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P1
Mapping Localization of Base Excision Repair Machinery to Sites of Genomic DNA Damage in Saccharomyces cerevisiae
Morris LP, Degtyareva N, Doetsch PW. Emory University, Atlanta, GA, United States
P3
Molecular Analysis of Chd2 in Tumor Suppression
Samann G, Venkatachalam S. University of Tennessee, Knoxville, TN, United States
P5
Exogenous Replication Stress Induces Genome-Wide Copy Number Changes in Mitotic Human Cells
Arlt MF1, Ozdemir AC1, Mulle JG1, Schaibley VM1, Warren ST1, Wilson TE1, Glover TW1. 1University of Michigan, Ann Arbor, MI, United States, 2Emory University, Atlanta, GA, United States
P7
A Novel, Defective Recombination Phenotype Specific to WRN Deficient Cells
Rahn JJ, Della-Coletta L, Lowery M, Limanni TD, Adair GM, Nairn RS. UT MD Anderson Cancer Center, Science Park Research Division, Smithville, TX, United States
P9
Comparative DNA Damage and Repair Kinetics Study in Mammalian Cells by Chloro-, Bromo-, and Iodoacetic Acid
Komaki Y, Pals J, Wagner E, Marinas B, Plewa MJ. University of Illinois, Urbana, IL, United States
P11
Development of an EGFP Reporter System to Study Homologous Recombination in Mice In Vivo
Sukup Jackson MR, Matsuguchi T, Jonnalagadda V, Engelward B. Massachusetts Institute of Technology, Cambridge, MA, United States
P13
Lack of Genotoxicity of Three Different Preparations of Aloe Barbadensis by the Salmonella/E. coli Mutagenicity (Ames) Assay
Swartz CD1, Recio L1, Green A1, Lentz C1, Witt KL2. 1Integrated Laboratory Systems, Research Triangle Park, NC, United States, 2National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States
P15
Transcription-Associated Base Substitution Mutations in Yeast
Lippert MJ, Begins KJ, Stott AR. Saint Michael's College, Colchester, VT, United States
P17
Bhas-42 Initiator and Promoter Cell Transformation Assay with 3-MCA and TPA
Pant K, Bruce SW, Sly JE, Klug ML, Springer SD, Cecil MW, Hsu CS. BioReliance, Rockville, MD, United States
P19
Cytogenetic Alterations and Changes of Global DNA Methylation Induced by Leukemogenic Chemicals In Vitro
Ji Z, Zhang L, Smith M. Division of Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, CA, United States
P21
Evidence Suggesting that Delayed HGPRT Mutations Induced by EMS Treatment of CHO Cells are Produced by a Different Mechanism than Early Mutations
Perez ML, Stamato TD. Lankenau Institute for Medical Research, Wynnewood, PA, United States
P23
N-acetyl Cysteine Protects against Ionizing Radiation-induced DNA Damage but Not against Cell Killing in Yeast and Mammals
Reliene R, Pollard JM, Sobol Z, Trouiller B, Gatti RA, Schiestl RH. University of California Los Angeles, Los Angeles, CA, United States
P25
Acrylamide and Glycidamide Induce cII Gene Mutations in Lung Tissue of Big Blue Mice
Guo L, Shelton S, Moore M, Manjanatha M. National Center for Toxicological Research, Jefferson, AR, United States
P27
ACB-PCR Measurement of K-Ras Codon 12 GAT Mutation in Rat Liver and Kidney Exposed to Aristolochic Acid
Wang Y, Mei N, Chen T, Parsons BL. US FDA, National Center for Toxicological Research, Jefferson, AR, United States
P29
Polymorphism of NAT2 Slow Acetylator Genotypes in Pesticide Exposed and Control Population of Northern India
Singh S1, Kumar V2, Thakur S1, Banerjee BD2, Grover SS1, Rawat DS1, Pasha ST3, Jain SK1, Rai A1. 1National Institute of Communicable Diseases, Delhi, India, 2University College of Medical Sciences & GTB Hospital, University of Delhi, Delhi, India, 3National Programme for Prevention and Control of Fluorosis, Delhi, India
P31
Benzo(a)pyrene (BP)-DNA Adduct Formation in XPA(-/-)p53(+/-) Transgenic Mice
John K, Pratt MM, McMullen G, Poirier MC. National Cancer Institute, NIH, Bethesda, MD, United States
P33
Molecular Evidence for DNA Damage in Chemical-Induced Bystander Effects
Asur R, Thomas R, Tucker J. Wayne State University, Detroit, MI, United States
P35
Reduction of Misleading ("False") Positive Results in Mammalian Cell Genotoxicity Assays. I: Choice of Cell Type
Fowler P1, Williams K1, Jeffrey L1, Young J1, Carmichael P3, Aardema M4, Diembeck W5, Fautz R6, Harvey J7, Hewitt N8, Latil A9, Pfuhler S10, Ouedraogo G11, Reisinger K12, Fairley M13, Kirkland D2. 1Covance laboratories, Harrogate, United Kingdom, 2Kirkland Consulting, Harrogate, United Kingdom, 3Unilever, Sharnbrook, United Kingdom, 4The Procter & Gamble Co., Cincinatti, OH, United States, 5Beiersdorf AG, Hamburg, Germany, 6KPSS, Darmstadt, Germany, 7GSK, Ware, United Kingdom, 8Hewitt, Erzhausen, Germany, 9Pierre Fabre, Castres, France, 10Procter & Gamble, Cosmital SA, Marly, Switzerland, 11L'Oreal Life Sciences Research, Aulnay sous Bois, France, 12Henkel AG & Co KGaA, Dusseldorf, Germany, 13COLIPA, Brussels, Belgium
P37
Validation of a Multi-Endpoint Assay in Rats: Bone Marrow Micronucleus, Comet and Flow Cytometric Peripheral Blood Micronucleus
Bowen DE1, Whitwell JH1, Henderson D1, Mcgarry S1, Kidd D1, Pearce G1, Lillford L1, Kirkland DJ1, Torous D2. 1Covance, Harrogate, United Kingdom, 2Litron Laboratories, Rochester, NY, United States
P39
Cytogenetic and Molecular Biomonitoring of Sprayers Exposed to Pesticides in Cotton Fields in Pakistan
Bhalli JA1,2, Khan QM2, Khalid ZM2. 1Division of Genetic and Reproductive Toxicology, National Center for Toxicology Research, Jefferson, United States, 2Environmental Toxicology Lab., National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan
P41
Performance Validation of the Peripheral Blood Human Lymphocyte Micronucleus Assay Using the Draft OECD 487 Guideline Reference Chemical List
Whitwell J, Smith R, Lloyd M, Allars S, Kirkland D. Covance Laboratories Ltd, Harrogate, United Kingdom.
P43
Genotoxicity Assessment of Heavy Metal Mixtures by Lemna minor L
Cvjetko P1, Tkalec M1, Sikic S2, Tolic S2, Vidakovic-Cifrek Z1, Pavlica M1. 1Faculty of Science, University of Zagreb, Zagreb, Croatia, 2Institute of Public Health, Zagreb, Croatia
P45
Metabolomics in Risk Assessment
Vulimiri SV, Sonawane B. U.S. Environmental Protection Agency, Washington, DC, United States
P47
Effects of High and Low LET Radiation Exposure on DNA Methylation
Goetz W, Morgan MNM, Belliveau BJ, Baulch JE. University of Maryland, Department of Radiation Oncology, Baltimore, MD, United States
P49
Fractionated Exposure to Low Doses of Ionizing Radiation Causes Region-Specific Genetic and Epigenetic Changes in Murine Brain and Leads to Altered Behavioral Patterns
Koturbash I, Jadavji N, Kutanzi K, Rodriguez-Juarez R, Kogosov D, Metz G, Kovalchuk O. University of Lethbridge, Lethbridge, AB, Canada
P51
Comparison of MicroRNA Expression Profiles from Large and Small Colony Thymidine Kinase Mutants of L5178Y Mouse Lymphoma Cells
Chen Y, Li Z, Chen T, Moore MM. FDA/NCTR, Jefferson, AR, United States
P53
Effect of P53 Genotype on Gene Expression Profile in Murine Testis
Kulkarni R, Petibone DM, Chang CW, Morris SM. National Center for Toxicological Research, Jefferson, AR, United States
P55
Comparison of the Preincubation and Plate Incorporation Methods in the MicroAmes: Lessons for Drug Discovery Screening
Wells M, Soelter SG, Schlosser MJ. Midwest BioResearch, Division of WIL Research Laboratories, Skokie, IL, United States
P57
Swimming in DBPS: Genotoxicity of Water Concentrates from Recreational Pools after Various Disinfection Methods
Wagner E1, Liviac D2, Lagunas A1,4, Mitch W3, Plewa MJ1,4. 1University of Illinois, Urbana, IL, United States, 2Universitat Autònoma de Barcelona, Barcelona, Spain, 3Yale University, New Haven, CT, United States, 4WaterCAMPWS Center, Urbana, IL, United States
P59
Use of the In Vivo Comet Assay to Evaluate Methyleugenol-Induced DNA Damage in Various Tissues of the Rat
Ding W1, Manjanatha M1, Lyn Cook L1, Bishop M1, Levy D2, Aidoo A1. 1FDA National Center for Toxicological Research, Jefferson, AR, United States, 2FDA Center for Food Safety and Applied Nutrition, College Park, MD, United States
P61
The Combined In Vitro and Acellular Comet Assay: Understanding the Mechanisms of Genotoxicity in Heterogeneous In Vivo Cell Populations
Vasquez MZ, Dewhurst N. Helix3 Inc., Morrisville, NC, United States
P63
Development of an OECD/GLP Compliant In Vitro Micronucleus Assay in TK-6 Cells
Scott AS, Cheung JC, Coffing SC, Muehlbauer PM, Schuler MS, Sobol JS, Spellman RS. Pfizer, Inc., Groton, CT, United States
P65
COLIPA Validation of the Reconstructed Human Skin Micronucleus Assay (RSMN): A Novel Micronucleus Assay in a 3D Human Skin Model
Aardema M1, Khambatta Z1, Barnett B1, Pfuhler S1, Reisinger K2, Quedraogo G3, Faquet B3, Mun G4, Dahl E4, Curren R4, Carmichael P5, Diembeck W6, Fautz R7, Harvey J8, Hewitt N9, Latil A10, Marrec-Fairley M11. 1The Procter & Gamble Co, Cincinnati, OH, United States, 2Henkel AG & Co KGaA, Duesseldorf, Germany, 3L'Oreal, Aulnay sous Bois, France, 4Institute for In Vitro Sciences, Inc, Gaithersburg, MD, United States, 5Unilever, Sharnbrook, United Kingdom, 6Beiersdorf AG, Hamburg, Germany, 7KPSS-Kao Professional Salon Services, Darmstadt, Germany, 8GSK, Ware, United Kingdom, 9Consultant, Erzhausen, Germany, 10Pierre Fabre, Toulose, France, 11Colipa, Brussels, Belgium
P67
Evaluation of 26 Chemicals Using Two Automated In Vitro Micronucleus Image Analysis Platforms against the Proposed OECD Guideline 487
Rubitski E, Engel M, Sherman J, Tartaro K, Wiersch C, Homiski M, Schuler M. Pfizer Global Research & Development, Groton, CT, United States
P69
Flow Cytometry Analysis of Responses in the In Vitro Micronucleus Assay
Mittelstaedt RA, Shaddock JG, Heflich RH. USFDA/National Center for Toxicological Research, Jefferson, AR, United States
P71
In Vitro Micronucleus Screening of Pharmaceutical Candidates by Flow Cytometry in Chinese Hamster V79 Cells
Nicolette J1, Bryce S2, Diehl M1, Sonders P1, Blomme EA1. 1Abbott Laboratories, Abbott Park, IL, United States, 2Litron Laboratories, Rochester, NY, United States
P73
Combining the
In Vivo Comet and Micronucleus Assays: A Practical Approach to Genotoxicity Testing and Data Interpretation
Vasquez MZ. Helix3 Inc., Morrisville, NC, United States
P75
Genetic Polymorphism of Phase I Metabolizing Enzymes and its Influence on DNA Damage in Pesticide Exposed Subjects
Singh S1, Kumar V2, Thakur S1, Banerjee BD2, Grover SS1, Rawat DS1, Pasha ST3, Jain SK1, Rai A1. 1National Institute of Communicable Diseases, Delhi, India, 2University College of Medical Sciences & GTB Hospital, University of Delhi, Delhi, India, 3National Programme for Prevention and Control of Fluorosis, Delhi, India
P77
Pig-a Mutation and Micronucleus Scoring by Flow Cytometry: Integration into an Acute Dosing Schedule
Phonethepswath S1, Franklin D1, Raja S1, Torous D1, Bryce S1, Bemis J1, MacGregor J2, Dertinger S1. 1Litron Laboratories, Rochester, NY, United States, 2Toxicology Consulting Services, Arnold, MD, United States
P79
In Vitro Cytotoxicity and Genotoxicity Testing of Gold Nanoparticles
Chung Y-S1, Kim JE2, Lee S2, Kang JS3, Yum YN2, Park SN2. 1Medvill Research Institute, Medvill Co., Ltd., Seoul, Republic of Korea, 2National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration, Seoul, Republic of Korea, 3Department of Biomedical Laboratory Science, Namseoul University, Cheonan, Republic of Korea
P81
Genotoxic Consequences of ABVD Treatment in Hodgkin’s Disease: Analysis of Chromosomal Aberrations by M-FISH
Frias S1, Ramos S1, Navarrete P1, Castro O1, Mendoza SP1, Molina B1, Avila S2, Largo C2, Lozano V3, Gallardo E4. 1Instituto Nacional de Pediatría, México City, Mexico, 2Laboratorio Genetadi, Bilbao, Spain, 3Instituto Nacional de Cancerología, México City, Mexico, 4Hospital General de México, México City, Mexico
P83
Relative Mutagenicity of Cigarette Smoke Condensates in Mouse Lymphoma Cells
Guo XQ1, Verkler TL1, Mei N1, Richter PA2, Polzin GM3, Moore MM1. 1National Center for Toxicological Research, Jefferson, AR, United States, 2National Center for Chronic Disease Prevention and Health Promotion, Atlanta, GA, United States, 3National Center for Environmental Health, Atlanta, GA, United States |
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