Registration

Saturday Workshop: On-Going Initiatives in Genetic Toxicology Testing and Risk Assessment
(Separate Registration Required)

Several regulatory and multi-stakeholder initiatives are currently underway at regional and international levels to update the genetic toxicology testing paradigm in order to enhance its utility for hazard and risk assessment. These initiatives include identification of strategies to follow-up on findings from the initial battery of in vitro tests, developing a weight of evidence approach for evaluating genotoxicity data, and the incorporation of animal alternative considerations (refine, reduce, and replace animal usage) in selecting and designing genetic toxicology studies. This workshop will provide a forum for discussing these new initiatives and how they might impact the field of genetic toxicology. The workshop will benefit not only those in industrial and regulatory settings, but also a cross-section of EMS membership by providing an update on new approaches and guidelines in genetic toxicology assessment.

Introduction

Choice of In Vivo Follow-up Testing in Case of In Vitro Positive Findings

Speaker: David Kirkland, Covance Laboratories Ltd. UK

In Vivo Comet Assay: Update on the On-Going Validation Coordinated by JaCVAM

Speaker: Yoshifumi Uno, Mitsubishi Pharma Corporation, Japan

Relevance and Follow-up of Positive Results in In Vitro Genetic Toxicity Assays: An ILSI-HESI Initiative

Speaker: Bhaskar Gollapudi, The Dow Chemical Company

Update on the Maintenance of the ICH S2 Genetic Toxicology Guidelines

Speaker: Makoto Hayashi, National Institute of Health Sciences, Japan

Break

Application of 3R’ Principle on Genetic Toxicology Evaluation: European Position for Cosmetics and Chemicals

Speaker: Raffaela Corvi, ECVAM, Italy

Application of 3R’ Principle on Genetic Toxicology Evaluation: Impact on Industry and On-Going Initiatives

Speaker: Marilyn Aardema, The Procter & Gamble Company

Use of Weight of Evidence and Mode of Action Approaches in Genetic Toxicology Risk Assessment

Speaker: Rita Schoeny, U.S. Environmental Protection Agency

Conclusion—Perspectives: Other On-Going Initiatives and Guideline Revisions

Speaker: Véronique Thybaud, Sanofi-aventis, France

Registration

Executive Board Meeting

Saturday Workshop: Predicting Chemical Carcinogenicity, Moving Beyond Batteries
(Separate Registration Required)

This workshop will present initial results from the ad hoc Working Group on Predicting Chemical Carcinogenicity and provide a forum for discussion. This ad hoc group is seeking to better identify the mechanisms of carcinogenicity, how these can be understood theoretically, and how they can be measured. The group seeks to determine whether application of greater understanding of biology and new tools, such as toxicogenomics, might improve assessment of carcinogenicity of chemicals. This workshop will present initial ideas and concepts on accelerated hazard identification. The group hopes to ultimately build support for improved methods that can support policy decisions.

The workshop objectives are:

• To discuss key developments in the understanding of cancer biology and their implications.
• To review progress to date by the Working Group on Predictive Carcinogenesis on the identification of modes of action for carcinogenesis and gain feedback.

Meeting Check In
(lunch available for registered participants)

Welcome and Review of Workshop Objectives

Speaker: Martyn T. Smith, University of California, Berkeley

Introduction of Participants

Approach of the Working Group: Overview

Speaker: Michael D. Waters, Integrated Laboratory Systems, Inc.

Where Have We Been and Where Do We Want To Go: Motivations for Change

Speakers: Bob Sonawane, U.S. Environmental Protection Agency, Office of Research and Development; and Vincent J. Cogliano, International Agency for Research on Cancer

Where Are We Now: Presentation of Mechanisms for Carcinogenesis and Critical Issues in Distinguishing Between Them

Speakers: David Eastmond, University of California, Riverside; Nagu Keshava, U.S. Environmental Protection Agency and Martha Sandy, California Environmental Protection Agency

Questions and Discussion

Impact of Recent Breakthroughs in Cancer Biology

Speaker: Martyn T. Smith, University of California, Berkeley

Break

Where Should We Go and What Do We Do Next?

Chairperson: Michael Waters, Integrated Laboratory Systems, Inc.

Predicting Animal Carcinogenicity

Speaker: Michael Waters, Integrated Laboratory Systems Inc.

In Vitro Tests to Predict Cancer

Speaker: Jiri Aubrecht, Pfizer Inc.

Biomarkers of Cancer Risk in Humans

Speaker: Luoping Zhang, University of California, Berkeley

Discussion

Future Directions: Implications for Research, Risk Assessment, and Public Policy

Speakers: Amy D. Kyle, University of California, Berkeley; and Kate Guyton, U.S. Environmental Protection Agency

Comments from Participants

Closing Comments

Chairpersons: Martyn T. Smith, University of California, Berkeley and Michael D. Waters, Integrated Laboratory Systems, Inc.

Young Investigator Workshop: Anatomy of a Successful Grant Application and a Research Project
(Separate Registration Required)

This educational session is designed to help the young investigator think about the whole grant writing process. Questions to be addressed in this workshop include: Do you have research or an idea worthy of a grant? How much preliminary data is needed? How much money do I ask for? What are NIH requirements? What does a study section really look for in a grant? How do I make my grant stand out from the competition? Do young investigators have a chance in the competition? How much of the work can I complete and still ask for a grant to fund it? And more.

Chairpersons: James S. Felton, Lawrence Livermore National Laboratory and Meredith Crosby, Yale University

Grant Application Writing Experience From a Veteran Who Has Won and Lost

Speaker: James S. Felton, Lawrence Livermore National Laboratory

Experiences of a Young Investigator

Speaker: Meredith Crosby, Yale University

NIH Extramural Grants Administrator

Speaker: Elizabeth G. Snyderwine, National Cancer Institute

Professional Grant Application Writer

Speaker: To be announced

EMS Council Meeting

Student and Postdoctoral Fellow Poster Session, Job Fair, and Welcome Reception

The Student and New Investigator Poster Session and Welcome Reception will highlight the research of students and new investigators and provide them with an extra opportunity to present and discuss their research. Alongside with the poster session, we will run a Job Fair, highlighting the opportunities that exist in the university and government labs. The concurrent job fair and poster session will allow the students and new investigators to present their research work to potential employers. The esteemed Education and Student Affairs Committee Award will be presented during this session in recognition for dedication to student activities.

This session will provide an opportunity for students and new or postdoctoral investigators to present their data to the meeting attendees prior to their formal presentation later in the week. This event is also a great time to become reacquainted with your colleagues before the meeting.

Co-Sponsored by Amgen, Inc.