Working, E. Zeiger |
| Approximate Number of Attendees |
423 |
| Approximate Size of EMS Membership |
|
| Student Award Winners Still with Society |
None Known |
| Keynote Presentation |
DNA Methods for Measuring the Human Heritable Mutation Rate;
Speaker: Mortimer L. Mendelsohn, Lawrence
Livermore National Laboratory |
| Workshops |
Application of CHO Cells in Industrial Toxicology;
Presiding: Albert P. Li, Monsanto
Company |
| National and International Programs in Environmental Mutagenesis and Carcinogenesis;
Presiding: F.J. de
Serres, NIEHS; Speakers: M. Waters, B. Farland, V. Delarco, J. Ashby, C. Ramel, and F. de Serres |
| Low pH and Salt Concentration: Apparent Genotoxicity in Cultured Mammalian Cells;
Presiding: D. Brusick,
Litton Bionetics, Inc.; Speakers: A. Thilagar, B. Myhr, S. Galloway, J. Rundell, J. Ashby |
| Symposia |
Chromosome Alterations and Cancer: Microscopic and Molecular Viewpoints;
Presiding: R. Julian Preston,
Oak Ridge National Lab; Speakers: T.C. Hsu, S. Pathak, J. Groffen |
| Origins of Spontaneous Mutation;
Presiding: Barry W. Glickman, York University;
Speakers: John W.
Drake, Thomas A. Kunkel, James A. Shapiro, Barry Glickman |
| The Utility of Genetic Toxicity Information in Safety Evaluation of Chemicals;
Presiding: Verne A. Ray,
Pfizer, Inc.; Speakers: J. Ashby, R.W. Tennant, G. Probst |
Poster Sessions
(Number of posters per topic) |
Session 1): Prokaryotic Systems: Methods and Mechanisms (12); Mammalian cells: Mutagenic Mechanisms and
Transformation (14); Cytogenetic: Methods and Mechanisms (15); Human Monitoring (7); Complex Mixtures (15) |
| Session 2): Prokaryotic Test Results (10); Non-mammalian Eukaroytics (6); Mammalian Cells
In Vitro (9);
Cytogenetic Testing (9); Mammalian Germ Cell Studies (5); DNA Damage and Repair (15) |
Platform Presentations Session 1
46 Short Talks
(Number of papers
per session title) |
Human Monitoring (11); Presiding: W.L. Bigbee, Lawrence Livermore Laboratory, and A.T.L. Chen, Centers
for Disease Control |
| Mammalian Cells In Vitro: Methods (11);
Presiding: T.G. Rossman, New York University Medical
Center, and P.E. Kirby, Sitek Research Laboratory |
| Non-mammalian Eukaroytes (12);
Presiding: L.K. Overton, SRI International, and A.J. Katz, Illinois State
Univ |
| Specific Chemicals Studies and Test Batteries (12);
Presiding: R. Langenbach, NIEHS, and F. Ratpan,
Polysar Ltd |
Platform Presentations Session 2
45 Short Talks
(Number of papers
per session title) |
Metabolic Activation and Mutagenesis: Plant Systems (11);
Presiding: J.M. Gentile, Hope College, and
M.J. Plewa, University of Illinois |
| Bacterial Mutagenesis (12);
Presiding: D.A. Pagano, NIEHS, and J.M. LaVelle, University of
Connecticut |
| Cytogenetic: Methods and Mechanisms (11);
Presiding: B.H. Margolin, NIEHS, and R.D. Benz, Brookhaven
National Lab |
| Mammalian In Vivo Systems (11);
Presiding: W.N. Choy, E.I. Dupont de Nemours & Co., and B.L.
Harper, University of Texas |
Platform Presentations Session 3
48 Short Talks
(Number of papers
per session title) |
Oncogenic Transformation/Germ Cell Mutagenesis (12);
Presiding: W. Suk, Northrop Services, Inc., and
P.B. Selby, Oak Ridge National Lab |
| Complex Mixtures (12); Presiding: T.M. Ong, NIOSH, and B.J. Dabney, IBM Corporation |
| DNA Damage and Repair (12);
Presiding: F.T. Hatch, Lawrence Livermore National Lab, and J.L. Schwartz,
University of Chicago Medical Center |
| Mammalian Cells In Vitro: Mechanisms (12);
Presiding: A.D. Burrell, IBM Corporation, and L.
Recio, University of Kentucky |
| ASTM Task Groups |
DNA Repair; Presiding: B.E. Butterworth |
| Ames Test; Presiding: L.D. Claxton |
| Dominant Lethal; Presiding: Sidney Green |
| Micronucleus Test; Presiding: James T. MacGregor |
| Cytogenetics; Presiding: R. Julian Preston |
| Drosophilia Bioassays;
Presiding: Charles S. Aaron |
| CHO/HGPRT; Presiding: Albert P. Li |
| Mouse Lymphoma L5178Y; Presiding: Don Clive |
(return to the top of this page)
|
17th Annual
Meeting Baltimore, Maryland
April 9 - 13,
1986 (Wednesday to Sunday) |
| Site |
Sheraton Inner Harbour Hotel |
| Administrative Officer |
Diane Taub |
Registration Fees
(pre-registered / on-site) |
Members $80/$90 Non-Members $90/$100 Student Members $20/$25 Student
Non-members $25/$30 Spouses $10/$15 |
| Program Committee |
John A. Heddle, Chairman, Chitra Chopra, Martha Lee Dixon, Andrew J. Grosovsky, Kanti Jain, Bernard A.
Kunz, A.S. Raj, David B. Couch, Barry W. Glickman, Hari K. Kaul, Richard R. Marshall, Michael F. Salamone
|
| Approximate Number of Attendees |
485 |
| Approximate Size of EMS Membership |
1035 |
| Number of Student Travel Award Winners |
13 |
| Student Winners Who Became Regular Members |
Cheryl B. Bast; Robert Best; Kirby Donnelly; W. Koch; Leslie Recio; Richard Winegar |
Public Affairs Presentation:
Status Report on Mutagens in the Diet |
Presiding: Mary Ester Gaulden;
Speaker: Frederick T. Hatch, Lawrence Livermore National Lab
(Toxicologic strategy for research on dietary mutagens); James R. Marshall, State University of NY, Buffalo (Cancer
case-control studies of food intake and preparation); Philip E. Hartman, The John Hopkins University (Nitrates and nitrites
in foods and water supplies); Sushma Palmer, National Academy of Sciences (Agency recommendations concerning the american
diet); Panel Discussion Topics Current status of toxicologic and epidemiologic information about some types of dietary
mutagens; Mutagens formed during the cooking and heat processing of foods; Research strategies for achieving an evaluation of
possible cancer risk from the consumption of dietary mutagens or precursor substances; Scientific basis, or lack thereof, for
recommendations on the American diet put forth by various agencies |
Special Lecture:
The Human Gene Map |
Speaker: V.A. McKusick |
Workshop I:
Analysis of Mutation at the DNA Level
(Title of
presentation) |
Presiding: Larry H. Thompson and J. Patrick O’Neill;
Speakers: Gerald Adair (Analysis of
structural alterations at the arpt locus); Kenneth Kraemer (Shuttle vectors to analyze mutations in mammalian
cells); Barry Glickman (The endogenous
aprt gene in CHO cells as a mutation target); Janice Nicklas (The
molecular analysis of HLA loss mutations in human lymphoblastoid cells) |
Workshop II:
Statistical Topics in Cytogenetic Studies |
Presiding: Barry H. Margolin;
Speakers: Not specified |
Workshop III:
Dose Rate Effect for Chemicals
(Title of presentation) |
Presiding: Ray Tice;
Speakers: Seymore Abrahamson (Dose rate effects: Experiences from studies
on ionizing radiation); J. Yeager (Experimental evidence for dose rate effects associated with chemical exposure: Somatic
cell effects); W. Generoso (Experimental evidence for dose rate effects associated with chemical exposure: Germ cell
effects); T. Tsongas (The impact of dose rate effects on regulatory decisions) |
Workshop IV:
The Differential Recovery of Mutants at the HGPRT Locus
vs. the TK
Locus in Cultured Mammalian Cells
(Title of presentation) |
Presiding: D.M. DeMarini;
Speakers: K.R. Tindall (Development of a system for the molecular
analysis of mutations in pSV2 gpt-transformed CHO cells); L.F. Stankowski (Quantitative and molecular analyses of
mutation at the gpt and
hprt loci in CHO cells); A.W. Hsie (Oxygen radicals induce mutations in mammalian
cells); H.H. Evans (The role of multilocus deletions in the locus specificity of mutation in L5178Y mouse lymphoma
cells); M.M. Moore (Genotoxicity of gamma irradiation and radiomimetic compounds in L5178Y/TR+/- 3.7.2C
cells); F.J. de Serres (Heterozygous loci in two-component heterokaryons of
Neurospora mimic heterozygous loci in
mammalian cells - permitting the recovery of both point mutations and multilocus deletions) |
Workshop V:
Possible Mechanisms of Tumor Promotion
(Title of
presentation) |
Presiding: J.E. Trosko;
Speakers: Thomas W. Kensler (Role of oxygen radicals in tumor
promotion); Peter M. Blumberg (Role of protein kinase C in tumor promotion); Rudolf Fahrig (Role of genetic
recombination in tumor promotion); Eugene Elmore (Role of intercellular communication in tumor promotion) |
Symposium 1:
The Role of Mutation, Recombination and Translocation in Oncogene
Activation
(Title of presentation) |
Presiding: J. Justin McCormick:
Speakers: Sarasawti Sukumar, Frederick Cancer Research Center
(Oncogene activation in chemically induced tumors); Ulf Rapp, Frederick Cancer Research Center (Action of
ras
and myc oncogenes); Joseph E. Tests, University of Maryland Cancer Center (Chromosomal rearrangements and oncogene
localization) |
Symposium 2:
Oxidative Damage and Strategies for its Prevention
(Title of
presentation) |
Presiding: Philip E. Harman;
Speakers: Robin W. Morgan, University of Delaware (Oxidative
stress in Salmonella typhimurium: Regulation of defenses); Robert L. Saul, University of California, Berkeley
(Oxidative damage in DNA); Richard G. Cutler, National Institute on Aging (Possible anti-aging role of defense
mechanisms against active oxygen species) |
Symposium 3:
Mutagenesis in mitochondria and chloroplasts
(Title of
presentation) |
Presiding: James M. Gentile;
Speakers: David Wilkie, University College of London (Aspects of
mutagenesis of mitochondria by chemical carcinogens); Barbara Sears, Michigan State University (Induction of chloroplast
DNA mutations by the action of a nuclear gene and by chemical agents) |
Symposium 4:
Strategies for Detecting Mutagens and Clastogens (and Carcinogens): A Decade
after 300 Chemicals
(Title of presentation) |
Presiding: Errol Zeiger
Speakers: Errol Zeiger, NIEHS (In Vitro
genotoxicity tests and rodent
tumors); H.D. Rosenkranz, Case Western Reserve University (Mutagens, carcinogens and computers); P.H.M. Lohman,
Netherlands Organization for Applied Scientific Research (The
in vivo, "Pac-Man" approach for
genotoxicants) |
Poster Sessions
134 Posters pre-registered
(Number of posters per
topic) |
Session 1): 67 posters, not organized by subject matter |
| Session 2): 67 posters, not organized by subject matter |
Platform Presentations Session 1:
34 Short Talks
(Number of papers
per session title) |
Testing I (12); Presiding: J.T. MacGregor and R. Daniel Benz |
| Cytogenetics I (10); Presiding: D.A. Shafer and G. Littlefield |
| Molecular Mechanisms (12);
Presiding: Howard L. Liber and A.J. Grosovsky |
Platform Presentations Session 2:
21 Short Talks
(Number of papers
per session title) |
Mammalian Cells In Vitro (6); Presiding: Regine Goth-Goldstein and D.A. Casciano |
| Testing II (5); Presiding: K.S. Loveday and Larry D. Claxton |
| Cytogenetics II (5); Presiding: R. Schlegel and S.E. Bloom |
| Activation in Plants (5); Presiding: M.J. Plewa and Te-Hsiu Ma |
Platform Presentations Session 3:
24 Short Talks
(Number of papers
per session title) |
Microbes (6); Presiding: R.K. Elespuru and U.G.G. Hennig |
| Cytogenetic II (6); Presiding: J.L. Wilmer and L.E. Dillehay |
| Mammalian Cells In Vivo I (6); Presiding: Alida P. Hugenholtz and Gary A. Sega |
| Activation in Animals (6);
Presiding: R. Langenback and D.B. Couch |
Platform Presentations Session 4:
47 Short Talks
(Number of
papers per session title) |
Complex Mixtures (12); Presiding: R.T. Taylor and J.R. Meier |
| Mammalian Cells In Vivo II (11); Presiding: Charles R. Geard and A.J. Raj |
| Human Population Monitoring (12);
Presiding: J.A. Nicklas and K. Messing |
| DNA Repair and Transformation (12);
Presiding: R.D. Snyder and H.E.
Brockman |
| Additional Events/Features |
Five day meeting, starting with workshops at 1:00 on Wednesday, ending at noon on Sunday |
| Reception: Sponsored by: Microbiological Associates |
| A free afternoon and evenings: Friday starting at 3:00 pm |
| A free evening: Saturday commencing at 7:00 pm |
(return to the top of this page)
|
18th Annual Meeting
San Francisco, California
April 8 - 12, 1987
(Wednesday to Sunday) |
| Site |
Hilton Hotel |
| Administrative Officer |
Diane Taub |
Registration Fees
(pre-registered/on-site) |
Members $80/$90 Non-Members $90/$100 Student Members $20/$25 Student
Non-members $25/$30 Spouses $10/$15 |
| Program Committee |
Anthony V. Carrano, Chairman, Brigitte Brandriff, Leilani K. Corell, Eugene L. Elmore, Barton L.
Gledhill, Regine Goth-Goldstein, James Felton, Irene Jones, Mortimer Mendelsohn, Dennis Pagano, Larry Thompson, James Tucker,
Andrew Wyrobek, Janice Yager |
| Approximate Number of Attendees |
545 |
| Approximate Size of EMS Membership |
1000+ |
| Student Award Winners Still with Society |
Not Known |
Keynote Presentation:
Interaction of Cancer Research and Environmental Mutagen
Studies-Past, Present and Future |
Speaker: Takashi Sugimura, President National Cancer Center, Japan;
Sponsor: Pharmakon Research
International, Inc. |
Workshop 1:
Research Needs for the Genotoxicity Testing of Industrial
Chemicals
(Title of presentation) |
Presiding: A.P. Li, Monsanto Company;
Speakers: A.P. Li (Introduction: Past, present and
future of genetic toxicology in industry); L.D. Kier, Monsanto Company (Need to fill present data gaps); F.B. Oleson,
Bristol Myers (Human testing systems); R.H. Heflich, National Center for Toxicological Research (Metabolic
approaches); L.F. Stankowsky, Pharmakon Research International, Inc. (Molecular approaches); R.J. Preston, Oak Ridge
National Lab (Role of basic research in genetic toxicology) |
Workshop 2:
The Spot Test with Mice |
Presiding: R. Fahrig and L.B. Russell;
Speakers: L.B. Russell, Oak Ridge National Lab; R. Fahrig,
Fraunhofer-Institut fur Toxikologie und Aerosolforschung, FRG; A. Neuhauser-Klaus and A. Luz, Gesellschaft fur Strahlen-und
Umweltforschung, FRG; R. Lang, and A.G. Schering, Berlin; J. Hart, National Agency of Environmental Protection,
Copenhagen |
Workshop 3:
Personal Computers and Data Management Systems in Genetic Toxicology |
Presiding L. Williams and L.D. Claxton;
Speakers: L.D. Claxton, US EPA; T.K. Rao, Integrated
Lab Systems; L. Kier, Monsanto Company; B. Shah, Research Triangle Institute, and N. Adams, Integrated Lab Systems |
Public Relations Symposium:
Bhopal-Genetic Consequences???
(Title of
presentation) |
Presiding: Henry E. Holden, Pfizer Inc.;
Speakers: H. Holden (Introductory remarks);
Richard Albertini, University of Vermont (Assessing genotoxicity in human populations: Tools, tactics and truth); Michael
Shelby, NIEHS (Genetic toxicity of methyl isocyanate), Herbert Rosenkranz, Case Western Reserve University (Commentary
and summary); Sponsors: The Lab of Radiobiology and Environmental Health of the University of California, San
Francisco; and Environmental Health Research and Testing Lab of Lexington, Kentucky |
Symposium:
Molecular Biology of DNA Repair
(Title of presentation) |
Presiding: Regine Goth-Goldstein;
Speakers: Graham Walker, MIT (Damage-inducible responses in
Bacteria); David Schild, Lawrence Berkeley Lab (Characterizing yeast DNA repair by use of cloned genes); Larry
Thompson, Lawrence Livermore National Lab (Mapping, isolation, and characterization of human DNA repair genes); Philip
Hanawalt, Stanford University (Intragenomic heterogeneity in mammalian DNA repair);
Sponsor: Arthur D. Little,
Inc. |
Symposium:
New Approaches in Environmental Mutagenesis
(Title of
presentation) |
Presiding: R. Tice;
Speakers: Daniel Pinkel, Lawrence Livermore National Lab (Fluorescence
hybridization techniques for the analysis of genetic damage); Raghbir Athwal, New Jersey Medical School (Analysis for
genotoxic effects using rodent-human monochromosomal hybrids); Narendra Singh, National Institute on Aging (A simple
technique for quantitation of low levels of DNA damage in single cells); Richard Irons, Chemical Industry Institute of
Toxicology (Selective activation of endogenous ecotropic retroviruses in the mouse);
Sponsor R.J.R.
Nabisco |
Alexander Hollaender Symposium:
Mutational Basis of Human Disease
(Title of
presentation) |
Presiding: John J. Mulvihill;
Speakers: Jorge Yunis, University of Minn Medical School
(Fragile sites and human cancer); Peter Byers, University of Washington (Mutants of collagen and
Osteogenesis
Imperfecta); Theodore Friedman, University of California, San Diego (Prospects for human gene therapy: Fact and fiction);
Udo Ehling, Gesellschaft fur Strahlen- und Umweltforschung, FRG (Germ cell mutation in mice: Standards for protecting the human
genome); James Neel, University of Michigan (Germ cell mutation in human beings: Current results from Japan); John J.
Mulvihill, National Cancer Institute (Other approaches: Sentinel phenotypes and offspring of cancer patients);
Sponsor: US EPA |
Symposium:
Role of Biotechnology in Genetic Analysis
(Title of
presentation) |
Presiding: James Felton;
Speakers: Elaine Heron, Applied Biosystems, Inc. (Automated DNA
sequencing); Christian Burks, Los Alamos National Lab (Errors in analysis of genetic sequences from the genebank
database); Mike Kriegler and Carl Perez, Cetus Inc. (Casette mutagenesis); Kay Mullis, Xytronyx, Inc. (In vitro
gene
amplification); Casandra Smith, Columbia University (Pulsed field electrophoresis in human gene mapping);
Sponsor: University of California Biotechnology Research and Education Program |
Symposium:
Short-Term Tests and the Rodent Bioassay - A Critical
Evaluation
(Title of presentation) |
Presiding: David J. Brusick;
Speakers: Barry Margolin, (Performance of short-term tests -
mutagenesis); Joseph Haseman, NIEHS (Performance of short-term tests - carcinogenesis); Stephen Nesnow, US EPA
(Performance of the rodent bioassays - carcinogenesis); Michael Shelby, NIEHS (Performance of the Rodent Bioassays -
mutagenesis); Discussion Panelists: John Ashby, Don Clive, Marvin Legator, Mortimer Mendelsohn, Ian Monroe, Verne Ray
and Herbert Rosenkranz; Sponsor: SRI International |
Poster Sessions
164 pre-registered Posters
(Number of posters per
topic) |
Session 1): Mammalian Cells
In Vitro (35), Complex Mixtures (15), Tumor Promotion (2), Cell
Transformation (3) |
| Session 2): Risk Assessment (6), DNA Repair (9), Prokaryotic Studies (20), Cytogenetics (22) |
| Session 3): Test Batteries (10), Plants, Fungi,
Drosophila (8), Fish, Amphibian, Birds (3), Metabolism
(11), Mammalian cells In Vivo (13), Mammalian Germ Cells (7) |
Platform Presentations Session 1
32 Contributed Short
Papers
(Number of papers per session title) |
Molecular Mechanisms-Prokaryotes (8);
Presiding: B. W. Glickman and E.C. McCoy |
| Cytogenetic Mechanisms (8);
Presiding: W.J. Bodell and M.E. Gaulden |
| Human Population Monitoring (8);
Presiding: B. Brandriff and G.R. Douglas |
| Mammalian Cell Mutagenesis (8);
Presiding: M.L. Meltz and C.J. Rudd |
Platform Presentations Session 2
24 Contributed Short
Papers
(Number of papers per session title) |
Cytogenetic Methods (6); Presiding: V.L. Sawin and J.W. Yager |
| Cytogenetic Testing I (6);
Presiding: J. Nath and E.B. Whorton, Jr |
| Complex Mixtures I (6); Presiding: P. Flessel and J. Lewtas |
| Cell Transformation (6); Presiding: J.R. Landolph and J.W. Spalding |
Platform Presentations Session 3
32 Contributed Short
Papers
(Number of papers per session title) |
DNA Repair (8); Presiding: J.L. Epler and K.K. Richardson |
| Human Population Monitoring II (8);
Presiding: W.L. Bigbee and J.A. Reidy |
| Complex Mixture II (8); Presiding: N.Y. Kado and S.J. Rinkus |
| Mammalian Cells In Vivo (8); Presiding: W.W. Au and M.T. Goldberg |
Platform Presentations Session 4
33 Contributed Short
Papers
(Number of papers per session title) |
Prokaryotic Mutagenesis (9);
Presiding: T. Ong and R.A. Pelroy |
| Molecular Mechanisms in Mammalian Cells (8);
Presiding: G.M. Adair and M. Mazur |
| Metabolism (8); Presiding: W.F. Blazak and B.S. Shane |
| Germ Cell and Heritable Mutations (8);
Presiding: R.L. Dobson and K.S. Lavappa |
Platform Presentations Session 5
19 Contributed Short
Papers
(Number of papers per session title) |
Cytogenetic Testing II (5);
Presiding: R.J. Preston |
| Test Strategies and Assessment (5);
Presiding: W.R. Lower |
| Mechanisms in Non-Mammalian Eukaryotes (4);
Presiding: R.C. von Borstel |
| Plant Genetic Toxicology (5);
Presiding: James M. Gentile |
| Additional Activities/Features |
Free evening Friday |
| Reception: Sponsors: Hazleton Laboratories American Inc.; and Microbiological Associates,
Inc. |
| "4" full days, meeting ended 6:00 PM on Saturday |
(return to the top of this page)
|
19th Annual
Meeting Charleston, South Carolina
March
27 - 31, 1988 (Sunday to Thursday) |
| Site |
Omni Hotel at Charleston Place |
| Administrative Officer |
Diane Taub |
Registration Fees
(Preregistration/on-site) |
Members $90/$115 Non-Members $100/$125 Student Members $30/$40 Student
Non-members $35/$45 Spouses $20/$25 |
| Program Committee |
Sheila M. Galloway, Chairperson, James W. Allen, Michael J. Armstrong, Christian L. Bean, Matthews O.
Bradley, Deni A. Deasy, John G. DeLuca, Eugene L. Elmore, Philip Hanawalt, Andrew R. Kraynak, Warren W. Nichols, Joseph F. Sina,
Richard D. Storer, Michael D. Waters |
| Approximate Number of Attendees |
560 |
| Approximate Size of EMS Membership |
1030 |
| Number of Student Travel Award Winners |
17 |
| Student Winners Who Became Regular Members |
Douglas Bell |
| Keynote/Special Presentation: |
A Re-analysis of the NTP Carcinogen Database: An Explanation for Recent Problems;
Speaker: John Ashby,
ICI, England |
Workshop I:
Mutagenicity Risk Assessment
(Title of presentation) |
Presiding: A. Auletta and D. Jacobson-Kram, U.S. EPA;
Speakers: L. Valcolvic, EPA Office of
Research and Development (U.S. EPA mutagenicity risk assessment guidelines); V. Vaughn-Dellarco, EPA Office of Research and
Development (Ethylene oxide risk assessment); M. Shelby, NIEHS (Comparison of the visible and biochemical specific locus
assays); K. Dearfield, Office of Pesticides and Toxic Substances (Use of mutagenicity test data at the EPA); A. Auletta
(Discussion);
Sponsors: U.S. EPA Office of Toxic Substances, and Office of Research and Development |
Workshop II:
Experience with Automated Microscopes in Cytogenetics and Genetic
Toxicology
(Title of presentation) |
Presiding: C. Bean, Merck Sharp and Dohme Research Laboratories;
Speakers: C. Bean (The
Magiscan [Joyce Loebl]); D. Shafer, Emory University (The Omnicon [Bausch and Lomb]); A Martin, Northwestern University
(The Magiscan and other systems); R. Peer, Bristol Myers (The IBAS [Zeiss]); D. Lloyd, National Radiological
Protection Board, England (The Cytoscan [Image Recognition Systems]); Panel-led open discussion
Sponsor: Image
Recognition Systems |
Workshop III:
New Research in Germ Cells and Zygotes
(Title of
presentation) |
Presiding: J. Allen and L. Russell;
Speakers: M. Moses, Dept of Anatomy, Duke University
(Synaptonemal complex structure and function); J. Allen, U.S. EPA, Genetic Toxicology Division (Chemical-induced
synaptonemal complex damage); L. Backer, Environmental Health Research and Testing, Inc. (Synaptonemal complex damage in
relation to chromosome aberrations); J. Allen, M. Moses, L. Backer, P. Poorman, Burroughs Wellcome Co., J. Gibson, Duke
University (Panel-led discussion: Strengths and weaknesses of synaptonemal complex analysis as an assay in genetic
toxicology); G. Sega, ORNL (Molecular events in mouse germ cells and their genetic consequences); W. Generoso, ORNL
(Exposure of zygotes to chemical mutagens produces high frequencies of developmental anomalies in mice); J. Rutledge,
University of Texas Medical Center (Analogies between spontaneous malformations in humans and mutagen-induced developmental
defects in mice) |
Workshop IV:
Genetic Activity Profiles: Evaluation of Quantitative Data
(Title
of presentation) |
Presiding: M. Waters, U.S. EPA, Genetic Toxicology Div.;
Speakers: M. Waters
(Introduction to genetic activity profiles: EPA/IARC supplement 6 data base and EPA non-carcinogen data base); L. Kier,
Monsanto Company (Potency data and the evaluation of carcinogen/noncarcinogen pairs and chemical classes); J. Ashby, ICI,
PLC, England (Use of profiles to distinguish genotoxic and nongenotoxic carcinogens) |
Workshop V:
Evaluation of Non-genotoxic Carcinogens
(Title of
presentation) |
Presiding: A. Li, Monsanto Company;
Speakers: A. Li (Overview: Toxicological significance of
nongenotoxic carcinogens); M. Waters, EPA, Genetic Toxicology Div. (Genetic activity profiles of some nongenotoxic
carcinogens); L. Loretz, Monsanto Company (Peroxisome induction assay for the detection of nongenotoxic hepatic
carcinogens); J. Mirsalis, SRI International (In vivo/in vitro
hepatocyte S-phase induction assay); F. Ennever,
Case Western Reserve University (Risk analysis of nongenotoxic carcinogens); Discussion |
Symposium:
Metabolism: The Cytochrome P-450 Enzymes as They Relate to Genetic
Toxicology
(Title of presentation) |
Presiding: B. Langenback, NIEHS, RTP;
Speakers: F. Guengerich, Vanderbilt University School
of Medicine, Nashville, TN (Cytochrome P-450 enzymes and the oxidation of pro-carcinogens in animals and humans); R.
Philpot NIEHS, RTP (Differences among tissues and species in the expression of homologs of rabbit cytochrome P-450 isozyme 5:
Implications for mutagenicity testing); F. Kadlubar, National Center for Toxicological Research, Jefferson, AR (Role of
specific monoxygenases and peroxidases in the metabolic activation of aromatic amines and nitroaromatic hydrocarbons); C.
Crespi, Gentest Corporation, Woburn MA (Improvements to the metabolic properties of target cells for genotoxicity assays using
DNA mediated gene transfer and other methods) |
Public Symposium:
Understanding and Treating Human Genetic Disease
(Title of
presentation) |
Speakers: Dr. C. Thomas Caskey, Director of the Institute for Molecular Genetics, Baylor College of
Medicine; Eric Juengst, Pennsylvania State College of Medicine; H. Hugh Fudenberg, Professor of Medicine and Immunology, Medical
University of South Carolina; and Barry Glickman, York University;
Sponsors: Environmental Health Research &
Testing, Inc., and R.J. Reynolds Tobacco Co. |
Symposium:
Molecular Biology of Centromere, Kinetochore and Nuclear Matrix
(Title of presentation) |
Presiding: M. Resnick, NIEHS;
Speakers: M. Resnick (Functional and molecular investigations
of the centromeres of yeast); B. Brinkley, University of Alabama at Birmingham, AL (Proteins of the centromere of mammalian
chromosomes: The kinetochore-microtublule connections); D. Coffey, The Johns Hopkins University School of Medicine, Baltimore,
MD (The nuclear matrix);
Sponsors: Bristol-Myers, Co., and Rohm and Haas, Co. |
Symposium:
Gene Regulation by Endogenous Promoters
(Title of
presentation) |
Presiding: N. Colburn, NCI-FCRF;
Speakers: N. Colburn, NCI (Genes that cooperate with tumor
promoters); H. Moses, Vanderbilt University School of Medicine, Nashville, TN (Transforming growth factors); P.
Herrlich, Institut fur genetik und toxikologie, Karlsruhe, Federal Republic of Germany (Cis- and trans- acting elements that
mediate transcriptional responses to stress factors);
Sponsors: Pharmakon Research International, Monsanto Co., and
Burroughs Wellcome, Co. |
Symposium:
Regulators of DNA Metabolism
(Title of presentation) |
Presiding: M. Mattern, Smith Kline and French Laboratories;
Speakers: W. Ross, University of
Florida College of Medicine (Altered functions of DNA topoisomerases as a basis for antineoplastic drug action); L. Liu,
Johns Hopkins University School of Medicine, Baltimore, MD (Cellular functions of DNA topoisomerase); D. DeMarini, U.S.
EPA, RTP, NC (Moderation of mutagenesis by topoisomerases) |
Alexander Hollaender Symposium:
Transgenic Mice Used in Studies of Oncogene Activity, Gene
Expression and Mutagenesis
(Title of presentation) |
Presiding: R. Pedersen, University of California, San Francisco;
Presiding: R. Pedersen,
University of California, San Francisco; Speakers: R. Pedersen (Introduction); J. Swain, Duke University Medical
School (Parental legacy determines methylation and expression of an autosomal transgene: A molecular mechanism for parental
imprinting); P. Soriano, Baylor College of Medicine (Retroviruses and mammalian development); J. Short, Stratagene
Cloning Systems, Inc. (A shuttle vector system in transgenic mice);
Sponsors: NIEHS, E.I. duPont de Nemours and
Co., and Arthur D. Little, Inc. |
Poster Presentations:
170 Posters registered
(Number of posters per
subject matter) |
Session 1) Cytogenetic Mechanisms and cell Cycle Kinetics (10), Oncogenes, Chromosomes in Tumors, and Fragile
Sites (5); Transformation (5), Molecular Analysis of Mutation -Prokaryotes (3) -Yeast and Neurospora (6) -Mammalian Cells (6),
Germ Cells, Development (8), Compounds Tested in Test Batteries (12) |
| Session 2) Activation and Metabolism (13), Unscheduled DNA Synthesis
In Vivo and In Vitro (10),
In Vivo Testing:
In Vivo vs. In Vitro Comparisons (11), Data Collections, Test Evaluation, Data Base,
Structure-Activity Relationships (7), Molecular Mechanisms of DNA Damage and Repair (18) |
| Session 3) Human Monitoring (4), Mammalian Cell Mutagenesis: Testing, Method Development and Locus Comparisons
(11), Cytogenetics In Vitro: Test Development and Testing (9), Prokaryotes: Testing and Test Development (8), Complex
Mixtures (20) |
Platform Presentations Session I
33 Short Talks
(Number of papers
per session title) |
Non-Mammalian Eukaryotes (8);
Presiding: T. Ma and L. Overton |
| Cytogenetics Testing and Dosimetry (8);
Presiding: G. Erexson and M. Manandhar |
| Molecular Mechanisms in Mammalian Cells (8);
Presiding: G. Adair and J. Hozier |
| Mouse Germ Cells (9); Presiding: J. Bishop and S. Niemann |
Platform Presentations Session II
30 Short Talks
(Number of papers
per session title) |
Human Population Monitoring (8);
Presiding: R. Leonard and K. Hooper
|
| Prokaryotes (7); Presiding: A. Gordon and R. Baker
|
| Mammalian Cell Mutagenesis and Molecular Mechanisms (8);
Presiding: J. O’Neill and N.
Biggart |
| Risk assessment, test strategies and theories of carcinogenesis (7);
Presiding: V. Dunkel and W.
Thilly |
Platform Presentations Session III
22 Short Talks
(Number of
papers per session title) |
DNA Damage and Repair (6);
Presiding: P. Smith and R. Okinaka |
| Molecular Methodology (4);
Presiding: T. Skopek and P. deJong |
| Tumorigenicity and SCE (1);
Presiding: T. Skopek and P. deJong |
| Cytogenetic Mechanism (5);
Presiding: J. Schwartz and C. Bast
|
| Complex Mixtures (6); Presiding: J. Lewtas and R. Taylor |
Platform Presentations Session IV
24 Short Talks
(Number of papers
per session title) |
Population Monitoring (6);
Presiding: K. Kelsey and D. Busch |
| Cytogenetics: Mechanisms (6);
Presiding: G. Hook and J. Tucker |
| Test Method Development (6);
Presiding: E. Matthews and B. Boyes |
| In vivo Testing (6);
Presiding: T. Barfknecht and T. Ong |
| Additional Activities/Features |
Reception: Co-Sponsored by: Hazleton Washington, and Microbiological Associates |
| Afternoon free time (12:00 pm to 7:30 pm), with plantation tours available. Symposium that
night |
| Five day meeting, starting with workshops at 1:00 PM on Sunday, ending 5:00 PM on Thursday |
| One free evening (after public symposium, which ended at 7:30 pm). Refreshments served prior to public
symposium |
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|
20th Annual
Meeting Cleveland, Ohio July 10 - 15,
1989 |
| |
|
| Administrative Officer |
|
Registration Fees
(pre-registered / on-site) |
Members $nn Non-members $nn Students $nn Spouses $nn |
| Program Committee |
|
| Approximate Number of Attendees |
|
| Approximate Size of EMS Membership |
|
| Student Award Winners Still with Society |
|
| Opening Address |
|
| Keynote Presentation |
|
| Workshops |
|
Symposia
(Title of speaker's presentation) |
; Chairman: ; Speakers: |
| ; Chairman: ; Speakers: |
| ; Chairman: ; Speakers: |
| ; Chairman: ; Speakers: |
| ; Chairman: ; Speakers: |
| Poster Sessions |
|
Platform Presentations
nn Short Talks (Number of papers per session
title) |
(nn); Chairman: ; Speakers: |
| (nn); Chairman: ; Speakers: |
(return to the top of this page)
|
21st Annual
Meeting Albuquerque, New Mexico
March 25 - 29,
1990 (Sunday to Thursday) |
| Site |
Albuquerque Hilton Hotel |
| Meeting Manager |
William G. Momberger |
Registration Fees
(pre-registered / on-site) |
Members $90/$115 Non-Members $100/$125 Student Members $30/$40 Student
Non-members $35/$45 Spouses $20/$25 |
| Program Committee |
George R. Hoffman, Chairman, Sky Benson, Marc Bichara, Sheila M. Galloway, James M. Gentile, Henry E.
Holden, Marc A. MacInnes, Jenness Majeska, Dale W. Matheson, Douglas McGregor, William Morgan, Michael Shelby |
| Approximate Number of Attendees |
|
| Approximate Size of EMS Membership |
|
| Student Award Winners Still with Society |
Not Known |
| Keynote/Special Presentations |
Transposable Elements and Their Relationship to Mutagenesis;
Speaker: Daniel L. Hartl, Washington Univ
School of Medicine St. Louis, Missouri; Sponsor: Environmental Health Research and Testing, Inc. |
| The Human Genome Project and its Implications for Mutation Research;
Speaker: Anthony V. Carrano,
Lawrence Livermore National Lab, Livermore, California; Sponsor: Monsanto Company and Genmap, Inc. |
Workshop 1:
Laboratory Safety Issues in Genetics Toxicology |
Presiding: David J. Brusick, Hazleton Lab Washington, Vienna, VA;
Speakers: Robert G. Nemchin,
Organon Teknika Corp (Potential nonbiological hazards: Chemicals and radiation); Andrew Losikoff, Hazleton Lab Washington
(Potential biological hazards: Microorganisms, cell culture contaminants and body fluids); James Ivett, Hazleton Lab
Washington (Potential biological hazards: Laboratory animals) |
Workshop 2:
Advances in Mammalian Cell Mutagenesis Applications in Industry
|
Presiding: Albert P. Li, Monsanto Company, St Louis;
Speakers: A.P. Li; Errol Zeiger, NIEHS; Leon
Stankowski, Jr., Pharmakon Research International; Martha Moore, US EPA; Brian Myhr, Hazleton Lab; S. Shabeg and R.S. Athwal, US
EPA and New Jersey Medical School; Ursula Hennig, Univ of Alberta, Canada |
Symposium I:
Molecular Analysis of Mutagenesis
(Title of presentation) |
Presiding: Thomas A. Kunkel, NIEHS;
Speakers: Thomas Kunkel (Analysis of fidelity
mechanisms with the human DNA replication complex); Roel Schaaper, National Institute of Environmental Health Sciences, RTP,
NC (Molecular analysis of mechanism of spontaneous mutagenesis in
E. coli); Norman D. Drinkwater, McArdle Lab for Cancer
Research, Univ of Wisconsin, Madison (Origins of spontaneous mutations in mammalian cells); Robert P. Fuchs, Institute de
Biologie Moleculaire et Cellulaire, CNRS, Strasbourg, France (Site-specific mutagenesis as relates to DNA conformation);
Sponsors: R.J.R.-Nabisco |
Symposium II:
Chromosomes: Molecular Organization and Target for
Mutagenesis
(Title of presentation) |
Presiding: B.R. Brinkley, Univ of Alabama at Birmingham;
Speakers: B.R. Brinkley (Overview of
chromsome structure and the kinetochore); Robert Moyzis, Los Alamos National Lab, New Mexico (Telomers); Gerald P.
Holmquist, Beckman Research Institute of the City of Hope, Duarte, CA;
Sponsor: Bristol-Myers Squibb |
Symposium III:
Are Short-Term Genetic Tests Useful for Predicting
Carcinogenicity?
(Title of presentation) |
A Panel Discussion: Moderator: J.M. Gentile, Hope College, Holland, Michigan;
Panel Members: John
Ashby, ICI Central Toxicology Lab, United Kingdom; Herman Brockman, Illinois State Univ, Norman; David J. Brusick, Hazleton Lab
American, Inc. Vienna, VA; Virginia C. Dunkel, FDA, Washington, DC; Raymond W. Tennant, NIEHS, RTP, NC;
Sponsor: SRI
International |
Symposium IV:
An Alexander Hollaender Symposium:
Provocative Models for DNA
Repair
(Title of presentation) |
Presiding: Philip C. Hanawalt;
Speakers: Philip C. Hanawalt (Provocative models for DNA
repair: An overview); Malcolm C. Paterson, Cross Cancer Institute, Edmonton, Alberta (Intermediates in the repair
processing of pyrimidine dimers); Isabel Mellon, Univ of Kentucky, Lexington (Implications of strand-specific DNA
repair); Miroslav Radman, NIEHS, RTP, NC (Role of mismatch repair in fidelity of recombination, chromosomal stability, and
evolution of species); Sponsor: US EPA |
Symposium V:
Human Health Effects of Mutagen Exposures: An Epidemilogical
Perspective
(Title of presentation) |
Presiding: Richard J. Albertini, Univ of Vermont, Burlington;
Speakers: Shirley Fry, Center for
Epidemiologic Research, Oak Ridge, Tenn (Epidemiology: The study of disease patterns and the factors that influence them);
Richard Albertini (Human environmental monitoring using
in vivo somatic cells gene mutations as indicators of adverse
effects); Bruce W. Kovacs, Women’s Hospital, Los Angeles (Detection and characterization of human germinal mutations with
hypervariable, short tandem repeat sequences); Anthony Herrmann, Johnson & Johnson, New Brunswick, NJ (Workplace
chromosome studies: An application and its limitations);
Sponsor: E.I. du Pont de Nemours & Co. |
Poster Sessions
172 pre-registered Posters
(Number of posters per
topic) |
Session 1): Genetic Toxicology Testing, Test Methods, and Metabolism (40), DNA Damage and Repair
(16); |
| Session 2): Mutational Mechanisms: Genetic and Molecular Analysis (30), Antimutagenesis, Structure-Activity
Relationships, and Complex Mixtures (26) |
| Session 3): Cytogenetics (28), Cell-Transformation and Oncogenes (5), Mutagenesis & DNA Damage in Mammalian
Cells In Vivo (8), Mammalian Germ-Cell Mutagenesis (7), Human Monitoring (12) |
Platform Presentations Session I:
24 Contributed Short Papers
(Number
of papers per session title) |
Bacterial Mutagenesis and Repair Mechanisms (8);
Presiding: T.A. Cebula and W.H. Koch |
| Mutagenesis and Transformation in Mammalian Cells (8);
Presiding: D.W. Matheson and W.B.
Mattes |
| Human Monitoring (8); Presiding: R.R. Tice and B. Hirsch |
| Sponsors of this Forum: Pharmakon Research International Inc. and Wellcome Research Lab |
Platform Presentations Session II:
24 Contributed Short Papers
(Number
of papers per session title) |
Mutation Spectra and Mutational Mechanisms in Eukaryotes (8);
Presiding: J.P. O'Neill and J.A.
Nicklas |
| Cytogenetic: Testing and Methodology (8);
Presiding: A.D. Kligerman and J.L. Wilmer |
| Germ Cell Mutagenesis (8);
Presiding: G.A. Sega and P.D. Sudman |
| Sponsors of this forum: Merck Sharp and Dohme Research Lab |
Platform Presentations Session III:
20 Contributed Short Papers
(Number
of papers per session title) |
DNA Repair (6); Presiding: M.A. MacInnes and J.S. Mudgett |
| Cytogenetic Mechanisms (7);
Presiding: W.F. Morgan and R.A. Winegar |
| Mutagenicity Testing and Test Methods (7);
Presiding: H.E. Holden and J.H. Carver |
| Sponsors of this forum: Pharmakon Research International, Inc., and Upjohn Company |
Platform Presentations Session IV:
16 Contributed Short Papers
(Number
of papers per session title) |
DNA Damage and Repair (6);
Presiding: K. Elespuru and D.A. Bell |
| Metabolism and Metabolic Activation (6);
Presiding: M.J. Plewa and S.R. Smith |
| Complex Mixtures and Chemical Analysis (4)
Presiding: L.D. Claxton and T.J. Hughes |
| Sponsors of this forum: Rohm and Haas, and United States Testing Company,
Inc. |
(return to the top of this page)
|
22nd Annual
Meeting Orlando, Florida
April 7 - 11,
1991 (Sunday to Thursday) |
| Site |
Hyatt Orlando Hotel |
| Administrative Officer |
William G. Momberger |
Registration Fees
(pre-registered / on-site) |
Members $90/$115 Non-Members $100/$125 Student Members $30/$40 Student
Non-members $35/$45 Spouses $20/$25 |
| Program Committee |
Michael D. Waters, Chairman, Jane A.S. Allen, Kerry L. Dearfield, David M. DeMarini, George R. Hoffman,
Robert J. Langenbach, Albert P. Li, Paul H.M. Lohman, Douglas B. McGregor, Wendell McKenzie, Martha M. Moore, Patricia Ostrosky,
Errol Zeiger |
| Approximate Number of Attendees |
|
| Approximate Size of EMS Membership |
|
| Student Award Winners Still with Society |
Not Known |
| Keynote/Special Presentations: |
none |
Special Topics Lectures:
(Title of presentation) |
Presiding: Paul H.M. Lohman, Univ of Leiden, Leiden, The Netherlands |
| Speaker: Bruce N. Ames, Univ of California at Berkeley (Animal cancer tests and the causes of
cancer); Sponsor: Hoechstr Celanese Corporation |
| Speaker: Raymond W. Tennant, NIEHS, RTP, NC (Mutation and proliferation as sufficient but not
necessary causes in neoplasia); Sponsor: Merck Sharp & Dohme |
| Speaker: Evelyn M. Witkin, Rutgers, The State Univ of New Jersey, Piscataway, NJ (Ultraviolet
mutagenesis and the SOS response ); Sponsor: Bristol-Myers Squibb Company |
Workshop I:
New Molecular Techniques Genome Analysis, Part A, The Role of the Polymerase
Chain Reaction in the Molecular Analysis of Mutations
(Title of presentation) |
Presiding: David M. DeMarini, US EPA, RTP, NC and Douglas Bell, NIEHS, RTP, NC;
Speakers: David
M. DeMarini (Introduction); Thomas Cebula, RS FDA, Washington, DC (Rapid molecular screening of
Salmonella
typhimurium histidine revertants); Ken R. Tindall, NIEHS, RTP, NC (Rapid localization of point mutations in PCR-products
facilitates the generation of mutational spectra); Veronica M. Maher, Michigan State Univ (Use of PCR amplification of cDNA
to analyze mutations in the HPRT gene and strain-specific repair in diploid human cells); Andrew J. Grosovsky, Univ of
California at Riverside (Use of PCR to characterize loss of heterozygosity in APRT-/- mutants of CHO cells); Neil F.
Cariello, Univ of NC, Chapel Hill, NC (Analysis of mutations using PCR and denaturing gradient gel
electrophoresis) |
Workshop II:
Micronuclei as an Index of Cytogenetic Damage: Past, Present and
Future
(Title of presentation) |
Presiding: James MacGregor, SRI International; and John Heddle, York Univ, Toronto;
Speakers: The
Past: John Heddle (An overview of micronuclei as an indicator of cytogenetic damage);
The Present:
Guidlines and protocols for mammalian erythrocyte assays; Speakers: USA/CANADA Michael C. Cimino, US EPA, Washington (New
micronucleus guidelines for the US EPA);
EUROPE: Phillipe van Parys, Janssen Pharmaceutica, Beerse, Belgium (EEC and
OECD guidelines mutagenicity testing: The micronucleus test);
JAPAN: Makoto Hyashi, National Institute of Hygienic
Sciences, Tokyo; Michael D. Shelby, NIEHS, RTP, NC (A comparison of test results from three
in vivo cytogenetic
assays); The Future: Speakers:
James MacGregor (Integration of micronucleus assays with routine toxicology
tests); Makoto Hayashi (Automation of micronucleus assay by image analysis and flow cytometry); Felix Romagna, Sandoz
Pharma Ltd, Basle, Switzerland (Rodent erythrocyte micronucleus assays - methodological improvements and automation by image
analysis); James Tucker, Lawrence Livermore National Lab (The use of molecular probes to characterize the contents of
micronuclei) |
Workshop III:
New Molecular Techniques in Genome Analysis, Part B, Molecular Analysis of
Large-Scale Genomic Lesions
(Title of presentation) |
Presiding: James C. Fuscoe, Environmental Health Research and Testing, RTP, NC, and John Hozier, Florida
Institute of Technology, Melbourne, Florida; Speakers: John Hozier (Introduction); Brigitte Brandriff, Lawrence
Livermore Natl Lab (DNA sequence mapping using fluorescence
in situ hybridization); Lisa Davis, Applied Genetics
Lab, Melbourne, FL (Molecular analysis of chromosomal rearrangements using pulsed field gel electrophoresis and somatic cell
hybrids); Jan Nicklas, Univ of Vermont (Analysis of human HPRT deletion mutations with X-linked probes and pulsed field gel
electrophoresis); Richard Gibbs, Baylor College of Medicine, Houston, TX (Multiplex PCR and direct fluorescence automated
DNA sequence analysis of human HPRT mutations); James C. Fuscoe (Molecular analysis of
in vivo HPRT deletion
mutations in human cells: PCR and DNA sequencing) |
Workshop IV:
Existing Methods and Emerging Technologies for Assessing Gene Mutation
In
Vivo
(Title of presentation) |
Presiding: Albert P. Li, Monsanto Agricultural Co., St. Louis, MO and Robert A. LeBoeuf, The Proctor and
Gamble Co., Cincinnati, OH; Speakers: Albert P. Li (Introduction: Existing methods); Liane B. Russell, ORNL, Oak
Ridge, TN (In vivo germ cell mutation assays); Susan Lewis, Research Triangle Institute, RTP (The biochemical specific
locus test and a new multiple-endpoint system for measuring germinal mutations in mice); Karin S. Bentley, E.I. du Pont de
Nemours and Co., Newark, DE (Mutagenicity risk assessment with alternative methods); Robert A. LeBoeuf (Introduction:
New technologies); Brian Myhr, Hazleton Washington, Kensington, MD (Validation studies with Muta™-Mouse-A transgenic
mouse model for detecting mutations in vivo); Jay Short, Stratagene Inc., La Jolla, CA (Analysis of spontaneous and induced
mutations in transgenic mice: Using a lambda ZAP/lac I shuttle vector); Raymond W. Tennant, NIEHS, RTP (A perspective on
measurement of mutations in vivo); Sponsor: American Industrial Health Council |
Symposium 1:
(Title of presentation) |
Genetic Basis of Cancer Induction;
Presiding: Curtis C. Harris, NCI, Bethesda, MD;
Speakers:
Curtis C. Harris (Oncogenes and tumor suppressor genes involved in human varcinogenesis); Webster K. Cavenee, Ludwig
Institute of Cancer Research, Montreal, Quebec, Canada (Molecular henetics of human cancer predisposition and progression);
Tom Curran, Roche Research Center, Nutley, NJ (Fos and jun: Oncogenic transcription factors); Channing Der, La Jolla Cancer
Research Foundation, La Jolla, California (The ras oncogenes and human carcinogenesis) |
Symposium 2:
Antimutagenesis and Anticarcinogenesis
(Title of
presentation) |
Presiding: Philip E. Hartman, The Johns Hopkins Univ Baltimore, and Delbert M. Shankel, Univ of Kansas,
Lawrence, KS; Speakers: Delbert M. Shankel (Introduction); Philip E. Hartman (Chemical interception of mutagens
and carcinogens); Herman E. Brockman, Illinois State Univ, Norman, IL (Antimutagenicity profiles); Paul Talalay, The
Johns Hopkins Univ Baltimore (Regulation of enzymes that detoxify electrophilic carcinogens); Winfred F. Malone, NCI
(Chemoprevention: Clinical trials);
Sponsor: SRI International |
Symposium 3:
Recombination: Mechanisms, Detection and Significance
(Title of
presentation) |
Presiding: Michael A. Resnick, NIEHS, RTP, and Friedrick E. Wügler, Swiss Federal Institute of
Technology and Univ of Zürich Schwartzenback, Switzerland; Speakers: Friedrick E. Wügler (Importance of
recombination in chemically induced genotoxic effects); Michael A. Resnick, (Rules and signals in recombinational
repair); R. Michael Liskay, Yale School of Medicine, New Haven, CT (Homologous recombination in mammalian chromosomes);
John Wilson, Baylor College of Medicine (Gene targeting in mammalian cells);
Sponsor: DuPont |
Symposium 4:
Genetic Susceptibility to Disease
(Title of presentation) |
Presiding: John Mulvihill, Univ of Pittsburgh, Pittsburgh;
Speakers: Barton Childs, The Johns
Hopkins Univ, Baltimore (Genetics and human disease: A unifying perspective); John Mulvihill (Clues to ecogenetics from
clinical observations); Frank J. Gonzalez, NCI, Bethesda, MD (Evolution and catalytic activities of human cytochromes P450
and their roles in promutagen and procarcinogen metabolism); Richard Setlow, Brookhaven Natl Lab, Upton, NY (A summary of
the cytotoxic responses to radiations and chemicals of fibroblast strains from normal individuals, irradiated individuals, and
individuals from cancer prone families);
Sponsor: Environmental Health Research and Testing, Inc. |
Poster Presentations:
201 Posters registered
(Number of posters per
subject matter) |
Session 1) Mutagenesis, Molecular Analysis, Mechanisms (32); Chemicals of Special Interest (18); Complex Mix,
Chemical Interactions (18) |
| Session 2) Structure Activity Relationships, Mutagenicity Information (16); Somatic and Germ Cell Mutagenesis
In Vivo (20); Human Monitoring (26);
Sponsor: R.J.R. Nabisco |
| Session 3) Prokaryotes (17); Non-Mammalian Eukaryotes (13); Cytogenetics, Genotoxicity (26); Mammalian Cell
Mutagenesis (15) |
Platform Presentations Session I
27 Short Talks
(Number of papers
per session title) |
DNA Damage/Repair Mechanisms (9);
Conveners: R.K. Elespuru and D.W. Matheson
|
| Mammalian Mutational Mechanisms (9);
Conveners: G.R. Mohn and M.M. Moore |
| Cytogenetic Methods (9); Conveners: S.M. Galloway and J.D. Tucker |
Platform Presentations Session II
24 Short Talks
(Number of papers
per session title) |
Prokaryotic Mutagenesis (4);
Conveners: F.H. Sobels and E. Zeiger |
| Mechanisms (4); Conveners: F.H. Sobels and E. Zeiger |
| Human Monitoring (4); Conveners: J.P. O'Neill and L.G. Littlefield |
| Cytogenetics (4); Conveners: J.P. O'Neill and L.G. Littlefield |
| Mammalian Genotoxicity Methods/Results (8);
Conveners: J.H. Carver and D.A. Casciano |
Platform Presentations Session III
18 Short Talks
(Number of papers
per session title) |
Complex Mixtures and Interactions (6);
Conveners: L.D. Claxton and M.F. Salamone |
| Mammalian Germ Cells (6); Conveners: J.W. Allen and G. Sega |
| Mammalian Cell Transformation (2);
Conveners: J.A.S. Allen and R.J. Langenbach |
| In Vivo Genotoxicity (4);
Conveners: J.A.S. Allen and R.J. Langenbach |
Platform Presentations Session IV
24 Short Talks
(Number of papers
per session title) |
Mammalian Cell Cytogenetics-Mechanisms (4);
Conveners: S. Wolff and J.M. Mason |
| Drosophila Mutagenesis (4);
Conveners: S. Wolff and J.M. Mason |
| Mammalian Cell Mechanisms (4);
Conveners: G.M. Adair and T.G. Rossman |
| Mammalian Cell Mutagenesis (4);
Conveners: G.M. Adair and T.G. Rossman |
| Human Monitoring II (8); Conveners: R.J. Albertini and P. Ostrosky-Wegman |
| Additional Activities/Features |
Reception: Co-Sponsored by: Hazleton Washington, and Microbiological Associates |
| Exhibitors Session: no host reception |
| Afternoon and evening free |
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|
23rd Annual Meeting
Reno, Nevada
March 15 - 19, 1992
(Sunday to Thursday) |
| Site |
John Ascuaga’s Nuggett Hotel |
| Administrative Officer |
Richard Guggolz |
Registration Fees
(on-site) |
Members $90/$115 Non-Members $100/$125 Student Members $30/$40 Student
Non-members $35/$45 Spouses $20/$25 |
| Program Committee |
James T. MacGregor, Chairman, Marilyn J. Aardema, Charles S. Aaron, George Douglas, Rosalie K. Elespuru,
James Felton, Philip C. Hanawalt, Jon C. Mirsalis, William F. Morgan, Toby G. Rossman, Martyn T. Smith, Raymond W. Tennant, Janice
Yager; Local Arrangements: Baldev Vig;
Program Organization: Edward Riccio, Colette Rudd, Richard Winegar, Erica
Ng |
| Approximate Number of Attendees |
440 |
| Approximate Size of EMS Membership |
1025 |
| Number of Student Travel Award Winners |
17 |
| Student Winners Who Became Regular Members |
Not yet determined |
| Keynote/Special Presentations: |
Mechanisms of Genetic Recombination;
Speaker: Stephen C. West, Imperial Cancer Research Fund, UK;
Sponsor: Warner-Lambert Company |
Kinetochore Protein and Centromere DNA: Role in Genesis of Aneuploidy and Expression of Primary Constriction;
Speaker: Baldev K. Vig, University of Nevada, Reno |
Understanding the Causes of Aging and Cancer;
Speaker: Bruce Ames, University of California,
Berkeley |
Workshop I:
Updated Worldwide Regulatory Guidelines for Genotoxicity Testing
(Title of presentation) |
Presiding: Marilyn Aardema, Proctor & Gamble, Cincinnati, OH;
Speakers: Marilyn Aardema
(Introduction); Angela Auletta, U.S. EPA, Washington, DC (U.S. EPA TSCA/FIFRA guidelines); Dan Benz, U.S. Food and
Drug Administration, Washington, DC FDA guidelines); George Douglas, Health and Welfare Canada, Ottawa, Canada (Canadian
guidelines); David Kirkland, Hazleton/Microtest, UK (European guidelines); Toshio Sofuni, National Institute of
Hygienic Sciences, Tokyo, Japan (Japanese guidelines); General Discussion;
Sponsor: The American Industrial
Health Council |
Workshop II:
New Methods in Genetic Toxicology
(Title of presentation) |
Presiding: James Felton, Lawrence Livermore National Laboratory, Livermore, CA and Jack Bishop, National
Institute of Environmental Health Science, RTP, NC; Speakers: James Felton (Introduction); Andrew Wyrobek, Lawrence
Livermore National Laboratory, Livermore, CA (Molecular detection of aneuploidy in sperm); Farid Chehab, University of
California, San Francisco, CA (New methods and applications to detect single base substitutions in human genetic disease);
Bruce Kovacs, University of Southern California, Los Angeles, CA (New technologies for detection of genetic instabilities);
Kenneth Turtletaub, Lawrence Livermore National Laboratory, Livermore, CA (Use of accelerator mass spectrometry for detection
of DNA adducts following low dose exposures); Marilyn Vine, University of North Carolina (The use of molecular methods in
human epidemiology studies); General Discussion;
Sponsor: Miles, Inc. Agriculture Division |
Workshop III:
Transgenic Animal Models for Detection of In Vivo Mutations
(Title of presentation) |
Presiding: Jon Mirsalis, SRI International;
Speakers: Jon Mirsalis (Introduction
); Jon
Mirsalis (Effects of cell proliferation, animal age, expression time, and dosing regimen on mutant frequency
); Brian C.
Myhr, Hazleton Laboratories, America, Kensington MD (Mutation, promotion, and cell proliferation in Muta™Mouse skin);
Jay M. Short, Stratagene Cloning Systems, La Jolla, CA (Genotoxicity testing utilizing
lacI transgenic mice); John
Ashby, ICI Central Toxicology Laboratory, UK (Initial experiences with the LacI and LacZ systems); Informal presentations
and discussion; Sponsor: Abbott Laboratories |
Workshop IV:
Experiences with Analysis of Human Health Effects from Radiation
Accidents>
(Title of presentation) |
Presiding: Ronald Jensen, University of California at San Francisco;
Speakers: Ronald Jensen
(Introduction); Paul Lohman, University of Leiden, The Netherlands (Accident in Goiania, Brazil); L. Gayle
Littlefield, Oak Ridge Associated Universities (Accident in Juarez, Mexico); Ronald Jensen (Accident in Chernobyl, The
Ukraine); Richard Albertini, University of Vermont (Necessity to establish storage banks of tissue samples from radiation
accident victims); Discussion |
Symposium I:
Human Genetics and Disease
(Title of presentation) |
Presiding: Rosalie Elespuru, FDA Center for Devices and Radiological Health;
Speakers: Rosalie
Elespuru (Introduction); Michael Dean, National Cancer Institute, Frederick, MD (New and old mutations in the cystic
fibrosis gene); Eric P. Hoffman, University of Pittsburgh School of Medicine, Pittsburgh, PA (Gene mutations in
Duchenne/Becker muscular dystrophy and hyperkalemic periodic paralysis); Judith G. Hall, University Hospital, Vancouver, B.C.
(Non-traditional inheritance ) |
Symposium II:
Mitosis: A Critical Event in the Life of a Cell
(Title of
presentation) |
Presiding: Robert T. Schimke, Stanford University;
Speakers: Robert T. Schimke
(Introduction); Andrew Murray, University of California, San Francisco (Regulating the exit from mitosis); Ted
Weinhart, University of Arizona (Cell cycle controls responsive to DNA replication and DNA damage); Steven Sherwood,
Stanford University (Mitotic controls and the mechanisms of drug toxicity in mammalian cells); Discussion;
Sponsors:
E.I. Du Pont de Nemours & Company, and The Proctor & Gamble Company |
Symposium III:
DNA Repair Mechanisms in Human Cells
(Title of
presentation) |
Presiding: Philip C. Hanawalt, Stanford University;
Speakers: Philip C. Hanawalt
(Introduction); Philip C. Hanawalt (Cellular responses to genetic damage: An overview); Jan Hoeijmakers, Erasmus
University, The Netherlands (Genes controlling DNA repair processes in mammalian cells
); Veronica Maher, Michigan State
University (Effect of repair on the spectrum of mutations induced in the HPRT gene of diploid human fibroblasts by
carcinogens); Albert Fornace, Jr., National Cancer Institute (DNA damage-inducible genes in mammalian cells: Overlap with
growth-arrest genes) |
Alexander Hollaender Symposium:
Assessment of Genetic Risk from Human Exposure to
Environmental Chemicals
(Title of presentation) |
Presiding: Frederick de Serres, Research Triangle Park, NC;
Speakers: Frederick de Serres
(Introduction); James F. Crow, University of Wisconsin (Historical approaches to human mutagenic risk assessment);
Frederick de Serres (Genetic specificity and its implications for risk assessment); Mortimer L. Mendelsohn, Lawrence
Livermore National Laboratory (Measurement of mutations in somatic and germ cells in human populations);
Sponsor:
Chevron Research and Technology Co. |
Poster Presentations:
219 Posters registered
(Number of posters per
subject matter) |
Session 1) Chairs: J.S. Allen and L.D. Claxton; Prokaryotic Mutagenesis (31), Non-Mammalian Eukaryotes
(15), Cytogenetics (37); Sponsor: Merck Sharpe & Dohme Research Laboratories) |
| Session 2) Chairs: I.M. Jones and C. Rudd; Mammalian Cells
In Vitro - Mechanisms (21), Mammalian
Germ Cells (6), Human Monitoring (7), Mammalian Cells In Vitro - Testing and Test Methods (18), Complex Mixtures (12), Test
Batteries (13); Sponsor: R.W. Johnson Pharmaceutical Institute |
| Session 3) Chairs: T.A. Cebula and T-M. Ong; DNA Damage and Repair (21), Unscheduled DNA Synthesis (4),
Transformation (9), Metabolism (6), Molecular Methodology (4), In Vivo Mammalian Mutagenesis (14);
Sponsor: Merck
Sharpe & Dohme Research Laboratories |
Platform Presentations Session 1
19 Short Talks
(Number of papers
per session title) |
Prokaryotic Mutagenesis (9);
Conveners: D.M. DeMarini and E.T. Snow |
| DNA Damage/Repair Mechanisms (10);
Conveners: V.M. Maher and R.A. Winegar;
Sponsor: American
Cyanamid Agricultural Research Division |
Platform Presentations Session II
18 Short Talks
(Number of papers
per session title) |
Mutational Spectra (9); Conveners: C.A.H. Bigger and J. Mason |
| Human Monitoring Risk Assessment Genetic Mechanism (9);
Conveners: W.L. Bigbee and M.M. Moore;
Sponsor: Environmental Health Research and Testing Inc. |
Platform Presentations Session III
19 Short Talks
(Number of
papers per session title) |
Cytogenetics (9); Conveners: G. Erexson and L.G. Littlefield;
Sponsor: Eli Lilly
Company |
| In Vivo Genotoxicity (4);
Conveners: S. Provost and P. Ostrosky-Wegman;
Sponsor: American
Cyanamid Co. - Medical Research Division |
| Additional Activities/Features |
Reception: Sponsors: Hazleton Washington, and Microbiological Associates |
| National Auto Museum tour and dinner,
Speaker: Bruce Ames |
| Exhibitors workshops, Stratagene: The Big Blue™ transgenic system: A simple technique for
in
vivo mutagenesis testing; Microbiological Associates: New methods for
in vitro technology; Hazleton: Guidelines for
in vivo mutagenic assays using Muta™Mouse; Spiral System Instruments: Spiral Systems User’s Workshop |
| Exhibitors Session: no host reception |
| Meeting five full days, equivalent of almost 6, started 8:30 AM Sunday morning with Workshops and ended
Thursday 5:00 PM |
| Afternoon free; tour to Virginia City |
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|
24th Annual
Meeting Norfolk, Virginia
April 17 - 22,
1993 (Saturday to Thursday) |
| Site |
Waterside Marriott Hotel |
| Administrative Officer |
Richard A. Guggolz |
Registration Fees
(on-site) |
Members $125 Non-Members $135 Student Members $40 Student Non-members
$45 Spouses $25 |
| Program Committee |
Philip Hanawalt, Chairman, Raghbir Athwal, Byron Butterworth, Tom Cebula, Eugene L. Elmore, James M.
Gentile, Jessie Levine, Patricia Ostrosky-Wegman, Toby G. Rossman, Colette Rudd, David Sedwick, Elizabeth Snow,
Larry Thompson |
| Program Organizers |
Colette Rudd, Larry Thompson, Richard Winegar, Allen Smith, David Koehler, Brian Donahue;
Local
Arrangements: Chris Osgood |
| Approximate Number of Attendees |
|
| Approximate Size of EMS Membership |
1050 |
| Student Award Winners Still with Society |
Not Known |
Keynote/Special Presentation:
|
Linking Basic Research to Public Health Issues;
Speaker: Kenneth Olden, Director of NIEHS;
Sponsor: Environmental Health Research and Testing, Inc. |
Biological Consequences of Oxidative DNA Damage;
Speaker: Susan C. Wallace, Univ of Vermont, Burlington,
VT; Sponsor: The Upjohn Company |
Sequence Polymorphism, Recombination and the Structure of Eukaryotic Chromosomes;
Speaker: Miroslav
Radman, Institut Jacques Monod CNRS, Universite Paris, France; Sponsor: Merck Research Lab |
Workshop I:
Mutational Spectrometry
(Title of presentation) |
Presiding: William G. Thilly, MIT, Cambridge, MA;
Speakers: W.G. Thilly (Definition of a
mutational spectrum); T. Spodex, Univ of NC, Chapel Hill, NC (Comparison of mutational spectra in humans and human
cells); N.F. Cariello, Univ of NC, Chapel Hill, NC (Human HPRT mutant database: Software for information retrieval and data
analysis); F. Hutchinson, Yale Univ, New Haven, CT (Mutational spectra: Development of a data base) |
Workshop II:
Transgenic Models for Cancer
(Title of presentation) |
Presiding: Larry H. Thompson, Lawrence Livermore National Lab, Livermore, CA;
Speakers: Larry
Thompson (Introduction); S.L. Gerson, Univ Hospital of Cleveland & Case Western Res. Univ, Cleveland, OH (Protection
from thymine lymphoma by the transgenic expression of the human 06 alkylguaninie-DNA alkyltransferase MGMT: Elucidation of the
role of DNA repair in carcinogenesis and oncogene activation); A.M. Boulet, Univ of Utah, Salt Lake City, UT (Methods of
gene replacement in mice); L.A. Donehower, Baylor College of Medicine, Houston, TX (Spontaneous and carcinogen-induced
tumorigenesis in p53-deficient mice); J. Lee, Mt Sinai Hospital, Toronto, Canada and Univ of Toronto, Toronto, Canada
(Transgenic mice expressing mutant alleles of p53 show increased resistance to gamma-radiation) |
Workshop III:
Population Heterogeneity in the Human Genotoxic Response
(Title of
presentation) |
Presiding: Lawrence Grossman, Johns Hopkins Univ, Baltimore, MD;
Speakers: L. Grossman (DNA
repair, aging and sex in basal cell carcinoma: A molecular epidemiology study); D.E. Brash, Yale School of Medicine, New
Haven, CT (Sunlight-induced mutations in human skin cancer); R.J. Albertini, Univ of Vermont, Burlington, VT (Somatic
mutations in humans: Clonal and individual differences); J. Cole, Univ of Sussex, Brighton, UK (HPRT mutant frequency in
circulating T-lymphocytes in normal and at risk groups in the human population) |
Workshop IV:
Methods for Studying PAH_DNA Interactions
(Title of
presentation) |
Presiding: William M. Baird, Purdue Univ, W. Lafayette, IN;
Speakers: W. Baird
(Introduction); D.H. Phillips, Inst of Cancer Res, Sutton, UK (Analysis of PAH-DNA adducts); E. Cavalieri, Univ of
Nebraska Med Center, Omaha, NE (Identification and quantitation of aromatic hydrocarbon - DNA depurination adducts formed
in vitro and
in vivo); R. Santella, Columbia Univ, NY, NY (Immunologic methods for quantitation of aromatic
hydrocarbon-DNA adducts); A. Dipple, NCI-R&D Center, Frederick, MD (Sequence specificity of PAH diol epoxide reactions
with DNA) |
Symposium I:
Global Responses to Genotoxic Stress
(Title of
presentation) |
Presiding: Toby G. Rossman, NYU Medical Center, Tuxedo, NY;
Speakers: Toby Rossman
(Introduction); T.D. Tlsty, Lineberger Comp, Cancer Research Center, Univ of NC, Chapel Hill, NC (Genetic regulation of
genomic fluidity in normal and neoplastic cells); M.B. Kastan, Johns Hopkins Hospital, Baltimore, MD (A cellular response
pathway to irradiation involved P53, GADD45 and the AT gene products); H.J. Rahmsdorf, A. Radler-Pohl, C. Sachsenmaier, P.
Herrlich, Kernforschungszentrum Karlsrube Institut für Genetik und Toxikologie, Karlsruhe, Germany (Common routes in DNA
damage and growth factor induced gene transcription); Z. Ronai, S.E. Rutberg and Y.M. Yang, American Health Fdn, Valhalla, NY
(Characterization of a UV-responsive element: From rat fibroblast to human melanomas) |
Symposium II:
DNA Damage Recognition
(Title of presentation) |
Presiding: Bennett van Houten, Univ of Vermont, Burlington, VT;
Speakers: A.P. Grollman, SUNY,
Stony Brook, NY (Mutagenic specificity and repair of 8-oxyguanine); R.S. Lloyd, R.D. Schrock III, M.L. Augustine, and M.L.
Dodson, Univ of Texas, Galveston, TX, and Univ of Calif at San Francisco, CA (Mechanism of endonuclease V - mediated incision
dimer sites - identification of the active residue); B. van Houton and A. Snowden, Univ of Vermont, Burlington, VT (E. coli
UvrABC nuclease system: A recognition enzyme with broad specificity); L. Grossman, Johns Hopkins Univ, Baltimore
(Nucleotide excision repair: A study in vectorial movement); M. Protic, M. McLenigan and A.S. Levine, NIH, Bethesda, MD
(Regulation of mammalian DNA damage-binding proteins by DNA insult) |
Symposium III:
How DNA Polymerases Behave at Lesion
(Title of
presentation) |
Presiding: Thomas A. Kunkel, NIEHS, RTP, NC;
Speakers: T.A. Kunkel, D.C. Thomas, D.T. Minnick,
NIEHS (Replication of UV-irradiated, double-stranded DNA
in vitro); H.Cai, L.B. Bloom and M.F. Goodman, USC (Nucleotide
insertion and extension at site-directed abasic template lesions: Effects of sequence context); C. Wang, L. Kroutil and J-S.
Taylor, Washington Univ, St Louis, MO (Photoproduct-induced frameshift and substitution mutations); P.E.M. Gibbs, M.J.
Horsfall, A. Borden, B.J. Kilbey and C.W. Lawrence, Univ of Rochester, Rochester, NY and Univ of Edinburgh, Scotland
(Mutagenic properties of UV-photoproducts in
E. coli and yeast); R.P.P. Fuchs and X. Veante, UPR Cancerogenese,
IBMC, CNRS, Strasbourg, France (Carcinogen-induced mutagenesis and replication asymmetry) |
Symposium IV:
Female Germ Cell Development and Toxicology
(Title of
presentation) |
Presiding: Jack B. Bishop and Richard J. Tasca;
Speakers: Jack B. Bishop, NIEHS, RTP, NC
(Introduction); C. Wylie, Wellcome/CRC Institute, Cambridge, UK (Migration and proliferation of primordial germ
cells); D. Albertini, Tufts Medicine School, Boston, MA (Meiosis in female germ cells: The somatic cell connection);
A.N. Hirshfield, Univ of MD, Baltimore, MD (Folliculogenesis); W.M. Generoso, ORNL, Oak Ridge, TN (Periods of
susceptibility to mutagenic insult in female mice) |
Minisymposia
/Discussion Sessions |
Fine Structure of DNA Repair (Poster numbers 27-47);
Discussion Leaders: Veronica Maher and Allen Smith;
Sponsor: Arthur D. Little |
| Germ Line and Embryonic Systems (Poster numbers 48-62);
Discussion Leaders: Jim Allen and Susan
Lewis |
| Transgenic Models for Mutagenesis (Poster numbers 63-69);
Discussion Leaders: Nancy Gorelick and John
Mirsalis; Sponsor: Pharmakon Research International, Inc. |
Poster Sessions
269 Posters pre-registered
(Number of posters per
topic) |
Session 1): Chairmen: D.M. DeMarini and R. Elespuru; Mutational Spectra (14), Metabolism of xenobiotics
(10), Mutagenic mechanisms: Structure-activity (8), Micronucleus assay (22), Mammalian cell test systems (12), Animal models:
Testing strategies (9), Human studies: Risk assessment (8); Sponsor: Sandoz Agro Inc. |
| Session 2): Chairmen: M. Liechty and R. Winegar; Mutagenic mechanisms: Molecular analysis (22),
Non-mammalian test systems (12), Testing strategies (8), DNA damage and repair (13), Cytogenetics (12), Cellular Transformation
and tumorigenesis (7), Complex mixtures (13); Sponsor: R.W. Johnson-Pharmaceutical Research Inc. |
| Session 3): Chairmen: K. Sweder and R. Young; Replication fidelity and translesion synthesis (13), DNA
repair genes and enzymes (13), Fine structure of DNA repair (21), Germline and embryonic systems (15), Transgenic models for
mutagenesis (7) Sponsor: Schering Plough Research Institute |
| Special Poster/Discussion |
Human Mutation and the Cancer Death Rate;
Convener: William G. Thilly, MIT, Cambridge, MA, (The
poster/discussion spanned all poster sessions) |
Platform Presentations Session 2
19 Short Talks
(Number of papers per
session title) |
DNA repair genes and deficiency syndromes (10);
Conveners: G. Adair and J. Schwartz;
Sponsor:
Boehringer Ingelheim |
| Transgenic mutation testing systems (9);
Conveners: N. Gorelick and J. Monoforte;
Sponsor:
Miles, Inc. |
Platform Presentations Session 2
30 Short Talks
(Number of papers per
session title) |
Molecular analysis of mutations (10);
Conveners: M. Moore and M. Veigl |
| Human studies (10); Conveners: D. Bell and J. Tucker;
Sponsor: BASF Corp |
| Cytogenetics (10); Conveners: C. Bean and G. Littlefield |
| Rapporteur Sessions |
Highlights form the ICEM and associated satellite meetings |
| Progress on International Harmonization of genotoxicity test procedures;
Presenters: Marilyn Aardema and
Michael Shelby |
| Additional Events/Features |
Get-Acquainted Mixer for students and post-doctorates;
Sponsor: Hoffmann-LaRoche,
Inc. |
| Exhibitors Session: no host reception |
| Student no host reception |
| Exhibits: List and schedule in a separate program brochure |
| Reception: Co-sponsored by Hazleton Washington, and Microbiological Associates |
| Exhibitors Workshops: two sessions, no sponsor specified |
| Free Afternoon and Evening (Wednesday), planned cruises |
| Free Evening (Tuesday) |
| Meeting five full days; starting 8:30 AM Sunday, ending 5:00 PM Thursday |
| Separate program brochure provides lists and maps for local attractions and
exhibits |
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|
25th Annual Meeting
Portland, Oregon
May 7 - 12, 1994
(Saturday to Thursday) |
| Site |
Marriott Hotel and Convention Center |
| Administrative Officer |
Richard Guggolz |
Registration Fees
(on-site) |
Members $225 Non-members $250 Student Members $60 Student Non-members
$70 Spouses $60 |
| Program Committee |
James Gentile Chairman, Marilyn Aardema, Sid Aaron, Thomas Cebula, David DeMarini, Rosalie Elespuru,
James Felton, Sheila Galloway, Glenda Gentile, George Hoffman, Gerald Holmquist, Carl Kelsey, William R. Lee, Veronica Maher, Ken
Tindall |
| Approximate Number of Attendees |
501 |
| Approximate Size of EMS Membership |
1060 |
| Number of Student Travel Award Winners |
20 |
| Student Winners Who Became Regular Members |
Not yet determined |
| Keynote/Special Presentations: |
Mutations and Cancer; Presiding: Philip Hanawalt, Stanford University;
Speaker: Lawrence A.
Loeb, University of Washington, Seattle; Sponsor: The Upjohn Co. |
Polymerase Chain Reaction Strategies;
Presiding: Paul Lohman, Leiden University;
Speaker: Norman
Arnheim, University of Southern California; Sponsor: Hoffmann-La Roche, Inc. |
DNA Polymerase Structure-Function Studies: Implications for Mutagenesis in Human Disease;
Presiding: Sheila
Galloway; Speaker: Thomas Kunkel, NIEHS;
Sponsor: Merck Research Laboratories |
Workshop I:
Career Development
(Title of presentation) |
Presiding: George Hoffman, The College of the Holy Cross and William Morgan, University of California,
San Francisco; Speakers: J. Preston, CIIT and M. Lippert (Graduate education); W. Morgan, UCSF and A. Abu-Shakra,
USEPA (Postdoctoral positions and fellowships); H. Brockman, Illinois State University and G. Hoffman (Opportunities in
academic institutions); S. Galloway, Merck Research Laboratories (Opportunities in industry); M. Waters, USEPA
(Opportunities in government);
Sponsor: FMC Corporation |
Workshop II:
Update on Mutation Assays in Transgenic Mice
(Title of
presentation) |
Presiding: Nancy Gorelick, Procter & Gamble Co., and Barry Glickman, University of Victoria;
Speakers: N. Gorelick (Overview of mutation assays in transgenic mice for routine testing); W. Piegorsch, University
of South Carolina (Sources of variability in mutation assays in transgenic mice: Implications for study design); B.
Glickman, University of Victoria (Assembling and assessing sequence data for lacI mutations in Big Blue™); J. Gossen,
Beth Israel Hospital (Application of lacZ plasmid-based transgenic mice in mutagenicity studies);
Sponsor:
American Industrial Health Council |
Workshop III:
In Vivo Cytogenetics
(Title of presentation) |
Presiding: Marilyn Aardema, Procter & Gamble Co.;
Speakers: M.D. Shelby, NIEHS (Do
in
vivo micronucleus and aberration results agree?); J. Mackay, ZENECA (Appropriate methods for dose); J. MacGregor, SRI
International (Combination of cytogenetic analyses with other tests); F. Angelosanto, Mobil Oil, Co. (Tissues other than
bone marrow that can be used for cytogenetic analysis); Discussion;
Sponsor: American Industrial Health
Council |
Workshop IV:
Germ Cell Risk Assessment
(Title of presentation) |
Presiding: William R. Lee, LSU; Speakers: W.R. Lee (Status of germ line mutagenesis); K.
Turtletaub, Lawrence Livermore National Lab (Molecular dosimetry of germ line adducts); J. Drost, LSU (Comparison of
germ cell development among Drosophila, mice and humans); R. Albertini, University of Vermont (Comparison of molecular \
mutational spectra for heritable and somatic mutations at three loci: HPRT, P53 and RB); H. Mohrenweiser, Lawrence Livermore
National Lab (Complexity of studying germ line mutation in humans) |
Workshop V:
Use of Cell Transformation Systems to Analyze Human and Animal Cell
Carcinogens
(Title of presentation) |
Presiding: J. Justin McCormick, Michigan State University;
Speakers: R. LeBoeuf, The Procter
& Gamble Co. (Cell transformation in Syrian hamster embryo cells: A useful method for assessing the carcinogenic potential
of chemicals); J. McCormick (Neoplastic transformation of human fibroblasts: A multistep process with individual steps that
can be quantitated); P. Boukamp, German Cancer Research Center (Molecular mechanisms involved in the multistep process of skin
carcinogenesis: HaCaT, an in vitro model); C. Reznikoff, University of Wisconsin-Madison (HPV16 E6, but not E7, confers
a chromosome mutator phenotype on human epithelial cells);
Sponsor: The Procter & Gamble Co. |
Symposium:
Molecular Genetic Toxicology
(Title of presentation) |
Presiding: David DeMarini, US EPA;
Speakers: W. Koch, FDA (Mutational events at
Salmonella
typhimurium base-substitution alleles as predictors of eukaryotic mutational specificity); D. DeMarini (Molecular
analysis of mutations detected at the frameshift allele hisD3052 of Salmonella typhimurium); K. Tindall, NIEHS
(Molecular analysis of mutations detected at the gpt locus in AS52 cells); M. Moore (Molecular analysis of the mutations
detected at the tk locus of L5178Y mouse lymphoma cells); A. Grosovsky, University of California, Riverside (Comparative
analysis of mutational mechanism at the tk, HPRT and APRT loci in human lymphoblastiod cell lines);
Sponsor:
Bristol-Myers Squibb Co. |
Symposium:
Directed Mutagenesis
(Title of presentation) |
Presiding: Thomas Cebula, FDA; Speakers: Thomas Cebula (Introduction); J. Cairnes,
Radcliffe Infirmary, UK (Antecedents and adaptive mutations); P. Foster, Boston University School of Medicine (Adaptive
mutation in E. coli); M. Prival, FDA (Effects of prolonged starvation on mutation spectra); J. Roth, University of Utah
(Could duplications explain selection-induced mutations?); F. Stahl, University of Oregon (Summary and comments);
Sponsor: Elsevier Science Publishers |
Symposium:
Sequence Specific DNA Damage
(Title of presentation) |
Presiding: Veronica Maher, Michigan State University
Speakers: Veronica Maher (Introductory
remarks); B. Glickman, University of Victoria (New approaches to studying damage distribution in DNA); B. van Houten,
University of Texas Medical Branch (Use of reiterative primer extension methodology to map UV-induced photoproducts at the
nucleotide level in the lacI gene from genomic DNA); S. Kunala, Yale University (Excision repair of cyclobutane pyrimidine
dimers at individual bases of E. coli genes); G.P. Pfeifer, City of Hope (slow repair of pyrimidine dimers at P53
mutation hot spots in skin cancer); G. Holmquist, City of Hope (Repair rate maps of cyclopyrimidine dimers along the human
pgk-1 gene); V. Maher, Michigan State University (Use of LM-PCR to determine the relationship between adducts and mutations
induced by BPDE in specific sequences in the human HPRT gene) |
Alexander Hollaender Symposium:
Molecular Genetic Toxicology
(Title of
presentation) |
Presiding: John Ashby, ZENECA;
Speakers: John Ashby (Introduction and overview); D.
Davies, Royal Postgraduate Medical School (Individual variability in response to drugs: The role of metabolic
polymorphisms); K. Hemminki, Karolinska Institute (Genetic variability in human surveillance studies); G. Cortopassi,
University of Southern California (Individual variations in bci-2 mutations among smokers); V. Garry, University of
Minnesota (Individual response of humans to the genomic challenges of some pesticides);
Sponsor: Sterling
Winthrop |
Minisymposium
|
Sensitive Methods for Detection and Mapping of DNA Lesions and Mutations;
Presiding: Gerry Holmquist,
City of Hope, and Barry Glickman, University of Victoria; Sponsor: American Cyanamid Co. |
| Diet, Mutagens and Antimutagens;
Presiding: Lynn Ferguson, University of Auckland and James Felton,
Lawrence Livermore National Lab; Sponsor: BASF Wyandotte Co. |
| Radiation, Chemicals and the Definition of Mutation;
Presiding: Charles Waldren, Colorado State
University and James Tucker, Lawrence Livermore National Lab; Sponsor: R.W. Johnson Pharmaceutical Institute |
Poster Presentations:
214 Posters registered
(Number of posters per
subject matter) |
Session 1) Mechanism of Mutagenesis/Carcinogens (56), Germ Line Studies (8), Human Studies/Risk Assessment
(14) |
| Session 2) Cytogenetics (25), Mammalian Cells
In Vitro (18), Prokaryotes and Non-Mammalian Eukaryotes
(13), Animal Models (24) |
| Session 3) Testing and Test Strategies (10), Metabolism of Xenobiotics (6), DNA Damage and Repair (26), Complex
Mixtures/Antimutagens (13) |
Platform Presentations Session I
54 Short Talks
(Number of papers
per session title) |
Biological Response to Mutagen Challenge/DNA Repair (12);
Conveners: Wai Nang Choy and David
Jacobson-Kram; Allied Signal, Inc. |
| Cytogenetics (14); Conveners: Gopala Krishna and Joginder Nath;
Glaxo Inc. |
| Molecular Mechanisms (14),
Conveners: Ursula Hennig and Toby Rossman;
Glaxo
Inc. |
| Germ Cell Damage/Human Studies (14);
Conveners: Jack Bishop and Alec Morley;
Environmental Health Research & Testing Inc. |
Platform Presentations Session II
23 Short Talks
(Number of papers
per session title) |
Mutational Spectra (7); Conveners: Larry Thompson and Malcolm Lippert |
| Cytogenetics (8); Conveners: Patricia Ostrosky-Wegman and Andrew Kligerman |
| Testing/Complex Mixtures (8);
Conveners: Hank Holden and Jay Means |
| Additional Activities/Features |
Reception: Co-Sponsored by: Hazleton Washington, and Microbiological Associates |
| Exhibitor's session; Applied Imaging, GenPharm, Hazleton Washington, Integrated Laboratory Systems,
Microbiological Associates, Microptics, Optomax, Pharmakon, SITEK, SRI International, Stratagene |
| Exhibitor’s workshops, Stratagene: New Development in Transgenic Mutagenesis Assays; Ingeny B V,
Leiden, The Netherlands: Use of LacZ transgenic mice for
in vivo mutation analysis |
| Afternoon free; organized optional trips; bus tour of Columbia River gorge; paddlewheel boat cruise of
Willamette River |
| Meeting six days, (five full days , plus a partial sixth day), starting with a workshop at 7:00PM Saturday,
ending 6:00 PM Thursday |
| Twenty-fifth anniversary celebration, Oregon Museum of Science and Industry;
Coordinators: Rosalie
Elespuru and Julian Preston |
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|
26th Annual
Meeting St. Louis, Missouri
March 12 - 16,
1995 (Sunday to Thursday) |
| Site |
Union Station Hyatt Regency |
| Administrative Officer |
Richard A. Guggolz |
Registration Fees
(pre-registered / on-site) |
Members $250 NonMembers $300 Students $75 NonMember Students $100
Spouses $35 |
| Program Committee |
R. Tice, Chair, Beth Anderson, D. Blakey, D. DeMarini, D. Jacobson-Kram, L. Kier, M. Lippert, E. McGhee,
P. Ostrosky-Wegman, L. Recio, J. Schwartz, T. Skopek, J. Yager |
| Approximate Number of Attendees |
410 |
| Approximate Size of EMS Membership |
1110 |
| Student Award Winners Still with Society |
None Known |
| Keynote Presentations |
Colon Cancers: From Molecular Mechanisms to Medical Intervention;
Presiding: R. Tice;
Speaker:
John Burn, Univ Newcastle-upon-Tyne, UK |
| Biotechnology: Promise and Problems;
Presiding: Mary Esther Gaulden;
Speaker: Rita R. Colwell,
University Maryland Biotechnology Institute; Sponser: RJ Reynolds Tobacco Co. |
| Mouse Models for Birth Defects;
Presiding: Liane Russell;
Speaker: Lisa Stubbs, Oak Ridge National
Lab |
| Student and Young Investigators Reception and Workshop |
Presiding: George Hoffman, The College of the Holy Cross, and W. Morgan, University of California SF;
Sponsor: Eli Lilly & Company |
Workshop:
The Mouse Lymphoma Microwell Assay |
Presiding: D. Kirkland, Hazleton Europe, and Jane Cole, MRC Cell Mutation Unit;
Speakers: J.
Cole, J. Clements, T. Sofuni and H. Shimada, B. Elliot and R. San, J Aldridge;
Sponsor: Stonybrook Laboratories,
Inc. |
Workshop:
The Single Cell Gel/Comet Assay: Advances and Applications |
Presiding: R. Tice, Integrated Lab Systems, and N.P. Singh, University of Washington;
Speakers:
N.P. Singh, E. Rojas, B. Burlinson, P.S. Schmezer, D. Anderson, R.J. Sram, M.L. Petras, R.R. Tice, M. Browne |
Workshop:
Future Approaches to Genetic Toxicology: Risk Assessment |
Presiding: R. Elespuru, US FDA/CDRH;
Speakers: R. Elespuru, R.J. Preston, J.T. MacGregor, R.
Tennant |
Workshop:
Legal and Ethical Issues in Science: Genetic Testing |
Presiding: E. Zeiger, NIEHS, and John Burns, University Newcastle-upon-Tyne |
The Alexander Hollaender Symposium:
Developing Biologically Based Risk Assessments: A Case
Study of Arsenic |
Presiding: Janice W. Yager, Electric Power Research Institute;
Speakers: J.W. Yager, D.W. North,
D.J. Thompson, P. Ostrosky-Wegman, J.K. Wiencke, H. Clewell |
Symposium:
Evaluation and Risk Assessment: A View from Inside the Regulatory Agencies
Data |
Presiding: D. Jacobson-Kram, Microbiological Associates;
Participants: A. Auletta, R.D. Benz, A.
Bigger, K.L. Dearfield, G.R. Douglas, R.K. Elespuru, L. Muller, T. Sofuni;
Sponsor: The Procter & Gamble
Company |
Symposium:
The New Human Genetics |
Presiding: Susan Lewis, Research Triangle Institute, and Vicki Dellarco, US EPA;
Speakers: R.P.
Erickson, L. Biesecker, B.A. Finette, S Bronson |
Symposium:
Cell Cycle Controls, Check Points, & Cancer |
Presiding: K. Tindall, NIEHS and E. McGhee, UCSF;
Sponsor: Merck Research Lab;
Speakers:
E. McGhee, J.C. Reed, A.J. Fornace, R. Paules, D. Yandell |
Symposium:
The Origin of Oncogenic Mutations: Somatic Mutation Rates and Mutator
Phenotypes In Vivo |
Presiding: John A. Heddle, York University;
Speakers: J.C. Mirsalis, P Shaver-Walker, W.G.
Thilly; Sponsor: Glaxo Inc. |
Poster Sessions
170 Posters pre-registered
(Number of posters per
session title) |
Session 1): Molecular Studies/DNA Replication (6), Mammalian Cells
In Vitro (46), DNA Damage/Repair (7),
Prokaryotes and Nonmammalian Eukaryotes (9), Environmental studies (4), Human Studies (13) |
| Session 2): DNA Damage/Repair (9), Environmental Studies (18), Mammalian Cells
In Vitro (23),
Prokaryotes and Nonmammalian Eukaryotes (11), Computerized Systems (1) Animal Models (23) |
Platform Presentations
69 Short Talks
(Number of papers per session
title) |
DNA Repair and Inducible Processes (13);
Conveners: J. Schwartz and L. Snow |
| Human Monitoring (13); Conveners: Irene Jones and J. Ward Jr |
| In Vivo Somatic Germ Cell Studies (13);
Conveners: J.B. Bishop and N. Holland |
| DNA and Chromosomal Damage (10);
Conveners: L. Ferguson and G. Krishna |
| Molecular Mechanisms (10);
Conveners: Amal Abu-Shakra and J. Curry |
| Transgenic Studies/Tumor Models (12);
Conveners: Not specified |
(return to the top of this page)
|
27th Annual
Meeting Victoria, British Columbia
March 23 -
28, 1996 (Saturday to Thursday) |
| Site |
Victoria Conference Center |
| EMS Business Office |
Drohan; Randall Price and Ashleigh A. Dockery |
Registration Fees
(on-site) |
Members $275 Non-Members $325 Student Members $75 Student Non-members
$100 Spouses $50 |
| Program Committee |
Ray Tennant, Chairman, Beth Anderson, Veronica Anthony, Marilyn Aardema, Vicki Dellarco, Barry Glickman,
Nancy Gorelick, Graham Hook, Tom Kunkel, Gil Omenn Julian Preston, Robert Przygoda, Colette Rudd, Judson Spalding, Bill Suk,
William Thilly, Ray Tice, Ken Tindall, Roger Wiseman, Kristine Witt
|
| Approximate Number of Attendees |
475 |
| Approximate Size of EMS Membership |
1100 |
| Number of Student Travel Award Winners |
28 |
| Student Winners Who Became Regular Members |
Not Known |
| Keynote Presentation |
Collaborating Oncogenes: c-myc, p53, p21 and Beyond;
Speaker: Philip Leder, Harvard Medical School,
Boston, MA; Sponsor: CanTox Inc |
| Public Lecture |
All Carcinogens are Not Created Equal;
Speaker: Robert Haynes, York University, Toronto, Canada;
Sponsor: The Environmental Mutagen Society |
| Plenary Lectures |
Mutagenesis and a Base Excision Repair Deficiency in DNA Beta-Polymerase Null Mice;
Speaker: Samuel H.
Wilson, Univ of Texas Medical Branch |
| Genetic and Molecular Ecotoxicology;
Speaker: Susan Anderson, Lawrence Berkeley Lab;
Sponsor:
R.J.R.-Nabisco |
| Alexander Hollaender Lecture |
No presentation scheduled |
| Student Reception |
Career Development; Presiding: Eva McGhee, Univ of Calif, San Francisco; and Malcolm Lippert, Harvard
School of Public Health; Speakers: Paul K. Strudler, Scientific Reviewer Administrator, NIH |
Workshop I:
Naturally Occurring Mutagens/Carcinogens and their Relevance in Risk
Evalualtion
(Title of presentation)) |
Presiding: Robert Przygoda, Exxon Biomedical Sciences, Inc and Bhaskar Gollapudi, The Dow Chemical
Company; Speakers: Robert Przygoda, and Bhaskar Gollapudi, (Introduction); K. Sankaranarayanan, State Univ of
Leiden, Leiden (Risk estimations for background radiation-induced mutations/cancers and the lessons to chemical
mutagens/carcinogens); B.N. Ames, Univ of California at Berkeley (Oxidative stress); R.C. Gupta, Univ of Kentucky
(DNA-adducts derived from endogenous/natural sources); R.W.Estabrook, Univ of Texas;
Sponsors: American Industrial
Health Council |
Workshop II:
Transgenic Models in Mutagenesis and Carcinogenesis
(Title of
presentation) |
Presiding: Barry Glickman, Univ of Victoria and Nancy Gorelick, Proctor and Gamble Company; Kenneth
Tindall, NIEHS; Speakers: Barry Glickman, Nancy Gorelick, and Kenneth Tindall, (Review of the satellite conference on
transgenic animals in mutation research); Ronald Cannon, NIEHS (Molecular characterization of the v-Ha-ras transgene of
TG.AC mice); Larry Donehower, Baylor College of Medicine (Mutation rates and chromosomal instability during tumorigenesis
in p53 deficient mice); Glenn Merlino, NCI (Peptide growth factors and transgenic models of oncogenes);
Sponsors: Proctor and Gamble Company |
Workshop III:
Genotoxic and Mutagenic Effects of Radiofrequency Radiation: Discussion of
Possible Mechanisms of Action and Research Approaches
(Title of presentation) |
Presiding: Julian Preston, Chemical Industries Institute of Toxicology and Graham Hook, CanTox, Inc.;
Speakers: Julian Preston (Introduction); David Brusick, Corning Hazleton Labs (Part I: Review of available
literature); Joseph Roti, Washington Univ (Part II: Genotoxic and mutagenic effects of radiofrequency radiation: An
overview of a research approach); Luc Verschaeve, VITO (On the synergy between mobile telephone frequencies and chemical
mutagens); Narendra Singh, Univ of Washington (Recent advances in microgel electrophoresis in light of experiments
involving radiofrequency radiation); Maria Stuchly, Univ of Victoria (Wireless communication and safety of the
user) |
Workshop IV:
Science on the Internet |
Presiding: Barry Glickman, Univ of Victoria;
Sponsors: Elsevier Science
Publishers |
Workshop V:
Protocol Issues of the Microtiter Method of the Mouse Lymphoma
Assay
(Title of presentation) |
Presiding: Toshio Sofuni, National Institute of Health Sciences, Japan, and Lutz Müller, Federal
Institute for Drugs and Medical Devices, Germany; Speakers: Lutz Müller (Introduction); H. Shimada, Daiichi
Pharmaceutical Co Inc (Some type of mutagens only detected by continuous treatment in the microtiter method); P. Wilcox,
Glaxo Group Research Limited (Significance of duplicate cultures in the microtiter method); T. Sofuni (Cytogenetic
parameters appropriate for result evaluation);
General Discussion Panel: J. Cole, Univ of Sussex; D. Clive, Glaxo
Welcome, US; J. Clements, Corning Hazleton Ltd, R. San, Microbiological Associates; M.-C. Ouldelhkim, Rhone-Poulene Rorer; J.
MacKay, Zeneca |
Workshop VI:
The Single Cell Gel/Comet Assay: Protocol Issues and Update |
Presiding: Raymond Tice, Integrated Lab Systems, and Brian Burlinson, Glaxo Research and
Development |
Workshop VII:
New Techniques in Molecular Genetics
(Title of
presentation) |
Presiding: Colette Rudd, SRI;
Speakers: Colette Rudd
(Introduction); Gerald Holmquist,
Beckman Research Institute of the City of Hope (Absolute quantitation of ligation-mediated PCR signals); Christopher H.
Becker, Gene Trace and SRI International (Rapid genetic analysis by mass spectrometry); Mellisa Liechty, Applied Genetics
Lab (Molecular tools for identification and analysis of large DNA rearrangements);
Sponsors: Xenometrix,
Inc |
Workshop VIII:
Aneuploidy: Etiology, Mechanisms and Implications
(Title of
presentation) |
Presiding: Marilyn Aardema, The Proctor and Gamble Co, and Vicki Dellarco, EPA;
Speakers:
Marilyn Aardema (Introduction: Part I); R.J. Preston, Chemical Industry Institute of Toxicology
(Review of
Mechanisms); M. Kirsch-Volders, Belgium (Advances in testing somatic cells); Vicki Dellarco (Introduction: Part
II); Jack Bishop, NIEHS (NIEHS/EPA workshop on aneuploidy); M.J. Aardema; Silvio Albertini, F. Hoffman LaRoche; Peter
Arni, CIBA Geigy; Leigh Henderson, Unilever; Michelene Kirsch-Volders, Vrije Univ; James MacKay, Zeneca; Awni Sarrif, Dupont and
Rob Taalman, Shell (ECETOC aneuploidy task force recommendations);
Sponsors: The Proctor and Gamble Co |
Workshop IX:
The Ins and Outs of Getting Grant $upport
(Title of
presentation) |
Presiding: William Suk, NIEHS;
Speakers: Peter J. Stambrook, Univ of Cincinnati (Grant
Writing: The joys and frustrations of applying to the NIH); Edmond Copeland, NIH (What things do well in peer reviews: A
scientist review administrators's perspective); Craig Boriko, International Lead-Zinc Research Organization (An industry's
perspective on funding); William Suk (Grantsmanship 101: Navigating the bureaucracy);
Sponsors: EMS |
Symposium I:
Making Science Count in Risk Management Decisions
(Title of
presentation) |
Presiding: Gil Omenn, Univ of Washington, Seattle, WA;
Speakers: Gil Omenn (Findings and
recommendations from the presidential/congressional commission on risk assessment and risk management); Bernard Schwetz, FDA
(Science-based decisions within the FDA); Michael McClain, Hoffman-La Roche, Inc (The use of mechanistic information
for the regulation and classification of chemical carcinogens);
Sponsor: Pharmacia & Upjohn, Inc |
Symposium II:
DNA Repair and Environmental Mutagenesis
(Title of
presentation) |
Presiding: Thomas A. Kunkel, NIEHS;
Speakers: Thomas A. Kunkel (Introduction); Philip C.
Hanawalt, Stanford Univ (Role of transcription in the cellular response to DNA damage); Paul L. Modrich, Duke Univ Medical
Center (hMutLalpha and hMutSalpha function as heterodimers in humans mismatch repair); Leona D.
Samson, Harvard School of Public Health (Cellular responses to alkylating agents);
Sponsor: E.I. du Pont de Nemours &
Co |
Symposium III:
Mouse Genomics
(Title of presentation) |
Presiding: Roger Wiseman, NIEHS
Speakers: Roger Wiseman (Mouse models for human cancer);
Richard Woychik, ORNL (Utilizing mutations in the mouse to study gene function and disease); Amy Moser, Clinical Science
Center, Univ of Wisconsin at Madison (Tumorigenesis in mice carrying Min, a mutant allele of APC) |
Symposium IV:
Somatic Mutations in Humans
(Title of presentation) |
Presiding: William Thilly; MIT;
Speakers: William Thilly (Mutations in mitochondrial
genes); Alec Morley, Flinders Medical Center (Origin and nature of in vivo mutations); James Sherley, Fox Chase Cancer
Center (p53-dependent asymmetric cell division);
Sponsors: Briston-Meyers Squibb and Pharmaceutical Research
Institute |
Poster Sessions
200 Posters preregistered
(number of posters per
topic) |
Session 1): Environmental Studies (9), Molecular Studies (24),
In Vitro Models (28), Animal Models
(21), Human Studies (21) |
| Session 2): Environmental Studies (8), Germ Cell Studies (9), Molecular Studies (19),
In Vitro Models
(24), Human Studies (12), Animal Models (19), SAR/Data Base Analyses(6) |
Platform Presentations Session 1
33 Contributed papers
(number of
papers per session title) |
Genetic Toxicology (10); Conveners: Louise Lutz-Mann and Wolfgang Muster |
| Human Studies I (7); Conveners: Bill Bigbee and William Au |
| Germ Cell Studies (8); Conveners: Paul Selby and Chris Osgood |
| Cytogenetics (8); Conveners: Sheila Galloway and Channa Keshava
|
| Sponsors for seesion 1: Chevron Research and Technology Company |
Platform Presentations Session 2
45 Contributed papers
(number of
papers per session title) |
Molecular Studies I (11); Conveners: Toby Rossman and Maria Ariza |
| Animal Models (10); Conveners: Hiroshi Nashino and JoAnna Wilson |
| DNA Repair (12); Conveners: Marina Veigl and Fred Christians |
| Non-DNA Targets (5); Convener: Lynn Ferguson |
| Micronucleus Studies (7); Convener: Errol Zeiger |
| Sponsor for session 2: American Cyanamid Company |
Platform Presentations Session 3
29 Contributed papers
(number of
papers per session title) |
Molecular Studies II (10);
Conveners: Michael Carty and Rajiv Agarwal |
| Fluorescence in situ Hybridization (FISH) (9);
Conveners: Al McFee and Kirby Johnson |
| Environmental Studies (10);
Conveners: David Brusick and Wolfgang Kusser |
| Sponsor for session 3: American Cyanamid Company |
| Additional Activities/Programs |
Exhibits: Exhibitors: Applied Imaging Corp; Corning Hazleton Inc; Elsevier Science; EMS; Epicentre
Technologies; Integrated Lab Systems; Loats Associates; Microbiological Associates; Pharmakon Research International; SRI
International; Stratagene; Taconic; Xenometrics |
| Exhibitors Lunch Workshop 1: Not Necessarily for Transgenic Users Only: New Products for Gene-tox
Research; Stratagene |
| Exhibitors Lunch Workshop 2: Ames II Assay... Enhanced for High Thru-put Screening;
Xenometrics |
| One free afternoon and evening starting at 1:30 pm |
| Reception: Sponsors: Corning Hazleton, Inc and Microbiological Associates, Inc |
| Six day meeting; first day devoted to council and students; last day ended at
6:00PM |
(return to the top of this page)
|
28th Annual
Meeting Minneapolis, Minnesota
April 19 - 23,
1997 (Saturday to Thursday) |
| Site |
Hyatt Regency Hotel |
EMS Business Office
Administrative Officer |
Drohan; Randall Price and Maureen Thompson |
Registration Fees
(on-site) |
Members $315 Non-Members $375 Student Members $90 Student Non-members
$110 Spouses $75 |
| Program Committee |
Sid Aaron, Chairman, Marilyn Aardema, William Au, Tom Cebula, Vicki Dellarco, George Douglas,
Rosie Elespuru, Barry Glickman, Nancy Gorelick, Helena Groot, Judy Mayo, Eva McGhee, Lutz Müller A.T. Natarajan, Toby
Rossman, Len Schechtman, Tom Skopek, Elizabeth T. Snow, Toshio Sofuni, Ken Tindall, Jack von Borstal and Jonathan Ward
Jr. |
| Approximate Number of Attendees |
483 |
| Approximate Size of EMS Membership |
|
| Student Award Winners Still with Society |
Not Known |
Keynote/Special Presentation:
|
Mutability and Infectious Disease;
Speaker: Joshua Lederberg, Rockefeller Univ, New York, NY;
Sponsor: Merck Research Laboratories |
Public Lecture
|
The Search for Our Genes: Progress and Promise;
Presiding: R.J. Albertini;
Speaker: Anthony V.
Carrano, Lawrence Livermore National Lab |
| Plenary Lectures |
Spectrum of Spontaneous Frameshift Mutations in Humans: A Genomic Approach;
Speaker: Lynn Ripley, Dept
of Microbiology and Molecular Biology |
Multiplex FISH and the Analysis of Intracellular Point Mutations;
Speaker: David Ward, Dept of Genetics,
Yale Univ, New Haven, CT |
| Alexander Hollaender Lecture |
The Role of Mutators in Adaptive Evolution;
Presiding: Ken Tindall;
Speaker: Miroslav Radman,
Institut Jacques Monod, CNRS, Paris |
| Student Reception |
Career Development: Targeting Job Applications in Science;
Presiding: Eva McGhee, Univ of Calif, San
Francisco; and Malcolm Lippert, Harvard School of Public Health |
Workshop I:
Structure Activity Relationships: Genetic Toxicology and Government
Regulation
(Title of presentation) |
Presiding: Daniel Benz, US FDA/CFSAN;
Speakers: A. Richard, EPA/HERL (An introduction to and
overview of SAR); V. Gombar, HDI (Structure-based toxicity assessment: Rational guidelines for acceptance); H.
Rosenkranz, Univ of Pittsburgh and G. Klopman, Case Western Reserve Univ (Expert systems for predicting metabolism and
toxicity); N. Greene, LHASA, UK (DEREK a computer system for toxicity prediction); F. Henry, Columbia Cascade,
Inc.(An intelligent toxicology prediction system); R. Bohacek, Ariad Pharm. Inc. (Computer modeling studies of enzyme
interactions); P. Wagner, EPA/OPPT (Use of SAR in health and ecological hazard assessment at EPA); E. Matthews,
US FDA/CDER (FDA’s use of QSAR decision support information); D. Benz (General discussion: Is this methodology ready for
routine use in government regulatory decision making?);
Sponsors: Crysalis PreClinical Services-North
America |
Workshop II:
Sources, Effects, and Potential Hazards of Genotoxic Complex Mixtures in the
Environment
(Title of presentation) |
Presiding: David DeMarini, US EPA, Environmental Carcinogenesis Division and Paul White, US EPA,
Atlantic Ecology Division; Speakers: L.D. Claxton, US EPA, Environmental Carcinogenesis Division (Sources: Genotoxicity
of industrial wastes and effluents); P.A. White, US EPA (Sources: Genotoxicity of municicpal wates in surface waters);
U. Varanasi, National Marine Fisheries Services, National Oceanic and Atmospheric Admin (Effects: Genotoxic effects of mutagens
in fish); D.M. DeMarini (Effects: Mutation spectra of complex environmental mixtures); Carol L. Yauk, McMaster Univ,
Hamilton, ON, Canada (Hazards: Heritable mutations in birds in industrialized areas); M. Lynch, Univ of Oregon, Dept of
Biology (Hazards: Mutation accumulation and extinction of small populations); R. Schoeny, US EPA, National Center for
Environmental Assessment (Hazards: Risk Assessment of complex mixtures) |
Workshop III:
The Use of Mechanistic Data in Cancer Risk Assessment
(Title of
presentation) |
Presiding: Rosalie Elespuru, US EPA;
Speakers: V. Dellarco, US EPA (EPA’s 1996 proposed
revisions to guidelines for carcinogen risk assessment: Use of non-tumor data in cancer dose-response assessment); S. Hecht,
Univ of Minnesota (Human exposure assessment using carcinogen-derived biomarkers); R.J. Preston, CIIT (The use of
cytogenetic data for estimating low dose cancer responses); B.L. Pool-Zobel, German Federal Research Center for
Nutrition); Roundtable discussion |
Workshop IV:
Integration of Genotoxicity Evaluation into General Toxicology
Studies
(Title of presentation) |
Presiding: Bhaskar Gollapudi, Dow Chemical Company and Gopala Krishna, Parke-Davis Pharmaceutical
Research; Speakers: B.B. Gollapudi (Introduction); J. MacGregor, SRI International (Evaluation of genotoxic risk
in conjunction with toxicology studies: Is current in vivo technology sufficient?); J.Swenberg, Univ of NC, Chapel Hill
(In vivo studies on the formation and repair of DNA adducts); M. Hayashi, Natl Institute of Health Sciences, Tokyo
(Blood micronucleus assay in rodents); G. Krishna (Genotoxicity assessment in sub-chronic studies practical
considerations); K. Dearfield, US EPA (Genetic/general toxicology: Regulatory perspective);
Sponsors: R.J.
Reynolds Tobacco Company and The Dow Chemical Company |
Symposium I:
Emerging Pathogens
(Title of presentation) |
Presiding: Tom Cebula, US FDA, Div of Molecular and Biol Research & Evaluation;
Speakers: T.
Cebula (Introduction); J. Mekalanos, Harvard Univ (Bacterial Virulence); J.E. LeClerc, US FDA (Mutators among
pathogenic E. coli and
Salmonella enterica); P. Sniegowski, Michigan State Univ (Evolution of high mutationrates in
experimental populations of E. coli); Sponsor: Pharmacia & Upjohn, Inc. |
Symposium II:
Germ Cell Effects
(Title of presentation) |
Presiding: Susan Lewis, RTP, Center for Life Science and Toxicology
Speakers: S.E. Lewis
(Developmental biology of the mammalian germ cell); W.R. Lee, Louisiana State Univ, Institute for Mutagenesis
(Spontaneous germ line mutations); J.V. Neel, The Univ of Michigan Medical School, Dept of Human Genetics (The doubling
dose of ionizing radiation in Drosophila, man and mouse); Y.E. Dubrova, Dept of Genetics, Univ Leicester, UK
(Radiation-induced mutation at minisatellite loci in mammals); H. Mohrenweiser, Lawrence Livermore National Lab (From
minisatellites and genes: When do germinal mutations occur?) |
Symposium III:
Photoactivation of Xenobiotics to Mutagens
(Title of
presentation) |
Presiding: Peggy J. Guzzie, Pfizer, Inc., Groton, CT;
Speakers: C. Chignell, NIEHS
(Photochemical aspects of photomutagenesis); F.P. Gasparro, Thomas Jefferson Univ (Psoralen photochemistry and its
relationship to photomutagenicity); D. Kirkland, Hazleton Europe, Ltd (Development and use of bacterial gene mutation and
in vitro chromosomal aberration methods to detect photomutagens); D. Forbes, Argus Res Labs (Photomutagenesis and
photocarcinogenesis: In search of biomarkers); L. Müller, BfArm, Germany (Photomutagenicity testing as a fundamental
element to assess the photocarcinogenic potential of pharmaceuticals);
Sponsor: American Industrial Health Council
and Pfizer, Inc. |
Symposium IV:
Biomarkers: Their Emerging Role in Public Health
Title of
presentation) |
Presiding: Richard J. Albertini, Univ of Vermont;
Speakers: R.J. Albertini (Overview: The
current armentarium); M. Vine, Dept of Epidemiology, Univ of NC (Transitional epidemiological studies: Bridging the gap
from laboratory to field); J. Lynch, Former President, American Industrial Hygiene Society (Exposure assessment: Where
studies often fall before they begin); A. Schatzkin, NCI Division of Cancer Prevention and Control (Biomarkers as
predictors of outcome: When is a biomarker a surrogate for disease?);
Sponsor: The Proctor and Gamble
Company |
Symposium V:
DNA Repair and Biological Effects
(Title of presentation) |
Presiding: A.A. van Zeeland, Dept of Radiation Genetics and Chemical Mutagenesis, Sylvius Lab, Leiden
Univ; Speakers: A.A. van Zeeland (Introduction, DNA repair and biological consequences); L.H.F. Mullenders, Dept of
Radiation Genetics and Chemical Mutagenesis, Sylvius Lab, Leiden Univ (Competition between transcription coupled repair and
global genome repair depends on the nature of DNA damage); G.P. Pfeifer, Dept of Biology, City of Hope (Mapping of UV- and
benzo(a)pyrene- induced DNA damage at the nucleotide level); J.M. Ford, Dept of Biological Sciences, Stanford Univ (The
role of p53 in DNA repair and apoptosis following UV-irradiation); G. Chu, Stanford Univ Med Center (The biochemical role
of Ku/DNA-dependent protein kinase in double-strand break repair and V(D)J recombination) |
Symposium VI:
Cell Cycle Checkpoints, DNA Damage, and Genomic Instability
(Title
of presentation) |
Presiding: William Kaufmann, Univ of NC at Chapel Hill; and Jeffrey Schwartz, Univ of Washington,
Seattle; Speakers: D. Scott, Paterson Institute for Cancer Research (Checkpoints and radiation-induced chromosome
damage); G. Wahl, The Salk Institute (p53: Ensuring genomic stability through multiple levels of checkpoint control);
W. Kaufmann (G2 checkpoint function may limit chromosomal instaqbility in human fibroblasts); D. Toczyski, Fred Hutchinson
Cancer Research Center (The isolation of mutants that are unable to adapt to the RAD9-dependent checkpoint in
S.
cerevisiae) |
Symposium VII:
Genetic Susceptibility
(Title of presentation) |
Presiding: William W. Au, UTMB Department PMCH;
Speakers: S.H. Wilson, NIEHS and NTP (DNA
repair deficiency and susceptibility to environmental carcinogenesis); F.P. Guengerich, Vanderbilt Univ (Involvement of
polymorphic genes in metabolism of environmental toxicants); W.W. Au (Cancer risk assessment based on inheritance of
polymorphic genes and exposure to environmental toxicants); R. Setlow, Brookhaven Natl Lab (Accounting for genetic
susceptibility in risk assessment); Sponsor: The Environmental Mutagen Society |
Poster Sessions
171 Posters pre-registered
(Number of posters per
topic) |
Session 1A & 1B [odd numbers Monday, even numbers Tuesday]) Germ Cell Studies (8), Molecular Studies
(16), In Vitro Studies (15), Animal Models (30), Chemical Studies (6), Human Studies (13) |
| Session 2A & 2B [odd numbers Wednesday, even numbers Thursday] ) Environmental Studies (19),
Chemical Studies (15), Molecular Studies (19), In Vitro Studies (20), Human Studies (11) |
Platform Presentation Session I:
31 Contributed Short Talk
Papers
(Number of talks per topic) |
Molecular Aspects Biological Response (8);
Conveners: W.B. Mattes and E.M. Donner |
| Mutational Spectra (8); Conveners: Tom Skopek and Julie Swisler |
| Germ Cell Studies (7); Conveners: J. Drost and X. Lowe
|
| Cytogenetics (8); Conveners: R.L. Yu and Eva McGhee |
Platform Presentation Session II:
28 Contributed Short Talk
Papers
(Number of talks per topic) |
Developmental Effects (7);
Conveners: R.L. Yu and Eva McGhee
|
| Transgenic Animals (9); Conveners: D. Zimmer and J. Curry |
| Studies with Human Subjects (12);
Conveners: Patricia Ostrosky-Wegman and J. Pluth |
| Special Breakfasts |
Special Interest Groups; DNA Repair; Risk Assessment; Transgenics; New Tests |
| Student Breakfast |
| EMS Committee Breakfasts |
| Additional Activities/Features |
Web Workshop: Three complete days of instruction for interested parties |
| Afternoon and evening free, planned excursions |
| Young investigators workshop;
Presiding: Eva McGhee |
| Reception: Sponsor: Microbiological Associates |
| Exhibitors Workshops; I. Litron Labs and Stratagene; II. Epicenter Technologies |
| EMM Editors Meeting |
| Meeting six days, first day limited to student functions/council meeting; meeting ended 3:30 PM
Thursday |
| Special Event: Dinner and night excursion of Minnesota Zoo |
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|
29th Annual
Meeting Anaheim, California
March 21 - 26,
1998 (Saturday to Thursday) |
| Site |
The Disneyland Hotel |
| Administrative Officer |
Drohan Management, Randall Price and Maureen Thompson |
| Registration Fees (on-site) |
Members $325 Non-Members $375 Student Members $100 Student Non-members
$125 Other Non-members $100 Daily Fees: Members $100, NonMembers $125, Students $35 |
| Program Committee |
Rosie Elespuru, Chair, David Jacobson-Kram, Robert Young; Leonard Schechtman, Barry Glickman, Marilyn
Aardema, Nancy Gorelick, Martina Veigl, Eva McGhee, Jane Vergnes, Philip Hanawalt, Kerry Dearfield, Vicki Dellarco, John
Wassom |
| Approximate Number of Attendees |
603 |
| Approximate Size of EMS Membership |
|
| Student Award Winners Still with Society |
Not Known |
Public Affairs Presentation:
Translating Advances in Cancer Research from the Laboratory
to the Clinic |
Speaker: Peter A. Jones, Director, USC/Norris Comprehensive Cancer Center |
Alexander Hollaender Lecture:
Genetic Epidemiology and the Environment Gene
Program |
Speaker: Jack Taylor, NIEHS |
Lecture:
DNA-Mediated Charge Transport: Chemistry at a Distance |
Speaker: Jacqueline Barton, California Institute of Technology |
Student Reception and Poster Session:
Career Advancement: New Investigator
Viewpoints |
Presiding: Mac Lippert, Allegheny College, and Candace Lippoli-Doepker, Proctor & Gamble; Speakers: Candace Lippoli-Doepker; Mats Ljungman, University of Michigan; Laura Schild, Oregon State University; Sponsor: Eli Lily & Co. |
New Investigators Breakfast Workshop:
Meet the Experts |
Presiding: Mac Lippert, Allegheny College |
ICH Workshop:
Harmonized Guidance on Genotoxicity Testing: Evolution, Guidelines, and
Impact |
Presiding: Leonard Schechtman, FDA; Rockville, MD, and Gregory Probst, Eli Lily & Co.; Speakers: L. Schechtman; G. Probst; Lutz Müller, Federal Institute for Drugs and Medical Devices, Berlin; Toshio
Sofuni, National Institute of Health Sciences, Tokyo; David Kirkland, Covance Lab, Europe, North Yorkshire, UK; Sheila Galloway,
Merck Research Lab; Martha Moore, EPA, RTP, NC; Sponsor: The R.W. Johnson Pharmaceutical Research Institute |
Workshop:
New Genomic Technologies
(Title of presentation) |
Presiding: Kenneth L. Beattie, Oak Ridge National Lab;
Speakers: Kenneth Beattie (Emerging
technologies for environmental genomics); Catherine Janish, Applied Spectral Imaging, Inc. (Mouse and human spectral
karyotyping [SKY]); Paul van Hummelen, Lawrence Livermore National Lab (cDNA microarray, a high throughput gene expression
monitoring system); Mitchel Doktycz, Oak Ridge National Lab (Flowthrough genosensor technology development); Daniel
Pinkel, University of California, San Francisco (Comparative genome hybridization on a chip); William Cowsar, Luminex Corp
(FlowMetrix technology); Spencer Farr, PHASE-1 Molecular Toxicology, Inc. (Application of gene arrays to
toxicology) |
Workshop:
In Vitro Micronucleus Assay: Program and Poster
Discussion
(Title of presentation) |
Presiding: Marilyn Aardema, Procter & Gamble;
Speakers: S. Albertini, Hoffmann-LaRoche, Basel
(In vitro micronucleus test as a replacement for the
in vitro chromosomal aberration assay; industrial experience,
literature data evaluation and newest developments); Lutz Müller, Federal Institute for Drugs and Medical Devices,
Berlin (The use of the in vitro micronucleus test in the regulatory environment and recent validation activities in
Europe); Toshio Sofuni, National Institute of Health Sciences, Tokyo; (Validation study of the
in vitro micronucleus
test using CHO cells); M. Aardema (The
in situ micronucleus assay: Utility for genotoxicity screening); Azeddine
Elhajouji (Spindle poisons can induce polyploidy by mitotic slippage and micronucleated mononucleates in the cytokinesis-block
assay); Posters Presentations 13 posters;
Sponsor: Procter & Gamble |
Symposium 1:
Genomic Analysis from Yeast to Human
(Title of
presentation) |
Presiding: Anthony Carrano, Lawrence Livermore National Lab;
Speakers: A. Carrano
(Introduction); Victoria Smith, Genetech (Yeast); Gerald Rubin, Univ Calif, Berkeley (Drosophila); Monica
Justice, ORNL (Mouse); Toshikazu Ushijima, National Cancer Research Institute, Tokyo (Rat); Harvey Mohrenweiser,
Lawrence Livermore National Lab (Human);
Sponsor: Pharmacia & Upjohn |
Symposium 2:
Transcription-coupled Repair |
Presiding: Philip Hanawalt, Stanford Univ, and Max Ljungman, Univ of Michigan;
Speakers: P.
Hanawalt; M Ljungman; Alain Sarasin, CNRS, Villejuif; Priscilla Cooper, Lawrence Berkeley Lab;
Sponsor: Merck Research
Lab |
Symposium 3:
Case Studies in Risk Assessment: Using Mechanistic Data;
(Title of
presentation) |
Presiding: Vicki Dellarco, US EPA, and David Jacobson-Kram, MA BioServices;
Speakers: David
Brusick, Covance Lab (Chloroform); Joseph DeGeorge, Center for Drugs, Food and Drug Administration
(Phenolphthalein); Julian Preston, CIIT (Arsenic) |
Symposium 4:
RAD and BRCA Proteins: Functions and Interactions in Response to DNA
Damage
(Title of presentation) |
Presiding: Larry Thompson, Lawrence Livermore National Lab
Speakers: Larry Thompson (Overview
of recombinational repair); Paul Lohman, Leiden Univ (Functions of RAD 54 genes in Drosophila); Shunichi Takeda,
Kyoto Univ Graduate School of Medicine (An essential role for RAD 51 protein in the vertebrate cell cycle); Greg Donoho,
Lexicon Genetics (Radiation sensitivity and premature replicative senescence in mouse cells lacking the MmRAD51-BRCA2
interaction) |
Symposium 5:
Spontaneous Mutagenesis
(Title of presentation) |
Presiding: Thomas Kunkel, NIEHS;
Speakers: Thomas Kunkel (Production and correction of DNA
replication errors); T. Nohmi, National Institute of Health Sciences, Tokyo (DinB/P: An SOS inducible frameshift mutator
gene in E. coli); Roel Schaaper, NIEHS (Mutagenesis and replication fidelity in E. coli); Jeffrey H. Miller, UCLA
(Selection of mutators from a normal population); Mark Meuth, Univ of Utah (Spontaneous mutation in human tumor
cells); Liane Russell, ORNL (Stage of occurrence of heritable spontaneous mutations in the mouse) |
Symposium 6:
Dose Response and Thresholds |
Presiding: G. Krishna, Parke-Davis Pharmaceutical Research, and B. Gollapudi, Dow Chemical Company;
Speakers: R.J. Preston, Chemical Industry of Toxicology, RTP, NC; J.E. Klaunig, Indiana Univ School of Medicine; E. Zeiger,
NIEHS; K. Dearfield, US EPA, Washington DC, G. Krishna; B. Gollapudi |
Symposium 7:
The Environmental and Human Heritable Mutations
(Title of
Presentation) |
Presiding: Richard Albertini, Univ of Vermont;
Speakers: Albertini (Introduction, overview and
HPRT evidence); Steve Sommer, City of Hope (Germline mutations; inferences from hemophilia B); Mark Greenblatt, NCI
(P53 mutation spectra in somatic tissue and germ cells); John Harris, California Birth Defects Registry (Environmental
epidemiology of birth defects); Sponsor: The American Petroleum Institute |
Symposium 8:
Mitochrondrial DNA Interactions: Aging, Apoptosis and Human Disease |
Presiding: Bennett van Houten, Univ Texas Medical Branch, Galveston;
Speakers: B. van Houten;
Simon Melox, Emory Univ; Junjian Chen, Univ of Guelph; Gino Cortopassi, Univ California, Davis; Ella Bossy-Wetrzel, La Jolla
Institute for Allergy and Immunology; Sponsor: Mitokor |
Symposium 9:
Human Monitoring, Genetic Susceptibility and Biomarkers |
Presiding: Diana Anderson, BIBRA;
Speakers: Diana Anderson; James Tucker, Lawrence Livermore
National Lab; Martyn Smith, Univ California, Berkeley; Richard Albertini, Univ of Vermont; Andrew Wyrobek, Lawrence Livermore
National Lab; Wendie Robbins, UCLA Center for Occupational and Environmental Health; Douglas Bell, NIEHS;
Sponsor: R.J.
Reynolds |
Symposium 10:
Role of Hormonal and Chemical Mutagenesis in Human Breast Cancer
Etiology
(Title of presentation) |
Presiding: Christine Ambrose, NCTR;
Speakers: Peter G. Shields, National Cancer Institute
(Overview of molecular carcinogenesis and variability in response to endogenous and exogenous agents): Christine Ambrose
and Patricia Thompson, NCTR (Risk factors and genetic risk modifiers for breast cancer: Breast cancer, tobacco smoke
carcinogens, NAT1 and NAT2: Breast cancer, body mass index and catechol-0-methyltransferase); James D. Yager, Johns Hopkins
Univ (Evidence for a role of estrogen metabolites in breast carcinogenesis); David Josephy, Univ of Guelph, Ont, Canada
(Chemical carcinogenesis in the breast: Role of aromatic amines);
Panel Discussion: Hormonally-responsive cancer:
Hormones? chemical carcinogens? genetics? |
| Transgenic Animal Mutagenicity Studies I |
Presiding: Barry Glickman, Univ of Victoria, BC, Canada;
Speakers: Barry Glickman; Takehiko Nohmi,
National Institute of Health Sciences, Tokyo; Johan de Boer, Univ of Victoria, BC, Canada |
| Transgenic Animal Mutagenicity Studies II |
Presiding: Jon Mirsalis, SRI;
Speakers: Hans-Jorg Martus, Novartis Pharma AG, Basel; Vasily
Dobrovolsky, National Center for Toxicological Research; Gregory Stuart, Univ of Victoria; Klaus Felix, National Center Institute;
Lidia Cosentino, York Univ; Kathleen Hill, City of Hope |
| Transgenic Animal Mutagenicity Studies III |
Presiding: Nancy Gorelick, Proctor & Gamble;
Speakers: Reginal Davies, Univ of Leicester;
Christopher Saranko, North Carolina State Univ and CIIT; Kathleen Dixon, Univ of Cincinnati College of Medicine; Robert Przygoda,
Exxon Biomedical Sciences; Sponsor: American Industrial Health Council |
Transgenic Animal Mutagenicity:
The Future of Transgenic Mutation Models (A Panel
Discussion) |
Presiding: Errol Zeiger, NIEHS;
Panelist/Speakers: James MacGregor, FDA; T. Skopek, Merck
Research Lab; John Heddle, York Univ |
| Transgenic Models Mini-Meeting: |
The Role of Transgenic Bioassay Data in Hazard Evaluation and Risk Assessment; Short Talks and
Panel Discussions, (specific information on speakers and panel members not provided) |
Poster Session 1:
49 Posters registered |
Transgenic Posters: Sponsor: American Industrial Health Council |
Poster Session 2:
84 Posters registered
(Number of posters per subject matter) |
New Technologies/Systems (8), Genomic Instability (8), DNA Repair: Genetic Studies (5), DNA Repair Enzymes: Base
Excision Repair (4), DNA Repair Enzymes: Nucleotide Excision Repair (8), Testing Results: Bacteria (7), Testing Results: Mammalian
Cells (5),Testing Results: Drosophila and Plants (4), Testing Results: Micronucleus/Cytogenetics (4), Testing Results:
Comet Assay (6), Testing Results: Battery of Assays (8), Test Analysis: Risk Assessment (4), Test Development (11) |
Poster Session 3:
129 Posters registered
(Number of posters per subject matter) |
Mutagenic Mechanisms (17); Cytogenetic Mechanisms (5); Carcinogenesis (8), Epigenetic Effects (6), Metabolic
Activation/Photo Activation (8), PAH Metabolism and Adduct Formation (4), Anticancer Effects (8), Germ Cells/Reproductive Effects:
Experimental (10), Germ Cells/Reproductive Effects: Humans (4), Genetic Susceptibility (8), P53 Functional Effects (12),
Environmental Monitoring: Sentinel Systems (8), Human Biomonitoring: Methods (8), Human Biomonitoring: Occupational (8), Human
Biomonitoring: Chemotherapy (3) |
| Platform Presentations |
No Short Talk sessions scheduled |
Special Interest Lunches:
Various interest groups meeting over lunch |
Germ Cells/Aneuploidy/Human Genetic Disease; Human Monitoring/Molecular Epidemiology |
| DNA Repair Group: Risk Assessment Group |
| New Tests Group and Workshop; 2 Speakers Unspecified |
| Additional Activities/Programs |
Web Workshop; Three complete days of hands-on web instruction for interested parties;
Primary
Presider: Neil Carriello |
| Mouse Lymphoma Working Group |
| BBQ Supper (Rained out), served indoors |
| Spouses Hospitality Room |
| Cocktail Hour |
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|
30th Annual Meeting
Washington, District of Columbia
March 27 - April 1,
1999 (Saturday to Thursday) |
| Site |
The Capitol Hilton Hotel |
| Administrative Officer |
Drohan Management, Randall Price and Maureen Thompson |
Registration Fees
(pre-registered / on-site) |
Members $365/$415 Non-members $415/$465 Student members $150/$175
Student Non-members $175/$200 Spouses/Guests non-members $100/$125 |
| Program Committee |
James Felton, Chair, Richard Albertini, William Baird, Thomas Cebula, Andrew Grosovsky, Thomas Kunkle,
Eva McGhee, Martha Moore, William Morgan, Takehio Nohmi, Peter Stambrook, Michael Shelby, James Tucker, Vincent Wilson, Andrew
Wyrobek |
| Approximate Number of Attendees |
594 |
| Approximate Size of EMS Membership |
|
| Number of Student Travel Award Winners |
22 |
| Student Winners Who Became Regular Members |
Yet to be determined |
| Alexander Hollaender Lecture |
Using Transgenic Mice to Understand the Mode of Action of Carcinogens;
Speaker: Frank Gonzalez, National
Cancer Institute |
| Public Lecture |
Soft Drinks: A Good Part of America;
Speaker: Richard Adamson, National Soft Drink Association,
Washington, DC |
| Plenary Lectures |
Predicting Protein Structure from DNA Sequence;
Speaker: John Moult, CARP, Rockville, MD |
| Nuclear Structure and DNA Organization and Function;
Speaker: Don Coffey, Johns Hopkins
University |
| Student Activities |
Student Poster Session, and Reception;
Sponsor: Genetic Toxicology Association |
| Student Breakfast Workshop;
Speakers: Alison Director-Myska; Judith Nyquist, National Research Council;
Kathleen Hill, EMS New Investigator; Lidia Cosentino, EMS Student Member; EMS Education Committee Award Presentation |
| Student /New Investigator Breakfast Round Table |
Workshop:
Interpretation of Mutation Data for Cancer Risk Assessment
(Title of
Presentation) |
Discussion Leaders: Martha Moore, US-EPA, Research Triangle Park, and Dan Casciano, National Center for
Toxicology Research, Jefferson, AR; Speakers: Martha Moore (Introduction); Jim Cogliano (Overview of the new EPA
cancer risk assessment guidelines - with an emphasis on use of mode of action information); Veronique Thybaud (Kinetics of
induction of DNA adducts, cell proliferation and gene mutations in MutaMice treated with 5,9-dimethyldibenzo(c,g)carbazole);
Martha Moore (Integration of genotoxicity data for trichloroethylene and its metabolites: Implications for risk
assessment); Cheryl Scott (Epidemiological/human data: How it informs the trichloroethylene risk assessment); Panel
Discussion with Dan Casciano as Chair; Sponsor: Baxter Healthcare |
Symposium 1:
Somatic Mutations In Vivo
(Title of Presentation) |
Presiding: John Heddle, York University, Toronto;
Speakers: T. Nohmi, Division of Genetics and
Mutagenesis, National Institute of Health Sciences, Tokyo, Japan (GPT-delta mouse as a new research tool for
in vivo
mutagenesis); D. Casciano, National Center for Toxicology Research, Jefferson, AR (Gene mutation in lacl transgenic rats:
Comparison of lacl in splenocytes and target organs and HPRT in splenocytes); L. Cosentino, York University, Toronto, Canada
(Preferential repair of endogenous loci during low chronic treatment
); J. Vig, Beth Israel Hospital, Boston, MA
(Organ-specific mutation frequencies and spectra in aging mice with defects in genome stability systems
); J. Tischfield,
Rutgers University (Loss of functional heterozygosity in a mouse model: Implications for human disease) |
Symposium 2:
Watershed and Drinking Water Technology: Studies at the
EPA
(Title of Presentation) |
Presiders: Thomas Hughes and Larry Claxton, Environmental Carcinogenesis Division (ECD), EPA, Research
Triangle Park, NC |
| Presiding Part 1: Thomas Hughes;
Speakers: Thomas Hughes (Introduction: Short term tests that
can detect genotoxicants in watersheds and drinking water); Michael Lewis, Gulf Ecology Division, Gulf Breeze, FL
(Sediments in our rivers and estuaries - are they toxic?); George Gardner, Atlantic Ecology Division, Naragansett, RI
(Tumors in fish as indicators of carcinogens in our watersheds); Rodney Johnson, Mid-Continent Ecology Division, Duluth,
MN (Laboratory studies with fish as indicators of toxicity) |
| Presiding Part 2: Larry Claxton, Director of ECD, RTP;
Speakers: Larry Reiter, Director of the
National Health and Environmental Effects Research Lab (NHEERL), RTP (Introduction: Drinking water research at the NHEERL,
EPA, RTP, NC ); Larry Claxton (Searching for water-borne carcinogens and their sources); Tony DeAngelo, ECD, RTP
(The carcinogenicity of dichloroacetic acid in drinking water); Jim Rabinowitz, ECD, RTP (Construction of a BBDR cancer
model for the water disinfectant dicholoracetic acid); Marc Mass, ECD, RTP (Arsenic in drinking water: More than one
proposed mechanism for cancer); Andy Kligerman, ECD, RTP (The micronucleus bioassay as a potential biomarker for toxicity
of drinking water); Rita Schoeny, EPA HQ, Washington, DC (2001 - Research data needed for the new drinking water
regulations) |
Symposium 3:
New Technologies in Cytogenetics and Gene Expression |
Chair: Joe Gray, U.C. San Francisco;
Speakers: Joe Gray (Introduction); David Ward, Yale
University (Prospects for mutation detection using FISH); Donna Albertson, U.C. San Francisco (Microarray analysis of
genomic aberrations in cancer); Andy Wyrobek, Lawrence Livermore National Laboratory (Expression array analysis of DNA
repair genes); David Eastmond, University California (FISH for interphase translocation detection);
Sponsor:
Chrysalis International Preclinical Services |
Symposium 4:
Chromosome Structure and Function
(Title of Presentation) |
Chair: Peter Stambrook, University of Cincinnati;
Speakers: Arthur Lustig, Tulane University
(Telomere dynamics in yeast); Kenji Fukasawa, University of Cincinnati (P53 mutation, centrosome hyperamplification and
chromosome instability in human Cancer); Frank McKeon, Harvard University (Mitotic checkpoints and human chromosome
segregation); Howard Cooke, Edinburgh (Mammalian centromeres and artificial chromosomes);
Sponsor: Bristol-Myers
Squibb Pharmaceutical Research Company |
Symposium 5:
Linking Cytogenetic and Somatic Cell Mutation Biomarkers to Future Cancer
Risk
(Title of Presentation) |
Chairs: Nathaniel Rothman, NCI, and Douglas Bell, NIEHS;
Speakers: Nathaniel Rothman, NIH/NCI
(Introduction: A molecular epidemiologic perspective); Stefano Bonassi, Dept. of Environmental Epidemiology, Instituto
Nazionale per la Ricerca sul Cancro, Genova, Italy (Chromosomal damage in peripheral blood lymphocytes and risk of cancer in
humans); Martyn Smith, School of Public Health, Division of Environmental Health Sciences, University of California, Berkeley
(Potential applications of mutational biomarkers in prospective epidemiology studies); Vincent L. Wilson, Laboratory of
Environmental and Human Toxicology, Institute for Environmental Studies, Institute for Mutagenesis, Louisiana State University
(Biology and below threshold mutation assays); Barbara L. Parsons, Division of Genetic and Reproductive Toxicology,
National Center for Toxicological Research (MutEx/ACB-PCR for the detection of point mutations in somatic cells);
Discussant: Richard Albertini, University of Vermont, Genetic Toxicology Laboratory;
Sponsor: The Procter &
Gamble Company |
Symposium 6:
Genetox Test Procedures
(Title of Presentation) |
Chairs: Jim MacGregor, FDA, and David Kirkland, Covance Laboratories;
Speakers: Micheline
Kirsch-Volders, Vrije Universiteit Brussel (In vitro micronucleus test); Elmar Gocke, F. Hoffman-La Roche, Ltd., Basel
(Photochemical induced mutation and clastogenicity); Martha Moore, US-EPA, Research Triangle Park (Mouse lymphoma);
Sheila Galloway, Merck Research Laboratories (Cytotoxicity in the chromosomal aberration test); Ray Tice, Integrated
Laboratory Systems, Research Triangle Park (Comet assay); Makoto Hayashi, National Institute of Health Services, Tokyo
(In vivo micronucleus test); John Heddle, York University, Toronto (In vivo
transgenic mutation assays); David
Phillip, Institute of Cancer Research, Sutton, Surrey, UK (Identification of adducts); David Lovell, Pfizer Central
Research, Sandwich, Kent, UK (Statistics in genotoxicity testing);
Sponsor: Olympus Optical Co., Ltd. |
Symposium 7:
The Continual Maintenance of Genomic Integrity: The Base Excision Repair
Pathway
(Title of Presentation) |
Chair: David M. Wilson, III, Biology and Biotechnology Research Program, Lawrence Livermore National
Laboratory; Speakers: David M. Wilson, III ( Introduction: The continual maintenance of genomic integrity: The base
excision repair pathway); Tom Ellenberger, Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
(Crystal structures and mechanistic insights for human and
E. coli 3-methyladenine DNA glycoyslase); Yoshihiro
Matsumoto, Dept. of Radiation Oncology, Fox Chase Cancer Center, Philadelphia (Two pathways of base excision repair: A DNA
polymerase beta-dependent pathway and a PCNA-dependent pathway); Alan Tomkinson, Dept. of Molecular Medicine, Institute of
Biotechnology, San Antonio (DNA ligases in base excision repair); Mark R. Kelley, Dept. of Pediatrics, Wells Center for
Pediatric Research, James Whitcomb Riley Hospital for Children, Indianapolis (Use of DNA base excision repair genes in gene
therapy; translational applications) |
Symposium 8:
Risk Assessment Principles
(Title of Presentation) |
Organized by: Martha Moore, US Environmental Protection Agency, Research Triangle Park;
Speakers: John Vandenberg, US EPA, RTP, NC (Risk assessment principles); Rory Conolly, CIIT, RTP, NC
(Formaldehyde cancer risk assessment: Combining mutagenic and cytotoxic modes of action); Justin Teeguarden, University of
Wisconsin, Madison (Incorporation of mechanistic information into cancer risk assessment: Dioxin); Panel Discussion;
Sponsor: Eli Lilly and Co. |
Symposium 9:
Mutator Phenotype in Cancer
(Title of Presentation) |
Chair: Snorri Thorgeirsson, National Cancer Institute;
Speakers: Dr. Manuel Perucho, The Burnham
Institute, La Jolla Cancer Research Center (Gastrointestinal cancer of the microsatellite mutator phenotype); Dr. Jan Vijg,
Harvard University (Tissue-specific accumulation of point mutations and genome rearrangements in aging Mice: Role of DNA damage
processing and repair); Dr. Lawrence Loeb, Gottstein Memorial Cancer Research Laboratory, Dept. of Pathology, University of
Washington, Seattle (Origins of a mutator phenotype of cancer); Dr. Thomas A. Kunkel, Laboratory of Molecular Genetics,
National Institute of Environmental Health Sciences, Research Triangle Park (Mutation Research Award Lecture: Studies of DNA
Replication Fidelity and DNA Mismatch Repair); Dr. Daniel P. Cahill, Research Laboratories, Johns Hopkins Oncology Center,
Baltimore, MD (Chromosomal instability in cancer) |
Symposium 10:
Common Diseases: Is it the Genes or the Exposures?
(Title of
Presentation) |
Chairman: Harvey Mohrenweiser, Biology and Biotechnology Research Program, Lawrence Livermore National
Laboratory; Speakers: Harvey Mohrenweiser (Variation as a tool for understanding biology: A key element in the
functional genomic era); Richard Weinshilboum, Department of Pharmacology, Mayo Medical School / Mayo Clinic
(Pharmacogenetics and individualization of therapy); Mike Province, Division of Biostatistics, Washington University School
of Medicine, St. Louis (Cardiovascular disease: A case study of a disease with multifactorial inheritance and genetic
susceptibility); David Hunter, Dept. of Epidemiology, Harvard School of Public Health (Screening for genetic variation and
disease susceptibility: Promises, pitfalls and reality);
Sponsor: Elsevier Science BV |
Symposium 11:
Structural and Biological Consequences of DNA Modification
(Title
of Presentation) |
Chairmen: William Baird, Oregon State University, and Anthony Dipple, National Cancer Institute;
Speakers: William Baird (Introduction to DNA adducts and their repair); Nick Geacintov, New York University (DNA
adduct structures in relation to biological effects); Michael Seidman, CODON, Gaithersburg, MD (Targeted gene knockouts
mediated by triple helix forming oligonucleotides); Tony Dipple (PAH adduct induced mutations and effects on cell
cycle); John Essigmann, MIT (Site specific mutagenesis with carcinogen adducts and oxidative damage
); Sponsor:
Merck & Co. |
Symposium 12:
DNA Repair: Structural and Functional Studies
(Title of
Presentation) |
Chairman: William F. Morgan
Speakers: Michael A. Resnick, Head, Chromosome Stability Group,
National Institute of Environmental Health Sciences, NIH, Research Triangle Park (Double-strand break repair and at-risk motifs
(ARMS) as factors in genome stability); Gloria C. Li, Dept. Medical Physics (Memorial Sloan Kettering cancer center role of
DNA-PK in DNA damage repair and lymphomagenesis); James P. Carney, Lawrence Berkeley National Laboratory, Life Sciences
Division (Structure-function studies of the human Mre11/Rad50 complex); John A. Tainer, Scripps Research Institute, Dept.
of Molecular Biology, La Jolla (Crystallographic structures of DNA repair complexes) |
| Continuing Education Course on the New EPA |
Cancer Risk Assessment Guidelines |
Poster Presentations
256 Preregistered
(Number of posters per
topic) |
Session 1 (88): Transgenics (31), Anti-Carcinogenesis/Mutagenesis (11), Genetic Susceptibility/Biomarkers (24),
Carcinogenic Mechanisms (4), Risk Assessment (10), Late Breaking -Misc (8);
Sponsor: Taconic Transgenic Division, Taconic
Farms, Inc. |
| Session 2 (86): DNA Repair (22), Genomic Instability (10), DNA and Protein Adducts (7), Metabolic Activation
(8), Genetic Toxicology Test Development/New Technologies (17), Mammalian genetic Toxicology Test Results (20);
Sponsor:
R.W. Johnson Pharmaceutical Research Institute |
| Session 3 (82):Cytogenetics (25), Mutagenic Mechanisms and Mutation Spectra (38), Germ Cell Studies (11),
Environmental Studies-Water (8); Sponsor: Astra Pharmaceuticals, L.P. |
Platform Presentations:
Short Contributed Talks |
None |
| Additional Activities/Events |
EMS committee breakfast meetings |
| Special Interest group breakfasts: Germ Cell; Repair; Transgenics; Environmental Genomics; Risk
Assessment |
| Free afternoon on Tuesday (12:30-6:30), followed by Odyssey Cruise evening |
| Continental Breakfasts: Sunday; Monday; Tuesday
Sponsor: Covance Laboratories, Inc. |
| Reception: Sponsors: BioReliance, Inc. and Covance Laboratories |
| Meeting 6 days, main meeting 5 days as first day, Saturday, the event scheduled was the student
reception and poster session. Meeting started Saturday at 7:00 PM and ended Thursday at 3:00PM |
| Odyssey Cruise Tuesday night |
| EMS Awards preceded Business Meeting rather than Reception as in previous years |
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|
31st Annual Meeting
New Orleans, Louisiana
April 8 - 13, 2000
(Saturday to Thursday) |
| Site |
Hyatt Regency Superdome |
| Administrative Officer |
Drohan Management, Randall Price and Maureen Thompson |
Registration Fees
(pre-registered / on-site) |
(Fee schedule not included in program booklet, values taken from a pre-meeting reservation
pamplet.) Members $365/$415 Non-members $415/$465 Student members $165/$190 Student
Non-members $190/$215 Spouses/Guests non-members $100/$125 |
| Program Committee |
Jim Tucker, Chair, Richard Albertini, Jim Cleaver, David DeMarini, George Douglas, David Eastmond, Lynn
Ferguson, Barry Glickman, Makoto Hayashi, Jim Ivett, David Jacobson-Kram, Fred Kadlubar, Tom Kunkel, Larry Loeb, Paul Lohman,
Harvey Mohrenweiser, Barbara Shane, Sid Aaron |
| Approximate Number of Attendees |
450 |
| Approximate Size of EMS Membership |
|
| Number of Student Travel Award Winners |
24 |
| Student Winners Who Became Regular Members |
Yet to be determined |
| Keynote Presentation |
None |
| Public/Plenary Lectures |
Mechanism of Trinucleotide Repeat Instability in Human Neurological Disease;
Speaker: Cynthia T.
McMurray, Mayo Clinic and Foundation |
| Risk Characterization of Dioxin;
Speaker: Linda S. Birnbaum, US Environmental Protection
Agency |
| Student/New Investigator Activity |
Student Poster Session, Workshop and Reception;
Presenters: Jennifer Sasaki, Lawrence Livermore National
Lab (Introduction); David DeMarini, U.S.E.P.A. (Welcome address); Carlos Sierra-Torres, University of Texas Medical
Branch at Galveston (Presentation); Krista Dobo and Bob Mauthe, Pfizer Central Research (Presentation); Presentation
of the EMS Education Committee Award and Best Student / New Investigator Poster Award;
Sponsor: Genetic Toxicology
Association |
Workshop:
Ames Test
(Title of Presentation) |
Presiding: Judy Mayo, Pharmacia & Upjohn Inc., and Jenness Majeska, Boehringer Ingelheim
Pharmaceuticals; Speakers: Leonard Schectman, USFDA (Overview of regulatory requirements); Jenness Majeska (Ames
survey results); Elmar Gocke, Roche Ltd (Artefacts in the Ames Test);
Method Modifications for Reduced Test Article
Requirement: Skip Wagner, BioReliance (Spot test update); Larry Claxton, USEPA (Spiral assay); Marilyn Diehl,
Abbott Laboratories and Judy Mayo, Pharmacia & Upjohn (MiniAmes using 6-well plates); Leon Stankowski, Chrysalis, and
Marque Todd, Chiron Corporation (Testing combinatorial libraries);
Discussion Panel: Audience and Survey
Questions |
Workshop:
Suitable Follow-up Testing and Risk Evaluation for
In Vitro Positive
Pharmaceuticals
(Title of Presentation) |
Presiding: Sheila Galloway, Merck Research Laboratories, and Lutz Müller, Federal Institute for
Drugs & Medical Devices, Berlin; Presenters: Sheila Galloway (Mechanistic studies on thresholds and the involvement of
cytotoxicity in induction of chromosome aberrations with drug candidates including angiotensin II receptor antagonists); Lutz
Müller (Evaluation of in vitro clastogens: Examples including catecholamines and acetylcholinesterase
inhibitors); Makoto Hayashi, National Institute of Health Sciences, Tokyo (Japanese regulatory approaches to clarify the
significance of positive results in in vitro mammalian cell genotoxicity assays); Joe Contrera, US Food and Drug
Administration (Examples from current experience with
in vitro genotoxins, with discussion of how transgenic mouse
tumorigenicity models are considered in clarifying genotoxicity issues); James MacGregor, US Food and Drug Administration
(Useful and scientifically sound follow-up test approaches for compounds that initially were only positive in mammalian cell
tests in vitro); Sponsors: Merck, The Procter & Gamble Co., Dow Corning Company, Astra-Zeneca, and Eli
Lily |
Symposium I:
Genomics and Evolution
(Title of Presentation) |
Co-Chairs Mark A. Batzer, Louisiana State University Health Sciences Center; and Prescott L. Deininger,
Tulane University Cancer Center; Speakers: Wen-Hsiung Li, University of Chicago (Human DNA variation in noncoding
regions in worldwide populations); Damian Labuda, University of Montreal (Genetic structure of human populations: Role of
founder effect and admixture); Bronya J.B. Keats, Louisiana State University Health Sciences Center (Trinucleotide repeat
expansions and evolution); Mark A. Batzer (Contribution of interspersed elements to human genomic diversity); Barbara
J. Trask, University of Washington (The complex genomic organization of the olfactory receptor gene family); Prescott L.
Deininger (Overview and summary) |
Symposium II:
Molecular Epidemiology
(Title of Presentation) |
Chair: Fred Kadlubar, National Center for Toxicological Research;
Speakers: Fred Kadlubar
(Introduction: Exposure and susceptibility biomarkers for colon and pancreas cancer); Tim Rebbeck, University of
Pennsylvania School of Medicine (Genotypes of hormone and drug metabolism in cancer predisposition); Rashmi Sinha, National
Cancer Institute (Role of heterocyclic amines and breast cancer); David Christiani, Harvard School of Medicine and Public
Health (Molecular epidemiology of lung cancer: A model for environmental-genetic interactions) |
Symposium III:
Pharmacogenomics
(Title of Presentation) |
Co-Chairs: Sid Aaron, Pharmacia & Upjohn Inc.;
Speakers: Sid Aaron (Pharmacogenomics: A
brave new/old world); Wendel Weber, University of Michigan (The Impact of pharmacogenetics on medicine); Emil Skamene,
McGill University (Genetic Susceptibility to Infectious Diseases); Sam Broder, Celera Genomics (Sequencing entire
genomes of free living organisms: Implications for pharmacology and toxicology); Michael Silber, Pfizer Central Research
(Application of pharmacogenomics to drug discovery and development);
Sponsors: Pharmacia & Upjohn |
Symposium IV:
Legal and Ethical Issues in DNA Sampling and Testing
(Title of
Presentation) |
Chairs: Errol Zeiger, OECD and NIEHS, and Ami Jaeger, Biolaw Group;
Speakers: Errol Zeiger
(Introduction); Ami Jaeger (General overview of legal and ethical issues in the use of genetic information); Robert
Schwartz, UNM School of Law (Health care: Legal considerations in the use of genetic information); Jean McEwen, National
Human Genome Research Institute (Forensics: Ethical, legal and social implications); Errol Zeiger (Panel Discussion:
Guidelines for genetic testing and the use of genetic samples);
Sponsor: NIEHS |
Symposium V:
DNA Mismatch Repair
(Title of Presentation) |
Chair: Tom Kunkel, National Institute of Environmental Health Services;
Speakers: Tom Kunkel
(Functional studies of DNA mismatch repair proteins in yeast); Wei Yang, Laboratory of Molecular Biology (DNA mismatch
repair: From structure to mechanism); Martina Veigl, Case Western Reserve University (Implications of DNA mismatch repair
inactivation for colon cancer development and treatment); Raju Kucherlapati, Albert Einstein College of Medicine (Role of
mismatch repair genes in mitosis and meiosis); Rhona Borts, University of Oxford (The many faces of mismatch repair in
meiosis) |
Symposium VI:
Dietary Supplementation (Nutriceuticals)
(Title of
Presentation) |
Chairs: Lynn Ferguson, Auckland Cancer Society Research Centre;
Speakers: Lynn Ferguson
(Overview: Nutriceuticals and their role in cancer prevention); Michael Fenech, CSIRO Division of Human Nutrition
(Vitamin and mineral supplementation: Effects on genomic stability); Michael Gould, Dept of Human Oncology, University of
Wisconsin, Dept of Human Oncology, University of Wisconsin (Monoterpenes with protective effects against breast cancer);
Michael Wargovich, South Carolina Cancer Center (Diet/gene interactions with emphasis on cell cycle control and
apoptosis); Roderick Dashwood, Linus Pauling Institute (Beta-catenin mutation in colon tumors promoted by dietary
phytochemicals); Sponsor: The Dow Chemical Company |
Symposium VII:
Hot Topics and Late-Breaking Ideas
(Title of Presentation) |
Chair: John Heddle, York University;
Speakers: Peter Rabinovitch, University of Washington
(Chromosomal instability in preneoplastic ulcerative colitis: A mutator phenotype?); Allen T. Christian, Lawrence Livermore
National Laboratory (The generation and utilization of tissue- and chromosome region-specific gene Expression Libraries);
Thomas R. Skopek, Merck Research Laboratories (Analysis of sequence alterations in a defined DNA region using
temperature-modulated heteroduplex analysis [TMHA™]: Efficient separation of mutant HPRT sequences); Roel M. Schaaper,
National Institute of Environmental Health Sciences (A novel fidelity system enabled by the dnaX gene); Robert E. Goldsby,
University of Utah (Mutator alleles affecting polymerase fidelity and cancer in mice); Mats Ljungman, University of
Michigan Comprehensive Cancer Center (RNA polymerase II as a sensor for DNA damage) |
Symposium VIII:
Apoptosis
(Title of Presentation) |
Co-Chairs: Mathieu Noteborn, Leadd BV and Leiden University Medical Center, and Prof. van der Eb, Leiden
University; Speakers: J. John Cohen, University of Colorado Medical School (The biology of apoptosis: Why does it occur
so readily?); J. Marie Hardwick, John Hopkins University (Regulation of virus-induced neuronal apoptosis by Bcl-2
proteins); George Prendergast, DuPont Pharmaceuticals (Loss of the Myc-Bin1 cell death pathway in cancer); Amy
Kronenburg, Lawrence Berkeley National Laboratory (Programmed cell death and allelic recombination); Mathieu H.M. Noteborn
(Apoptin induces tumor-specific apoptosis) |
Symposium IX:
Hypermutation and Disease
(Title of Presentation) |
Chair: Lawrence A. Loeb, University of Washington;
Speakers: Lawrence A. Loeb (Lethal
mutagenesis of HIV: Pushing the virus over the cliff); Bradley Preston, University of Utah (Mechanisms driving HIV-1
variation); Carol Sibley, University of Washington (Analysis of yeast anti-folate resistance in the malarium parasite,
P. falciparum); Ursula Storb, University of Chicago (Somatic hypermutation of Ig genes causes mutations at many
thousand-fold higher than spontaneous mutation rate); Miroslav Radman, Inst. Jacques Monod (Fine-tuning of mutagenesis:
Genetic gambling while climbing the slopes of evolutionary landscapes);
Sponsor: Merck Research
Laboratories |
Symposium X:
Transgenics
(Title of Presentation) |
Co-Chairs: Barry Glickman, University of Victoria, and Peter Stambrook, University of Cincinnati College
of Medicine; Speakers: Johan de Boer, University of Victoria Centre for Environmental Health (The Big Blue world: An
overview); Elizabeth Snyderwine, Laboratory of Experimental Carcinogenesis (Mutagenicity and carcinogenicity of a
food-derived heterocyclic amine in c-myc/lacZ Bitransgenic Mice); Takehiko Nohmi, National Institute of Health Sciences
(Transgenic mouse gpt delta: Development, recent progress and future directions); Jim Stringer, University of Cincinnati,
College of Medicine (Mismatch repair and somatic mutation in Individual cells of diverse mouse tissues); Harry Vrieling,
Leiden University Medical Center (Acute and long term effects of DNA damage in NER deficient transgenic mice) |
Symposium XI:
Molecular Cytogenetics
(Title of Presentation) |
Chair: David Ward, Yale University;
Speakers: Michael Speicher, Institut fur Anthropologie und
Human Genetik (High resolution multicolor analysis in 2- and 3-dimensions); Fred Kramer, Public Health Research Institute
(Multicolor molecular beacons for the identification of single-nucleotide polymorphisms); Joe Gray, University of
California, San Francisco (Two molecular cytogenetic views of cancer: An instability paradox); Dave Ward (Rolling circle
DNA amplification: A new diagnostic paradigm) |
Symposium XII:
Homologous Recombinational Repair, BRCA Proteins, and Cancer
(Title of Presentation) |
Chair: Larry Thompson, Lawrence Livermore National Laboratory;
Speakers: Larry Thompson
(Overview of double-strand breaks in mammalian Cells); Larry Thompson (Homologous recombination is not a minor DNA
repair pathway in vertebrates); Gerald Adair, University of Texas Cancer Center (Effects of ERCC1 gene knock-out on
homologous recombination in CHO cells); Wen-Hwa Lee, University of Texas Health Science Center at San Antonio (Roles of
BRCA1 and BRCA2 in DNA Repair and Cancer); Maria Jasin, Sloan Kettering Institute (Dsb Repair, Homologous Recombination,
and Genomic Integrity: A Role for BRCA1) |
Poster Presentations
211 Preregistered
(Number of posters per
topic) |
Session 1 (70): Test Results: Drosophila, Plant, Fish (4), Test Results: Micronucleus/Cytogenetics (11),
Mutagenic Mechanisms (7), Test Results: Mammalian Cells (8), Molecular Studies (3), Genetic Susceptibility (8), DNA Adducts (4),
Oxidative Damage (3), Mutational Spectra (11); Sponsor: DuPont Pharmaceuticals Company |
| Session 2 (71): Assessment (6), Transgenic: Test Results (9), Environmental Studies (8), Test Development (12),
Germ Cell Studies (13), Test Results: Other (4), Cytogenetics (15), Test Results: Bacteria (5);
Sponsor: The R.W. Johnson
Pharmaceutical Research Institute |
| Session 3 (70): New Technologies/Systems (4), SAR/Computer Modeling (4), Metabolic Activation/Photo Activation
(7), Animal Studies (5), DNA Repair, Genetic Studies (9), Cancer Genes (6), Transgenics (18), Anti-Cancer Effects (9), Cell Cycle
(1), Apoptosis (2), Carcinogenesis (2), Genomic Instability (3); Sponsor: Chrysalis Preclinical Services |
Platform Presentations:
Short Contributed Talks |
None |
| Additional Activities/Events |
EMS committee breakfast meetings |
| Special Interest group breakfasts: Germ Cell Mutagenesis, Human Genetics, Aneuploidy Group, Risk
Assessment Group, DNA Repair Group, Molecular Epidemiology Group, Transgenic Group |
| Free afternoon on Tuesday, New Orleans visitors' guide (12:30-6:30), followed by Mardi Gras
evening |
| Social Event: Mardi Gras evening (6:30-10:30) |
| EMS Awards and Reception: Sponsors: BioReliance, Inc. and Covance Laboratories |
| Meeting 6 days, main meeting 5 days as first day, Saturday, the event scheduled was the student
reception and poster session. Meeting started Saturday at 6:00 PM and ended Thursday at 1:00PM |
| Lunch provided at annual business meeting |
| Student / New Investigator Breakfast, meet the experts |
| Each day’s program had its own motif: Sunday, Genomics; Monday, Human Genetic Variability; Tuesday,
Mechanisms of Mutation and Cancer; Wednesday, Disease Models; Thursday, Mechanisms of DNA Repair &
Cancer |
(return to the top of this page)
|
32nd Annual Meeting
San Diego, California
March 16 - 21, 2001
(Friday to Wednesday) |
| Site |
Paradise Point Resort Hotel |
| Administrative Officer |
Drohan Management, Randall Price and Matt Barr |
Registration Fees
(pre-registered / on-site) |
Members $575 Non-Members $625 Post-Doctorate Members $535 Post-Doctoral
Non-member $585 Student Members $435 Student Non-members $485 Spouse/Guest $150
Other Non-Members Daily Fees (Members $100, NonMembers $125, Students $35) |
| Program Committee |
David DeMarini, Chairman, Amal Abu-Shakra, William Au, Jack Bishop, Stefano Bonassi, Jurjian Chen, Rod
Dashwood, Vicki Dellarco, D. DeMarini, R. Elespuru, James Fuscoe, Barry Glickman, Andrew Grosovsky, Makoto Hayashi, Gerald
Holmquist, David Josephy, Micheline Kirsch-Volders, Susan Lewis, Suzanne Morris, Hannu Norppa, Toby Rossman, Barbara Shane, T.
Skopek, Martyn Smith, Steve Sommer, Peter Stambrook, J. Tainer, L. Thompson, R. Tice, K. Tindall, Ben Van Houten, Jane Vergnes,
R.C. von Borstel, Joseph Wachsman, Paul White |
| Approximate Number of Attendees |
554 |
| Approximate Size of EMS Membership |
853 |
| Number of Student Travel Award Winners |
19 |
| Student Winners Who Became Regular Members |
None at this time |
| Keynote Presentation |
Speaker: Stephen J. Gould, Harvard University, Cambridge, MA |
| Robert H. Haynes Memorial Lecture and Toast |
DNA Repair: A Global Perspective;
Speaker: Philip Hanawalt, Stanford University, Stanford,
CA |
| Public/Plenary Lectures |
Mutability of Repeated DNA Sequences in Humans and Mice;
Speaker: Sir Alec Jeffreys, University
Leicester, Leicester England |
| Genomic Biology; Speaker: Roger Brent, The Molecular Sciences Institute, Berkeley, CA |
| Student/New Investigator Activity |
Reception and poster session; Student/Young Investigator Presentations-Jenness Majeska presiding;
Sponsors: AstraZeneca and Genetic Toxicology Association |
Shortcourse:
Overview of Molecular Epidemiology |
PART I: Speakers: James Tucker, LLNL (Introduction); Stefano Bonassi, INRC, Genoa, Italy
(Course overview);
METHODOLOGICAL ISSUES Montserrat Gracia-Closas, NIH/NCI, Bethesda, MD (Study design in
molecular epidemiology); Errol Zeiger, J.D., Chapel Hill, NC (Ethical considerations in human studies); Nina Holland,
University CA, Berkeley (Biological sample collection and processing);
BIOMARKERS OF EXPOSURE AND EARLY
EFFECT Stephen Rappaport, University NC (Using biomarkers in exposure assessment); David DeMarini, US EPA, RTP, NC
(From DNA damage to mutation); Richard Albertini, University of Vermont (Somatic cell mutations in cancer research);
Discussion |
| PART II: GENETIC SUSCEPTIBILITY James Tucker, LLNL, Livermore, CA (Cytogenetic markers);
Russell Higuchi, Roche Molecular Systems, Alameda, CA (New genomic technologies); Frederick Kadlubar, NCTR, Jefferson, AR
(Genotype vs. phenotype in molecular epidemiology studies);
ANALYSIS OF DATA Montserrat Gracia-Closas,
NIH/NCI, Bethesda, MD (Bias, confounding and effect modification in molecular epidemiology studies); Stefano Bonassi
(Statistical analysis of molecular epidemiology studies);
CASE STUDIES Martyn Smith, University CA, Berkeley
(Studies of workers exposed to benzene and butadiene); Stephen London, NIEHS, RTP, NC (Molecular epidemiology of lung
disease); Discussion; Sponsors: AstraZeneca and Genetic Toxicology Association |
Shortcourse:
Advanced Methods of 32P-Postlabeling for DNA Adducts |
Instructors: Jeffrey Ross and Leon King US EPA, RTP, NC;
Presentation Titles Introduction to
32P-postlabeling; DNA isolation and hydrolysis; Adduct enrichment; Labeling conditions; HPLC methods; TLC methods;
Quantitation; Adduct identification; Sponsor: Dow Chemical Company |
Shortcourse:
New Developments and Applications of the Comet Assay |
Speakers: Ray Tice, ILS, RTP, NC (Introduction and general technical aspects); Eva Agurell, AB
Astra Södertälje, Sweden (Genetic toxicology: General guidelines); Andreas Hartmann, Novartis Pharma AG, Basel,
Switzerland (Genetic toxicology: In vitro applications and high-throughout screening); Yu F. Sasaki, Hachinohe Natl.
College of Technology, Hachinohe, Japan (Genetic toxicology:
in vivo studies in experimental animals); Scott
Steinert, Computer Sciences Corp., San Diego, CA (Environmental biomonitoring: Aquatic systems); Emilio Rojas del Castillo,
Inst. Invest. Biomedicas UNAM, Mexico City, Mexico (Human biomonitoring: Environmental pollutants); Peggy Olive, BC Cancer
Research Centre, Vancouver, BC, Canada (Use of the comet assay in cancer research);
Sponsor: Integrated Laboratory
Systems, Inc. |
Shortcourse:
Quality Assurance (QA) Practices in Government, Industrial, and
Pharmaceutical Laboratories |
Speakers: Thomas Hughes, US EPA, RTP (Relationships among QC, peer review, and QA procedures at the
US EPA); Brenda Culpepper, US EPA, RTP (QA and data management techniques); James Allen, US EPA, RTP (Regulations
and guidelines for using animals in toxicology research); Patricia Pomerleau, CIIT, RTP, NC (Overview of GLP
regulations); Thomas Barfknecht, Dow Corning, Midland, MI (Management of GLP studies at contract research organizations
[CROs]); John Haw, Glaxo Wellcome, RTP, NC (QA of computer technology in the pharmaceutical industry);
Sponsor: Dow
Chemical Company |
Symposium:
New Technologies |
Co-Chairs: Junjian Chen, NCTR, Jefferson, AR, and Martyn Smith, UC-Berkeley;
Speakers: Jorma
Lampinen, Thermo Labsystems, Franklin, MA (Vitotox: A bioluminescence assay for genotoxicity and cytotoxicity studies);
Barry W. Glickman, University of Victoria, Victoria, BC, Canada (DNA sequencing by the Li-Cor system); Mary Jane
Cunningham, Genometrix, Inc., The Woodlands, TX (Toxicity profiling using a high-throughput gene expression microarray
platform) |
Symposium:
Molecular Genetics of Cancer |
Chair: James C. Fuscoe, US Environmental Protection Agency, Research Triangle Park, NC;
Speakers: Douglas Hanahan, University of California, San Francisco (The Hallmarks of cancer); Webster K. Cavenee,
The Ludwig Institute for Cancer Research, La Jolla, CA (Tumor-suppressor genes: Mechanisms and consequences of gene
inactivation); Jerry W. Shay, University of Texas Southwest Medical Center, Dallas, TX (Telomeres and cancer); Peter K.
Vogt, The Scripps Research Institute, La Jolla, CA (Oncogenes and cancer) |
Symposium:
Genomics, Proteomics, Bioinformatics |
Chairs: Peter J. Stambrook, University of Cincinnati, OH and William Suk, National Institute of
Environmental Health Sciences, Research Triangle Park, NC; Speakers: David Botstein, Stanford University, CA
(Microarray, bioinformatics, and human health); Peter Mose Larsen, Odense University, Denmark (From protein
fractionation to proteomics); John R. Yates III, The Scripps Research Institute, La Jolla, CA (Mass spectrometry: From
genomics to proteomics); Edward M. Marcotte, University of California, Los Angeles, CA (Bioinformatics: A pathway to gene
function); Sponsors: Pharmacia and the National Institute of Environmental Health Sciences | |
Symposium:
Toxicogenomics |
Chairs: Marilyn J. Aardema, Procter & Gamble; Richard S. Paules, National Institute of Environmental
Health Sciences; James T. MacGregor, US Food and Drug Administration;
Speakers: Mark Egerton, Incyte Genomics, Palo Alto,
CA (Gene expression profiling in molecular toxicology); N. Leigh Anderson, Large-Scale Biology Corporation, Rockville, MD
(Proteomics in molecular toxicology); Spencer Farr, Phase I Molecular Toxicology, Santa Fe, NM (Use of gene-expression
profiles to predict individual patient responses to the adverse effects of drugs); Richard S. Paules, National Institute of
Environmental Health Sciences, Research Triangle Park, NC (Toxicogenomics at NIEHS); Marilyn J. Aardema, Procter &
Gamble, Cincinnati, OH (International Life Sciences Institute (ILSI) genomics project); James T. MacGregor, US Food and
Drug Administration, Rockville, MD (Toxicogenomics and proteomics: Potential impact on pharmaceutical development and
regulation); Sponsor: Eli Lilly and Company |
Public Symposium:
Agricultural Genomics and the Promise of Improved Nutrition and
Healthcare: Safety, Environmental, and Legal Issues |
Chairs: Bhaskar Gollapudi and Timothy D. Landry, Dow Chemical Company, Midland, MI;
Speakers:
Timothy D. Landry (Symposium Overview); Steven P. Briggs, Novartis Agricultural Discovery Institute, San Diego, CA
(Agricultural biotechnology explained); Henry I. Miller, Hoover Institute, Stanford Univ., CA (Designer genes in your
food: Boon or bane?); Angela A. Wasunna, The Hastings Institute, Garrison, NY (The ethics of genetically modified food: A
view from the developing world); John C. Matheson, US Food and Drug Administration, Rockville, MD (Genetically engineered
organisms: A regulatory perspective); Bhaskar Gollapudi (Summary and questions) |
Symposium:
Functional Analysis of the Mammalian Genome: Humans and Mice |
Chairs: Susan E. Lewis, Cary, NC; Michael D. Shelby, National Institute of Environmental Health
Sciences, Research Triangle Park, NC; Speakers: Susan E. Lewis, Cary, NC (Introduction
); Andrew J. Wyrobek,
Lawrence Livermore National Laboratory, Livermore, CA (Risk factors and mechanisms of paternally transmitted
abnormalities); Lisa Stubbs, Lawrence Livermore National Laboratory, Livermore, CA (Discovering new links between genes,
diseases, and susceptibilities through analysis of heritable translocations in mice
); Eugene M. Rinchik, Oak Ridge National
Laboratory, Oak Ridge, TN (Functional annotation of mammalian DNA sequence by large-scale, phenotype-driven recovery of mouse
mutations); Muriel Davisson, Jackson Laboratory, Bar Harbor, ME (Mouse models and strain-background
effects) |
Symposium:
Ethical Issues Associated with Gene Therapy |
Chair: Errol Zeiger, National Institute of Environmental Health Sciences, Research Triangle Park, NC;
Speakers: Errol Zeiger (Overview of intersection of ethics and gene therapy
); Robert Erickson, University of
Arizona, Phoenix (Gene therapy: Science, medicine, art, and ethics
); Vicki Michel, Los Angeles, CA (Gene therapy:
Ethical and legal issues); Scott Frickel, University of Pennsylvania, Philadelphia (Social and political origins of the
EMS) |
Symposium:
Chromosomal Aberrations, Somatic Mutations, and Cancer Risk: Past, Present, and
Future |
Chairs: Stefano Bonassi, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy; Nathaniel Rothman,
National Cancer Institute, Bethesda, MD; Speakers: Nathaniel Rothman, National Cancer Institute, Bethesda, MD (A
molecular epidemiologic perspective: Two years later ); Martyn T. Smith, University of California, Berkeley (Past, present,
and future of biomarkers relevant to cancer ); James D. Tucker, Lawrence Livermore National Laboratory, Livermore, CA
(Past, present, and especially the future of chromosomal aberration assays for predicting cancer risk
); Qingyi Wei, MD
Anderson, Houston, TX (Genetic susceptibility to induced chromosomal aberrations and cancer risk
); Stefano Bonassi,
Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy (Are chromosomal aberrations an intermediate end-point of
cancer?); Richard J. Albertini, University of Vermont, Burlington (Somatic mutation in humans); Dale Hattis, Clark
University, Worcester, MA (Chromosomal aberrations, somatic mutations, and cancer risk assessment: A public health
perspective) |
Symposium:
Cell-Cycle Checkpoints and Signal Transduction |
Chair: Toby Rossman, New York University, Tuxedo, NY; Peter J. Stambrook, University Cincinnati, OH;
Speakers: Steven Reed, The Scripps Research Institute, La Jolla, CA (Cell cycle overview: Historical perspectives);
Erik Knudsen, University of Cincinnati, OH (RB-Mediated G1/S checkpoint regulation
); Anthony M. Carr, University Sussex,
England (S-Phase checkpoint); Clare McGowan, The Scripps Research Institute, La Jolla, CA (G2/M checkpoint); Peter
Sorger, Massachusetts Institute of Technology, Cambridge, MA (Mitotic checkpoints in animal cells
) |
The Annual Elsevier Mutation Research Symposium:
Translesion Synthesis and SOS Response:
How Lesions are Misread |
Chair: Gerald P. Holmquist, City of Hope, Duarte, CA;
Speakers: Gerald P. Holmquist
(Introduction); Errol C. Friedberg, University of Texas Southwest Medical Center, Dallas, TX (DNA polymerase kappa: A
novel DNA polymerase in search of a function); Roger Woodgate, National Institutes of Health, Bethesda, MD (Translesion DNA
synthesis: A conserved mechanism from bacteria to humans); Myron F. Goodman, University of Southern California, Los Angeles,
CA (The biochemical basis of SOS lesion-targeted mutagenesis involving errant DNA polymerases
); Paul W. Doetsch, Emory
University School of Medicine, Atlanta, GA (Translesion synthesis by RNA polymerases: Transcriptional mutagenesis in bacterial
and mammalian cells ); Sponsors: Elsevier Publishers and the National Institute of Environmental Health
Sciences |
Symposium:
DNA Repair and Genomic Instability |
Chair: Larry H. Thompson, Lawrence Livermore National Laboratory, Livermore, CA;
Speakers: Geoff
Wahl, The Salk Institute, La Jolla, CA (P53, Oncogene activation, genetic instability, and tumor progression); Lisiane
Meira, University of Texas Southwest Medical Center, Dallas, TX (Cancer predisposition in mutant mice defective in DNA repair
genes ); Eva Lee, University of Texas, San Antonio, TX (ATM and other kinases in DNA-damage signaling pathways
);
Gilbert Chu, Stanford University, Stanford, CA (Significance analysis of microarrays applied to the ionizing radiation
response); Sponsor: The National Institute of Environmental Health Sciences |
Symposium:
Antimutagenesis/Chemoprevention |
Chair: Rod Dashwood, Oregon State University, Corvallis; Lynnette Ferguson, University of Auckland, New
Zealand; Speakers: Thomas W. Kensler, Johns Hopkins University, Baltimore, MD (Strategies for protection against
aflatoxin-induced hepatocarcinogenesis: Insights from clinical trials in China); Fred F. Kadlubar, National Center for
Toxicological Research, Jefferson, AR (Glutathione S-transferase: Nature versus nurture); Roderick H. Dashwood
(Antimutagenesis/chemoprevention mechanisms of tea
); Lynnette R. Ferguson (Contribution of animal studies to
understanding gene-diet interactions);
Sponsors: The Stash Tea Company |
Symposium:
Complexity in Genome Stability: Structure and Function of DNA Repair
Complexes |
Chair: John A. Tainer, The Scripps Research Institute, La Jolla, CA;
Speakers: John A. Tainer,
The Scripps Research Institute, La Jolla, CA (Complexes acting in DNA double-strand break repair); Richard Kolodner,
University of California, San Diego (Mismatch repair protein interactions in yeast); Steve Kowalczykowski, University of
California, Davis, CA (Recombinational repair of DNA breaks); Priscilla Cooper, Lawrence Berkeley Laboratory, Berkeley, CA
(Pathway interactions in transcription-coupled repair directed by XPG complexes);
Sponsor: The National Institute of
Environmental Health Sciences |
Symposium:
Genotoxic Risks of Perinatal Exposures to Antiretroviral Reverse Transcriptase
Inhibitors (NRTIs) |
Chairs: Miriam Poirier, National Cancer Institute, Bethesda, MD; Vernon Walker, New York State
Department of Health, Albany; Speakers: Vernon Walker (Overview of antiretroviral nucleoside analogs: Clinical use and
toxicities); Dale Walker, New York State Department of Health, Albany (Transplacental carcinogenicity of AZT in
rodents); Vernon Walker (Observational cohort study of the genotoxic risks arising from perinatal NRTI therapies);
Quanxin Meng, New York State Department of Health, Albany (Plasma and cellular markers of AZT metabolism as indicators of DNA
incorporation of AZT in infants exposed in utero to combination antiretroviral therapies); Ainsley Weston, National
Institute of Occupational Safety and Health, Morgantown, WV (Pharmacogenomics of AZT); William Bigbee, University of
Pittsburgh, PA (Glycophorin A (GPA) Locus Somatic Mutations in Umbilical Cord Blood Erythroid Cells of Infants Exposed
in
utero to NRTIs); J. Patrick O’Neill, University of Vermont, Burlington (HPRT mutant frequency and mutation spectrum in
newborns with perinatal exposure to antiretroviral drugs);
Discussion Break: Frederick A. Beland, National Center for
Toxicological Research, Jefferson, AR (DNA adduct formation and mutation induction in neonatal mice treated with antiretroviral
nucleoside analog drugs); Ofelia Olivero, National Cancer Institute, Bethesda, MD (Incorporation of NRTIs into fetal DNA
following transplacental drug exposures in humans and experimental animal models); Miriam Poirier, National Cancer Institute,
Bethesda, MD (Animal models of NRTI mitochondrial toxicity); Stephane Blanche, Hospital Necker, Paris, France
(Mitochondrial dysfunction in infants exposed
in utero to NRTIs);
Discussion |
Poster Presentations
230 Preregistered (Number of posters per topic) |
Session 1 (79): Mutational Mechanism (9), Mutation Spectra (8), Gene Expression (7), New Technologies (5),
Transgenics (11), Adducts (5), Biomonitoring (8), Metals (13), Germ Cells (6), Micronucleus (7) |
| Session 2 (75): DNA Repair (14), Gene Expression (9), Genetic Susceptibility (5), Comet (8), Cytogenetics
(10), Carcinogenesis (6), Environmental Studies (11), Test Development (13) |
| Session 3 (76): Genomic Instability (5), Mutational Mechanisms (10), DNA Repair (14), Transgenics (10),
Antimutagenesis (10), Micronucleus (7), Bacterial Studies (12), Biomonitoring (8) |
Platform Presentations:
Short Contributed Talks |
None |
| Additional Activities/Events |
EMS committee breakfast meetings |
| Special Interest group breakfasts: Molecular Epidemiology; DNA Repair Group; Risk Assessment Group;
Transgenic Group and Exhibitor’s breakfast; Sponsor: Taconic |
| Free afternoon with planned excursions: San Diego Old & New Tour; California Coastline &
Tidepool Walk Tour; Coronado Mini-Trek Tour; Old Town - Where San Diego Began Tour; Walking Tour of the Gaslamp District
Tour |
| EMS Awards and Reception: Sponsors: BioReliance, Inc. and Covance Laboratories |
| Meeting 6 days, main meeting 4 full days and 2 one half days, starting with short courses on Friday at
2:00 PM and ending on Wednesday at 1:00 PM |
| Tuesday, lunch provided in the Sunset ballroom;
Sponsor: Covance |
| Lunch provided at annual business meeting for first fifty people |
| IAEMS meeting |
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