Germ Cells and Human Disease

Recent Papers in Germ Cell Research from GeSteHug members:

Ahuja, A.K., Barber, R.C., Hardwick R.J., Weil, M.M., Genik, P.C., Brenner, D.J., Dubrova, Y.E. The effects of Atm haploinsufficiency on mutation rate in the mouse germline and somatic tissue. Mutagenesis, 23, 367–370, 2008.

Allen, D., Herbert, D.C., McMahan, C.A., Rotrekl, V., Sobol, R.W., Wilson, S.H., and Walter, C.A. Mutagenesis is elevated in male germ cells obtained from DNA polymerase-beta heterozygous mice. Biol Reprod. 79824–831, 2008.

Barber, R.C., Hardwick, R.J., Shanks, M.E., Glen, C.D., Mughal, S.K., Voutounou, M., Dubrova, Y.E. The effects of in utero irradiation on mutation induction and transgenerational instability in mice. Mutat. Res. 664, 6–12, 2009.

Dubrova, Y.E., Hickenbotham, P., Glen, C.D., Monger, K., Wong, H-P., Barber, R.C. Paternal exposure to ethylnitrosourea results in transgenerational genomic instability in mice. Environ. Mol. Mutagen. 49, 308–311, 2008.

Elespuru, R.K and Sankaranarayanan, K. New approaches to assessing the effects of mutagenic agents on the integrity of the human genome. Mutation Research 616: 83–89, 2007.

Hardwick, R.J., Tretyakov, M.V., Dubrova, Y.E. Age-related accumulation of mutations supports a replication-dependent mechanism of spontaneous mutation at tandem repeat DNA loci in mice. Mol. Biol. Evol. 26, 2647–2654, 2009.

Leland, S., Nagarajan, P., Polyzos, A., Thomas, S., Samaan, G., Donnell, R., Marchetti, F., Venkatachalam, S. Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice. PNAS, 106:12776–12781, 2009.

Marchetti, F., Essers, J., Kanaar, R., Wyrobek, A.J. Disruption of maternal DNA repair increases sperm-derived chromosomal aberrations. PNAS, 104:17725–17729, 2007.

Marchetti, F., Wyrobek A.J. DNA repair decline during mouse spermiogenesis results in the accumulation of heritable DNA damage. DNA Repair, 7:572–581, 2008.

Marchetti, F., Bishop, J., Xiu, L., Wyrobek A.J. Chromosomal mosaicism in mouse two-cell embryos after paternal exposure to acrylamide. Tox. Sci., 107:194–205, 2009.

Piña-Guzman, B., Sanchez-Gutierrez, M., Marchetti, F., Hernandez-Ochoa, I., Solis-Heredia, M.J., Quintanilla-Vega, B. Methyl-parathion decreases sperm function and fertilization capacity after targeting spermatocytes and maturing spermatozoa. Tox. Appl. Pharmacol., 238:141–149, 2009.

Polyzos., A., Schmidt, T.E., Piña-Guzman, B., Quintanilla-Vega, B., Marchetti, F. Differential sensitivity of male germ cells to mainstream and sidestream tobacco smoke. Tox. Appl. Pharmacol., 237:298–305, 2009.

Rubes, J., Rybar, R., Prinosilova, P. Veznik, Z., Chvatalova, I., Solansky, I., Sram, R.J. Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution. Mutat. Res., 283, 9–5, 2010.

Shanks, M., Riou, L., Fouchet, P., Dubrova, Y.E. Stage-specificity of spontaneous mutation at a tandem repeat DNA locus in the mouse germline. Mutat. Res., 641, 58–60, 2008.

Shanks, M.E., May, C.A., Dubrova, Y.E., Balaresque, P., Rosser, Z.H., Adams, S.M., Jobling, M.A. Complex germline and somatic mutation processes at a haploid human minisatellite shown by single-molecule analysis. Mutat. Res. 2008 Sep 25.

Somers C.M., Valdes E.V., Kjoss V.A., Vaillancourt A.L., Quinn J.S. Influence of a contaminated fish diet on germline-expanded-simple-tandem-repeat mutation frequency in mice. Environ. Mol. Mutagen. 49:238–248. 2008.

Somers, C.M., Cooper, D.N. Air pollution and mutations in the germline: are humans at risk? Human Genetics, 125:119–130, 2009.

Verhofstad, N., Linschooten, J.O., van Benthem, J., Dubrova, Y.E., van Steeg, H., van Schooten, F.J., Godschalk, R.W.L. New methods for accessing male germ line mutations in humans and genetic risks in their offspring. Mutagenesis, 23, 241–247, 2008.

Wade, M., Lee, A., Williams, A., Yauk, C.L. Methoxyacetic Acid-Induced Spermatocyte Death Is Associated with Histone Hyperacetylation, Bio. Repro. 78(5), 822–31, 2008.

Wyrobek, A.J., Mulvihill, J.J., Wassom, J.S., Malling, H.V., Shelby, M.D., Lewis, S.E., Witt, K.L., Preston, R.J., Perrault, S.D., Allen, J.W., DeMarini, D.M., Woychik, R.P., Bishop, J.B., Assessing human germ-cell mutagenesis in the postgenome era: A celebration of the legacy of William Lawson (Bill) Russell. Environ. Mol. Mutagen. 48, 71–95, 2007.

Yauk, C.L., Polyzos, A., Rowan-Carroll, A., Kortubash, I., Williams, A., Kovalchuk, O. Tandem repeat mutation, global DNA methylation and regulation of DNA methyltransferases in cultured mouse embryonic stem cells chronically exposed to chemicals with different modes of action. Environ. Mol. Mutagen., 49(1), 26–35, 2008.

Yauk, C.L., Polyzos, A., Rowan-Carroll, A., Somers, C.M., Godschalk, F., VanSchooten, F., Berndt, L., Pogribny, I., Kortubash, I., Williams, A., Douglas, G.R., Kovalchuk, O. Germline Mutations, DNA Damage and Epigenetic Modifications in Response to Exposure to Particulate Air Pollution in an Industrial Location. Proceedings of the National Academy of Sciences USA. 105(2), 605–10, 2008.

Young, S., Eskenazi, B., Marchetti, F., Block, G., Wyrobek, A.J. The association of folate, zing and antioxidant intake on sperm aneuploidy in healthy non-smoking men. Human Reproduction, 23, 1014–22.

Xu, G., Intano, G.W., McCarrey, J.R., Walter, R.B., McMahan, C.A., and Walter, C.A. Recovery of a low mutant frequency after ionizing radiation-induced mutagenesis during spermatogenesis. Mutat. Res., 654, 150–157, 2008.