| |
P2
TAT-Mediated Delivery of a DNA Repair Enzyme to Human Skin Cells Rapidly Catalyzes Repair of UV-Induced DNA Damage
Johnson JL, Kumari A, Lowell BC, Earley L, Ryabinina OP, Lloyd RS, McCullough AK. Oregon Health and Science University, Portland, OR, United States.
P4
FANCD2 Deficiency in Human Hematopoietic Cells Increases Sensitivity to Formadehyde Toxicity
Ren X, Ji Z, Yuh J, Tang M, Bersonda J, Smith M, Zhang L. University of California, Berkeley, Berkely, CA, United States.
P6
High Levels of Transcription Stimulate A-to-C Transversions in AP Endonuclease I Deficient Yeast
Begins KJ, Lippert MJ. Saint Michael’s College, Colchester, VT, United States.
P8
The Effect of Elevated Transcription Level on the Distribution of Gross Chromosomal Rearrangement Breakpoints
Palermo MP, Lippert MJ. Saint Michael’s College, Colchester, VT, United States.
P10
The Role of Werner Syndrome Protein in Protecting against Cr(VI)-Induced Telomere Associated Instability and Mutagenesis
Liu F, Knickelbein K, Strutt S, Opresko P. University of Pittsburgh, Pittsburgh, PA, United States.
P12
Bloom Syndrome Protein and Rad51 Promote Genomic Stability
Bergeron KL, Murphy EL, Almeida KH. Rhode Island College, Providence, RI, United States.
P14
Identification of Escherichia coli MUG as a Robust Xanthine DNA Glycosylase
Lee H-W, Brice AR, Wright CB, Dominy BN, Cao W. Clemson University, Clemson, SC, United States.
P16
DNA Damage and Repair Kinetics Study of Monohaloacetonitriles in Mammalian Cells
Komaki Y, Pals J, Wagner ED, Marinas BJ, Plewa MJ. University of Illinois, Urbana, IL, United States.
P18
Bypass of N2-Deoxyguanosine Interstrand Cross-Links by Human DNA Polymerase Eta
Minko IG, Klug AR, Harbut MB, Lloyd RS. Oregon Health & Science University, Portland, OR, United States.
P20
Can the Mycobacterium Tuberculosis Ku Protein Sensitize Mammalian Cells to DNA Damage?
Castore R1, Hughes C1, DeBeaux A1, Tatchell K1, Zeng C2, Wang S-Y2, Chen D2, Harrison L1. 1LSU Health Sciences Center, Shreveport, LA, United States, 2UT Southwestern, Dallas, TX, United States.
P22
Y-Family DNA Polymerases: Heroes or Villains?
Baptiste BA, Eckert KA. Penn State College of Medicine, Hershey, PA, United States.
P24
A Novel XPD Mutation in a Compound Heterozygote Patient with Mild Sun Sensitivity
Falik-Zaccai TC2,3, Erel-Segal R2, Horev-Yakir L5, Biterman-Deutsch O2, Zohar K2, Limor K2, Slor H4, Spivak G1, Hanawalt PC1. 1Stanford University, Stanford, CA, United States, 2Western Galilee Hospital, Naharia, Israel, 3Technion, Israeli Institute of Technology, Haifa, Israel, 4Tel Aviv University, Tel Aviv, Israel, 5Hadassah Medical Center, Jerusalem, Israel.
P26
Loss of Breast Cancer Susceptibility Protein 1 (BRCA1) is Associated with an Increase in Error-Prone DNA Repair
Thompson EG, Dixon K. University of Arizona, Tucson, AZ, United States.
P28
The Potential Role of DNA Polymerase θ (POLQ) in DNA Damage Processing
Yousefzadeh MJ1,2, Takata K-I1, Wood RD1,2. 1University of Texas M.D. Anderson Cancer Center, Science Park Research Division, Smithville, TX, United States, 2University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, United States.
P30
DNA Glycosylase Expression and Modulation of PARP Inhibitor Response
Svilar D1,2, Tang J-B1, Trivedi R1,2, Wang X-H1, Goellner E1,2, Brown A1, Sobol R1,2. 1Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States, 2Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
P32
Mitochondrial Fusion and Autophagy Aid in Removal of Helix-Distorting Mitochondrial DNA Damage
Bess AS, Crocker TL, Meyer JN. Duke University, Durham, NC, United States.
P34
Disruption of Human Mitochondrial DNA Polymerase γ Replication by the Endogenous Aldehyde Adduct of DNA, M1dG
Cline SD1, Marnett LJ2, Copeland WC3. 1Mercer University School of Medicine, Macon, GA, United States, 2Vanderbilt University School of Medicine, Nashville, TN, United States, 3National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States.
P36
Artemis Over-Expression Confers Radioresistance to Both High and Low LET Exposures
Sridharan D1, Whalen M1, Almendrala D1, Cucinotta F2, Yannone SM1, Pluth JM1. 1Lawrence Berkeley National Laboratory, Berkeley, CA, United States, 2NASA, Lyndon B. Johnson Space Center, Houston, TX, United States.
P38
Double-Strand Break Repair in DNA Structure-Induced Genetic Instability
Wang G1, Kha DT1, Natrajan N1, Harrison L2, Vasquez KM1. 1Department of Carcinogenesis, University of Texas M.D. Anderson Cancer Center, Science Park, Research Division, Smithville, TX, United States, 2Department of Molecular and Cellular Physiology, Louisiana Health Sciences Center, Shreveport, LA, United States.
P40
Validation of the In Vitro Comet Assay to Screen Drug Candidates with Potential to Inhibit DNA Repair
Sawant SG. Amgen Inc., Thousand Oaks, CA, United States.
P42
Reduced Rad51 Foci Formation in Rad51D Null CHO Cells during Disruption of DNA Replication is Uncoupled from Cell Killing
Urbin SS1, Hinz JM2, Thompson LH1. 1Lawrence Livermore National Laboratory, Livermore, CA, United States, 2Washington State University, Pullman, WA, United States.
P44
Multiple Roles of ATR and ATM in a Model Replication-Stressed Stem-Cell-Niche System: Rescue of Blocked Forks vs. Activation of Programmed Death
Curtis MB, Tominey CM, Wilcox BW, Hays JB. Oregon State University, Corvallis, OR, United States.
P46
REV3L: A Specialized Mammalian DNA Polymerase Critical for Cell Survival
Lange SS, Wittschieben JP, Wood RD. Department of Molecular Carcinogenesis, University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, TX, United States.
P48
Non-B DNA-Forming Sequences and WRN Deficiency Independently Increase the Frequency of Spontaneous Base Substitution in Human Cells
Bacolla A4, Wang G4, Jain A4, Chuzhanova NA1, Cooper DN2, Bohr VA3, Vasquez KM1. 1School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom, 2Institute of Medical Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom, 3Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States, 4Department of Carcinogenesis, Science Park—Research Division, The University of Texas, M.D. Anderson Cancer Center, Smithville, TX, United States.
P50
Translesion Synthesis Past an Acrolein-Derived DNA Adduct, Gamma-Hydroxypropano-Deoxyguanosine, by Human Mitochondrial DNA Polymerase Gamma
Kasiviswanathan R1, Minko IG2, Lloyd RS2, Copeland WC1. 1Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States, 2Center for Research on Occupational and Environmental Toxicology, Oregon Health & Science University, Portland, OR, United States.
P52
DNA Repair Proteins Influence DNA Structure-Induced Genomic Instability
Zhao J1, Wang G1, Jain A1, Freudenreich CH2, Vasquez KM1. 1Department of Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, TX, United States, 2Department of Biology, Tufts University, Medford, MA, United States.
P54
Regulation of DNA Damage Responses by Chromodomain Helicase DNA Binding Protein 2
Venkatachalam S, Rajagopalan S, Samaan G. University of Tennessee, Knoxville, TN, United States.
P56
Genetic Variations in Alpha Tropomyosin Gene in HCM and DCM Patients from India
Nallari P1, Rani DS2, Calambur N3, Thangaraj K2. 1Department of Genetics, Osmania University, Hyderabad, India, 2Centre For Cellular and Molecular Biology, Hyderabad, India, 3Care Hospitals, Hyderabad, India.
P58
Association between Estrogen Receptor: A Gene & Metallothionein-1 Gene Polymorphisms in Obese Type 2 Diabetic Women of Indian Population
Ganasyam SR, Murthy S, Talluri B. Osmania University, Hyderabad, AP, India.
P60
A Rare Case of Short—Chain Acyl—CoA Dehydrogenase Deficiency: The Apparent Rarity of the Disorder Results in Under Diagnosis in the Developing Countries
Ganasyam SR, Madireddy S. Osmania University, Hyderabad, AP, India.
P62
Human Genomic Disorders: Single Events or Destabilized Meiosis?
Manchester DK. University of Colorado Denver School of Medicine, The Children’s Hospital, Aurora, CO, United States.
P64
Genetic Variation at the Human Tissue-Type Plasminogen Activator (tPA) Locus and the Risk of Stroke
Munshi A, Jyothy A. Institute of Genetics and Hospital for Genetic Diseases, OU, Hyderabad, AP, India.
P66
Role of a Single Nucleotide Polymorphism in the MMP 9 Promoter and Serum MMP 9 Levels in the Development of Gastric Cancer Disease
Venkateshwari A1, Bhayal A1, Srimanjari K1, Nallari P1, Vidyasugar A2, Jyothy A1. 1Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Hyderabad, AP, India, 2Gandhi Hospital, Secunderabad, AP, India.
P68
Genotoxicity of X-Ray Contrast Agent-Contaminated Water after Disinfection
Osiol JL1, Duirk JS2, Ternes TA3, Richardson SD2, Wagner ED1, Plewa MJ1. 1University of Illinois, Urbana, IL, United States, 2U.S. EPA, Athens, GA, United States, 3Federal Inst. Hydrology, Koblenz, Germany.
P70
Nitrosamines are Drinking Water Disinfection Byproducts: Comparison of Genotoxicity in Bacterial and Mammalian Cells
Wagner ED, Hsu K, Lagunas A, Plewa MJ. University of Illinois, Urbana, IL, United States.
P72
AZT is Predominately Clastogenic, Not Mutagenic. Results from a Seven Day Study in Rats
Zeller A1, Struwe M1, Koenig J1, Festag M1, Dertinger SD2, Gocke E1. 1F. Hoffmann-La Roche Ltd., Basel, Switzerland, 2Litron Laboratories, Rochester, NY, United States.
P74
Polymorphism Studies in CYP1A1, GSTMI, GSTTI Genes in Traffic Police Exposed to Vehicular Exhaust
Mundluru HP, Badabagni SP, Peddireddy V, Varre S, Kadali K, Penagaluru PR, Akka J. Institute of Genetics, Osmania University, Hyderabad, A.P, India.
P76
Genotoxic Damage in Oral Epithelial Cells Induced by Fluoride in Drinking-Water on Students of Tula Mexico
Vaquez-Alvarado P1, Prieto-Garcia F2, Gordillo-Martínez A2, Coronel-Olivarez C2, Ortiz-Espisnosa RM1, Hernández-Ceruelos A1. 1Instituto de Ciencias de la Salud Universidad Autónoma del Estado de Hidalgo, Pachuca, HG, Mexico, 2Instituto de Ciencias Básicas e Ingenieria, Pachuca, HG, Mexico.
P78
Micronucleus Induction by Ochratoxin A in CHO and TK6 Cells
Ali R1,2, Mittelstaedt RA1, Shaddock JG1, Bhalli JA1, Heflich RH1. 1National Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (U.S. FDA), Jefferson, AR, United States, 2National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan.
P80
Evaluation of the Mutagenic/Non-Mutagenic Pair Benzo[a]pyrene/Pyrene in the Pig-a Mutation and Micronucleated Reticulocyte Assays
Torous DK1, MacGregor JT2, Phonethepswath S1, Weller P1, Bemis JC1, Dertinger SD1. 1Litron Laboratories, Rochester, NY, United States, 2Toxicology Consulting Services, Arnold, MD, United States.
P82
Integrated Assessment of 7,12-dimethylbenz(a)anthracene (DMBA) Induced Genotoxicity by the Pig-a, Micronucleus and Comet Assays Following a 28-Day Repeated Treatment
Shi J1, Krsmanovic L1, Paranjpe M1, Bruce S1, Kelley T1, Springer S1, Sly J1, Klug M1, Arevalo M1, Atta-Safoh S1, Debelie F1, Sareen P1, Dertinger S1,2. 1BioReliance Corporation, Rockville, MD, United States, 2Litron Laboratories, Rochester, NY, United States.
P84
Searching for New Markers of Instability in the Germline of Mice: Are Simple Tandem Repeats (STR) the Needle in the Haystack?
Beal MA, Shepherd GL, Somers C. University of Regina, Regina, SK, Canada.
P86
Pig-a Mutation Assay: Evaluation of Inter-laboratory Transferability and Reproducibility
Dertinger SD1, Phonethepswath S1, Weller P1, Stankowski Jr LF2, Roberts DJ2, Shi J3, Krsmanovic L3, Vohr H-W4, Custer L5, Gleason C5, Henwood A5, Sweder K5, Giddings A6, Lynch AM6, Gunther WC7, Thiffeault CJ7, Shutsky TJ7, Fiedler RD7, Bhalli JA8, Heflich RH8. 1Litron Laboratories, Rochester, NY, United States, 2Covance Laboratories, Vienna, VA, United States, 3BioReliance, Rockville, MD, United States, 4Bayer Schering Pharma AG, Wuppertal, Germany, 5Bristol-Myers Squibb, Syracuse, NY, United States, 6GlaxoSmithKline, Ware, Hertfordshire, United Kingdom, 7Pfizer Global R&D, Groton, CT, United States, 8U.S. FDA/NCTR, Jefferson, AR, United States.
P88
Extended Recovery Periods Improve the Sensitivity of the OECD TG487 Compliant In Vitro Micronucleus Assay in TK-6 Cells
Scott AB, Dickinson DA, Homiski ML, Munzner JB, O’Lone SD, Sanok KE, Schuler MJ, Sherman JR, Sobol Z, Spellman RA. Pfizer, Inc., Groton, CT, United States.
P90
Sensitivity and Specificity of the In Vivo Rodent Micronucleus Assay towards the Detection of Rodent Carcinogens: An Updated Analysis of National Toxicology Program Data
Levy DD1, McDaniel LP2, Witt KL3. 1U.S. FDA Center for Food Safety and Applied Nutrition, College Park, MD, United States, 2U.S. FDA National Center for Toxicological Research, Jefferson, AR, United States, 3U.S. NIH National Toxicology Program, Research Triangle Park, NC, United States.
P92
The Development Program Abstract of Tradescantia Paludosa Micronucleus Research Restarted by Guangxi Institute of Botany, Academia Sinica
Mao SH, Tang WX, Luo WH, Ding L, Chen RH. Guangxi Institute of Botany, GuiLin, China.
P94
Automatic Analysis of the Micronucleus Test in Primary Human Lymphocytes Using the ROBIAS System
Frieauff W, Martus H-J, Suter W, Elhajouji A. Preclinical Safety, NIBR, Novartis Pharma AG, Basel, Switzerland.
P96
Evaluation of the Mouse Lymphoma Mutation Assay (MLA) Data of the U.S. National Toxicology Program (NTP) Using International Workshop on Genotoxicity Tests (IWGT) Criteria
Schisler MR1, Gollapudi BB1, Moore MM2. 1The Dow Chemical Company, Midland, MI, United States, 2National Center for Toxicological Research, Jefferson, AR, United States.
P98
Utility of the In Vitro Mutagenicity Assay in Muta™Mouse FE1 Cells for Regulatory Assessment of Genotoxicity
Long AS, White PA. Mechanistic Studies Division, Environmental and Radiation Health Sciences Directorate, HECSB, Health Canada, Ottawa, ON, Canada.
P100
Evaluation of Pig-a Gene Mutation Data: A Post-Hoc Analysis of Sample Size as Related to the Variability, Statistical Significance, and Biological Relevance of Observed Responses
Stankowski Jr LF, Roberts DJ, Chen H, Thakur A. Covance Laboratories, Inc., Vienna, VA, United States.
P102
Measuring DNA Damage in 3D Human Skin Models Using the Comet Assay
Downs T1, Reus A2, Reisinger K3, Krul Cyrille2, Pfuhler S1. 1Procter & Gamble Co., Cincinnati, OH, United States, 2TNO Quality of Life, Zeist, Netherlands, 3Henkel AG & Co KgaA, Dusseldorf, Germany.
P104
Altered Expression Levels of Mitochondria-Related Genes in Acrylamide- and Glycidamide-Treated Transgenic Big Blue Mice
Desai VG1, Lee T2, Moland CL1, Branham WS1, Fuscoe JC1, Ali AA3, Collins JB4, Shelton SD5, Manjanatha MG5. 1Center for Functional Genomics, Division of Systems Biology, National Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (U.S. FDA), Jefferson, AR, United States, 2Department of Information and Mathematics, Korea University, Jochiwon, Chungnam, Republic of Korea, 3Toxicology Pathology Association, Jefferson, AR, United States, 4Office of Scientific Coordination, NCTR, U.S. FDA, Jefferson, AR, United States, 5Division of Genetic Toxicology, NCTR, U.S. FDA, Jefferson, AR, United States.
P106
Formaldehyde Exposure Alters MicroRNA Expression Profiles in Human Lung Cells
Rager JE, Smeester L, Jaspers I, Sexton KG, Fry RC. University of North Carolina, Chapel Hill, NC, United States.
P108
In Vitro Evaluation of Carcinogenic and Genotoxic Properties of Chemicals Using a Transcriptomics-Based Approach
Magkoufopoulou C, Jennen DGJ, Claessen SMH, Kleinjans JCS, van Delft JHM. Department of Health Risk Analysis and Toxicology, Netherlands Toxicogenomics Center, Maastricht University, Maastricht, Netherlands.
P110
Adaptations of the In Vitro Cytochalasin-B Micronucleus Assay for Nanoparticle Testing
Gonzalez L1, Sanderson BJS2, Kirsch-Volders M1. 1Vrije Universiteit Brussel, Brussels, Belgium, 2Flinders University, Adelaide, Australia.
P112
Identifying Concomitant Metals in Dust, Urine, and Fingernails from Children in Detroit, Michigan
Sanders AP1, Gallagher JE2, McGee J2, Rhoney S2, Hudgens E2, Fry RC1. 1University of North Carolina, Chapel Hill, Chapel Hill, NC, United States, 2U.S. Environmental Protection Agency, Research Triangle Park, NC, United States.
P114
Lessons Learned from Late Mutagenicity Testing of Lead Pharmaceutical Series
Diehl M, Sonders P, Vasudevan A, Nicolette J. Abbott Laboratories, Abbott Park, IL, United States.
P116
Analysis of Genetox Structural Alerts
Patlewicz G2, Myatt G1. 1Leadscope, Columbus, OH, United States, 2DuPont, Newark, DE, United States.
|
General Information