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P2
Functional Analysis of Chromodomain-Helicase-DNA-Binding Protein 2 (CHD2) Mediated Genomic Stability
Rajagopalan S1, Nagarajan P2, Samaan G1, Nepa J1, Venkatachalam S1. 1The University of Tennessee, Knoxville, TN, United States, 2The Ohio State University, Columbus, OH, United States
P4
Assessment of DNA Damage and Repair in Human Lymphocytes of Melanoma Patients Exposed In Vitro to Cisplatin
Shimabukuro F1, Neto CF2, Sanches Jr JA2, Gattás GJ1. 1Department of Legal Medicine, Medical Ethics and Occupational Health, Medical School, University of São Paulo, São Paulo, SP, Brazil, 2Department of Dermatology, Clinics Hospital of São Paulo, São Paulo, SP, Brazil
P6
A UV-Sensitive Syndrome Patient with a Specific CSA Mutation Reveals Separable Roles for CSA in Response to UV and Oxidative DNA Damage
Spivak G1, Mortier L2, Hanawalt PC1, Sarasin A3, Stefanini M4. 1Stanford University, Stanford, CA, United States, 2Clinique de Dermatologie, Lille, France, 3Institute Gustave Roussy, Villejuif, France, 4Istituto di Genetica Molecolare, Pavia, Italy
P8
Cockayne Syndrome (CS)-A and CS-B Cells are Defective in Host-Cell Reactivation of Plasmids Containing an 8,5’(S)-Cyclodeoxyadenosine Lesion
Marietta CA, Brooks PJ. NIH, Rockville, MD, United States
P10
Human Neuroblastoma Response to UVc and Oxidative Stress, DNA Repair Implications
Ramos P, Valverde M, Rojas E. UNAM, Mexico, Mexico
P12
The Effect of UV on Templated Mutagenesis in Bacteriophage T4 Involving Imperfect Direct or Indirect Sequence Repeats
Schultz Jr GE1, Drake JW2. 1Marshall University, Huntington, WV, United States, 2NIEHS, Research Triangle Park, NC, United States
P14
Mutagenicity Studies with 4-nitropyridine in Salmonella TA100
McCoy EC. CUNY/College of Staten Island, Staten Island, NY, United States
P16
The Effect of Elevated Transcription Level on Gross Chromosomal Rearrangements in Yeast
Lippert MJ, Dolbeare CR, Palermo MR. Saint Michael's College, Colchester, VT, United States
P18
XRCC1-Mediated Single Strand Break Repair Capacity and Inflammation Associated DNA Damage
Mutamba JT, Engelward BP. MIT, Cambridge, MA, United States
P20
Bloom Syndrome Protein: A Study of Protein Partnerships
Bergeron KL, Murphy EL, Almeida KH. Rhode Island College, Providence, RI, United States
P22
DNA Damage Induced in AT Lymphoblastoid Cell Line by Exposure to Low-Dose Beta and Alpha Radiation
Villegas F1, Sordo M1, Benitez-Bribiesca L3, Brandan ME2, Ostrosky-Wegman P1. 1Instituto de Investigaciones Biomedicas, UNAM, Mexico City, Mexico, 2Instituto de Fisica, UNAM, Mexico City, Mexico, 3Instituto Mexicano del Seguro Social Siglo XXI, Mexico City, Mexico
P24
Chromosomal Aberrations in Mice Irradiated with Protons
Doppalapudi R, Menda S, Davis Z, Bakke J, Chang P. SRI International, Menlo Park, CA, United States
P26
Mutagenicity of Acrylamide and Glycidamide in Rat Thyroid
McDaniel LP, Guo XQ, Doerge DR, Heflich RH, Mei N. National Center for Toxicological Research, Jefferson, AR, United States
P28
In Vivo Comet Assay in Mouse Skin Basal Epidermal Cells
Krsmanovic L, Shi J, Paranjpe M, Bruce S. BioReliance Corporation, Rockville, MD, United States
P30
Simultaneous Measurement of Benzo[a]pyrene-Induced pigA and lacZ Mutations, and Micronuclei in Muta™Mouse
Lemieux CL1, Gingerich JD1, Soper LM1, Phonethepswath S2, Torous D2, Dertinger S2, White PA1, Douglas GR1. 1Mechanistic Studies Division, Environmental Health Sciences and Research Bureau, Health Canada, Ottawa, ON, Canada, 2Litron Laboratories, Rochester, NY, United States
P32
Genetic Variability of HVRII mtDNA in Cord Blood and Respiratory Morbidity in Children
Schmuczerova J, Brdicka R, Dostal M, Sram RJ, Topinka J. Institute of Experimental Medicine ASCR, Prague, Czech Republic
P34
Genetic Toxicology Databases and Predictive Models
Myatt GJ, Bower D, Cross KP, Quigley DP. Leadscope, Columbus, OH, United States
P36
Reduction of Misleading ("False") Positive Results in Mammalian Cell Genotoxicity Assays. II: Importance of Accurate Toxicity Measurement
Fowler P1, Williams K1, Jeffrey L1, Young J1, Carmichael P3, Aardema M4, Diembeck W5, Fautz R6, Harvey J7, Hewitt N8, Latil A9, Pfuhler S10, Ouedraogo G11, Reisinger K12, Fairley M13, Kirkland D2. 1Covance Laboratories, Harrogate, United Kingdom, 2Kirkland Consulting, Harrogate, United Kingdom, 3Unilever, Sharnbrook, United Kingdom, 4The Procter & Gamble Co., Cincinatti, OH, United States, 5Beiersdorf AG, Hamburg, Germany, 6KPSS, Darmstadt, Germany, 7GSK, Ware, United Kingdom, 8Hewitt, Erzhausen, Germany, 9Pierre Fabre, Castres, France, 10Procter & Gamble, Cosmital SA, Marly, Switzerland, 11L’Oreal Life Sciences Research, Alunay sous Bois, France, 12Henkel AG & Co KgaA, Dusseldorf, Germany, 13COLIPA, Brussels, Belgium
P38
Measurement of Multiple Genotoxic In Vivo Endpoints Using the Comet
Coffing SL, Dickinson DA, Engel ME, Gunther WC, Fiedler FD, O’Lone SD, Sanok KE, Schuler MJ, Shutsky TJ, Traverso BA, Thiffeault CJ. Pfizer, Groton, CT, United States
P40
A New Polymorphism in MicroRNA-Binding Site of CDKN2A and a Polymorphism of XPD in Malignant Melanoma Patients from Brazil
Gonçalves FT1, Francisco G2, Souza SRP3, Luiz OC3, Chammas R2, Eluf-Neto J3, Gattás GJ1. 1Departamento de Medicina Legal, Ética Médica, Medicina Social e do Trabalho, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil, 2Departamento de Radiologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil, 3Departamento de Medicina Preventiva, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil
P42
In Vivo Rat Pig-a Mutation Assessment by Flow Cytometry: Inter-Laboratory Comparison of ENU Treated Rats
Fiedler RD1, Gunther WC1, Thiffeault CJ1, Shutsky TJ1, Phonethepswath S2, Franklin D2, Raja S2, Dertinger SD2. 1Pfizer Global R&D, Groton, CT, United States, 2Litron Laboratories, Inc., Rochester, NY, United States
P44
Thalidomide Induces Germinal Mutations at Low Concentrations
Ramos-Morales P, Muñoz-Hernandez A, Rivas H, Hernandez BR, Muñoz JA. UNAM, Distrito Federal, Mexico
P46
Role of Altered Hepatic microRNA Expression in the Pathogenesis of Nonalcoholic Hepatosteatosis in Mice Induced by Methyl-Deficiency
Starlard-Davenport A, Tryndyak V, Beland F, Pogribny I. National Center for Toxicological Research, Jefferson, AR, United States
P48
Radiation-Induced Age-Related Epigenetic Changes in Mouse Liver
Montgomery BA1, Koturbash I2, Kovalchuk O2, Pogribny IP1. 1National Center for Toxicological Research, Jefferson, AR, United States, 2University of Lethbridge, Lethbridge, AB, Canada
P50
Germ Cell Mutations: Genetic Disease in Offspring of Cancer Survivors in Two Countries
Mulvihill JJ1, Boice JD2,3, Winther JF4, Malila N5, Olsen JH4, Lahteenmaki PM6, Madanat-Harjuoja L5, Sankila R5, Stovall M7, Tawn EJ8. 1University of Oklahoma Health Sciences Center, Pediatrics-Genetics, Oklahoma City, OK, United States, 2International Epidemiology Institute, Rockville, MD, United States, 3Vanderbilt University, Department of Medicine, Nashville, TN, United States, 4Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark, 5Institute for Statistical and Epidemiological Cancer Research, Finnish Cancer Registry, Helsinki, Finland, 6Turku University Hospital, Turku, Finland, 7The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, Houston, TX, United States, 8University of Central Lancashire/Westlakes Research Institute, Cumbria, United Kingdom
P52
Effect of p53 Genotype on Gene Expression in the Livers of ENU-Exposed Mice
Petibone D, Kulkarni R, Chang C-W, Morris S. National Center for Toxicological Research, Jefferson, AR, United States
P54
Development of Novel Salmonella typhimurium Tester Strain YG3206 for Selective Detection of the Mutagenicity of Oxidized DNA Pyrimidines
Yamada M, Matsui K, Katafuchi A, Takamune M, Nohmi T. National Institute of Health Sciences, Tokyo, Japan
P56
Induction of an Adaptive Response to Hydrogen Peroxide in Yeast: Conditions of Induction, Time Course, and Dose-Response Relationships
Moczula AV, Laterza AM, MacNeil LK, Tartaglione JP, Hoffmann GR. College of the Holy Cross, Worcester, MA, United States
P58
Cyanogen Halide Drinking Water Disinfection By-Products
Pals J1,2, Clay J1,2, Komaki Y1,2, Marinas B1,2, Wagner E1, Plewa MJ1,2. 1University of Illinois, Urbana, IL, United States, 2WaterCAMPWS Center, Urbana, IL, United States
P60
Appraisal of Comet Tail Length in Pesticide Exposed Cotton Field Females during Picking Season
Ali T1, Bhalli JA2, Khan QM1. 1National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan, 2National Centre for Toxicological Research (NCTR), Jefferson, AR, United States
P62
The Comet Assay: Breaking with Tradition
Vasquez MZ. Helix3 Inc., Morrisville, NC, United States
P64
Photogenotoxicity Evaluation in the In Vitro Micronucleus Assay Using Human Peripheral Blood Lymphocytes
Farabaugh CS, Chan MM, Valliere AN, Middendorf CA, Roy SK, Stankowski Jr LF. Covance Laboratories, Inc., Vienna, VA, United States
P66
Different Approaches to Automation of the In Vitro Micronucleus Assay Using Image Analysis
Homiski M, Rubitski E, Scott A. Pfizer Global Research & Development, Groton, CT, United States
P68
Comparison of Micronucleus Induction in Duodenum, Colon and Bone Marrow in Sprague-Dawley Rats
Coffing SL, Dickinson DA, Engel ME, Thiffeault CJ, Shutsky TJ, Spellman RA, Schuler MJ. Pfizer Global Research & Development, Groton, CT, United States
P70
Flow Cytometric In Vitro Micronucleus Scoring Provides Simultaneous Mode of Action Information
Bryce S, Avlasevich S, Raja S, Torous D, Bemis J, Dertinger S. Litron Labs, Rochester, NY, United States
P72
Evaluation of Proposed Cytotoxicity Endpoints for the In Vitro Mammalian Micronucleus Assay in the Presence and Absence of Cytochalasin B in CHO and TK-6 Cells
Thiffeault C, Boyes RW, Cheung JR, Dickinson DA, Engel ME, Sherman J, Schuler MJ. Pfizer, Groton, CT, United States
P74
Improving Genotoxicity Testing: Comet Assay with 3D Skin Models
Reisinger K1, Krul C2, Ouédraogo G3, Puhler S4, Reus A2, Zeller A4, Corvi R5, Carmichael P6, Hewitt N7, Aardema M8, Diembeck W9, Fautz R10, Harvey J11, Latil A12, Marrec-Fairley M13. 1Henkel AG & Co KgaA, Duesseldorf, Germany, 2TNO-Quality of Life, Zeist, Netherlands, 3L’Oréal, Aulnay-sous-Bois, France, 4Procter & Gamble-Cosmital SA,, Marly, Switzerland, 5EC/JRC/ECVAM, Ispra, Italy, 6Unilever, Sharnbrook, United Kingdom, 7SWS, Erzhausen, Germany, 8The Procter & Gamble Co., Cincinnati, OH, United States, 9Beiersdorf AG, Hamburg, Germany, 10KPSS-Kao Professional Salon Services, Darmstadt, Germany, 11GSK, Ware, United Kingdom, 12Institut de Recherche, Pierre Fabre, France, 13COLIPA, Brussels, Belgium
P76
Successful Transfer of Cytotoxicity Assessment by Flow Cytometry (FCM) Confirms Superior Reproducibility of Mitotic Index (MI) Measurements
Roberts DJ1, Spellman RA2, Sanok K2, Chen H1, Chan M1, Yurt P1, Thakur AK1, Devito GL2, Murli H1, Stankowski Jr LF1. 1Covance Laboratories, Genetic & Molecular Toxicology Department, Vienna, VA, United States, 2Pfizer Global Research and Development, Groton, CT, United States
P78
Enhanced Susceptibility to Genotoxic Damage in Wistar Han Rats Compared to Fischer 344/N Rats
Hobbs CA1, Recio L1, Shepard K1, Baldetti C1, Winters J1, Green A1, Allen P1, Streicker M2, Caspary W3, Witt KL3. 1Genetic Toxicology Division, Integrated Laboratory Systems, Inc., Research Triangle Park, NC, United States, 2Investigative Toxicology Division, Integrated Laboratory Systems, Inc., Research Triangle Park, NC, United States, 3Biomolecular Screening Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States
P80
Technologies for Assessing Exposures and Health Risks from Hazardous Air Pollutants in Communities
Ward Jr JB1, Olaguer EP2. 1University of Texas Medical Branch, Galveston, TX, United States, 2Houston Advanced Research Center, The Woodlands, TX, United States
P82
Bulky DNA Adducts Induced by Tobacco Smoke and Environmental Pollutants in Mothers and Their Transplacental Transfer to the Foetus
Topinka J1, Milcova A1, Libalova H1, Novakova Z1, Rossner Jr P1, Balascak I2, Sram RJ1. 1Institute of Experimental Medicine ASCR, v.v.i., Prague, Czech Republic, 2Charles University, Prague, Czech Republic
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