EMS 2011 Annual Meeting

Tuesday, October 18
7:00 AM–5:00 PM
	Registration	Inscription
7:00 AM–5:00 PM
	Speaker Ready Room Open	Inscription 2
7:00 AM–8:30 AM
	Breakfast Meetings
	Breakfast Pick-Up for Meetings (Ticket Required—Breakfast Available at 6:45 AM)	Net Café
	Executive Board Meeting	Longueuil
	Epigenetics Special Interest Group Leaders: Janet E. Baulch, University of Maryland, Baltimore and Dana C. Dolinoy, University of Michigan	Fontaine F
	New Technologies Special Interest Group Leaders: Brinda Mahadevan, Abbott Laboratories and Jennifer C. Sasaki, Alkermes, Inc.	Fontaine G
8:30 AM–9:30 AM
	EMS Award Lecture (PL3) Human Exposure Unraveling the Mystery of a Global Environmental Disease Chairperson: Catherine B. Klein, New York University School of Medicine Lecturer: Arthur P. Grollman, Stony Brook University	Outremont
8:30 AM–12:00 NOON
	Posters and Exhibits Open Last Chance to View Posters and Exhibits!	Fontaine B
9:45 AM–12:15 PM
	Symposium 9 Whole Genome Mutational Profiling of Environmentally Induced Cancer Chairpersons: James C. Fuscoe, National Center For Toxicological Research, U.S. FDA and David A. Wheeler, Baylor College of Medicine Supported in part by: Quaility and Regulatory, Global Occupational Toxicology	Mont-Royal
9:45 AM–10:10 AM	Updates on Next-Generation Sequencing and Bioinformatics David A. Wheeler, Baylor College of Medicine
10:10 AM–10:35 AM	Targeted Resequencing Using the PacBio RS Platform John D. McPherson, Ontario Institute for Cancer Research
10:35 AM–11:00 AM	Paired-End Sequencing Reveals Characteristic Patterns of Structural Variations in Epithelial Cancer Genomes Guillaume Bourque, McGill University
11:00 AM–11:15 AM	Break—In the Exhibit Hall
11:15 AM–11:40 AM	Landscape of Somatic Alterations in Cancer and Their Relationship to the Environment Kristian Cibulskis, The Eli and Edythe L. Broad Institute
11:40 AM–12:05 PM	The Human SNP Site-Frequency-Spectrum Richard A. Gibbs, Baylor College of Medicine
12:05 PM–12:15 PM	Discussion
9:45 AM–12:15 PM
	Symposium 10 Transcription and Genetic Instability Chairpersons: Malcolm J. Lippert, Saint Michael’s College and Mats Ljungman, The University of Michigan Organized by the DNA Repair and Mutagenic Mechanisms Special Interest Group	Outremont
9:45 AM–10:10 AM	Role for Topoisomerase I in Transcription-Associated Mutagenesis Malcolm J. Lippert, Saint Michael’s College
10:10 AM–10:35 AM	Transcription Impacts Genomic Stability via Multiple Mechanisms Nayun Kim, Duke University Medical Center
10:35 AM–11:00 AM	Transcription Associated Recombination at Replication Forks in Mammalian Cells Thomas Helleday, Gray Institute for Radiation Oncology and Biology
11:00 AM–11:15 AM	Break—In the Exhibit Hall
11:15 AM–11:45 AM	Transcription-Blockage by Lesions and Unusual DNA Structures Philip C. Hanawalt, Stanford University
11:45 AM–12:15 PM	The Transcriptome and the DNA Repairome Mats Ljungman, University of Michigan
9:45 AM–12:15 PM
	Symposium 11 Low Dose Mutagenesis and Carcinogenesis Chairpersons: Errol Zeiger, Errol Zeiger Consulting and David M. DeMarini, U.S. Environmental Protection Agency Supported in Part by: ILSI-HESI IVGT Project Committee	Verdun
9:45 AM–9:50 AM	Low-Dose Mutagenesis and Carcinogenesis: Why Is This Issue Important Errol Zeiger, Errol Zeiger Consulting
9:50 AM–10:15 AM	Low-Dose Mutagenicity Case Studies: MMS and MNU Lynn H. Pottenger, The Dow Chemical Company
10:15 AM–10:40 AM	Low-Dose In Vivo Study of Acrylamide Errol Zeiger, Errol Zeiger Consulting
10:40 AM–11:00 AM	Low-Dose Carcinogenicity Studies David M. DeMarini, U.S. Environmental Protection Agency
11:00 AM–11:15 AM	Break—In the Exhibit Hall
11:15 PM–11:40 PM	Analysis of Low-Dose Mutagenicity Responses and the Applicability of Genotoxicity Tests for Carcinogen Potency Prediction Lya Hernandez, National Institute for Public Health and the Environment
11:40 PM–12:05 PM	Dose Response Issues in the Regulation of Chemicals Rita Schoeny, U.S. Environmental Protection Agency
12:05 PM–12:15 PM	Discussion
12:15 PM–2:00 PM
	Lunch on your own
12:30 PM–1:45 PM
	Lunch Meeting (Advance Registration Required) Women in the EMS Special Interest Group Leaders: Janice M. Pluth, Lawrence Berkeley National Laboratory and Glenda J. Gentile, University of Arizona Lecturer: Geraldine L. Richmond, COACh Program, University of Oregon	Fontaine F
2:00 PM–3:15 PM
	Symposium 12 Risks Associated with Inadvertent Exposures to Pharmaceutical and Prescription Drugs Chairpersons: Brinda Mahadevan, Abbott Laboratories and Ainsley Weston, Centers for Disease Control and Prevention Organized by the New Technologies Special Interest Group and the Applied Genetic Toxicology Special Interest Group	Mont-Royal
2:00 PM–2:15PM	Inadvertent Exposures to Pharmaceutical Drugs: Overview Ainsley Weston, National Institute for Occupational Safety and Health, CDC
2:15 PM–2:35 PM	Risk-Based Manufacture of Pharmaceutical Products Brinda Mahadevan, Abbott Laboratories
2:35 PM–2:55 PM	Considerations for Risk Assessments of Genotoxic or Carcinogenic Impurities in Industry John Nicolette, Abbott Laboratories
2:55 PM–3:15 PM	Preventing Occupational Exposures to Antineoplastic Drugs in Health Care Settings Thomas H. Connor, National Institute for Occupational Safety and Health, CDC
2:00 PM–3:15 PM
	Symposium 13 Using DNA Adducts in Risk Assessment: Approaches, Considerations, and Significance Chairpersons: Lynn H. Pottenger, The Dow Chemical Company and Annie Jarabek, National Center for Environmental Assessment, U.S. EPA Primary Sponsor: ILSI-HESI DNA Adducts Project Committee	Outremont
2:00 PM–2:25 PM	ILSI-HESI DNA Adducts Project Committee: Review of Case Study Outcomes: Tamoxifen, AFB₁, and VCI Lynn H. Pottenger, The Dow Chemical Company
2:25 PM–2:40 PM	Application of Decision Analytic Approach to Case Studies Annie Jarabek, National Center for Environmental Assessment, U.S. EPA
2:40 PM–3:00 PM	Mutagenesis and Repair of O⁶- and N7-Alkylguanine Adducts Robert Fuchs, Centre National de la Recherche Scientifique
3:00 PM–3:15 PM	Relevance of DNA Adduct Approaches to Regulatory Risk Assessment Rita Schoeny, U.S. Environmental Protection Agency
2:00 PM–4:45 PM
	Platform Session 2 Mutagenesis and Carcinogenesis Mechanisms Chairpersons: Ofelia A. Olivero, National Cancer Institute, NIH and Sandy K. Weiner, Johnson & Johnson Presenting author is underlined.	Verdun
2:00 PM–2:15 PM	Subchronic Oral Exposure to Benzo[a]Pyrene Induces Changes in Gene Expression Associated with Cellular Transformation in Mouse Lungs: A Toxicogenomics Study Labib S¹, Williams A², Lemieux CL², White PA², Halappanavar S². ¹University of Ottawa, Ottawa, ON, Canada, ²Health Canada, Ottawa, ON, Canada
2:15 PM–2:30 PM	The Mouse Diversity Genotyping Array Profiles Tissue- and Genotype-Specific Mutations across the Mouse Genome Eitutis ST, Wishart AE, Hill KA. The University of Western Ontario, London, ON, Canada
2:30 PM–2:45 PM	DNA Structure-Induced Genetic Instability in Mammals Wang G, Vasquez K. University of Texas at Austin, Austin, TX, United States
2:45 PM–3:00 PM	Identification of Different Mechanisms of Non-Genotoxic Carcinogens Based on Gene Expression Profiling in Primary Mouse Hepatocytes Schaap MM^1,2, Jonker MJ³, Zwart PE¹, Wackers P³, van de Water B⁴, Breit TM³, Schoonen WG⁵, Polman J⁵, van Steeg H^1,2, Luijten M¹. ¹National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands, ²Department of Toxicogenetics, Leiden University Medical Center, Leiden, Netherlands, ³MicroArray Department and Integrative Bioinformatics Unit, University of Amsterdam, Amsterdam, Netherlands, ⁴Leiden Amsterdam Center for Drug Research (LACDR), Leiden University, Leiden, The Netherlands, ⁵Merck Sharp & Dome, Oss, Netherlands
3:00 PM–3:15 PM	Tissue Specificity of Aristolochic Acid-Induced Carcinogenesis Examined by ACB-PCR Quantification of H-Ras Codon 61 CTA Mutant Fraction Wang Y¹, McKim KL¹, Myers MB¹, Arlt VM², Parsons BL¹. ¹National Center for Toxicological Research, U.S. FDA, Jefferson, AR, United States, ²Institute of Cancer Research, Sutton, Surrey, United Kingdom
3:15 PM–3:30 PM	Break
3:30 PM–3:45 PM	Toxicogenomic Late Effects of Antineoplastic Therapies for Lymphomas Marcondes JPC¹, Torres BP¹, Niéro-Melo L¹, Gaiolla RD¹, Luisi FAV², Salvadori DMF¹. ¹São Paulo State University, Botucatu, SP, Brazil, ²São Paulo Federal University, São Paulo, SP, Brazil
3:45 PM–4:00 PM	Functional Studies of Single-Nucleotide Polymorphic Variants of Human Glutathione Transferase T1-1 Involving Residues in the Dimer Interface Josephy PD¹, Pan D¹, Ianni MD¹, Mannervik B^2,3. ¹University of Guelph, Guelph, Canada, ²Uppsala University, Uppsala, Sweden, ³Stockholm University, Stockholm, Sweden
4:00 PM–4:15 PM	Analyzing the Relationship between Radiation-Induced Phospho-Protein Signaling and Surrogate Cancer Endpoints Using Novel Flow-Based Assays Whalen MK¹, Sridharan DM¹, Wilson W¹, Chapell L², Cucinotta FA², Pluth JM¹. ¹Lawrence Berkeley National Laboratory, Berkeley, CA, United States, ²Lyndon B. Johnson Space Center, Houston, TX, United States
4:15 PM–4:30 PM	Lethal Mutagenesis of HIV and Cancer Cells by Nucleoside Analogs Fox EJ¹, Shen JC¹, Prindle MJ¹, Harris KS⁴, Mullins JI³, Essigmann JM⁵, Loeb LA^1,2. ¹Department of Pathology, University of Washington, Seattle, WA, United States, ²Department of Biochemistry, University of Washington, Seattle, WA, United States, ³Department of Microbiology, University of Washington, Seattle, WA, United States, ⁴Koronis Pharmaceuticals, Seattle, WA, United States, ⁵Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, United State
4:30 PM–4:45 PM	Role of the Circadian Clock in UV-Induced Skin Carcinogenesis Gaddameedhi S, Selby CP, Sancar A. University of North Carolina, Chapel Hill, NC, United States
3:15 PM–3:30 PM
	Break
3:30 PM–4:45 PM
	Symposium 14 Environmental Oil Contamination: Effects on Marine Life and Human Life Chairpersons: Christopher M. Somers, University of Regina and Miriam C. Poirier, National Cancer Institute, NIH Organized by the Molecular Epidemiology Special Interest Group and the Environmental Genetic Toxicology Special Interest Group	Mont-Royal
3:30 PM–3:45 PM	Voyage 2 of the Odyssey: The Impact of the Oil Crisis on Health Using Whales As an Indicator Species John Wise, University of Southern Maine
3:45 PM–4:00 PM	NIOSH Health Hazard Evaluation Conducted in the Aftermath of the Deepwater Horizon (DWH) Disaster Ainsley Weston, National Institute for Occupational Safety and Health, CDC
4:00 PM–4:15 PM	Are Seafood Safety Considerations Adequate to Prevent Chronic Health Effects of the Deep Water Horizon Oil Spill on Coastal Louisiana Residents? Patricia L. Williams, University of New Orleans
4:15 PM–4:30 PM	Overview of the Toxicity of the Oil Dispersant Corexit David M. DeMarini, U.S. Environmental Protection Agency
4:30 PM–4:45 PM	Panel Discussion
3:30 PM–4:45 PM
	Symposium 15 Intestinal Microbiota: A Key Player in Obesity, Genomic Instability, and Lymphoma Chairperson: Robert H. Schiestl, UCLA School of Medicine and Public Health	Outremont
3:30 PM–4:00 PM	Intestinal Microbiota Affect Genetic Instability, Longevity and Lymphoma Latency in Atm^-/- Mice Robert H. Schiestl, UCLA School of Medicine and Public Health
4:00 PM–4:15 PM	The Intestinal Host-Microbial Ecosystem: A Systems Biology Approach to Inflammation and Cancer Risk Jonathan Braun, David Geffen School of Medicine at UCLA
4:15 PM–4:30 PM	Intestinal Microbiota Involved in Rheumatoid Arthritis Jose U. Scher, New York University Langone Medical Center
4:30 PM–4:45 PM	Discussion
5:30 PM–6:50 PM
	Public Lecture (L1) Cancer in Beluga Whales from the St. Lawrence Estuary, Québec, Canada: A Case of “One Health, One Medicine” Lecturer: Daniel Martineau, University of Montréal	Outremont