Breakfast Meetings

Germ Cell, Stem Cell, and Human Genetics Special Interest Group (GeSteHuG SIG)

Agenda

New Technologies Special Interest Group

Agenda

Student and New Investigator Breakfast

Symposium 7
Global Health in the Americas: The Impact of the Environment

A Symposium Showcasing Latin American Scientists

Contributing Sponsors: March of Dimes, National Cancer Institute, and NASA Space Radiation Program, NASA Johnson Space Center

Chairpersons: Graciela Spivak, Stanford University and Ofelia A. Olivero, National Cancer Institute, NIH

Discussant: Helena Groot, Universidad de Los Andes, Bogota, Columbia

Introduction
Speaker: Graciela Spivak (Argentina), Stanford University

Genetic Diversity of Latin American Populations
Speaker: Andrés Ruiz-Linares (Columbia), University College London

Arsenic as a Diabetes Inductor
Speaker: Patricia Ostrosky Wegman, Universidad Nacional Autonoma de Mexico, Mexico

Nuclear Neighborhoods and Chromosome Translocations
Speaker: Gustavo A. Folle, Instituto De Investigaciones Biologicas Clemente Estable, Uruguay

Break

Centrosome Amplification: A New Endpoint?
Speaker: Ofelia A. Olivero (Argentina), National Cancer Institute, NIH

DNA Repair in Caulobacter crescentus
Speaker: Carlos F. Menck, University of Sao Paulo, Brazil

A Pesticide or its Commercial Formula, Which of the Two is More Deleterious?
Speaker: Marcelo L. Larramendy, Universidad Nacional de la Plata, Argentina

New Insights Into the Role of DNA Repair in Breast Cancer
Speaker: Jaime L. Matta, Ponce School of Medicine, Puerto Rico

Symposium 8
Formaldehyde and Leukemia: Epidemiology, Potential Mechanisms, and Implications for Risk Assessment

Primary Sponsor: U.S. Environmental Protection Agency

Chairpersons: Babasaheb Sonawane, U.S. Environmental Protection Agency and Luoping Zhang, University of California, Berkeley

Formaldehyde and Leukemia: Epidemiology, Potential Mechanisms, and Implications for Rist Assessments
Speaker: Babasaheb Sonawane, U.S. Environmental Protection Agency

An Overview of Formaldehyde Exposure and Leukemia
Speaker: Luoping Zhang, University of California, Berkeley

Epidemiology of Formaldehyde and Leukemia
Speaker: Laura Beane-Freeman, National Cancer Institute, NIH

DNA Damage Response to Formaldehyde
Speaker: Jun Nakamura, University of North Carolina

Break

Detection of Formaldehyde-DNA Adducts in Rats and Humans
Speaker: Stephen S. Hecht, University of Minnesota

Uncertainties in the Health Risk Evaluation of Formaldehyde
Speaker: John Vandenberg, U.S. Environmental Protection Agency

Panel Discussion
Speaker: Martyn T. Smith, University of California, Berkeley

Symposium 9
Methylphenidate Treatment of ADHD: Are Pediatric Patients at Risk of Induced Genetic Damage?

Contributing Sponsors: National Center for Toxicological Research, U.S. FDA, National Institute of Child Health and Human Development and National Institute of Environmental Health Sciences

Chairpersons: Donald R. Mattison, National Institute of Child Health and Human Development, NIH and Michael D. Shelby, National Institute of Environmental Health Sciences, NIH

Organizers: Kristine L. Witt, National Institute of Environmental Health Sciences, NIH and Suzanne M. Morris, National Center for Toxicological Research, U.S. FDA

Introduction and Overview of the Best Pharmaceuticals for Children Act (BPCA)
Speaker: Donald R. Mattison, Institute of Child Health and Human Development, NIH

CERHR Evaluations of Methylphenidate and Amphetamines
Speaker: Michael D. Shelby, National Institute of Environmental Health Sciences, NIH

Attention Deficit/Hyperactivity Disorder (ADHD) and its Treatment
Speaker: Benedetto Vitiello, National Institute of Mental Health

Chromosomal Aberrations, Sister Chromatid Exchanges, and Micronucleus Frequencies in Lymphocytes of Pediatric ADHD Patients Treated with Stimulant Drugs.
Speaker: Kristine L. Witt, National Institute of Environmental Health Sciences, NIH

Factors to Consider When Evaluating the Cytogenetic Effects of Methylphenidate Treatment in Pediatric Patients
Speaker: James D. Tucker, Wayne State University

Break

The Genetic Toxicology and Pharmacokinetics of MPH in Non-Human Primates
Speaker: Suzanne M. Morris, National Center for Toxicological Research, U.S. FDA

Genotoxicity of Methylphenidate Hydrochloride in Big Blue Mice
Speaker: Mugimane Manjanatha, National Center for Toxicological Research, U.S. FDA

Recent Experiences in Pediatric Drug Development and Safety Issues with Methylphenidate and Other Drugs
Speaker: William J. Rodriguez, U.S. Food and Drug Administration

Pharmacological Effects of Methylphenidate in the Developing Primate
Speaker: William Slikker, Jr., National Center for Toxicological Research, U.S. FDA

Summary
Speakers: Donald R. Mattison, National Institute of Child Health and Human Development, NIH and Michael D. Shelby, National Institute of Environmental Health Sciences, NIH

Buffet Lunch with Exhibitors

Open Time

Committee Meetings

Awards Committee

Hollaender Committee

Public Relations and Communications Committee

Publications Policy Committee

Mutagenesis by Error-Prone DNA Polymerase I: Optimization and Applications
Alexander D., Allen J., Marquette J., Troll C., Camps M.

Effect of p53 Codon-72 Polymorphisms on Radiation Responses In Vitro (Apoptosis, Cell Cycle Progression, Chromosome Damage), and In Vivo (Cancer Risk, Graft-Versus-Host Disease)
Schwartz J.L., Slovik J., Whiteside T., Plotnik D., Leisenring W.M., Deeg H.J., Friedman D.L.

Non-B DNA Structure-Induced Genetic Instability in Mammalian Cells
Wang G., Vasquez K.

Mrell Nuclease Activity has Essential Roles in DNA Repair and Genomic Stability Distinct from ATM Activation
Buis J, Wu Y, Ferguson DO. Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI, United States

The D160N Gastric Cancer-Associated Variant of DNA Polymerase Beta Induces Cellular Transformation and Genomic Instability
Sweasy J.B., Donigan K.

Replication of Cisplatin-Induced DNA Lesions: A Mutagenic Event
Leising J., Berdis A.

Enhancing the Effectiveness of Chemotherapeutic Agents by Inhibiting Pro-Mutagenic DNA Synthesis
Berdis A., Ramos-Serrano A.

Cell Death and Cell Cycle Pathways as Potential Targets for Tumor Suppression by Pol Iota: A Systems Biology Approach
Stallons L.J., Kalbfleisch T.S., McGregor W.G.

Symposium 10
DNA Damage in Neurodegeneration, Aging and Cancer

Contributing Sponsor: The Ellison Medical Foundation

Chairpersons: Laura J. Niedernhofer, Univeristy of Pittsburgh Cancer Institute and Patricia L. Opresko, University of Pittsburgh

Role of MRE11 in Dysfunctional Telomere-Initiated DNA Damage Response and Repair
Speaker: Laura J. Niedernhofer, Univeristy of Pittsburgh Cancer Institute

Aging and Cancer in Mouse Models of Telomere Dysfunction
Speaker: Sandy Chang, MD Anderson Cancer Center

The Werner Syndrome Protein in Telomere Preservation and Repair
Speaker: Patricia L. Opresko, University of Pittsburgh

DNA Double-Strand Break Repair in Drosophila: Alternative Pathways, Aging, and Cancer
Speaker: Mitch McVey, Tufts University

Base Excision Repair in Cancer Susceptibility and Neurodegeneration
Speaker: David M. Wilson III, National Institute on Aging, NIH

A Toxic Oxidation Cycle: Aging in Huntington’s Disease
Speaker: Cynthia McMurray, Mayo Clinic

Symposium 11
New Perspectives and Issues Emerging from 30 Years of Research on Drinking Water Disinfection By-Products

Contributing Sponsor: U.S. Environmental Protection Agency

Epidemiologic Studies of Cancer and Disinfection Byproducts
Speaker: Kenneth P. Cantor, National Cancer Institute, NIH

Formation and Occurrence of Disinfection By-Products
Speaker: Susan D. Richardson, U.S. Environmental Protection Agency

Genotoxicity of Disinfection By-Products in Drinking Water
Speaker: Michael J. Plewa, University of Illinois

Carcinogenicity of Disinfection By-Products and Research Needs
Speaker: David M. DeMarini, U.S. Environmental Protection Agency

Mode of Action and Risk Assessment of Emerging Disinfection By-Products
Speaker: Rita Schoeny, U.S. Environmental Protection Agency

Discussion

Dinner on Own

Plenary Lecture (PL2)
Aging and Cancer: Are Telomeres and Telomerase the Connection?
Speaker: Jerry W. Shay, University of Texas Southwestern Medical Center

Contributing Sponsor: NASA Space Radiation Program, NASA Johnson Space Center

Poster Session II and Exhibits