Breakfast Meetings

DNA Repair and Mutagenic Mechanisms Special Interest Group

New Technologies Special Interest Group

Exhibit Hall Open

Networking Room Open

Symposium 4
Genetic Polymorphisms in Metabolism of Xenobiotics: Implications for Health Risk Assessment of Drugs and Environmental Agents

Contributing Sponsor: Office of Rare Diseases, NIH

Chairpersons: Babasaheb R. Sonawane, U.S. Environmental Protection Agency and
William Slikker, Jr., National Center for Toxicological Research, U.S. FDA

Role of Genetic Polymorphism in Metabolism of Drugs and Environmental Agents in Disease and in Health Risk Assessment
Speaker: Babasaheb R. Sonawane, U.S. Environmental Protection Agency

Benzene Induced Hematotoxicity: Susceptibility Genes and DNA Repair Mechanisms
Speaker: LuoPing Zhang, University of California, Berkeley

Organophosphate Pesticide Gene-Environment Interactions: Lessons Learned and Future Challenges
Speaker: William C. Griffith, University of Washington

Break

Genetic Variation at the N-acetyltransferase (NAT) Genes in Global Populations
Speaker: Holly Mortensen, National Center for Computational Toxicology,
ORD, U.S. EPA

Polymorphisms in ATP-Binding Cassette (ABC) Transporters:
Tangier Disease and Other High-Density Lipoprotein Deficiencies
Speaker: Berverly Lyn-Cook, Office of Regulatory Activities, NCTR, U.S. FDA

Genetic Polymorphisms and Population Distribution: Phase I and
Phase II Xenobiotic Enzymes: Implications of Health Assessments
Speaker: Gary Ginsberg, Connecticut Department of Public Health

Panel Discussion

Symposium 5
The Comet Assay: Theory and Application Studies on the Public Health and the Environment

Chairperson: Diana Anderson, University of Bradford, UK

Introduction
Speaker: Diana Anderson, University of Bradford, UK

Overview of the Use of Comet Assay in Occupational and
Environmental Human Monitoring: a Mexican Experience
Speaker: Emilio Rojas, Universidad Nacional Autonoma de Mexico

Use of Single Cell Gel Electrophoresis Assays in Human Intervention Trials for the Detection of DNA Protective Dietary Components
Speaker: Siegfried Knasmueller, The Medical University of Vienna, Austria

Break in Exhibit Hall

The Effect of Zinc Oxide and Titanium Dioxide Nanoparticles in
the Comet Assay with UVA Photoactivation of Human Sperm and
Lymphocytes
Speaker: Diana Anderson, University of Bradford, UK

Human Cell Toxicogenomic Analysis of the Monohaloacetic Acid Drinking Water Disinfection By-Products
Speaker: Michael J. Plewa, University of Illinois at Urbana-Champaign

Genomic DNA Damage and Repair Induced by Paint Thinner in Human Lymphocytes
Speaker: Luz Stell Hoyos, Univesidad del Cauca, Colombia

Lunch Meetings

Student and New Investigator Brunch

Chairpersons: Olga Kovalchuk, University of Lethbridge and Catherine B. Klein, New York University School of Medicine

Executive Board Meeting

EMM Editorial Board

Lunch on Own

Committee Meeting

Hollaender Committee

Chairperson: Mats Ljungman, The University of Michigan Medical School

Symposium 6
Genetic Toxicology in the 21^st Century

Contributing Sponsor: Research Corporation for Science Advancement

Chairpersons: Brinda Mahadevan, Schering-Plough Research Institute and Raymond Tice, National Institute of Environmental Health Sciences

Evolution of Genetic Toxicology from Ames to Toxicogenomics
Speaker: Ronald D. Snyder, Schering-Plough Research Institute

The Use of Quantitative High Throughput Screens (qHTS) in
Genetic Toxicology
Speaker: Raymond R. Tice, National Institute of Environmental Health
Sciences

Chemical and Biological Profiling Approaches for Exploring Mutagenicity and Carcinogenicity of EPA ToxCast^TM Chemicals
Speaker: Ann M. Richard, National Center for Computational
Toxicology, ORD, U.S. EPA

In Silico Genotoxicity Prediction in the Pharmaceutical Industry: 
Current Practice and Future Directions
Speaker: Raymond A. Kemper, Boehringer Ingelheim Pharmaceuticals, Inc.

Computational Approaches for Predicting Genetic Toxicity/ Cancer
Speaker: R. Daniel Benz, U.S. Food and Drug Administration

Symposium 7
Environmental Effects on the Germline: Classic Genetics Meets Epigenetics

Contributing Sponsors: National Institute of Allergy and Infectious Disease, NIH and Office of Rare Diseases, NIH

Chairpersons: Carole Yauk, Health Canada and Yuri E. Dubrova, University of Leicester

The Hunt for Epialleles
Speaker: Vardhman K. Rakyan, Barts and The London School of Medicine and Dentistry

Human Sperm Chromosomal Damage: Causes and Consequences
Speaker: Andrew J. Wyrobek, Lawrence Berkeley National Laboratory

Transgenerational Genetic Instability and Epigenetic Effects
Speaker: Yuri E. Dubrova, University of Leicester

Histone Hyperacetylation Preceeds Spermatocyte Apoptosis Induced by Methoxyacetic Acid
Speaker: Micheal Wade, Health Canada

Platform Session 1
DNA Damage/Repair

Platform presenter designated by underlined author.

Chairperson: Erik Larson, Illinois State University

Role of Chromatin Remodeling in DNA Damage Responses and Tumor Suppression
Venkatachalam S, Rajagopalan S, Samaan G, Stebbins N, Donnell R

The Chromatin Architecture behind Somatic Hypermutation
Borchert GM, Larson ED

Is Ionizing Radiation Induced Microhomology Mediated End Joining Dose-Dependent?
Scuric Z, Schiestl RH

DNA Double Strand Break Repair Pathways and Its Dependence on Cell Cycle Phases in Human Lymphoblastoid Cells
Honma M, Takashima Y, Sakuraba M, Sakamoto H, Koizumi T, Hayashi M

Role of Homologous Recombinational Repair in Radiosensitivity through the Cell Cycle in CHO Cells
Wilson PF, Hinz JM, Urbin SS, Nham PB, Thompson LH

Platform Session 2
Toxicogenomics Gene Expression

Platform presenter designated by underlined author.

Time-Course Study of MicroRNA Gene Expression in Liver of Mice Treated with One Dose of N-ethyl-N-nitrosourea
Li Z, Shi L, Pearce M, Wang Y, Guo L, Branham WS, Chen T

Age and Sex Differences in Hepatic Gene Expression during the Rat Life Cycle
Kwekel JC, Melvin CD, Desai VG, Branham WS, Moland CL, Han T, Fuscoe JC

Liver Gene Expression Changes in Mice Exposed to Acrylamide
Mei N, McDaniel LP, Guo L, Dial SL, Manjanatha MG

Activation of FA-BRCA1 Pathway by Intracellular Alcohol Metabolism: Implications for Alcohol-Related Cancers
Abraham J, Marietta C, Brooks PJ

Clinical Molecular Diagnosis in the Era of Massively Parallel Sequencing: A Personalized Cancer Oncology Program
Sommer S

Plenary Lecture 3
The Structural Logic of DNA Repair Enzymes

Contributing Sponsor: Office of Rare Diseases, NIH

Chairperson: Priscilla K. Cooper, Lawrence Berkeley National Laboratory

Lecturer: Tom E. Ellenberger, Washington University School of Medicine

Poster Session 2 and Exhibits
Even numbered abstracts attended

Committee Meetings

Awards and Honors Committee

Chairperson: Andrew B. Buermeyer, Oregon State University

Education, Student, and New Investigator Affairs Committee

Chairpersons: Olga Kovalchuk, University of Lethbridge and Catherine B. Klein, New York University School of Medicine

Public Relations and Communications Committee

Chairpersons: Mugimane Manjanatha, National Center for Toxicological Research, U.S. FDA and Pamela Lee, SRI International