Breakfast Meetings

EMS Executive Board

Molecular Epidemiology Special Interest Group

Leaders: Radim J. Sram, Institute of Experimental Medicine and
Miriam Poirier, National Cancer Institute

Risk Assessment Special Interest Group

Leaders: Nagu Keshava, U.S. Environmental Protection Agency and
David A. Eastmond, University of California, Riverside

Symposium 8
The DNA Damage Response as a Therapeutic Target

Contributing Sponsor: National Institute of Allergy and Infectious Diseases, NIH and Office of Rare Diseases, NIH

Chairpersons: Mats Ljungman, University of Michigan and Robert G. Bristow, University of Toronto

The DNA Damage Response as a Therapeutic Target
Speaker: Mats Ljungman, University of Michigan

Contextual Synthetic Lethality: Exploiting Hypoxia and the DNA
Damage Response for Novel Therapeutics
Speaker: Robert G. Bristow, University of Toronto

Exploiting Homologous Recombination Repair Defects in Cancer Cells
Speaker: Natalia Isaeva, University of Michigan

DNA Damage Mimetics: Safe Substitutes for Conventional
Genotoxic Anticancer Drugs
Speaker: Andrei V. Gudkov, Roswell Park Cancer Institute

The Intimate Relationship between Base Excision Repair and NAD⁺ Biosynthesis in the Response to Chemotherapy-Induced DNA Damage
Sobol RW, Tang J, Goellner EM, Wang X, Trivedi RN, St. Croix CM, Jelezcova E, Brown AR. University of Pittsburgh, Pittsburgh, PA, United States

Symposium 9
Aneuploidy: Cancer Cause or Consequence?

Contributing Sponsor: Office of Rare Diseases, NIH

Chairpersons: Maik J. Schuler, Pfizer Inc. and Ofelia A. Olivero, National Cancer Institute, NIH

Centrosomal Amplification (CA)
Speaker: Ofelia A. Olivero, National Cancer Institute, NIH

Characterizing Aneugens by Flow Cytometry
Speaker: Maik J. Schuler, Pfizer Inc.

Aneuploidy, Chromosome Instability and Tumor Biology: The Telomere Connection
Speaker: Jeffrey L. Schwartz, University of Washington Medical Center

Aneuploidy in Carcinogenesis: Evidence for an Unstable Tetraploid Intermediate in the Development of Cervical Cancer
Speaker: David A. Eastmond, University of California, Riverside

Centrosomal Amplification Induced by Nucleoside Reverse Transcriptase Inhibitors (NRTIs) in Cultured Human Breast Epithelial MCF 10A Cells
Davila K^1,2, Yu M², Poirier MC², Olivero OA². ¹University of Texas San Antonio, San Antonio, TX, United States, ²National Cancer Institute, Bethesda, MD, United States

Early and Persistent Estrogen-Induced Epigenetic Dysregulation Underlies Genome Instability in the Rat Mammary Gland
Kutanzi K, Koturbash I, Kovalchuk O. University of Lethbridge, Lethbridge, AB, Canada

EMS Business Meeting

Travel Awards Presented

Lunch on Own

Plenary Lecture 4
DNAzyme and Aptamer Sensors for On-site and Real-time Detection of a Broad Range of Environmental Toxins

Lecturer: Yi Lu, University of Illinois

Symposium 10
Assessing the Relative Cancer Risks of Genotoxic and Non-Genotoxic Exposures in Light of
Mixed Mechanisms of Action

Chairpersons: Barbara L. Parsons, National Center for Toxicological Research, U.S. FDA and
Andrew D. Kligerman, U.S. Environmental Protection Agency

Introduction
Speaker: Andrew D. Kligerman, U.S. Environmental Protection Agency

Theoretical Implications of Polyclonal Tumor Origin and Tumor-
Associated Mutations, Which are Not Rare Events, in Interpreting
Chemical Mode of Action
Speaker: Barbara L. Parsons, National Center for Toxicological Research,
U.S. FDA

Genomic Instability Induced By Low-Dose Ionizing Radiation, the
Oxidative Response, and Tumor Necrosis Factor-Alpha
Speaker: Catherine F. Gibbons, U.S. Environmental Protection Agency

MicroRNA Expression and Genomic Gene Expression, Rather
Than DNA Adduct and Mutation Induction, Indicate the Carcinogenic Tissue of Aristolochic Acid in Rats
Speaker: Tao Chen, National Center for Toxicological Research, U.S. FDA

Epigenetic Alterations in Radiation Induced Genomic Instability
Aypar U¹, Morgan WF², Baulch JE¹. ¹University of Maryland School of Medicine, Baltimore, MD, United States, ²Pacific Northwest National Laboratory, Richland, WA, United States

Symposium 11
Development and Application of Rapid Detection Devices for Environmental Toxins

Primary Sponsor: U.S. Department of Homeland Security

Chairperson: Lance R. Brooks, U.S. Department of Homeland Security

Rapid and Multiplex Detection of Biothreat Toxin Agents in Environmental Samples
Speaker: Kodumudi Venkat Venkateswaran, Radix BioSolutions

Introduction to the Human Micronucleus Project (HUMN)
Speaker: Errol Zeiger, Errol Zeiger Consulting

The Micronucleus Assay in Buccal Cells as a Tool for Biomonitoring Genetic Damage in Human Populations
Speaker: Nina Holland, School of Public Health, University of California, Berkeley

Requirements for Automation of the Human Micronucleus Cytome Assay for High Throughput Analysis
Speaker: Micheline Kirsch-Volders, Laboratory for Cell Genetics, Vrije Universiteit Brussel

Development of an Integrated Genome-Wide Assay to Detect Copy Number Mutations Generated by Exposure to Chemical Stressors
Freeman JL, Peterson S. Purdue University, West Lafayette, IN, United States

Effect of Extreme Low Dose Radiation in Wet Condition Detected by Trad-MCN Assay
Ma TH, Davies BM. Western Illinois University, Macomb, IL, United States

Symposium 12
Advanced Technologies for Cancer Epidemiology

Chairpersons: Miriam C. Poirier, Laboratory of Cancer Biology and Genetics, NCI, NIH and
Rao L. Divi, Division of Cancer Control and Population Sciences, NCI, NIH

The Epigenetic Status of Subfamilies of DNA Repeats as Differentiation—Independent Metrics for Genome Instability in Cancer Epidemiology
Speaker: Paul Lizardi, Yale University School of Medicine

Bridging the Gap from Emerging Laboratory Technologies to Bio-
Repositories for Epidemiologic Studies
Speaker: Graham Colditz, Alvin J. Siteman Cancer Center

Applying Phenotypic Carcinogen Biomarkers in Epidemiology
Studies
Speaker: Stephen S. Hecht, University of Minnesota

NCI Funding Opportunities for Cancer Epidemiology
Speaker: Mukesh Verma, National Cancer Institute

Elucidating the Relationship between the Effects of Various Radiation Qualities and Surrogate Cancer Endpoints Using Novel Flow-Based Assays
Whalen MK, Sridharan D, Pluth JM. Lawrence Berkeley National Lab, Berkeley, CA, United States

Development of a High Throughput DNA Damage Quantification Assay for Characterization of Chemotherapeutic Sensitivity and DNA Repair Capacity
Wood DK, Weingeist DM, Bhatia SG, Engelward BP. Massachusetts Institute of Technology, Cambridge, MA, United States

Symposium 13
Epigenome and the Environment: From Understanding the Mechanisms to Risk Assessments

Contributing Sponsor: National Institute of Allergy and Infectious Diseases, NIH and Office of Rare Diseases, NIH

Chairpersons: Olga Kovalchuk, University of Lethbridge and Catherine B. Klein, New York University School of Medicine

Nutrition and Carcinogenesis: Epigenomic Approaches to Cancer
Prevention
Speaker: Igor Pogribny, National Center for Toxicological Research, U.S.
FDA

Epigenetic Changes Underlie Organismal Adaptation to Changing
Environments
Speaker: Igor Kovalchuk, University of Lethbridge

Persistence of Epigenetic Changes Induced by Chronic
Submicromolar Arsenic
Speaker: Catherine B. Klein, New York University School of Medicine

Role of Epigenetic Deregulation in Radiation-Induced Genome Instability and Carcinogenesis
Speaker: Olga Kovalchuk, University of Lethbridge

Cash Bar/Networking

EMS Banquet

Awards Presentation by President Priscilla K. Cooper

Alexander Hollaender Award

EMS Award

EMS Service Award