Speaker: Jeffrey L. Schwartz, University of Washington
9:30 AM–11:30 AM
Centennial III Ballroom
PLATFORM SESSION 1: DNA Damage and Repair
(presenting author is in italics)
Abstracts 1 – 8
A Novel Target for Human Exonuclease1 (hExo1) in Class Switch RecombinationVallur A, Maizels N
Physical and Functional Interaction of NEIL2 With XPG, CSB and RNA Polymerase II: Implications for Transcription-Coupled Repair of Oxidative DNA Damage Sarker A, Hazra T, Haltiwanger B, Ng C, Nogales E, Sankar M, Cooper P
Telomeric Protein POT1 Regulates Processing of Telomeric Ends by the Werner Syndrome Helicase/Exonuclease
Sowd G, Lei M, Opresko PL
DNA Polymerase h Reduces the g-H2AX Response to Psoralen Interstrand Crosslinks in Human Cells Mogi S, Butcher CE, Oh DH
The Mismatch Repair Proteins, MSH2 and MLH1, Contribute Differently to Cellular Responses to DNA Interstrand Crosslinks in Human Cells Wu Q, Vasquez K
Impact of Pathogenic Mutations in Human MLH1 on MutLalpha Heterodimer Stability and Function in Mammalian Cells Buermeyer AB, Mohd AB, Hippchen KJ, Nelson SE, Ing B, Palama BK
Repair of Oxidative-DNA Damage and the Risk of Smoking-Related Cancers Paz-Elizur T, Elinger D, Ben-Yosef R, Krupsky M, Leitner-Dagan Y, Vexler A, Svilya Z, Schechtman E, Freedman L, Livneh Z
Generation of Mutant ABH2 Enzymes Showing Enhanced Protection Against Methylation Toxicity Camps M, Adman ET, Bower CN, Johnson BP, Lindahl T, Sedgwick B, Loeb LA
Chairpersons: David M. Wilson III, , National Institute on Aging, NIH, and
Thomas E. Schmid, Lawrence Berkeley National Laboratory
9:30 AM–11:30 AM
Centennial IV Ballroom
PLATFORM SESSION 2: Epigenetics, Germ Cells
(presenting author is in italics)
Abstracts 9-16
Role of Chromodomain Helicase DNA Binding Protein 2 in Mammalian Development and Tumorigenesis
Nagarajan P, Onami T, Rajagopalan S, Donnell R, Venkatachalam S
Variable Histone Modifications at the Viable Yellow Agouti (Avy) Metastable Epiallele
Dolinoy DC, Jirtle RL
MicroRNAome De-Regulation in Breast Cancer Drug Resistance Filkowski JN, Meservy J, Ilnytsky Y, Chekhun VF, Pogribny IP, Kovalchuk O
Epigenetic Signature of Radiation Exposure in the Male Germline
Tamminga J, Kovalchuk O
Evaluation of Spermatozoa as a Predictor of Germline Mutations Using λ Transgenic Medaka Norris MB, Winn RN
Tobacco Smoking Compromises the Genetic Integrity of Mouse Sperm Polyzos AA, Schmid TE, Piña-Guzmán B, Quintanilla-Vega B, Marchetti F
Effect of Chlorophenoxy Herbicides on Development and Growth of Drosophila melanogaster During Multi Generational Exposure
Bata MA, Blunck BM, Gienger HM, van Gijssel HE
Variance in Radiation Induced Tandem Repeat Mutation Rates Among Families and Stages of Spermatogenesis in the Medakafish Glenn TC, Tsyusko OT, Aizawa K, Yi Y, Coughlin D, Jones KL, Hinton TG, Zimbrick JD
Chairpersons: W. David Sedwick, Case Western Reserve University and
Dana C. Dolinoy, Duke University
11:30 AM–12:30 PM
Centennial IV Ballroom
PLENARY LECTURE: DNA Repair, Genetic Instability
and Cancer: What are the Connections?
Speaker: Paul Doetsch, Emory University School of Medicine
1:30 PM–3:30 PM
Centennial III Ballroom
PLATFORM SESSION 3: Mutagenesis, Carcinogenesis
(presenting author is in italics)
Abstracts 17-24
High Mobility Group Protein B1 Affects Mutagenesis and Cell Death Caused by UVC and Psoralen-Induced DNA Damage
Lange S, Vasquez K
DNA Polymerase Theta (POLQ) Can Extend From Mismatches and From Bases Opposite a (6-4) Photoproduct
Seki M, Wood R
Expression Microarray Analysis Identified Gamma-Glutamyl Transferase Expression Level as a Possible Biomarker forArsenic Sensitivity
Rossman TG, Komissarova EV, Uddin AN
Mutation Showers Over the DNA Landscape Wang J, Buettner VL, Gonzalez KD, Scaringe WA, Tsai K, Liu N, Gu D, Li W, Hill KA,Sommer SS
Intestinal Bacteria Play a Crucial Role in the Carcinogenic Risk From 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine Vanhaecke L, Knize MG, Derycke L, Le Curieux F, Bracke M, Verstraete W
SNPs in the Transcribed Regions of the Human Genome: Relative Effects of Mutability and Selection Gorlov IP, Gorlova OY, Amos CI
Evidence From Mutation Spectra That DNA Polymerase η is the Preferred Translesion DNA Polymerase and May Be Error-Free or Error-Prone Stallons LJ, Burke TJ, McGregor WG
Genotoxic Effects of Formaldehyde on Human Blood Stem and Progenitor Cells Zhang L, Guo W, Ji Z, Xin K, Yang B, Smith MT
Chairpersons: Steve S. Sommer, City of Hope and Nina Holland,
University of California, Berkeley
1:30 PM–3:30 PM
Centennial IV Ballroom
PLATFORM SESSION 4: Genotoxins, Mutagens, Antimutagens, Biodosimetry, Risk Assessment (presenting author is in italics)
Abstracts 25-32
Mode of Action Frameworks for Risk Assessment: A Critical Analysis
Guyton KZ, Barone Jr S, Brown RC, Euling SY, Jinot J, Makris S
Investigations Into the Mode of Action (MOA) of Arsenic Using the Single Cell Gel (SCG) Assay and Cytogenetics
Kligerman AD, Campbell JA, Tennant AH
Evaluation of Dosimetry and Genotoxic Effects of Low-Dose Acrylamide Exposure Using the Mouse Micronucleus Assay
Zeiger E, Recio L, Fennell T, Haseman J, Swenberg J, Marroni D, Friedman M
Multiwalled Carbon Nanotube-Induce Cytotoxicity, Genotoxicity and Apoptosis in Normal Human Dermal Fibroblast Cells Patlolla A, Tchounwou P
Use of Gene Expression Analysis Incorporating Operon-Transcriptional Coupling and Toxicant Dose Response to Distinguish Among Structural Homologues of MX Ward B, Swartz C, Hanley N, Warren S, DeMarini D
ATM Represses DNA End Degradation in an ATP-Dependent Manner Rahal E, Li Y, Henricksen LA, Turchi JJ, Dixon K
Epigallocatechin Gallate (EGCG), a Major Constituent of Green Tea, Poisons Human Type II Topoisomerases Bandele OJ, Osheroff N
Bioinformatics Analyses of Low-and High-Dose Radiation Induced Signaling Pathways in Mouse Brain Tissue as Predicted from Transcript Profiling Bhattacharya S, Marchetti F, Wyrobek AJ
Chairperson: Andrew D. Kligerman , U.S. Environmental Protection
3:45 PM–5:45 PM
Centennial III Ballroom
SYMPOSIUM 14: Base Excision Repair as a Tumor Suppressor Mechanism
Base excision repair (BER) is responsible for the repair of over 20,000
lesions per cell per day, most of which arise endogenously. DNA damage
that remains in the genome or that is not repaired correctly can result
in genomic instability, which is known to lead to cancer. This symposium
focuses on the links between compromised BER and cancer. The four speakers
cover topics ranging from cancer epidemiology to enzymatic studies
and discuss the relationship between genetic variation and skin cancer,
functional studies of BER variant proteins, and the importance of balanced
expression of BER proteins.
Chairpersons: Joann B. Sweasy, Yale University School of Medicine,
and Susan S. Wallace, University of Vermont
3:45 PM–4:15 PM
Genetic Variation in Base Excision Repair Genes in Relation to Skin Cancer Risk
Speaker: Jiali Han, Harvard University
4:15 PM–4:45 PM
Genome Stability Calls for Balanced Base Excision Repair
Protein Expression
Speaker: Robert W. Sobol, Jr., University of Pittsburgh
4:45 PM–5:15 PM
From 8-oxo-G to MAP: Insights into Lesion Recognition and
Base Removal by MutY and MUTYH
Speaker: Sheila David, University of California, Davis
5:15 PM–5:45 PM
Cancer-Associated Variants of DNA Polymerase Beta
Speaker: Joann Sweasy, Yale University School of Medicine
3:45 PM–5:45 PM
Centennial IV Ballroom
SYMPOSIUM 15: Hot Topics in Human Genetics and Ecogenetics
The aftermath of the Genome Project, as predicted, has spawned a plethora
of insights and potential applications in human and medical genetics, in
clinical and laboratory practice, as well as in public health. In this
Symposium, national leaders illustrate the progress and the challenges
across the human life span, from conception to old age.
Chairperson: John J. Mulvihill, University of Oklahoma Health Sciences
Center
3:45 PM–4:15 PM
Prenatal Genetics: Current Status
Speaker: W. Allen Hogge, University of Pittsburgh
4:15 PM–4:45 PM
Really Treating Genetic Diseases: Enzyme Replacement and
Gene Therapy
Speaker: John A. Barranger,
University of Pittsburgh
4:45 PM–5:15 PM
Oncogenes and Human Malformation Syndromes
Speaker: Margaret P. Adam, Emory University
5:15 PM–5:45 PM
Polygenic Estimation of Breast Cancer Risk
Speaker: John J. Mulvihill, University of Oklahoma
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