Breakfast Meetings

DNA Repair Special Interest Group

Agenda

Epigenetics Special Interest Group

Agenda

Transgenic & In Vivo Mutagenesis Special Interest Group

Agenda

Symposium 1
Transcription Meets DNA Damage

Contributing Sponsor: NASA Space Radiation Program, NASA Johnson Space Center

Transcription Encumbrances and Their Implications for Human Disease
Speaker: Philip C. Hanawalt, Stanford University

Cellular Responses to Transcription Stalling
Speaker: Mats Ljungman, The University of Michigan Medical School

RNA Polymerase Encounters with DNA Damage: Assembly of Repair Factors and Chromatin Remodellers for Transcription-Coupled Repair
Speaker: Leon H.F. Mullenders, Leiden University Medical Center

Break

Cellular Complexes of TCR Proteins, RNA Polymerase II, and the BER Glycosylase NEIL2
Speaker: Altaf H. Sarker, Lawrence Berkeley National Laboratory

DNA-PK Interacts With and Phosphorylates XPG and is Required for Recovery of RNA Synthesis After UV
Speaker: Kelly S. Trego, Lawrence Berkeley National Laboratory

XPD Structural Biology and Insights into the Cancer, Development, and Aging Defects from XPD Mutations
Speaker: John A. Tainer, Lawrence Berkeley National Laboratory and The Scripps Research Institute

DNA Adducts as Mediators of Human Disease and Structural Probes of Transcription Mechanism
Speaker: P.J. Brooks, National Institutes of Health

Symposium 2
Systems Toxicology: An Emerging Approach for Investigating Mechanisms of Toxicity and Risk Assessment

Contributing Sponsors: Pfizer Inc. and U.S. Environmental Protection Agency

Chairpersons: Jiri Aubrecht, Pfizer Inc. and Martyn T. Smith, University of California, Berkeley

Systems Toxicology: An Emerging Approach for Investigating Mechanisms of Toxicity and Risk Assessment
Speaker: Jiri Aubrecht, Pfizer Inc. and Martyn T. Smith, University of California, Berkeley

Toward Agent-Specific Signatures: Pathway Analysis of Molecular Responses to Stress With a Systems Biology Approach
Speaker: Al Fornace, Georgetown University, Washington DC

Systems Approaches for Evaluating Genotoxic and Carcinogenic Mechanisms, Current Status and Application for Risk Assessment
Speaker: Jiri Aubrecht, Pfizer Groton, CT

Toxicogenomic Analysis of Carcinogenic Mechanisms In vivo—Potential Utility for Cancer Risk Assessment
Speaker: Heidrun Ellinger-Ziegelbauer, Bayer Healthcare, Germany

Break

Toxicogenomic Studies in Humans Using a Systems Biology Approach: Benzene as an Example
Speaker: Martyn Smith, University of California, Berkeley

Experimental Pharmacogentic Approaches to Understand Toxic Responses in Populations
Speaker: Ivan Rusyn University of North Carolina, Chapel Hill

Opportunities for Progress in the Applications of Mechanistic Information in Risk Assessment
Speaker: Kate Z. Guyton: US EPA

Symposium 3
Mode-of-Action Cancer Research and Risk Assessment: A Case Study Using Propylene Oxide

Primary Sponsor: American Chemical Council: Global PO Toxicology Research

Chairpersons: Lynn H. Pottenger, The Dow Chemical Company and Rita Schoeny, U.S. Environmental Protection Agency

Mode-of-Action Cancer Research & Risk Assessment: A Case Study Using Propylene Oxide: Review of Research Strategy
Speaker: Lynn H. Pottenger, The Dow Chemical Company

A Physioloical Toxicokinetic Model for Inhaled Propylene Oxide
Speaker: Johannes G. Filser, GSF-Institute of Toxicology, Munich

Review of Research Results on Propylene Oxide Mode of Action Studies
Speaker: James A. Swenberg, University of North Carolina, Chapel Hill

Propylene Oxide: Genotoxicity Profile of a Rodent Nasal Carcinogen
Speaker: Richard J. Albertini, University of Vermont

Break

Propylene Oxide: Integration of MOA Data Into a Cancer Rist Assessment
Speaker: Michael L. Gargas, The Sapphire Group, Inc.

Mode of Action/Human Relevance Analysis for Incorporating Mechanistic Data in Human Health Risk
Speaker: Vicki Dellarco, Office of Pesticide Program, U.S. EPA

Panel Discussion

Lunchtime Workshop
Rapid In Vivo Mutation Analysis Using the Endogenous PIG-A Gene

Contributing Sponsors: Litron Laboratories, National Center for Toxicological Research, U.S. FDA, and TEIJIN Pharma Limited

Chairpersons:  Richard J. Albertini, University of Vermont and James T. MacGregor, Toxicology Consulting Services

Introduction to the Pig-A Gene and its Function
Speaker: James T. MacGregor, Toxicology Consulting Services

Development of a High Throughput Assay for Use in Preclinical Testing
Speaker: Stephen D. Dertinger, Litron Laboratories

Molecular Aspects and Potential Advantages of Pig-A Gene High Throughput Assay in the Rat
Speaker: Daishiro Miura, Teijin Pharma

PIG-A as a Reporter Gene for Somatic Mutations in Humans
Speaker: Richard J. Albertini, University of Vermont

Using PIG-A Mutation as a Biomarker in a Human Biomonitoring Study
Speaker: Radim J. Sram, Institute of Experimental Medicine, Prague

Lunchtime Workshop
Women in Environmental Mutagen Society (WEMS)

Contributing Sponsor: Office of Research in Women's Health, National Institutes of Health

Chairpersons: Glenda J. Gentile, University Arizona and Janice M. Pluth, Lawrence Berkeley National Laboratory

Workshop Keynote Speaker
Are Science Based Regulations Putting Science at Risk?
Speaker: Katherine S. Squibb, University of Maryland School of Medicine

Lunch and Networking

Committee Meetings

2009 Program Committee (first meeting)

Membership and Professional Development Committee

Education, Student and New Investigator Affairs Committee

Finance and Resource Committee

SIG Leader Meeting

Symposium 4
Consequences of Genotoxic Damage to Mitochondrial DNA

Contributing Sponsor: The Ellison Medical Foundation

Chairperson: Bennett Van Houten, University of Pittsburgh, Cancer Institute

Mitochondrial DNA Mutagenesis in Mitochondrial Diseases Due to Defects in DNA Polymerase Gamma
Speaker: William C. Copeland, National Institute of Environmental Health Sciences, NIH

Random Mitochondrial Mutations in Human Age—Dependent Pathologies
Speaker: Lawrence A. Loeb, University of Washington

Keeping DNA on Track at ROS Central: Repair of Oxidized Abasic Sites in Mitochondrial DNA
Speaker: Bruce Demple, Harvard University

Mitochondrial DNA Damage is a Hallmark of Chemically-Induced and the R6/2 Transgenic Models of Huntington's Disease
Speaker: Sylvette Ayala-Torres, University of Puerto Rico

The Use of C. elegans to Study Mitochondrial DNA Damage, Fission/Fusion Events and Autophagy
Speaker: Joel N. Meyer, Duke University

Altered Gene Expression and DNA Damage In Peripheral Blood Cells from Friedreich’s Ataxia Patients
Speaker: Bennett Van Houten, University of Pittsburgh, Cancer Institute

Symposium 5
Insights Into Germline Mutagenesis

Contributing Sponsor: NASA Space Radiation Program, NASA Johnson Space Center

Chairperson: Steve S. Sommer, City of Hope

Germ Cells Mediate Untargeted Mutagenesis In the Maternal Genome of Progeny
Speaker: Richard N. Winn, Aquatic Biotechnology and Environmental Laboratory

Germline Indelogenesis Reflects Error-Prone Processes
Speaker: Victoria Buettner, City of Hope

When Is a Mutation Hot Spot Not a Hot Spot: Germline Selective Advantage of Unexpectedly Common Human Disease Mutations
Speaker: Norman Arnheim, University of Southern California

Micronutrients and Antioxidants Intake Affect Semen Quality and Genetic Integrity of Sperm in Healthy Non-Smoking Men
Speaker: Francesco Marchetti, Lawrence Berkeley National Laboratory

Symposium 6
Global Warming and Environmental Health

Contributing Sponsor: National Institute of Environmental Health Sciences

Chairperson: Nina T. Holland, University of California, Berkeley and Christopher J. Portier, National Institutes of Health Sciences, NIH

Research Gaps for Environmental Health Science: Facing Global Warming
Speaker: Christopher J. Portier, National Institutes of Health Sciences, NIH

Assessing Links Between Air Pollution, Climate Change, and Public Health Using Atmospheric Chemical Transport Models
Speaker: Jason West, University of North Carolina, Chapel Hill

Biomarkers of Air Pollution in the Age of Global Warming
Speaker: Nina T. Holland, University of California, Berkeley

Plenary Lecture (PL1)
The Unique Vulnerabilty of the Developing Human Brain to Early Neurotoxic Exposures
Plenary Lecturer:  Philip J. Landrigan, Mount Sinai School of Medicine