Saturday Workshop 1
Bacterial Mutagenicity Screening for Discovery Support and Drug Candidate Selection

Separate Registration Required

Contributing Sponsor : sanofi aventis

Organized by: New Technologies Special Interest Group

Chairpersons: Patricia A. Escobar, Boehringer Ingelheim Pharmaceuticals and Brinda Mahadevan, Schering-Plough Research Institute

Introduction
Patricia A. Escobar, Boehringer Ingelheim Pharmaceuticals

Mini-Ames Assay in Six Well Plates
Speaker: John J. Nicolette, Abbott Laboratories

Cross-Validation Results from the Miniaturized Ames Studies
Speaker: Satin G. Sawant, Amgen, Inc.

Bacterial Mutagenicity Screening Technology (BioLum Ames)
Speaker: Michelle Kenyon, Pfizer, Global Research and Development

The Merck Experience with the Ames MPF Assay and its Correlation with the Standard Ames and the 5-Fluorouracil (FU) Assay
Speaker: Timothy E. Johnson, Merck Research Laboratories

The Use of Ames II ™ Screening Assay for Drug Development
Speaker: Knut Braun, sanofi aventis

Break

Performance of the SOS Chromotest as an Initial Mutagenicity Screen
Speaker: Laura L. Custer, Bristol-Myers Squibb

The SOS/umu Test: Experience Screening Pharmaceutical Research Compounds
Speaker: Michael O’Donnavan, AstraZenca

Summary of the Case Studies
Speaker: Brinda Mahadevan, Schering-Plough Research Institute

Panel Discussion /Concluding Remarks
Moderator: Sheila M. Galloway, Merck Research Laboratories

Saturday Workshop 2
Gene Mutation Assays Based on the Endogenous Pig-A Locus

Separate Registration Required

Contributing Sponsors: ILSI-HESI, Project Committee on Relevance and Follow-up of Positive Results in In Vitro Genetic Toxicity (IVGT) Testing, Litron Laboratories, and sanofi aventis

Welcome
Speakers: Stephen D. Dertinger, Litron Laboratories and Robert H. Heflich, National Center for Toxicological Research, U.S. FDA

Historical Perspective: From Studying PNH Etiology to Mutagenesis
Speaker: Russell E. Ware, St. Jude Children’s Research Hospital

Gene Mutation Assays Based on the Endogenous Pig-A Locus: Rodent Mutation Data, Kinetics, DNA Sequencing Results
Speaker: Daishiro Miura,TEIJIN Pharma Limited

Rodent RBC-Based Assay, Inter-Laboratory Trial Update
Speakers: Stephen D. Dertinger, Litron Laboratories and Ronald D. Fiedler, Pfizer Global Research & Development

ILSI-HESI Perspective on Assay’s Preclinical Value
Speaker: James H. Kim, ILSI Health and Environmental Sciences Institute

Break

Human Blood-Based Assay, RBCs
Speaker: Vasily N. Dobrovolsky, National Center for Toxicological Research, U.S. FDA

PIGA: A Novel Reporter Gene for the Molecular Epidemiology of Cancer
Speaker: Vernon E. Walker, BioMosaics Inc.

Panel Discussion

Plenary Lecture 1
National Science Education Policy (40th Anniversary Event)

Chairperson: Michael J. Plewa, University of Illinois at Urbana-Champaign

Introductory Comments
Speaker: Michael J. Plewa, University of Illinois at Urbana-Champaign

Rising Above the Gathering Storm: Scientific Societies Must Meet the Challenge
Speaker: James M. Gentile, Research Corporation for Science Advancement

Welcome Reception and Student and New Investigator Poster Session

Contributing Sponsor: Genetic Toxicology Association